LOCUS NP_001277575 365 aa linear ROD 24-DEC-2024
DEFINITION LIM/homeobox protein Lhx2 isoform b [Mus musculus].
ACCESSION NP_001277575 XP_006497800
VERSION NP_001277575.1
DBSOURCE REFSEQ: accession NM_001290646.2
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 365)
AUTHORS Leybova,L., Biswas,A., Sharan,R., Trejo,B.M., Kim,K.,
Soto-Muniz,Y., Jones,R.A., Phillips,B.K. and Devenport,D.
TITLE Radially patterned morphogenesis of murine hair follicle placodes
ensures robust epithelial budding
JOURNAL Dev Cell 59 (24), 3272-3289 (2024)
PUBMED 39413781
REFERENCE 2 (residues 1 to 365)
AUTHORS Alvarez,S., Gupta,S., Mercado-Ayon,Y., Honeychurch,K.,
Rodriguez,C., Kawaguchi,R. and Butler,S.J.
TITLE Netrin1 patterns the dorsal spinal cord through modulation of Bmp
signaling
JOURNAL Cell Rep 43 (11), 114954 (2024)
PUBMED 39547237
REFERENCE 3 (residues 1 to 365)
AUTHORS Yang,H., Ryu,J., Gil,Y., Ma,Y., Nam,K.H., Jang,S.W. and Shim,S.
TITLE A role of Lhx2 in the migration and axonal projection of cortical
postmitotic neurons in the cortical upper layer of the mouse
neocortex
JOURNAL Biochem Biophys Res Commun 734, 150780 (2024)
PUBMED 39362030
REMARK GeneRIF: A role of Lhx2 in the migration and axonal projection of
cortical postmitotic neurons in the cortical upper layer of the
mouse neocortex.
REFERENCE 4 (residues 1 to 365)
AUTHORS Olczak,A., Pieczonka,T.D., Lawicki,S., Lukaszyk,K.,
Pulawska-Czub,A., Cambier,L. and Kobielak,K.
TITLE The overexpression of R-spondin 3 affects hair morphogenesis and
hair development along with the formation and maturation of the
hair follicle stem cells
JOURNAL Front Physiol 15, 1424077 (2024)
PUBMED 39351282
REMARK Publication Status: Online-Only
REFERENCE 5 (residues 1 to 365)
AUTHORS Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
TITLE Developmental emergence of first- and higher-order thalamic neuron
molecular identities
JOURNAL Development 151 (18) (2024)
PUBMED 39348458
REFERENCE 6 (residues 1 to 365)
AUTHORS Ben-Arie,N., McCall,A.E., Berkman,S., Eichele,G., Bellen,H.J. and
Zoghbi,H.Y.
TITLE Evolutionary conservation of sequence and expression of the bHLH
protein Atonal suggests a conserved role in neurogenesis
JOURNAL Hum Mol Genet 5 (9), 1207-1216 (1996)
PUBMED 8872459
REFERENCE 7 (residues 1 to 365)
AUTHORS Matsumoto,K., Tanaka,T., Furuyama,T., Kashihara,Y., Ishii,N.,
Tohyama,M., Kitanaka,J., Takemura,M., Mori,T. and Wanaka,A.
TITLE Differential expression of LIM-homeodomain genes in the embryonic
murine brain
JOURNAL Neurosci Lett 211 (3), 147-150 (1996)
PUBMED 8817562
REFERENCE 8 (residues 1 to 365)
AUTHORS Pfaff,S.L., Mendelsohn,M., Stewart,C.L., Edlund,T. and Jessell,T.M.
TITLE Requirement for LIM homeobox gene Isl1 in motor neuron generation
reveals a motor neuron-dependent step in interneuron
differentiation
JOURNAL Cell 84 (2), 309-320 (1996)
PUBMED 8565076
REFERENCE 9 (residues 1 to 365)
AUTHORS Roberson,M.S., Schoderbek,W.E., Tremml,G. and Maurer,R.A.
TITLE Activation of the glycoprotein hormone alpha-subunit promoter by a
LIM-homeodomain transcription factor
JOURNAL Mol Cell Biol 14 (5), 2985-2993 (1994)
PUBMED 7513049
REFERENCE 10 (residues 1 to 365)
AUTHORS Xu,Y., Baldassare,M., Fisher,P., Rathbun,G., Oltz,E.M.,
Yancopoulos,G.D., Jessell,T.M. and Alt,F.W.
TITLE LH-2: a LIM/homeodomain gene expressed in developing lymphocytes
and neural cells
JOURNAL Proc Natl Acad Sci U S A 90 (1), 227-231 (1993)
PUBMED 7678338
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL929186.7 and BX813320.2.
On Mar 15, 2014 this sequence version replaced XP_006497800.1.
Transcript Variant: This variant (2) contains an alternate 5'
terminal exon and it thus differs in the 5' UTR and initiates
translation at a downstream in-frame start codon, compared to
variant 1. The encoded isoform (b) is shorter at the N-terminus,
compared to isoform a. Variants 2, 5, and 6 all encode the same
isoform (b).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC086638.1, SRR7652917.894695.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849375, SAMN00849386
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..365
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="2"
/map="2 24.31 cM"
Protein 1..365
/product="LIM/homeobox protein Lhx2 isoform b"
/note="LIM/homeobox protein Lhx2; homeobox protein LH-2;
LIM homeo box protein 2"
/calculated_mol_wt=39878
Region 2..65
/region_name="LIM1_Lhx2"
/note="The first LIM domain of Lhx2; cd09469"
/db_xref="CDD:188853"
Site order(12,15,33,36,39,42,61,64)
/site_type="other"
/note="Zn binding site [ion binding]"
/db_xref="CDD:188853"
Region 70..128
/region_name="LIM2_Lhx2_Lhx9"
/note="The second LIM domain of Lhx2 and Lhx9 family;
cd09377"
/db_xref="CDD:188763"
Site order(74,77,96,99,102,105,124,127)
/site_type="other"
/note="Zn binding site [ion binding]"
/db_xref="CDD:188763"
Region <206..337
/region_name="COG5576"
/note="Homeodomain-containing transcription factor
[Transcription]"
/db_xref="CDD:227863"
Region 226..282
/region_name="Homeodomain"
/note="pfam00046"
/db_xref="CDD:459649"
CDS 1..365
/gene="Lhx2"
/gene_synonym="ap; apterous; Lh-2; LH2A; Lim2"
/coded_by="NM_001290646.2:540..1637"
/note="isoform b is encoded by transcript variant 2"
/db_xref="CCDS:CCDS71048.1"
/db_xref="GeneID:16870"
/db_xref="MGI:MGI:96785"
ORIGIN
1 mpsissdraa lcagcggkis dryyllavdk qwhmrclkcc ecklnlesel tcfskdgsiy
61 ckedyyrrfs vqrcarchlg isasemvmra rdlvyhlncf tcttcnkmlt tgdhfgmkds
121 lvycrlhfea llqgeypahf nhadvaaaaa aaaaaksagl gsaganplgl pyyngvgtvq
181 kgrprkrksp gpgadlaayn aalscnenda ehldrdqpyp ssqktkrmrt sfkhhqlrtm
241 ksyfainhnp dakdlkqlaq ktgltkrvlq vwfqnarakf rrnllrqent gvdktsdatl
301 qtgtpsgpas elsnaslsps stpttltdlt sptlptvtsv ltsvpgnleg hephspsqtt
361 ltnlf
//