LOCUS NP_001029140 1146 aa linear ROD 14-JUN-2024
DEFINITION large proline-rich protein BAG6 isoform 1 [Rattus norvegicus].
ACCESSION NP_001029140
VERSION NP_001029140.1
DBSOURCE REFSEQ: accession NM_001033968.2
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 1146)
AUTHORS Mock,J.Y., Xu,Y., Ye,Y. and Clemons,W.M. Jr.
TITLE Structural basis for regulation of the nucleo-cytoplasmic
distribution of Bag6 by TRC35
JOURNAL Proc Natl Acad Sci U S A 114 (44), 11679-11684 (2017)
PUBMED 29042515
REFERENCE 2 (residues 1 to 1146)
AUTHORS Topalidou,I., Cattin-Ortola,J., Pappas,A.L., Cooper,K.,
Merrihew,G.E., MacCoss,M.J. and Ailion,M.
TITLE The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo
Sorting to Dense-Core Vesicles
JOURNAL PLoS Genet 12 (5), e1006074 (2016)
PUBMED 27191843
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 1146)
AUTHORS Rusakiewicz,S., Perier,A., Semeraro,M., Pitt,J.M., Pogge von
Strandmann,E., Reiners,K.S., Aspeslagh,S., Piperoglou,C., Vely,F.,
Ivagnes,A., Jegou,S., Halama,N., Chaigneau,L., Validire,P.,
Christidis,C., Perniceni,T., Landi,B., Berger,A., Isambert,N.,
Domont,J., Bonvalot,S., Terrier,P., Adam,J., Coindre,J.M.,
Emile,J.F., Poirier-Colame,V., Chaba,K., Rocha,B., Caignard,A.,
Toubert,A., Enot,D., Koch,J., Marabelle,A., Lambert,M.,
Caillat-Zucman,S., Leyvraz,S., Auclair,C., Vivier,E., Eggermont,A.,
Borg,C., Blay,J.Y., Le Cesne,A., Mir,O. and Zitvogel,L.
TITLE NKp30 isoforms and NKp30 ligands are predictive biomarkers of
response to imatinib mesylate in metastatic GIST patients
JOURNAL Oncoimmunology 6 (1), e1137418 (2016)
PUBMED 28197361
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 1146)
AUTHORS Osorio,F.G., Soria-Valles,C., Santiago-Fernandez,O., Bernal,T.,
Mittelbrunn,M., Colado,E., Rodriguez,F., Bonzon-Kulichenko,E.,
Vazquez,J., Porta-de-la-Riva,M., Ceron,J., Fueyo,A., Li,J.,
Green,A.R., Freije,J.M. and Lopez-Otin,C.
TITLE Loss of the proteostasis factor AIRAPL causes myeloid
transformation by deregulating IGF-1 signaling
JOURNAL Nat Med 22 (1), 91-96 (2016)
PUBMED 26692333
REFERENCE 5 (residues 1 to 1146)
AUTHORS Kadowaki,H., Nagai,A., Maruyama,T., Takami,Y., Satrimafitrah,P.,
Kato,H., Honda,A., Hatta,T., Natsume,T., Sato,T., Kai,H., Ichijo,H.
and Nishitoh,H.
TITLE Pre-emptive Quality Control Protects the ER from Protein Overload
via the Proximity of ERAD Components and SRP
JOURNAL Cell Rep 13 (5), 944-956 (2015)
PUBMED 26565908
REFERENCE 6 (residues 1 to 1146)
AUTHORS Desmots,F., Russell,H.R., Lee,Y., Boyd,K. and McKinnon,P.J.
TITLE The reaper-binding protein scythe modulates apoptosis and
proliferation during mammalian development
JOURNAL Mol Cell Biol 25 (23), 10329-10337 (2005)
PUBMED 16287848
REFERENCE 7 (residues 1 to 1146)
AUTHORS Wu,Y.H., Shih,S.F. and Lin,J.Y.
TITLE Ricin triggers apoptotic morphological changes through caspase-3
cleavage of BAT3
JOURNAL J Biol Chem 279 (18), 19264-19275 (2004)
PUBMED 14960581
REFERENCE 8 (residues 1 to 1146)
AUTHORS Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
TITLE The genomic sequence and comparative analysis of the rat major
histocompatibility complex
JOURNAL Genome Res 14 (4), 631-639 (2004)
PUBMED 15060004
REFERENCE 9 (residues 1 to 1146)
AUTHORS Fernandez-Chacon,R., Achiriloaie,M., Janz,R., Albanesi,J.P. and
Sudhof,T.C.
TITLE SCAMP1 function in endocytosis
JOURNAL J Biol Chem 275 (17), 12752-12756 (2000)
PUBMED 10777571
REFERENCE 10 (residues 1 to 1146)
AUTHORS Ozaki,T., Hanaoka,E., Naka,M., Nakagawara,A. and Sakiyama,S.
TITLE Cloning and characterization of rat BAT3 cDNA
JOURNAL DNA Cell Biol 18 (6), 503-512 (1999)
PUBMED 10390159
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000020.1.
Transcript Variant: This variant (1) encodes the longer isoform
(1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC100141.1, SRR26643296.39347.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA5760383,
SAMEA5760389 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
is not conserved
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..1146
/organism="Rattus norvegicus"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="20"
/map="20p12"
Protein 1..1146
/product="large proline-rich protein BAG6 isoform 1"
/note="large proline-rich protein BAT3; large proline-rich
protein BAG6; HLA-B-associated transcript 3;
BCL2-associated athanogene 6"
/calculated_mol_wt=119882
Site 1
/site_type="acetylation"
/note="N-acetylmethionine.
