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leucine repeat adapter protein 25 [Rattus norvegicus]

NCBI Reference Sequence: NP_001015013.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001015013             189 aa            linear   ROD 03-FEB-2024
DEFINITION  leucine repeat adapter protein 25 [Rattus norvegicus].
ACCESSION   NP_001015013 XP_219519
VERSION     NP_001015013.1
DBSOURCE    REFSEQ: accession NM_001015013.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 189)
  AUTHORS   Lee,I.C.J., Leung,T. and Tan,I.
  TITLE     Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related
            Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in
            lamellipodial F-actin dynamics
  JOURNAL   J Biol Chem 289 (39), 26989-27003 (2014)
   PUBMED   25107909
  REMARK    GeneRIF: the functional relevance of the LRAP25-MRCK complex in
            LIMK1-cofilin signaling and the importance of LRAP adaptors as key
            determinants of MRCK cellular localization and downstream
            specificities.
REFERENCE   2  (residues 1 to 189)
  AUTHORS   Kokura,K., Kim,H., Shinagawa,T., Khan,M.M., Nomura,T. and Ishii,S.
  TITLE     The Ski-binding protein C184M negatively regulates tumor growth
            factor-beta signaling by sequestering the Smad proteins in the
            cytoplasm
  JOURNAL   J Biol Chem 278 (22), 20133-20139 (2003)
   PUBMED   12646588
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC093377.1.
            
            On Apr 20, 2005 this sequence version replaced XP_219519.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093377.1, EV779280.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..189
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     Protein         1..189
                     /product="leucine repeat adapter protein 25"
                     /note="protein FAM89B; mammary tumor virus receptor 2"
                     /calculated_mol_wt=20037
     Site            28
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N5H3; propagated from
                     UniProtKB/Swiss-Prot (Q566R4.1)"
     Region          55..81
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q566R4.1)"
     Region          86..114
                     /region_name="LRR. /evidence=ECO:0000305|PubMed:25107909"
                     /note="propagated from UniProtKB/Swiss-Prot (Q566R4.1)"
     Region          141..174
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q566R4.1)"
     Site            188
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N5H3; propagated from
                     UniProtKB/Swiss-Prot (Q566R4.1)"
     CDS             1..189
                     /gene="Fam89b"
                     /gene_synonym="Mtvr2"
                     /coded_by="NM_001015013.1:118..687"
                     /db_xref="GeneID:309170"
                     /db_xref="RGD:1311544"
ORIGIN      
        1 mnglpsteap ggagcalagl pplprglsgl lnasggswre lervysqrsr ihdelsraar
       61 apdgprhaag sanlgsaagp rrpvnldsal aalrkemvgl rqldmsllcq lwglyesiqd
      121 ykhlcqdlsl cqdlssslhs dssyppdagl sdddeppdas lppdpppltv pqthnardqw
      181 lqdafqisl
//
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Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the Fam89b gene (NM_001015013.1).
  • RefSeq protein isoforms
    See the other reference sequence protein isoform for the Fam89b gene (XP_038935546.1).

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