LOCUS NP_082503 591 aa linear ROD 01-JUL-2024
DEFINITION BRCA1-associated protein isoform 1 [Mus musculus].
ACCESSION NP_082503
VERSION NP_082503.2
DBSOURCE REFSEQ: accession NM_028227.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 591)
AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
Jackson,S.P. and Balmus,G.
CONSRTM Sanger Mouse Genetics Project
TITLE Genetic determinants of micronucleus formation in vivo
JOURNAL Nature 627 (8002), 130-136 (2024)
PUBMED 38355793
REFERENCE 2 (residues 1 to 591)
AUTHORS Zheng,J., Wang,H., Wang,J., Peng,Z., Yao,X., Weber,H.C., Qin,X.,
Xiang,Y., Liu,C., Ji,M., Liu,H. and Qu,X.
TITLE Bombesin receptor-activated protein homolog deficiency altered the
pattern of pathological changes of psoriasis - like skin lesion in
mice
JOURNAL Int J Med Sci 21 (2), 357-368 (2024)
PUBMED 38169666
REMARK GeneRIF: Bombesin receptor-activated protein homolog deficiency
altered the pattern of pathological changes of psoriasis - like
skin lesion in mice.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 591)
AUTHORS Wang,H., Zuo,S., Zheng,J., Peng,Z., Yao,X., Wang,J., Weber,H.C.,
Qin,X., Xiang,Y., Liu,C., Ji,M., Liu,H., Pan,L. and Qu,X.
TITLE Knockout of the BRAP homolog in mice leads to abnormal tracheal
cilia
JOURNAL FEBS Lett 597 (21), 2626-2642 (2023)
PUBMED 37715941
REMARK GeneRIF: Knockout of the BRAP homolog in mice leads to abnormal
tracheal cilia.
REFERENCE 4 (residues 1 to 591)
AUTHORS Guo,Y., Chomiak,A.A., Hong,Y., Lowe,C.C., Kopsidas,C.A., Chan,W.C.,
Andrade,J., Pan,H., Zhou,X., Monuki,E.S. and Feng,Y.
TITLE Histone H2A ubiquitination resulting from Brap loss of function
connects multiple aging hallmarks and accelerates neurodegeneration
JOURNAL iScience 25 (7), 104519 (2022)
PUBMED 35754718
REMARK Publication Status: Online-Only
REFERENCE 5 (residues 1 to 591)
AUTHORS Chomiak,A.A., Guo,Y., Kopsidas,C.A., McDaniel,D.P., Lowe,C.C.,
Pan,H., Zhou,X., Zhou,Q., Doughty,M.L. and Feng,Y.
TITLE Nde1 is required for heterochromatin compaction and stability in
neocortical neurons
JOURNAL iScience 25 (6), 104354 (2022)
PUBMED 35601919
REMARK Publication Status: Online-Only
REFERENCE 6 (residues 1 to 591)
AUTHORS Fatima,S., Wagstaff,K.M., Loveland,K.L. and Jans,D.A.
TITLE Interactome of the negative regulator of nuclear import
BRCA1-binding protein 2
JOURNAL Sci Rep 5, 9459 (2015)
PUBMED 25820252
REMARK GeneRIF: Together the results indicate for the first time that
BRAP2 may play an important NRNI role in germ cells of the testis,
with an additional, scaffold/structural role in mature spermatozoa.
Publication Status: Online-Only
REFERENCE 7 (residues 1 to 591)
AUTHORS Davies,R.G., Wagstaff,K.M., McLaughlin,E.A., Loveland,K.L. and
Jans,D.A.
TITLE The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention
factor for nuclear and nuclear envelope-localizing testicular
proteins
JOURNAL Biochim Biophys Acta 1833 (12), 3436-3444 (2013)
PUBMED 23707952
REMARK GeneRIF: ectopic expression of BRAP2 inhibits nuclear localization
of HMG20A and NuMA1, and prevents nuclear envelope accumulation of
SYNE2.
REFERENCE 8 (residues 1 to 591)
AUTHORS Lanctot,A.A., Peng,C.Y., Pawlisz,A.S., Joksimovic,M. and Feng,Y.
TITLE Spatially dependent dynamic MAPK modulation by the Nde1-Lis1-Brap
complex patterns mammalian CNS
JOURNAL Dev Cell 25 (3), 241-255 (2013)
PUBMED 23673330
REMARK GeneRIF: A molecular complex composed of Nde1, Lis1, and Brap
regulates the dynamic MAPK signaling threshold in a spatially
dependent fashion.
