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PDB: 4QW4_R
Identical Proteins FASTA Graphics
LOCUS 4QW4_R 260 aa linear PLN 20-SEP-2023 DEFINITION Chain R, Proteasome subunit alpha type-5. ACCESSION 4QW4_R VERSION 4QW4_R DBSOURCE pdb: molecule 4QW4, chain R, release Sep 20, 2023; deposition: Jul 16, 2014; class: HYDROLASE/HYDROLASE INHIBITOR; source: Mmdb_id: 126674, Pdb_id 1: 4QW4; Exp. method: X-ray Diffraction. KEYWORDS . SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. REFERENCE 1 (residues 1 to 260) AUTHORS Huber,E.M., Heinemeyer,W. and Groll,M. TITLE Bortezomib-resistant mutant proteasomes: structural and biochemical evaluation with carfilzomib and ONX 0914 JOURNAL Structure 23 (2), 407-417 (2015) PUBMED 25599643 REFERENCE 2 (residues 1 to 260) AUTHORS Huber,E.M., Heinemeyer,W. and Groll,M. TITLE Direct Submission JOURNAL Submitted (16-JUL-2014) COMMENT yCP in complex with carfilzomib. FEATURES Location/Qualifiers source 1..260 /organism="Saccharomyces cerevisiae S288C" /db_xref="taxon:559292" Region 8..222 /region_name="proteasome_alpha_type_5" /note="The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming...; cd03753" /db_xref="CDD:239722" Site order(10..13,15..16,18..19,23,26,29..30,33,41,56,58..59, 82..84,86..87,118,121,124..125,134..138,156,161..162,164, 166..167,169) /site_type="other" /note="alpha subunit interaction site [polypeptide binding]" /db_xref="CDD:239722" SecStr 14..17 /sec_str_type="sheet" /note="strand 189" SecStr 19..22 /sec_str_type="sheet" /note="strand 190" SecStr 23..33 /sec_str_type="helix" /note="helix 88" Site order(35,51,53,66,174) /site_type="active" /db_xref="CDD:239722" SecStr 35..43 /sec_str_type="sheet" /note="strand 191" SecStr 44..52 /sec_str_type="sheet" /note="strand 192" SecStr 66..71 /sec_str_type="sheet" /note="strand 193" SecStr 73..81 /sec_str_type="sheet" /note="strand 194" SecStr 86..102 /sec_str_type="helix" /note="helix 89" SecStr 109..117 /sec_str_type="helix" /note="helix 90" SecStr 139..148 /sec_str_type="sheet" /note="strand 195" SecStr 152..160 /sec_str_type="sheet" /note="strand 196" SecStr 162..167 /sec_str_type="sheet" /note="strand 197" SecStr 168..174 /sec_str_type="sheet" /note="strand 198" SecStr 176..186 /sec_str_type="helix" /note="helix 91" SecStr 193..207 /sec_str_type="helix" /note="helix 92" SecStr 216..224 /sec_str_type="sheet" /note="strand 199" SecStr 225..231 /sec_str_type="sheet" /note="strand 200" SecStr 233..248 /sec_str_type="helix" /note="helix 93" ORIGIN 1 mfltrseydr gvstfspegr lfqveyslea iklgstaigi atkegvvlgv ekratsplle 61 sdsiekivei drhigcamsg ltadarsmie hartaavthn lyydedinve sltqsvcdla 121 lrfgegasge erlmsrpfgv alliaghdad dgyqlfhaep sgtfyrynak aigsgsegaq 181 aellnewhss ltlkeaellv lkilkqvmee kldennaqls citkqdgfki ydnektaeli 241 kelkekeaae speeadvems //
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