/evidence=ECO:0000250|UniProtKB:P46379; propagated from
UniProtKB/Swiss-Prot (Q6MG49.2)"
Region 17..87
/region_name="Ubl_BAG6"
/note="ubiquitin-like (Ubl) domain found in
BCL2-associated athanogene 6 (BAG6) and similar proteins;
cd01809"
/db_xref="CDD:340507"
Site order(22..25,58,60,62..65,83..87)
/site_type="other"
/note="ZF interaction site [polypeptide binding]"
/db_xref="CDD:340507"
Region 87..128
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
Site 96
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P46379; propagated from
UniProtKB/Swiss-Prot (Q6MG49.2)"
Site 117
/site_type="phosphorylation"
/note="Phosphothreonine.
/evidence=ECO:0000250|UniProtKB:P46379; propagated from
UniProtKB/Swiss-Prot (Q6MG49.2)"
Region 186..268
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
Region 236..650
/region_name="4 X 29 AA approximate repeats.
/evidence=ECO:0000250|UniProtKB:P46379"
/note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
Region 272..386
/region_name="BAG6"
/note="BCL2-associated athanogene 6; pfam12057"
/db_xref="CDD:463449"
Region 381..436
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
Region 457..525
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
Region 555..618
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
Region 666..711
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
Region <919..1110
/region_name="PRK07764"
/note="DNA polymerase III subunits gamma and tau;
Validated"
/db_xref="CDD:236090"
Region 961..1146
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
Site 978
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P46379; propagated from
UniProtKB/Swiss-Prot (Q6MG49.2)"
Site 987
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q6MG49.2)"
Site 1015..1016
/site_type="cleavage"
/note="Cleavage, by CASP3.
/evidence=ECO:0000250|UniProtKB:P46379; propagated from
UniProtKB/Swiss-Prot (Q6MG49.2)"
Region 1024..1054
/region_name="Required for interaction with GET4.
/evidence=ECO:0000250|UniProtKB:P46379"
/note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
Region 1026..1068
/region_name="Nuclear localization site.
/evidence=ECO:0000250|UniProtKB:P46379"
/note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
Region 1036..1146
/region_name="Sufficient for the delivery of client
proteins to the endoplasmic reticulum.
/evidence=ECO:0000250|UniProtKB:P46379"
/note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
Site 1067
/site_type="phosphorylation"
/note="Phosphothreonine.
/evidence=ECO:0000250|UniProtKB:P46379; propagated from
UniProtKB/Swiss-Prot (Q6MG49.2)"
Region 1072..1129
/region_name="BAG-similar domain, required and sufficient
for interaction with UBL4A.
/evidence=ECO:0000250|UniProtKB:P46379"
/note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
Site 1095
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q6MG49.2)"
Site 1131
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P46379; propagated from
UniProtKB/Swiss-Prot (Q6MG49.2)"
CDS 1..1146
/gene="Bag6"
/gene_synonym="Bat3"
/coded_by="NM_001033968.2:114..3554"
/note="isoform 1 is encoded by transcript variant 1"
/db_xref="GeneID:94342"
/db_xref="RGD:71064"
ORIGIN
1 mepsdststa meepdslevl vktldsqtrt fivgaqmnvk efkehiaasv sipsekqrli
61 yqgrvlqddk klqdynvggk vihlverapp qtqlpsgass gtgsasathg ggplpgtrgp
121 gasghdrnan syvmvgtfnl psdgsavdvh inmeqapiqs eprvrlvmaq hmirdiqtll
181 srmecrggtq aqasqpppqt ptvasetval nsqtsepves eapprepmes eemeerpptq
241 tpelppsgpa pagpapapet napnhpspae hvevlqelqr lqrrlqpflq rycevlgaaa
301 ttdynnnheg reedqrlinl vgeslrllgn tfvalsdlrc nlacapprhl hvvrpmshyt
361 tpmvlqqaai piqinvgttv tmtgngarpp papgaeaasp gsgqasslpp ssatvdsste
421 gapppgpapp patshprvir ishqsvepvv mmhmniqdsg aqpggvpsap tgplgppghg
481 qslgqqvpgf ptaptrvvia rptppqarps hpggppvsga lqgaglgtnt slaqmvsglv
541 gqllmqpvlv aqgtpgmapa sasapataqa qapapapapa papatasasa gttntattag
601 papggpaqpp ppqpsaadlq fsqllgnllg pagpgaggps lasptitvav pgvpaflqgm
661 teflqasqaa pppppppppp ppapeqqttp ppgspsggta spgglgpesl ppefftsvvq
721 gvlssllgsl garagssesi aafiqrlsgs snifepgadg algffgalls llcqnfsmvd
781 vvmllhghfq plqrlqpqlr sffhqhylgg qeptssnirm athtlitgle eyvresfslv
841 qvqpgvdiir tnleflqeqf nsiaahvlhc tdsgfgarll elcnqglfec lalnlhclgg
901 qqmelaavin grirrmsrgv npslvswltt mmglrlqvvl ehmpvgpdai lryvrrigdp
961 pqalpeepme vqgaertspe pqredaspap gttaeeamsr gpppapeggs rdeqdgasad
1021 aepwaaavpp ewvpiiqqdi qsqrkvkpqp plsdaylsgm pakrrktmqg egpqlllsea
1081 vsraakaaga rpltspesls rdleapevqe syrqqlrsdi qkrlqedpny spqrfpnahr
1141 afaddp
//