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putative mitogen-activated protein kinase kinase MKK2 [Saccharomyces cerevisiae S288C]

NCBI Reference Sequence: NP_015185.1

Identical Proteins FASTA Graphics 

LOCUS       NP_015185                506 aa            linear   PLN 17-DEC-2024
DEFINITION  putative mitogen-activated protein kinase kinase MKK2
            [Saccharomyces cerevisiae S288C].
ACCESSION   NP_015185
VERSION     NP_015185.1
DBLINK      BioProject: PRJNA128
DBSOURCE    REFSEQ: accession NM_001183954.1
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (residues 1 to 506)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (residues 1 to 506)
  AUTHORS   Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E.,
            Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K.,
            Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J.,
            Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K.,
            Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI
  JOURNAL   Nature 387 (6632 SUPPL), 103-105 (1997)
   PUBMED   9169875
REFERENCE   3  (residues 1 to 506)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (residues 1 to 506)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 506)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (residues 1 to 506)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   7  (residues 1 to 506)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. The reference
            sequence is identical to DAA11294.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..506
                     /organism="Saccharomyces cerevisiae S288C"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="XVI"
     Protein         1..506
                     /product="putative mitogen-activated protein kinase kinase
                     MKK2"
                     /EC_number="2.7.12.2"
                     /calculated_mol_wt=56627
     Region          212..499
                     /region_name="PKc_Pek1_like"
                     /note="Catalytic domain of fungal Pek1-like
                     dual-specificity Mitogen-Activated Protein Kinase Kinases;
                     cd06621"
                     /db_xref="CDD:270793"
     Site            order(220..224,228,241,243,274,292..295,298..299,302,342,
                     344..347,349,359..360,363,375..378,380,407,416)
                     /site_type="active"
                     /db_xref="CDD:270793"
     Site            order(220..224,226,228,241,243,274,292..295,298..299,
                     301..302,344,346..347,349,360)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270793"
     Site            order(223..224,342,344..346,363,375..378,380,407,416)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270793"
     Site            359..380
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270793"
     CDS             1..506
                     /gene="MKK2"
                     /locus_tag="YPL140C"
                     /gene_synonym="LPI6; SSP33"
                     /coded_by="NM_001183954.1:1..1521"
                     /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
                     [PMID:12361575]"
                     /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
                     [PMID:26928762]"
                     /experiment="EXISTENCE:direct assay:GO:0005934 cellular
                     bud tip [PMID:12361575]"
                     /experiment="EXISTENCE:direct assay:GO:0005935 cellular
                     bud neck [PMID:12361575]"
                     /experiment="EXISTENCE:direct assay:GO:0043332 mating
                     projection tip [PMID:12361575]"
                     /experiment="EXISTENCE:genetic interaction:GO:0000196 cell
                     integrity MAPK cascade [PMID:8386320]"
                     /experiment="EXISTENCE:genetic interaction:GO:0000425
                     pexophagy [PMID:20385774]"
                     /experiment="EXISTENCE:genetic interaction:GO:0060237
                     regulation of fungal-type cell wall organization
                     [PMID:8386320]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal
                     transduction [PMID:8386320]"
                     /note="MAPKK involved in the protein kinase C signaling
                     pathway; involved in control of cell integrity; upon
                     activation by Bck1p phosphorylates downstream target,
                     Slt2p; functionally redundant with Mkk1p; MKK2 has a
                     paralog, MKK1, that arose from the whole genome
                     duplication"
                     /db_xref="GeneID:855963"
                     /db_xref="SGD:S000006061"
ORIGIN      
        1 masmfrppes nrshqktpkl tlpvnlvqna kstndgqhln rspyssvnes pysnnstsat
       61 sttssmasns tllynrsstt tiknrpvppp lpplvltqkk dgieyrvagd sqlserfsnl
      121 hvditykell ssapistkls nidttfikkd ldtpegedsy pstllsaydf sssgsnsapl
      181 sanniiscsn liqgkdvdql eeeawrfghl kdeittlgil gegaggsvak crlkngkkvf
      241 alktintmnt dpeyqkqifr elqfnksfks dyivqyygmf tdeqsssiyi ameymggksl
      301 eatyknllkr ggriservig kiaesvlrgl sylherkvih rdikpqnill nekgeiklcd
      361 fgvsgeavns lamtftgtsf ymaperiqgq pysvtcdvws lgltllevag grfpfesdki
      421 tqnvapiell tmiltfspql kdepeldisw sktfrsfidy clkkdarerp sprqmlkhpw
      481 ivgqmkkkvn merfvkkcwe kekdgi
//
Feature
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Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the MKK2 gene (NM_001183954.1).

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