LOCUS ZNF2_CAEEL 422 aa linear INV 27-NOV-2024
DEFINITION RecName: Full=Zinc finger protein zfp-2.
ACCESSION Q20082
VERSION Q20082.1
DBSOURCE UniProtKB: locus ZNF2_CAEEL, accession Q20082;
class: standard.
created: Jul 5, 2017.
sequence updated: Nov 1, 1996.
annotation updated: Nov 27, 2024.
xrefs: BX284602.5, CAA85325.1, T21820, NP_496055.1
xrefs (non-sequence databases): AlphaFoldDB:Q20082, SMR:Q20082,
STRING:6239.F35H8.3.1, PaxDb:6239-F35H8.3,
EnsemblMetazoa:F35H8.3.1, EnsemblMetazoa:F35H8.3.1,
EnsemblMetazoa:WBGene00009448, GeneID:174505,
KEGG:cel:CELE_F35H8.3, UCSC:F35H8.3, AGR:WB:WBGene00009448,
CTD:174505, WormBase:F35H8.3, WormBase:CE00981, eggNOG:KOG1721,
GeneTree:ENSGT00940000171158, HOGENOM:CLU_652527_0_0_1,
InParanoid:Q20082, OMA:QIVEMDG, OrthoDB:2953226at2759,
PhylomeDB:Q20082, Reactome:R-CEL-8951664, Reactome:R-CEL-983168,
PRO:PR:Q20082, Proteomes:UP000001940, Bgee:WBGene00009448,
GO:0005634, GO:0001228, GO:0046872, GO:0000978, GO:0006357,
FunFam:3.30.160.60:FF:000064, Gene3D:3.30.160.60,
InterPro:IPR036236, InterPro:IPR013087, PANTHER:PTHR24394:SF29,
PANTHER:PTHR24394, Pfam:PF00096, SMART:SM00355, SUPFAM:SSF57667,
PROSITE:PS00028, PROSITE:PS50157
KEYWORDS DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
Transcription; Transcription regulation; Zinc; Zinc-finger.
SOURCE Caenorhabditis elegans
ORGANISM Caenorhabditis elegans
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
REFERENCE 1 (residues 1 to 422)
CONSRTM C. elegans Sequencing Consortium
TITLE Genome sequence of the nematode C. elegans: a platform for
investigating biology
JOURNAL Science 282 (5396), 2012-2018 (1998)
PUBMED 9851916
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940}
Erratum:[Science 1999 Jan 1;283(5398):35]
REFERENCE 2 (residues 1 to 422)
AUTHORS Ceron,J., Rual,J.F., Chandra,A., Dupuy,D., Vidal,M. and van den
Heuvel,S.
TITLE Large-scale RNAi screens identify novel genes that interact with
the C. elegans retinoblastoma pathway as well as splicing-related
components with synMuv B activity
JOURNAL BMC Dev Biol 7, 30 (2007)
PUBMED 17417969
REMARK FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
PHENOTYPE.
Publication Status: Online-Only
COMMENT On Sep 14, 2005 this sequence version replaced gi:7500572.
[FUNCTION] Probable zinc finger transcription factor that acts as a
transcriptional repressor. Acts redundantly with the
transcriptional repressor lin-35 to control the development of
somatic gonad lineages. May, in addition, suppress sensitivity to
RNAi. {ECO:0000269|PubMed:17417969}.
[SUBCELLULAR LOCATION] Nucleus {ECO:0000305|PubMed:17417969}.
[TISSUE SPECIFICITY] Expressed in vulval cells and all somatic
gonad structures such as spermatheca, sheath cells, uterine cells
and distal tip cells. {ECO:0000269|PubMed:17417969}.
[DISRUPTION PHENOTYPE] No visible phenotype. Double knockout with
lin-35 results in sterility, defects in gonad migration and vulval
morphology. {ECO:0000269|PubMed:17417969}.
FEATURES Location/Qualifiers
source 1..422
/organism="Caenorhabditis elegans"
/db_xref="taxon:6239"
gene 1..422
/gene="zfp-2"
/locus_tag="F35H8.3"
Protein 1..422
/product="Zinc finger protein zfp-2"
/UniProtKB_evidence="Evidence at transcript level"
Region 1..422
/region_name="Mature chain"
/note="Zinc finger protein zfp-2. /evidence=ECO:0000305.
/id=PRO_0000441015."
Region 95..119
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Region 95..116
/region_name="Compositionally biased region"
/note="Polar residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Region 171..194
/region_name="Zinc finger region"
/note="C2H2-type 1.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
Region 173..194
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site order(178,180,182,184..185,188..189,193,207,209,213..214,
217..218,221,236,238,240,242..243,246..247,250)
/site_type="other"
/note="putative nucleic acid binding site [nucleotide
binding]"
/db_xref="CDD:275368"
Region 200..222
/region_name="Zinc finger region"
/note="C2H2-type 2.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
Region 202..222
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 229..251
/region_name="Zinc finger region"
/note="C2H2-type 3.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
Region 231..251
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region <251..>358
/region_name="COG5048"
/note="FOG: Zn-finger [General function prediction only]"
/db_xref="CDD:227381"
Region 255..278
/region_name="Zinc finger region"
/note="C2H2-type 4.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
Region 257..278
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 300..322
/region_name="Zinc finger region"
/note="C2H2-type 5.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
Region 302..322
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site order(307,309,311,313..314,317..318,321,335,337,341..342,
345..346,349,363,365,367,369..370,373..374)
/site_type="other"
/note="putative nucleic acid binding site [nucleotide
binding]"
/db_xref="CDD:275368"
Region 318..339
/region_name="zf-H2C2_2"
/note="Zinc-finger double domain; pfam13465"
/db_xref="CDD:463886"
Region 328..350
/region_name="Zinc finger region"
/note="C2H2-type 6.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
Region 330..350
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 356..379
/region_name="Zinc finger region"
/note="C2H2-type 7.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00042."
Region 358..374
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
ORIGIN
1 meemmmndps amviyeeevt tapnlpcsli qqrswdeekp igyeltntkc yktpngvqkt
61 atiqreqlst skdfgeqqiv emdgefsieg tdmhaipcts ssmqpstssn pssgehqpvp
121 lrrmaikigq rvlrfkvisa eeapeapldt qdswindpkp vttpkalagl yrctncktyf
181 gnkevyqrhi qevhgdarpf rcfncgmrfa nktsmthhlk dhsllkpmfs cdycprifsk
241 lesktrhhkm hftrstcqtc mrffttedal rhhqstahpa tfdsgppped llpngksary
301 scsycnlrfh fkkdmlvher ihtgekpysc gycmksfaqs qaltahirth tkelpygcgk
361 cdkrfrdnsc lrkhelaaht depivrpisv aysnqvqkqm qrqrenrrkq elliaerhpy
421 ri
//