U.S. flag

An official website of the United States government

RecName: Full=Olfactory receptor 8G5; AltName: Full=Olfactory receptor 8G6; AltName: Full=Olfactory receptor OR11-298

UniProtKB/Swiss-Prot: Q8NG78.2

Identical Proteins FASTA Graphics 

LOCUS       OR8G5_HUMAN              346 aa            linear   PRI 27-NOV-2024
DEFINITION  RecName: Full=Olfactory receptor 8G5; AltName: Full=Olfactory
            receptor 8G6; AltName: Full=Olfactory receptor OR11-298.
ACCESSION   Q8NG78
VERSION     Q8NG78.2
DBSOURCE    UniProtKB: locus OR8G5_HUMAN, accession Q8NG78;
            class: standard.
            extra accessions:B2RND3,Q6IEU6
            created: Jul 19, 2005.
            sequence updated: Apr 16, 2014.
            annotation updated: Nov 27, 2024.
            xrefs: AB065958.1, BAC06171.1, AP002965.3, BC136820.1, AAI36821.1,
            BK004516.1, DAA04914.1, NP_001005198.1, XP_011540964.1,
            XP_011540965.1, XP_011540966.1, XP_011540967.1, XP_011540968.1,
            XP_011540969.1
            xrefs (non-sequence databases): AlphaFoldDB:Q8NG78, SMR:Q8NG78,
            BioGRID:128586, STRING:9606.ENSP00000477014, GlyCosmos:Q8NG78,
            GlyGen:Q8NG78, iPTMnet:Q8NG78, PhosphoSitePlus:Q8NG78,
            BioMuta:OR8G5, MassIVE:Q8NG78, PaxDb:9606-ENSP00000477014,
            PeptideAtlas:Q8NG78, DNASU:219865, GeneID:219865, KEGG:hsa:219865,
            UCSC:uc031yio.1, AGR:HGNC:19622, CTD:219865, DisGeNET:219865,
            GeneCards:OR8G5, HGNC:19622, neXtProt:NX_Q8NG78,
            eggNOG:ENOG502SJS1, HOGENOM:CLU_012526_1_0_1, InParanoid:Q8NG78,
            OrthoDB:5317957at2759, PathwayCommons:Q8NG78,
            Reactome:R-HSA-9752946, BioGRID-ORCS:219865, GeneWiki:OR8G5,
            GenomeRNAi:219865, Pharos:Q8NG78, PRO:PR:Q8NG78,
            Proteomes:UP000005640, RNAct:Q8NG78, GO:0005886, GO:0004930,
            GO:0005549, GO:0004984, GO:0007186, GO:0007608, CDD:cd15406,
            FunFam:1.20.1070.10:FF:000004, Gene3D:1.20.1070.10,
            InterPro:IPR000276, InterPro:IPR017452, InterPro:IPR000725,
            PANTHER:PTHR48018, PANTHER:PTHR48018:SF48, Pfam:PF13853,
            PRINTS:PR00237, PRINTS:PR00245, SUPFAM:SSF81321, PROSITE:PS50262
KEYWORDS    Cell membrane; Disulfide bond; G-protein coupled receptor;
            Glycoprotein; Membrane; Olfaction; Receptor; Reference proteome;
            Sensory transduction; Transducer; Transmembrane; Transmembrane
            helix.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 346)
  AUTHORS   Suwa,M., Sato,T., Okouchi,I., Arita,M., Futami,K., Matsumoto,S.,
            Tsutsumi,S., Aburatani,H., Asai,K. and Akiyama,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (??-JUL-2001) to the EMBL/GenBank/DDBJ databases
  REMARK    NUCLEOTIDE SEQUENCE [GENOMIC DNA].
REFERENCE   2  (residues 1 to 346)
  AUTHORS   Taylor,T.D., Noguchi,H., Totoki,Y., Toyoda,A., Kuroki,Y., Dewar,K.,
            Lloyd,C., Itoh,T., Takeda,T., Kim,D.W., She,X., Barlow,K.F.,
            Bloom,T., Bruford,E., Chang,J.L., Cuomo,C.A., Eichler,E.,
            FitzGerald,M.G., Jaffe,D.B., LaButti,K., Nicol,R., Park,H.S.,
            Seaman,C., Sougnez,C., Yang,X., Zimmer,A.R., Zody,M.C.,
            Birren,B.W., Nusbaum,C., Fujiyama,A., Hattori,M., Rogers,J.,
            Lander,E.S. and Sakaki,Y.
  TITLE     Human chromosome 11 DNA sequence and analysis including novel gene
            identification
  JOURNAL   Nature 440 (7083), 497-500 (2006)
   PUBMED   16554811
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
REFERENCE   3  (residues 1 to 346)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
            Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
REFERENCE   4  (residues 1 to 346)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    IDENTIFICATION.
            Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   5  (residues 1 to 346)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101, 7205-7205 (2004)
  REMARK    ERRATUM OF PUBMED:14983052.
COMMENT     On Apr 18, 2014 this sequence version replaced Q8NG78.1.
            [FUNCTION] Odorant receptor. {ECO:0000305}.
            [SUBCELLULAR LOCATION] Cell membrane; Multi-pass membrane protein.
            [SIMILARITY] Belongs to the G-protein coupled receptor 1 family.
            {ECO:0000255|PROSITE-ProRule:PRU00521}.
            [SEQUENCE CAUTION] Sequence=BAC06171.1; Type=Erroneous initiation;
            Note=Truncated N-terminus.; Evidence={ECO:0000305}.
            [WEB RESOURCE] Name=Human Olfactory Receptor Data Exploratorium
            (HORDE);
            URL='http://genome.weizmann.ac.il/horde/card/index/symbol:OR8G5'.
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
     gene            1..346
                     /gene="OR8G5"
                     /gene_synonym="OR8G5P"
                     /gene_synonym="OR8G6"
     Protein         1..346
                     /product="Olfactory receptor 8G5"
