U.S. flag

An official website of the United States government

bifunctional coenzyme A synthase precursor [Danio rerio]

NCBI Reference Sequence: NP_001004577.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001004577             554 aa            linear   VRT 16-SEP-2024
DEFINITION  bifunctional coenzyme A synthase precursor [Danio rerio].
ACCESSION   NP_001004577
VERSION     NP_001004577.1
DBSOURCE    REFSEQ: accession NM_001004577.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 554)
  AUTHORS   Mignani L, Zizioli D, Khatri D, Facchinello N, Schiavone M, De
            Palma G and Finazzi D.
  TITLE     Bi-Allelic Mutations in Zebrafish pank2 Gene Lead to Testicular
            Atrophy and Perturbed Behavior without Signs of Neurodegeneration
  JOURNAL   Int J Mol Sci 23 (21), 12914 (2022)
   PUBMED   36361705
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 554)
  AUTHORS   Kamoshita M, Kumar R, Anteghini M, Kunze M, Islinger M, Martins Dos
            Santos V and Schrader M.
  TITLE     Insights Into the Peroxisomal Protein Inventory of Zebrafish
  JOURNAL   Front Physiol 13, 822509 (2022)
   PUBMED   35295584
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 554)
  AUTHORS   Kim YI, Nam IK, Lee DK, Bhandari S, Charton L, Kwak S, Lim JY, Hong
            K, Kim SJ, Lee JN, Kwon SW, So HS, Linka N, Park R and Choe SK.
  TITLE     Slc25a17 acts as a peroxisomal coenzyme A transporter and regulates
            multiorgan development in zebrafish
  JOURNAL   J Cell Physiol 235 (1), 151-165 (2020)
   PUBMED   31187491
REFERENCE   4  (residues 1 to 554)
  AUTHORS   Pagani F, Trivedi A, Khatri D, Zizioli D, Garrafa E, Mitola S and
            Finazzi D.
  TITLE     Silencing of pantothenate kinase 2 reduces endothelial cell
            angiogenesis
  JOURNAL   Mol Med Rep 18 (5), 4739-4746 (2018)
   PUBMED   30221726
  REMARK    GeneRIF: when pank2 or coasy expression was suppressed in zebrafish
            evident perturbation of neuronal development was observed, as well
            as severe defects in vasculature formation.
REFERENCE   5  (residues 1 to 554)
  AUTHORS   Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A,
            Choudhary JS, Emes RD and Grant SG.
  TITLE     Evolution of complexity in the zebrafish synapse proteome
  JOURNAL   Nat Commun 8, 14613 (2017)
   PUBMED   28252024
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 554)
  AUTHORS   Khatri D, Zizioli D, Tiso N, Facchinello N, Vezzoli S, Gianoncelli
            A, Memo M, Monti E, Borsani G and Finazzi D.
  TITLE     Down-regulation of coasy, the gene associated with NBIA-VI, reduces
            Bmp signaling, perturbs dorso-ventral patterning and alters
            neuronal development in zebrafish
  JOURNAL   Sci Rep 6, 37660 (2016)
   PUBMED   27892483
  REMARK    GeneRIF: The abrogation of coasy expression led to strong reduction
            of CoA content, high lethality and a phenotype resembling to that
            of dorsalized mutants.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 554)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081650.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081650.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505373,
                                           SAMEA3505382 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..554
                     /organism="Danio rerio"
                     /db_xref="taxon:7955"
                     /chromosome="24"
                     /map="24"
     Protein         1..554
                     /product="bifunctional coenzyme A synthase precursor"
                     /note="Coenzyme A synthase"
                     /calculated_mol_wt=59369
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2044
     Region          182..323
                     /region_name="PPAT_CoAS"
                     /note="phosphopantetheine adenylyltransferase domain of
                     eukaryotic and archaeal bifunctional enzymes; cd02164"
                     /db_xref="CDD:173915"
     Site            order(186..187,215,275)
                     /site_type="active"
                     /db_xref="CDD:173915"
     Site            192..195
                     /site_type="other"
                     /note="(T/H)XGH motif"
                     /db_xref="CDD:173915"
     Region          348..527
                     /region_name="DPCK"
                     /note="Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24)
                     catalyzes the phosphorylation of dephosphocoenzyme A
                     (dCoA) to yield CoA, which is the final step in CoA
                     biosynthesis; cd02022"
                     /db_xref="CDD:238980"
     Site            order(352,377,433,460..461,506)
                     /site_type="other"
                     /note="CoA-binding site [chemical binding]"
                     /db_xref="CDD:238980"
     Site            order(353..355,358..359,487,522)
                     /site_type="other"
                     /note="ATP-binding [chemical binding]"
                     /db_xref="CDD:238980"
     CDS             1..554
                     /gene="coasy"
                     /gene_synonym="zgc:92337"
                     /coded_by="NM_001004577.1:184..1848"
                     /db_xref="GeneID:447838"
                     /db_xref="ZFIN:ZDB-GENE-040912-137"
ORIGIN      
        1 msmfstgilv ltsplhvlpl riapvltsaa qvvertlyvh lhpglnlgtg gqvrpvyipp
       61 vvdlctlisr lysnaadicg hldvrvlltn irgqsaassa angpfpapqt lshspevvlt
      121 dfpipdsgqs slitqclrky aghcyvctpg lssvllhpql kevsgdedrg aqmkpletfs
      181 dvvvggtfdr lhgahktlln isclmanrrf iigvcdqell knkvlkelie pydqrveklh
      241 dflndvkpsl kydivplsdp fgpsitepel qcivvseetr kggeavnkrr vqnglaelvl
      301 yeipllkdah radieeekis ssslrtrllg tllkppspel dlplcpyvig ltggsgsgks
      361 siarrledlg aeridcdllg heaylpetsa yhrviqefgt dilnedksin rrvlggkvfg
      421 nqerlkaltd ivwpeiarlv kkridqakqq gkrvcvvdaa vlleagwthl vhevwvatip
      481 eeeavkrivq rdgvkeedav rrlksqwpna klidyanvvl ctlwepevtq kqvlkawsll
      541 qqriqkrqet rssl
//
Feature
Display: FASTA GenBank Help
Details

Supplemental Content

Change region shown

Customize view

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
External link. Please review our privacy policy.