LOCUS OR8G5_HUMAN 346 aa linear PRI 27-NOV-2024
DEFINITION RecName: Full=Olfactory receptor 8G5; AltName: Full=Olfactory
receptor 8G6; AltName: Full=Olfactory receptor OR11-298.
ACCESSION Q8NG78
VERSION Q8NG78.2
DBSOURCE UniProtKB: locus OR8G5_HUMAN, accession Q8NG78;
class: standard.
extra accessions:B2RND3,Q6IEU6
created: Jul 19, 2005.
sequence updated: Apr 16, 2014.
annotation updated: Nov 27, 2024.
xrefs: AB065958.1, BAC06171.1, AP002965.3, BC136820.1, AAI36821.1,
BK004516.1, DAA04914.1, NP_001005198.1, XP_011540964.1,
XP_011540965.1, XP_011540966.1, XP_011540967.1, XP_011540968.1,
XP_011540969.1
xrefs (non-sequence databases): AlphaFoldDB:Q8NG78, SMR:Q8NG78,
BioGRID:128586, STRING:9606.ENSP00000477014, GlyCosmos:Q8NG78,
GlyGen:Q8NG78, iPTMnet:Q8NG78, PhosphoSitePlus:Q8NG78,
BioMuta:OR8G5, MassIVE:Q8NG78, PaxDb:9606-ENSP00000477014,
PeptideAtlas:Q8NG78, DNASU:219865, GeneID:219865, KEGG:hsa:219865,
UCSC:uc031yio.1, AGR:HGNC:19622, CTD:219865, DisGeNET:219865,
GeneCards:OR8G5, HGNC:19622, neXtProt:NX_Q8NG78,
eggNOG:ENOG502SJS1, HOGENOM:CLU_012526_1_0_1, InParanoid:Q8NG78,
OrthoDB:5317957at2759, PathwayCommons:Q8NG78,
Reactome:R-HSA-9752946, BioGRID-ORCS:219865, GeneWiki:OR8G5,
GenomeRNAi:219865, Pharos:Q8NG78, PRO:PR:Q8NG78,
Proteomes:UP000005640, RNAct:Q8NG78, GO:0005886, GO:0004930,
GO:0005549, GO:0004984, GO:0007186, GO:0007608, CDD:cd15406,
FunFam:1.20.1070.10:FF:000004, Gene3D:1.20.1070.10,
InterPro:IPR000276, InterPro:IPR017452, InterPro:IPR000725,
PANTHER:PTHR48018, PANTHER:PTHR48018:SF48, Pfam:PF13853,
PRINTS:PR00237, PRINTS:PR00245, SUPFAM:SSF81321, PROSITE:PS50262
KEYWORDS Cell membrane; Disulfide bond; G-protein coupled receptor;
Glycoprotein; Membrane; Olfaction; Receptor; Reference proteome;
Sensory transduction; Transducer; Transmembrane; Transmembrane
helix.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 346)
AUTHORS Suwa,M., Sato,T., Okouchi,I., Arita,M., Futami,K., Matsumoto,S.,
Tsutsumi,S., Aburatani,H., Asai,K. and Akiyama,Y.
TITLE Direct Submission
JOURNAL Submitted (??-JUL-2001) to the EMBL/GenBank/DDBJ databases
REMARK NUCLEOTIDE SEQUENCE [GENOMIC DNA].
REFERENCE 2 (residues 1 to 346)
AUTHORS Taylor,T.D., Noguchi,H., Totoki,Y., Toyoda,A., Kuroki,Y., Dewar,K.,
Lloyd,C., Itoh,T., Takeda,T., Kim,D.W., She,X., Barlow,K.F.,
Bloom,T., Bruford,E., Chang,J.L., Cuomo,C.A., Eichler,E.,
FitzGerald,M.G., Jaffe,D.B., LaButti,K., Nicol,R., Park,H.S.,
Seaman,C., Sougnez,C., Yang,X., Zimmer,A.R., Zody,M.C.,
Birren,B.W., Nusbaum,C., Fujiyama,A., Hattori,M., Rogers,J.,
Lander,E.S. and Sakaki,Y.
TITLE Human chromosome 11 DNA sequence and analysis including novel gene
identification
JOURNAL Nature 440 (7083), 497-500 (2006)
PUBMED 16554811
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
REFERENCE 3 (residues 1 to 346)
AUTHORS Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
Makowski,K.A., Bosak,S. and Malek,J.
CONSRTM MGC Project Team
TITLE The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC)
JOURNAL Genome Res 14 (10B), 2121-2127 (2004)
PUBMED 15489334
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
Morin, Ryan]]
REFERENCE 4 (residues 1 to 346)
AUTHORS Malnic,B., Godfrey,P.A. and Buck,L.B.
TITLE The human olfactory receptor gene family
JOURNAL Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
PUBMED 14983052
REMARK IDENTIFICATION.
Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE 5 (residues 1 to 346)
AUTHORS Malnic,B., Godfrey,P.A. and Buck,L.B.
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101, 7205-7205 (2004)
REMARK ERRATUM OF PUBMED:14983052.
COMMENT On Apr 18, 2014 this sequence version replaced Q8NG78.1.
