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BRCA1-associated protein isoform 1 [Mus musculus]

NCBI Reference Sequence: NP_082503.2

Identical Proteins FASTA Graphics 

LOCUS       NP_082503                591 aa            linear   ROD 01-JUL-2024
DEFINITION  BRCA1-associated protein isoform 1 [Mus musculus].
ACCESSION   NP_082503
VERSION     NP_082503.2
DBSOURCE    REFSEQ: accession NM_028227.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 591)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 591)
  AUTHORS   Zheng,J., Wang,H., Wang,J., Peng,Z., Yao,X., Weber,H.C., Qin,X.,
            Xiang,Y., Liu,C., Ji,M., Liu,H. and Qu,X.
  TITLE     Bombesin receptor-activated protein homolog deficiency altered the
            pattern of pathological changes of psoriasis - like skin lesion in
            mice
  JOURNAL   Int J Med Sci 21 (2), 357-368 (2024)
   PUBMED   38169666
  REMARK    GeneRIF: Bombesin receptor-activated protein homolog deficiency
            altered the pattern of pathological changes of psoriasis - like
            skin lesion in mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 591)
  AUTHORS   Wang,H., Zuo,S., Zheng,J., Peng,Z., Yao,X., Wang,J., Weber,H.C.,
            Qin,X., Xiang,Y., Liu,C., Ji,M., Liu,H., Pan,L. and Qu,X.
  TITLE     Knockout of the BRAP homolog in mice leads to abnormal tracheal
            cilia
  JOURNAL   FEBS Lett 597 (21), 2626-2642 (2023)
   PUBMED   37715941
  REMARK    GeneRIF: Knockout of the BRAP homolog in mice leads to abnormal
            tracheal cilia.
REFERENCE   4  (residues 1 to 591)
  AUTHORS   Guo,Y., Chomiak,A.A., Hong,Y., Lowe,C.C., Kopsidas,C.A., Chan,W.C.,
            Andrade,J., Pan,H., Zhou,X., Monuki,E.S. and Feng,Y.
  TITLE     Histone H2A ubiquitination resulting from Brap loss of function
            connects multiple aging hallmarks and accelerates neurodegeneration
  JOURNAL   iScience 25 (7), 104519 (2022)
   PUBMED   35754718
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 591)
  AUTHORS   Chomiak,A.A., Guo,Y., Kopsidas,C.A., McDaniel,D.P., Lowe,C.C.,
            Pan,H., Zhou,X., Zhou,Q., Doughty,M.L. and Feng,Y.
  TITLE     Nde1 is required for heterochromatin compaction and stability in
            neocortical neurons
  JOURNAL   iScience 25 (6), 104354 (2022)
   PUBMED   35601919
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 591)
  AUTHORS   Fatima,S., Wagstaff,K.M., Loveland,K.L. and Jans,D.A.
  TITLE     Interactome of the negative regulator of nuclear import
            BRCA1-binding protein 2
  JOURNAL   Sci Rep 5, 9459 (2015)
   PUBMED   25820252
  REMARK    GeneRIF: Together the results indicate for the first time that
            BRAP2 may play an important NRNI role in germ cells of the testis,
            with an additional, scaffold/structural role in mature spermatozoa.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 591)
  AUTHORS   Davies,R.G., Wagstaff,K.M., McLaughlin,E.A., Loveland,K.L. and
            Jans,D.A.
  TITLE     The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention
            factor for nuclear and nuclear envelope-localizing testicular
            proteins
  JOURNAL   Biochim Biophys Acta 1833 (12), 3436-3444 (2013)
   PUBMED   23707952
  REMARK    GeneRIF: ectopic expression of BRAP2 inhibits nuclear localization
            of HMG20A and NuMA1, and prevents nuclear envelope accumulation of
            SYNE2.
REFERENCE   8  (residues 1 to 591)
  AUTHORS   Lanctot,A.A., Peng,C.Y., Pawlisz,A.S., Joksimovic,M. and Feng,Y.
  TITLE     Spatially dependent dynamic MAPK modulation by the Nde1-Lis1-Brap
            complex patterns mammalian CNS
  JOURNAL   Dev Cell 25 (3), 241-255 (2013)
   PUBMED   23673330
  REMARK    GeneRIF: A molecular complex composed of Nde1, Lis1, and Brap
            regulates the dynamic MAPK signaling threshold in a spatially
            dependent fashion.
REFERENCE   9  (residues 1 to 591)
  AUTHORS   Czyzyk,J., Chen,H.C., Bottomly,K. and Flavell,R.A.
  TITLE     p21 Ras/impedes mitogenic signal propagation regulates cytokine
            production and migration in CD4 T cells
  JOURNAL   J Biol Chem 283 (34), 23004-23015 (2008)
   PUBMED   18577512
  REMARK    GeneRIF: p21 Ras/Imp regulate cytokine production and migration in
            CD4 T cells
REFERENCE   10 (residues 1 to 591)
  AUTHORS   Nakajima,A., Kataoka,K., Hong,M., Sakaguchi,M. and Huh,N.H.
  TITLE     BRPK, a novel protein kinase showing increased expression in mouse
            cancer cell lines with higher metastatic potential
  JOURNAL   Cancer Lett 201 (2), 195-201 (2003)
   PUBMED   14607334
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY739796.1, BC062932.1 and AC116104.7.
            