                     /note="Olfactory receptor 8G6; Olfactory receptor
                     OR11-298"
                     /UniProtKB_evidence="Evidence at transcript level"
     Region          1..346
                     /region_name="Mature chain"
                     /note="Olfactory receptor 8G5. /id=PRO_0000150664."
     Region          1..60
                     /region_name="Topological domain"
                     /note="Extracellular. /evidence=ECO:0000255."
     Site            16
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255."
     Site            40
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255."
     Region          51..340
                     /region_name="7tmA_OR8D-like"
                     /note="olfactory receptor subfamily 8D and related
                     proteins, member of the class A family of
                     seven-transmembrane G protein-coupled receptors; cd15406"
                     /db_xref="CDD:320528"
     Region          61..87
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320528"
     Region          61..81
                     /region_name="Transmembrane region"
                     /note="Helical; Name=1. /evidence=ECO:0000255."
     Region          82..89
                     /region_name="Topological domain"
                     /note="Cytoplasmic. /evidence=ECO:0000255."
     Region          90..110
                     /region_name="Transmembrane region"
                     /note="Helical; Name=2. /evidence=ECO:0000255."
     Region          94..120
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320528"
     Region          111..134
                     /region_name="Topological domain"
                     /note="Extracellular. /evidence=ECO:0000255."
     Site            order(116,119..120,132..137,139..140,143,188,190..194,230,
                     233..235,237..239,241..242,287,290..291,293..294,297,
                     303..304,306..308,311,314..315)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320528"
     Bond            bond(132,214)
                     /bond_type="disulfide"
                     /note="/evidence=ECO:0000255|PROSITE-ProRule:PRU00521."
     Region          132..162
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320528"
     Region          135..155
                     /region_name="Transmembrane region"
                     /note="Helical; Name=3. /evidence=ECO:0000255."
     Region          156..174
                     /region_name="Topological domain"
                     /note="Cytoplasmic. /evidence=ECO:0000255."
     Region          175..196
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320528"
     Region          175..195
                     /region_name="Transmembrane region"
                     /note="Helical; Name=4. /evidence=ECO:0000255."
     Region          196..232
                     /region_name="Topological domain"
                     /note="Extracellular. /evidence=ECO:0000255."
     Region          230..260
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320528"
     Region          233..252
                     /region_name="Transmembrane region"
                     /note="Helical; Name=5. /evidence=ECO:0000255."
     Region          253..272
                     /region_name="Topological domain"
                     /note="Cytoplasmic. /evidence=ECO:0000255."
     Region          267..297
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320528"
     Region          273..293
                     /region_name="Transmembrane region"
                     /note="Helical; Name=6. /evidence=ECO:0000255."
     Region          294..306
                     /region_name="Topological domain"
                     /note="Extracellular. /evidence=ECO:0000255."
     Region          304..329
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320528"
     Region          307..327
                     /region_name="Transmembrane region"
                     /note="Helical; Name=7. /evidence=ECO:0000255."
     Region          328..346
                     /region_name="Topological domain"
                     /note="Cytoplasmic. /evidence=ECO:0000255."
ORIGIN      
        1 miiykqgitf lqkennntih lntmfflspa ethqrmaaen hsfvtkfilv gltekselql
       61 plflvflgiy vvtvlgnlgm itliglsshl htpmycflss lsfidfchst vitpkmlvnf
      121 vtekniisyp ecmtqlyffl vfaiaechml aamaydgyva icspllysii isnkacfsli
      181 lvvyviglic asahigcmfr vqfckfdvin hyfcdlisil klscsstyin ellilifsgi
      241 nilvpsltil ssyifiiasi lrirytegrs kafstcsshi savsvffgsa afmylqpssv
      301 ssmdqgkvss vfytivvpml npliyslrnk dvhvalkktl gkrtfl
//
Feature
Display: FASTA GenBank Help
Details

Supplemental Content

Change region shown

Customize view

Reference sequence information

  • RefSeq protein
    See the reference protein sequence for olfactory receptor 8G5 (NP_001005198.2).

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
External link. Please review our privacy policy.