LOCUS NP_001004577 554 aa linear VRT 16-SEP-2024
DEFINITION bifunctional coenzyme A synthase precursor [Danio rerio].
ACCESSION NP_001004577
VERSION NP_001004577.1
DBSOURCE REFSEQ: accession NM_001004577.1
KEYWORDS RefSeq.
SOURCE Danio rerio (zebrafish)
ORGANISM Danio rerio
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE 1 (residues 1 to 554)
AUTHORS Mignani L, Zizioli D, Khatri D, Facchinello N, Schiavone M, De
Palma G and Finazzi D.
TITLE Bi-Allelic Mutations in Zebrafish pank2 Gene Lead to Testicular
Atrophy and Perturbed Behavior without Signs of Neurodegeneration
JOURNAL Int J Mol Sci 23 (21), 12914 (2022)
PUBMED 36361705
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 554)
AUTHORS Kamoshita M, Kumar R, Anteghini M, Kunze M, Islinger M, Martins Dos
Santos V and Schrader M.
TITLE Insights Into the Peroxisomal Protein Inventory of Zebrafish
JOURNAL Front Physiol 13, 822509 (2022)
PUBMED 35295584
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 554)
AUTHORS Kim YI, Nam IK, Lee DK, Bhandari S, Charton L, Kwak S, Lim JY, Hong
K, Kim SJ, Lee JN, Kwon SW, So HS, Linka N, Park R and Choe SK.
TITLE Slc25a17 acts as a peroxisomal coenzyme A transporter and regulates
multiorgan development in zebrafish
JOURNAL J Cell Physiol 235 (1), 151-165 (2020)
PUBMED 31187491
REFERENCE 4 (residues 1 to 554)
AUTHORS Pagani F, Trivedi A, Khatri D, Zizioli D, Garrafa E, Mitola S and
Finazzi D.
TITLE Silencing of pantothenate kinase 2 reduces endothelial cell
angiogenesis
JOURNAL Mol Med Rep 18 (5), 4739-4746 (2018)
PUBMED 30221726
REMARK GeneRIF: when pank2 or coasy expression was suppressed in zebrafish
evident perturbation of neuronal development was observed, as well
as severe defects in vasculature formation.
REFERENCE 5 (residues 1 to 554)
AUTHORS Bayes A, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A,
Choudhary JS, Emes RD and Grant SG.
TITLE Evolution of complexity in the zebrafish synapse proteome
JOURNAL Nat Commun 8, 14613 (2017)
PUBMED 28252024
REMARK Publication Status: Online-Only
REFERENCE 6 (residues 1 to 554)
AUTHORS Khatri D, Zizioli D, Tiso N, Facchinello N, Vezzoli S, Gianoncelli
A, Memo M, Monti E, Borsani G and Finazzi D.
TITLE Down-regulation of coasy, the gene associated with NBIA-VI, reduces
Bmp signaling, perturbs dorso-ventral patterning and alters
neuronal development in zebrafish
JOURNAL Sci Rep 6, 37660 (2016)
PUBMED 27892483
REMARK GeneRIF: The abrogation of coasy expression led to strong reduction
of CoA content, high lethality and a phenotype resembling to that
of dorsalized mutants.
Publication Status: Online-Only
REFERENCE 7 (residues 1 to 554)
AUTHORS Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
Hertzano R.
TITLE RFX transcription factors are essential for hearing in mice
JOURNAL Nat Commun 6, 8549 (2015)
PUBMED 26469318
REMARK Publication Status: Online-Only
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC081650.1.
##Evidence-Data-START##
Transcript exon combination :: BC081650.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA3505373,
SAMEA3505382 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: inferred from homology
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..554
/organism="Danio rerio"
/db_xref="taxon:7955"
/chromosome="24"
/map="24"
Protein 1..554
/product="bifunctional coenzyme A synthase precursor"
/note="Coenzyme A synthase"
/calculated_mol_wt=59369
sig_peptide 1..19
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
/calculated_mol_wt=2044
Region 182..323
/region_name="PPAT_CoAS"
/note="phosphopantetheine adenylyltransferase domain of
eukaryotic and archaeal bifunctional enzymes; cd02164"
/db_xref="CDD:173915"
Site order(186..187,215,275)
/site_type="active"
/db_xref="CDD:173915"
Site 192..195
/site_type="other"
/note="(T/H)XGH motif"
/db_xref="CDD:173915"
Region 348..527
/region_name="DPCK"
/note="Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24)
catalyzes the phosphorylation of dephosphocoenzyme A
(dCoA) to yield CoA, which is the final step in CoA
biosynthesis; cd02022"
/db_xref="CDD:238980"
Site order(352,377,433,460..461,506)
/site_type="other"
/note="CoA-binding site [chemical binding]"
/db_xref="CDD:238980"
Site order(353..355,358..359,487,522)
/site_type="other"
/note="ATP-binding [chemical binding]"
/db_xref="CDD:238980"
CDS 1..554
/gene="coasy"
/gene_synonym="zgc:92337"
/coded_by="NM_001004577.1:184..1848"
/db_xref="GeneID:447838"
/db_xref="ZFIN:ZDB-GENE-040912-137"
ORIGIN
1 msmfstgilv ltsplhvlpl riapvltsaa qvvertlyvh lhpglnlgtg gqvrpvyipp
61 vvdlctlisr lysnaadicg hldvrvlltn irgqsaassa angpfpapqt lshspevvlt
121 dfpipdsgqs slitqclrky aghcyvctpg lssvllhpql kevsgdedrg aqmkpletfs
181 dvvvggtfdr lhgahktlln isclmanrrf iigvcdqell knkvlkelie pydqrveklh
241 dflndvkpsl kydivplsdp fgpsitepel qcivvseetr kggeavnkrr vqnglaelvl
301 yeipllkdah radieeekis ssslrtrllg tllkppspel dlplcpyvig ltggsgsgks
361 siarrledlg aeridcdllg heaylpetsa yhrviqefgt dilnedksin rrvlggkvfg
421 nqerlkaltd ivwpeiarlv kkridqakqq gkrvcvvdaa vlleagwthl vhevwvatip
481 eeeavkrivq rdgvkeedav rrlksqwpna klidyanvvl ctlwepevtq kqvlkawsll
541 qqriqkrqet rssl
//