            On Jul 8, 2005 this sequence version replaced NP_082503.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062932.1, AF321920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..591
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 61.9 cM"
     Protein         1..591
                     /product="BRCA1-associated protein isoform 1"
                     /EC_number="2.3.2.27"
                     /note="impedes mitogenic signal propagation; RING-type E3
                     ubiquitin transferase BRAP2"
                     /calculated_mol_wt=66860
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z569; propagated from
                     UniProtKB/Swiss-Prot (Q99MP8.1)"
     Region          82..124
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MP8.1)"
     Site            116
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z569; propagated from
                     UniProtKB/Swiss-Prot (Q99MP8.1)"
     Site            118
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z569; propagated from
                     UniProtKB/Swiss-Prot (Q99MP8.1)"
     Region          159..242
                     /region_name="RRM_BRAP2"
                     /note="RNA recognition motif (RRM) found in
                     BRCA1-associated protein (BRAP2); cd12718"
                     /db_xref="CDD:410117"
     Region          261..304
                     /region_name="RING-H2_BRAP2"
                     /note="RING finger, H2 subclass, found in BRCA1-associated
                     protein (BRAP2) and similar proteins; cd16457"
                     /db_xref="CDD:438121"
     Region          316..378
                     /region_name="zf-UBP"
                     /note="Zn-finger in ubiquitin-hydrolases and other
                     protein; pfam02148"
                     /db_xref="CDD:460464"
     Region          <396..564
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          563..591
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MP8.1)"
     CDS             1..591
                     /gene="Brap"
                     /gene_synonym="3010002G07Rik; BRAP2; IMP"
                     /coded_by="NM_028227.3:205..1980"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS19640.1"
                     /db_xref="GeneID:72399"
                     /db_xref="MGI:MGI:1919649"
ORIGIN      
        1 msvslvvirl elaghspvpt dfgfsaaage msdeeikkkt lasavacleg ksagekaaii
       61 hqhlgrremt dviietmkar adevrdtvee kkpsaapvsa qrsreqsesv ntapespskq
      121 lpdqisffsg npsveivhgi mhlyktnkmt slkedvrrsa mlcvltvpat mtshdlmkfv
      181 apfndvieqm kiirdstpnq ymvlikfsaq adadsfymac ngrqfnsied dvcqlvyver
      241 aevlksedga slpvmdltel pkctvclerm desvngiltt lcnhsfhsqc lqrwddttcp
      301 vcrycqtpep veenkcfecg vqenlwicli cghigcgryv srhaykhfee tqhtyamqlt
      361 nhrvwdyagd nyvhrlvask tdgkivqyec egdtcqeeki dalqleysyl ltsqlesqri
      421 ywenkivrie kdtaeeinnm ktkfketiek cdslelrlsd llkekqsver kctqlntrva
      481 klstelqeeq elnkclranq lvlqnqlkee ekllketcaq kdlqiteiqe qlrdvmfyle
      541 tqqqishlpa etrqeiqegq iniamasapn ppssgaggkl qsrkgrskrg k
//
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