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LIM/homeobox protein Lhx2 isoform b [Mus musculus]

NCBI Reference Sequence: NP_001277575.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001277575             365 aa            linear   ROD 24-DEC-2024
DEFINITION  LIM/homeobox protein Lhx2 isoform b [Mus musculus].
ACCESSION   NP_001277575 XP_006497800
VERSION     NP_001277575.1
DBSOURCE    REFSEQ: accession NM_001290646.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 365)
  AUTHORS   Leybova,L., Biswas,A., Sharan,R., Trejo,B.M., Kim,K.,
            Soto-Muniz,Y., Jones,R.A., Phillips,B.K. and Devenport,D.
  TITLE     Radially patterned morphogenesis of murine hair follicle placodes
            ensures robust epithelial budding
  JOURNAL   Dev Cell 59 (24), 3272-3289 (2024)
   PUBMED   39413781
REFERENCE   2  (residues 1 to 365)
  AUTHORS   Alvarez,S., Gupta,S., Mercado-Ayon,Y., Honeychurch,K.,
            Rodriguez,C., Kawaguchi,R. and Butler,S.J.
  TITLE     Netrin1 patterns the dorsal spinal cord through modulation of Bmp
            signaling
  JOURNAL   Cell Rep 43 (11), 114954 (2024)
   PUBMED   39547237
REFERENCE   3  (residues 1 to 365)
  AUTHORS   Yang,H., Ryu,J., Gil,Y., Ma,Y., Nam,K.H., Jang,S.W. and Shim,S.
  TITLE     A role of Lhx2 in the migration and axonal projection of cortical
            postmitotic neurons in the cortical upper layer of the mouse
            neocortex
  JOURNAL   Biochem Biophys Res Commun 734, 150780 (2024)
   PUBMED   39362030
  REMARK    GeneRIF: A role of Lhx2 in the migration and axonal projection of
            cortical postmitotic neurons in the cortical upper layer of the
            mouse neocortex.
REFERENCE   4  (residues 1 to 365)
  AUTHORS   Olczak,A., Pieczonka,T.D., Lawicki,S., Lukaszyk,K.,
            Pulawska-Czub,A., Cambier,L. and Kobielak,K.
  TITLE     The overexpression of R-spondin 3 affects hair morphogenesis and
            hair development along with the formation and maturation of the
            hair follicle stem cells
  JOURNAL   Front Physiol 15, 1424077 (2024)
   PUBMED   39351282
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 365)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   6  (residues 1 to 365)
  AUTHORS   Ben-Arie,N., McCall,A.E., Berkman,S., Eichele,G., Bellen,H.J. and
            Zoghbi,H.Y.
  TITLE     Evolutionary conservation of sequence and expression of the bHLH
            protein Atonal suggests a conserved role in neurogenesis
  JOURNAL   Hum Mol Genet 5 (9), 1207-1216 (1996)
   PUBMED   8872459
REFERENCE   7  (residues 1 to 365)
  AUTHORS   Matsumoto,K., Tanaka,T., Furuyama,T., Kashihara,Y., Ishii,N.,
            Tohyama,M., Kitanaka,J., Takemura,M., Mori,T. and Wanaka,A.
  TITLE     Differential expression of LIM-homeodomain genes in the embryonic
            murine brain
  JOURNAL   Neurosci Lett 211 (3), 147-150 (1996)
   PUBMED   8817562
REFERENCE   8  (residues 1 to 365)
  AUTHORS   Pfaff,S.L., Mendelsohn,M., Stewart,C.L., Edlund,T. and Jessell,T.M.
  TITLE     Requirement for LIM homeobox gene Isl1 in motor neuron generation
            reveals a motor neuron-dependent step in interneuron
            differentiation
  JOURNAL   Cell 84 (2), 309-320 (1996)
   PUBMED   8565076
REFERENCE   9  (residues 1 to 365)
  AUTHORS   Roberson,M.S., Schoderbek,W.E., Tremml,G. and Maurer,R.A.
  TITLE     Activation of the glycoprotein hormone alpha-subunit promoter by a
            LIM-homeodomain transcription factor
  JOURNAL   Mol Cell Biol 14 (5), 2985-2993 (1994)
   PUBMED   7513049
REFERENCE   10 (residues 1 to 365)
  AUTHORS   Xu,Y., Baldassare,M., Fisher,P., Rathbun,G., Oltz,E.M.,
            Yancopoulos,G.D., Jessell,T.M. and Alt,F.W.
  TITLE     LH-2: a LIM/homeodomain gene expressed in developing lymphocytes
            and neural cells
  JOURNAL   Proc Natl Acad Sci U S A 90 (1), 227-231 (1993)
   PUBMED   7678338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929186.7 and BX813320.2.
            
            On Mar 15, 2014 this sequence version replaced XP_006497800.1.
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon and it thus differs in the 5' UTR and initiates
            translation at a downstream in-frame start codon, compared to
            variant 1. The encoded isoform (b) is shorter at the N-terminus,
            compared to isoform a. Variants 2, 5, and 6 all encode the same
            isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086638.1, SRR7652917.894695.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.31 cM"
     Protein         1..365
                     /product="LIM/homeobox protein Lhx2 isoform b"
                     /note="LIM/homeobox protein Lhx2; homeobox protein LH-2;
                     LIM homeo box protein 2"
                     /calculated_mol_wt=39878
     Region          2..65
                     /region_name="LIM1_Lhx2"
                     /note="The first LIM domain of Lhx2; cd09469"
                     /db_xref="CDD:188853"
     Site            order(12,15,33,36,39,42,61,64)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188853"
     Region          70..128
                     /region_name="LIM2_Lhx2_Lhx9"
                     /note="The second LIM domain of Lhx2 and Lhx9 family;
                     cd09377"
                     /db_xref="CDD:188763"
     Site            order(74,77,96,99,102,105,124,127)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188763"
     Region          <206..337
                     /region_name="COG5576"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]"
                     /db_xref="CDD:227863"
     Region          226..282
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..365
                     /gene="Lhx2"
                     /gene_synonym="ap; apterous; Lh-2; LH2A; Lim2"
                     /coded_by="NM_001290646.2:540..1637"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS71048.1"
                     /db_xref="GeneID:16870"
                     /db_xref="MGI:MGI:96785"
ORIGIN      
        1 mpsissdraa lcagcggkis dryyllavdk qwhmrclkcc ecklnlesel tcfskdgsiy
       61 ckedyyrrfs vqrcarchlg isasemvmra rdlvyhlncf tcttcnkmlt tgdhfgmkds
      121 lvycrlhfea llqgeypahf nhadvaaaaa aaaaaksagl gsaganplgl pyyngvgtvq
      181 kgrprkrksp gpgadlaayn aalscnenda ehldrdqpyp ssqktkrmrt sfkhhqlrtm
      241 ksyfainhnp dakdlkqlaq ktgltkrvlq vwfqnarakf rrnllrqent gvdktsdatl
      301 qtgtpsgpas elsnaslsps stpttltdlt sptlptvtsv ltsvpgnleg hephspsqtt
      361 ltnlf
//
Feature
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