LOCUS NP_005731 105 aa linear PRI 20-SEP-2024
DEFINITION dynein axonemal light chain 4 [Homo sapiens].
ACCESSION NP_005731
VERSION NP_005731.1
DBSOURCE REFSEQ: accession NM_005740.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 105)
AUTHORS Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
Harper,J.W. and Gygi,S.P.
TITLE Dual proteome-scale networks reveal cell-specific remodeling of the
human interactome
JOURNAL Cell 184 (11), 3022-3040 (2021)
PUBMED 33961781
REFERENCE 2 (residues 1 to 105)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 3 (residues 1 to 105)
AUTHORS Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
Clark,A.G. and Yu,H.
TITLE Extensive disruption of protein interactions by genetic variants
across the allele frequency spectrum in human populations
JOURNAL Nat Commun 10 (1), 4141 (2019)
PUBMED 31515488
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 105)
AUTHORS Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
TITLE An inter-species protein-protein interaction network across vast
evolutionary distance
JOURNAL Mol Syst Biol 12 (4), 865 (2016)
PUBMED 27107014
REMARK Publication Status: Online-Only
REFERENCE 5 (residues 1 to 105)
AUTHORS Meneret,A., Trouillard,O., Vidailhet,M., Depienne,C. and Roze,E.
TITLE Congenital mirror movements: no mutation in DNAL4 in 17 index cases
JOURNAL J Neurol 261 (10), 2030-2031 (2014)
PUBMED 25236653
REMARK GeneRIF: No mutation in DNAL4 in Congenital mirror movements.
REFERENCE 6 (residues 1 to 105)
AUTHORS Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
Roth,F.P., Braun,P. and Vidal,M.
TITLE Next-generation sequencing to generate interactome datasets
JOURNAL Nat Methods 8 (6), 478-480 (2011)
PUBMED 21516116
REFERENCE 7 (residues 1 to 105)
AUTHORS Iwasaki,M., Kuwata,T., Yamazaki,Y., Jenkins,N.A., Copeland,N.G.,
Osato,M., Ito,Y., Kroon,E., Sauvageau,G. and Nakamura,T.
TITLE Identification of cooperative genes for NUP98-HOXA9 in myeloid
leukemogenesis using a mouse model
JOURNAL Blood 105 (2), 784-793 (2005)
PUBMED 15454493
REFERENCE 8 (residues 1 to 105)
AUTHORS Collins,J.E., Goward,M.E., Cole,C.G., Smink,L.J., Huckle,E.J.,
Knowles,S., Bye,J.M., Beare,D.M. and Dunham,I.
TITLE Reevaluating human gene annotation: a second-generation analysis of
chromosome 22
JOURNAL Genome Res 13 (1), 27-36 (2003)
PUBMED 12529303
REFERENCE 9 (residues 1 to 105)
AUTHORS Yano,H., Lee,F.S., Kong,H., Chuang,J., Arevalo,J., Perez,P.,
Sung,C. and Chao,M.V.
TITLE Association of Trk neurotrophin receptors with components of the
cytoplasmic dynein motor
JOURNAL J Neurosci 21 (3), RC125 (2001)
PUBMED 11157096
REFERENCE 10 (residues 1 to 105)
AUTHORS Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
al.
TITLE The DNA sequence of human chromosome 22
JOURNAL Nature 402 (6761), 489-495 (1999)
PUBMED 10591208
REMARK Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL035366.1.
This sequence is a reference standard in the RefSeqGene project.
Summary: This gene encodes an axonemal dynein light chain which
functions as a component of the outer dynein arms complex. This
complex acts as the molecular motor that provides the force to move
cilia in an ATP-dependent manner. The encoded protein is expressed
in tissues with motile cilia or flagella and may be involved in the
movement of sperm flagella. [provided by RefSeq, Dec 2014].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AL035366.1, SRR3476690.696320.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA2142586,
SAMEA2145245 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000216068.9/ ENSP00000216068.4
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..105
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="22"
/map="22q13.1"
Protein 1..105
/product="dynein axonemal light chain 4"
/note="dynein light chain, outer arm 4; dynein, axonemal,
light polypeptide 4; proliferation-inducing gene 27;
proliferation-inducing protein 27"
/calculated_mol_wt=11878
Region 21..103
/region_name="DLC-like_DNAL4"
/note="dynein light chain (DLC)-like domain found in
axonemal dynein light chain 4 (DNAL4) and similar
proteins; cd21453"
/db_xref="CDD:412001"
CDS 1..105
/gene="DNAL4"
/gene_synonym="MRMV3; PIG27"
/coded_by="NM_005740.3:216..533"
/db_xref="CCDS:CCDS13979.1"
/db_xref="GeneID:10126"
/db_xref="HGNC:HGNC:2955"
/db_xref="MIM:610565"
ORIGIN
1 mgetegkkde adykrlqtfp lvrhsdmpee mrvetmelcv tacekfsnnn esaakmiket
61 mdkkfgsswh vvigegfgfe ithevknlly lyfggtlavc vwkcs
//