[FUNCTION] Odorant receptor. {ECO:0000305}.
[SUBCELLULAR LOCATION] Cell membrane; Multi-pass membrane protein.
[SIMILARITY] Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
[SEQUENCE CAUTION] Sequence=BAC06171.1; Type=Erroneous initiation;
Note=Truncated N-terminus.; Evidence={ECO:0000305}.
[WEB RESOURCE] Name=Human Olfactory Receptor Data Exploratorium
(HORDE);
URL='http://genome.weizmann.ac.il/horde/card/index/symbol:OR8G5'.
FEATURES Location/Qualifiers
source 1..346
/organism="Homo sapiens"
/db_xref="taxon:9606"
gene 1..346
/gene="OR8G5"
/gene_synonym="OR8G5P"
/gene_synonym="OR8G6"
Protein 1..346
/product="Olfactory receptor 8G5"
/note="Olfactory receptor 8G6; Olfactory receptor
OR11-298"
/UniProtKB_evidence="Evidence at transcript level"
Region 1..346
/region_name="Mature chain"
/note="Olfactory receptor 8G5. /id=PRO_0000150664."
Region 1..60
/region_name="Topological domain"
/note="Extracellular. /evidence=ECO:0000255."
Site 16
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255."
Site 40
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255."
Region 51..340
/region_name="7tmA_OR8D-like"
/note="olfactory receptor subfamily 8D and related
proteins, member of the class A family of
seven-transmembrane G protein-coupled receptors; cd15406"
/db_xref="CDD:320528"
Region 61..87
/region_name="TM helix 1"
/note="TM helix 1 [structural motif]"
/db_xref="CDD:320528"
Region 61..81
/region_name="Transmembrane region"
/note="Helical; Name=1. /evidence=ECO:0000255."
Region 82..89
/region_name="Topological domain"
/note="Cytoplasmic. /evidence=ECO:0000255."
Region 90..110
/region_name="Transmembrane region"
/note="Helical; Name=2. /evidence=ECO:0000255."
Region 94..120
/region_name="TM helix 2"
/note="TM helix 2 [structural motif]"
/db_xref="CDD:320528"
Region 111..134
/region_name="Topological domain"
/note="Extracellular. /evidence=ECO:0000255."
Site order(116,119..120,132..137,139..140,143,188,190..194,230,
233..235,237..239,241..242,287,290..291,293..294,297,
303..304,306..308,311,314..315)
/site_type="other"
/note="putative ligand binding pocket [chemical binding]"
/db_xref="CDD:320528"
Bond bond(132,214)
/bond_type="disulfide"
/note="/evidence=ECO:0000255|PROSITE-ProRule:PRU00521."
Region 132..162
/region_name="TM helix 3"
/note="TM helix 3 [structural motif]"
/db_xref="CDD:320528"
Region 135..155
/region_name="Transmembrane region"
/note="Helical; Name=3. /evidence=ECO:0000255."
Region 156..174
/region_name="Topological domain"
/note="Cytoplasmic. /evidence=ECO:0000255."
Region 175..196
/region_name="TM helix 4"
/note="TM helix 4 [structural motif]"
/db_xref="CDD:320528"
Region 175..195
/region_name="Transmembrane region"
/note="Helical; Name=4. /evidence=ECO:0000255."
Region 196..232
/region_name="Topological domain"
/note="Extracellular. /evidence=ECO:0000255."
Region 230..260
/region_name="TM helix 5"
/note="TM helix 5 [structural motif]"
/db_xref="CDD:320528"
Region 233..252
/region_name="Transmembrane region"
/note="Helical; Name=5. /evidence=ECO:0000255."
Region 253..272
/region_name="Topological domain"
/note="Cytoplasmic. /evidence=ECO:0000255."
Region 267..297
/region_name="TM helix 6"
/note="TM helix 6 [structural motif]"
/db_xref="CDD:320528"
Region 273..293
/region_name="Transmembrane region"
/note="Helical; Name=6. /evidence=ECO:0000255."
Region 294..306
/region_name="Topological domain"
/note="Extracellular. /evidence=ECO:0000255."
Region 304..329
/region_name="TM helix 7"
/note="TM helix 7 [structural motif]"
/db_xref="CDD:320528"
Region 307..327
/region_name="Transmembrane region"
/note="Helical; Name=7. /evidence=ECO:0000255."
Region 328..346
/region_name="Topological domain"
/note="Cytoplasmic. /evidence=ECO:0000255."
ORIGIN
1 miiykqgitf lqkennntih lntmfflspa ethqrmaaen hsfvtkfilv gltekselql
61 plflvflgiy vvtvlgnlgm itliglsshl htpmycflss lsfidfchst vitpkmlvnf
121 vtekniisyp ecmtqlyffl vfaiaechml aamaydgyva icspllysii isnkacfsli
181 lvvyviglic asahigcmfr vqfckfdvin hyfcdlisil klscsstyin ellilifsgi
241 nilvpsltil ssyifiiasi lrirytegrs kafstcsshi savsvffgsa afmylqpssv
301 ssmdqgkvss vfytivvpml npliyslrnk dvhvalkktl gkrtfl
//