REFERENCE 9 (residues 1 to 591)
AUTHORS Czyzyk,J., Chen,H.C., Bottomly,K. and Flavell,R.A.
TITLE p21 Ras/impedes mitogenic signal propagation regulates cytokine
production and migration in CD4 T cells
JOURNAL J Biol Chem 283 (34), 23004-23015 (2008)
PUBMED 18577512
REMARK GeneRIF: p21 Ras/Imp regulate cytokine production and migration in
CD4 T cells
REFERENCE 10 (residues 1 to 591)
AUTHORS Nakajima,A., Kataoka,K., Hong,M., Sakaguchi,M. and Huh,N.H.
TITLE BRPK, a novel protein kinase showing increased expression in mouse
cancer cell lines with higher metastatic potential
JOURNAL Cancer Lett 201 (2), 195-201 (2003)
PUBMED 14607334
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BY739796.1, BC062932.1 and AC116104.7.
On Jul 8, 2005 this sequence version replaced NP_082503.1.
Transcript Variant: This variant (1) encodes the longest isoform
(1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC062932.1, AF321920.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849374, SAMN00849375
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..591
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="5"
/map="5 61.9 cM"
Protein 1..591
/product="BRCA1-associated protein isoform 1"
/EC_number="2.3.2.27"
/note="impedes mitogenic signal propagation; RING-type E3
ubiquitin transferase BRAP2"
/calculated_mol_wt=66860
Site 52
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q7Z569; propagated from
UniProtKB/Swiss-Prot (Q99MP8.1)"
Region 82..124
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q99MP8.1)"
Site 116
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q7Z569; propagated from
UniProtKB/Swiss-Prot (Q99MP8.1)"
Site 118
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q7Z569; propagated from
UniProtKB/Swiss-Prot (Q99MP8.1)"
Region 159..242
/region_name="RRM_BRAP2"
/note="RNA recognition motif (RRM) found in
BRCA1-associated protein (BRAP2); cd12718"
/db_xref="CDD:410117"
Region 261..304
/region_name="RING-H2_BRAP2"
/note="RING finger, H2 subclass, found in BRCA1-associated
protein (BRAP2) and similar proteins; cd16457"
/db_xref="CDD:438121"
Region 316..378
/region_name="zf-UBP"
/note="Zn-finger in ubiquitin-hydrolases and other
protein; pfam02148"
/db_xref="CDD:460464"
Region <396..564
/region_name="SMC_prok_B"
/note="chromosome segregation protein SMC, common
bacterial type; TIGR02168"
/db_xref="CDD:274008"
Region 563..591
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q99MP8.1)"
CDS 1..591
/gene="Brap"
/gene_synonym="3010002G07Rik; BRAP2; IMP"
/coded_by="NM_028227.3:205..1980"
/note="isoform 1 is encoded by transcript variant 1"
/db_xref="CCDS:CCDS19640.1"
/db_xref="GeneID:72399"
/db_xref="MGI:MGI:1919649"
ORIGIN
1 msvslvvirl elaghspvpt dfgfsaaage msdeeikkkt lasavacleg ksagekaaii
61 hqhlgrremt dviietmkar adevrdtvee kkpsaapvsa qrsreqsesv ntapespskq
121 lpdqisffsg npsveivhgi mhlyktnkmt slkedvrrsa mlcvltvpat mtshdlmkfv
181 apfndvieqm kiirdstpnq ymvlikfsaq adadsfymac ngrqfnsied dvcqlvyver
241 aevlksedga slpvmdltel pkctvclerm desvngiltt lcnhsfhsqc lqrwddttcp
301 vcrycqtpep veenkcfecg vqenlwicli cghigcgryv srhaykhfee tqhtyamqlt
361 nhrvwdyagd nyvhrlvask tdgkivqyec egdtcqeeki dalqleysyl ltsqlesqri
421 ywenkivrie kdtaeeinnm ktkfketiek cdslelrlsd llkekqsver kctqlntrva
481 klstelqeeq elnkclranq lvlqnqlkee ekllketcaq kdlqiteiqe qlrdvmfyle
541 tqqqishlpa etrqeiqegq iniamasapn ppssgaggkl qsrkgrskrg k
//