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large proline-rich protein BAG6 isoform 1 [Rattus norvegicus]

NCBI Reference Sequence: NP_001029140.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001029140            1146 aa            linear   ROD 14-JUN-2024
DEFINITION  large proline-rich protein BAG6 isoform 1 [Rattus norvegicus].
ACCESSION   NP_001029140
VERSION     NP_001029140.1
DBSOURCE    REFSEQ: accession NM_001033968.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1146)
  AUTHORS   Mock,J.Y., Xu,Y., Ye,Y. and Clemons,W.M. Jr.
  TITLE     Structural basis for regulation of the nucleo-cytoplasmic
            distribution of Bag6 by TRC35
  JOURNAL   Proc Natl Acad Sci U S A 114 (44), 11679-11684 (2017)
   PUBMED   29042515
REFERENCE   2  (residues 1 to 1146)
  AUTHORS   Topalidou,I., Cattin-Ortola,J., Pappas,A.L., Cooper,K.,
            Merrihew,G.E., MacCoss,M.J. and Ailion,M.
  TITLE     The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo
            Sorting to Dense-Core Vesicles
  JOURNAL   PLoS Genet 12 (5), e1006074 (2016)
   PUBMED   27191843
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1146)
  AUTHORS   Rusakiewicz,S., Perier,A., Semeraro,M., Pitt,J.M., Pogge von
            Strandmann,E., Reiners,K.S., Aspeslagh,S., Piperoglou,C., Vely,F.,
            Ivagnes,A., Jegou,S., Halama,N., Chaigneau,L., Validire,P.,
            Christidis,C., Perniceni,T., Landi,B., Berger,A., Isambert,N.,
            Domont,J., Bonvalot,S., Terrier,P., Adam,J., Coindre,J.M.,
            Emile,J.F., Poirier-Colame,V., Chaba,K., Rocha,B., Caignard,A.,
            Toubert,A., Enot,D., Koch,J., Marabelle,A., Lambert,M.,
            Caillat-Zucman,S., Leyvraz,S., Auclair,C., Vivier,E., Eggermont,A.,
            Borg,C., Blay,J.Y., Le Cesne,A., Mir,O. and Zitvogel,L.
  TITLE     NKp30 isoforms and NKp30 ligands are predictive biomarkers of
            response to imatinib mesylate in metastatic GIST patients
  JOURNAL   Oncoimmunology 6 (1), e1137418 (2016)
   PUBMED   28197361
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1146)
  AUTHORS   Osorio,F.G., Soria-Valles,C., Santiago-Fernandez,O., Bernal,T.,
            Mittelbrunn,M., Colado,E., Rodriguez,F., Bonzon-Kulichenko,E.,
            Vazquez,J., Porta-de-la-Riva,M., Ceron,J., Fueyo,A., Li,J.,
            Green,A.R., Freije,J.M. and Lopez-Otin,C.
  TITLE     Loss of the proteostasis factor AIRAPL causes myeloid
            transformation by deregulating IGF-1 signaling
  JOURNAL   Nat Med 22 (1), 91-96 (2016)
   PUBMED   26692333
REFERENCE   5  (residues 1 to 1146)
  AUTHORS   Kadowaki,H., Nagai,A., Maruyama,T., Takami,Y., Satrimafitrah,P.,
            Kato,H., Honda,A., Hatta,T., Natsume,T., Sato,T., Kai,H., Ichijo,H.
            and Nishitoh,H.
  TITLE     Pre-emptive Quality Control Protects the ER from Protein Overload
            via the Proximity of ERAD Components and SRP
  JOURNAL   Cell Rep 13 (5), 944-956 (2015)
   PUBMED   26565908
REFERENCE   6  (residues 1 to 1146)
  AUTHORS   Desmots,F., Russell,H.R., Lee,Y., Boyd,K. and McKinnon,P.J.
  TITLE     The reaper-binding protein scythe modulates apoptosis and
            proliferation during mammalian development
  JOURNAL   Mol Cell Biol 25 (23), 10329-10337 (2005)
   PUBMED   16287848
REFERENCE   7  (residues 1 to 1146)
  AUTHORS   Wu,Y.H., Shih,S.F. and Lin,J.Y.
  TITLE     Ricin triggers apoptotic morphological changes through caspase-3
            cleavage of BAT3
  JOURNAL   J Biol Chem 279 (18), 19264-19275 (2004)
   PUBMED   14960581
REFERENCE   8  (residues 1 to 1146)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   9  (residues 1 to 1146)
  AUTHORS   Fernandez-Chacon,R., Achiriloaie,M., Janz,R., Albanesi,J.P. and
            Sudhof,T.C.
  TITLE     SCAMP1 function in endocytosis
  JOURNAL   J Biol Chem 275 (17), 12752-12756 (2000)
   PUBMED   10777571
REFERENCE   10 (residues 1 to 1146)
  AUTHORS   Ozaki,T., Hanaoka,E., Naka,M., Nakagawara,A. and Sakiyama,S.
  TITLE     Cloning and characterization of rat BAT3 cDNA
  JOURNAL   DNA Cell Biol 18 (6), 503-512 (1999)
   PUBMED   10390159
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100141.1, SRR26643296.39347.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1146
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     Protein         1..1146
                     /product="large proline-rich protein BAG6 isoform 1"
                     /note="large proline-rich protein BAT3; large proline-rich
                     protein BAG6; HLA-B-associated transcript 3;
                     BCL2-associated athanogene 6"
                     /calculated_mol_wt=119882
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P46379; propagated from
                     UniProtKB/Swiss-Prot (Q6MG49.2)"
     Region          17..87
                     /region_name="Ubl_BAG6"
                     /note="ubiquitin-like (Ubl) domain found in
                     BCL2-associated athanogene 6 (BAG6) and similar proteins;
                     cd01809"
                     /db_xref="CDD:340507"
     Site            order(22..25,58,60,62..65,83..87)
                     /site_type="other"
                     /note="ZF interaction site [polypeptide binding]"
                     /db_xref="CDD:340507"
     Region          87..128
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
     Site            96
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P46379; propagated from
                     UniProtKB/Swiss-Prot (Q6MG49.2)"
     Site            117
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P46379; propagated from
                     UniProtKB/Swiss-Prot (Q6MG49.2)"
     Region          186..268
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
     Region          236..650
                     /region_name="4 X 29 AA approximate repeats.
                     /evidence=ECO:0000250|UniProtKB:P46379"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
     Region          272..386
                     /region_name="BAG6"
                     /note="BCL2-associated athanogene 6; pfam12057"
                     /db_xref="CDD:463449"
     Region          381..436
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
     Region          457..525
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
     Region          555..618
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
     Region          666..711
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
     Region          <919..1110
                     /region_name="PRK07764"
                     /note="DNA polymerase III subunits gamma and tau;
                     Validated"
                     /db_xref="CDD:236090"
     Region          961..1146
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
     Site            978
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P46379; propagated from
                     UniProtKB/Swiss-Prot (Q6MG49.2)"
     Site            987
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6MG49.2)"
     Site            1015..1016
                     /site_type="cleavage"
                     /note="Cleavage, by CASP3.
                     /evidence=ECO:0000250|UniProtKB:P46379; propagated from
                     UniProtKB/Swiss-Prot (Q6MG49.2)"
     Region          1024..1054
                     /region_name="Required for interaction with GET4.
                     /evidence=ECO:0000250|UniProtKB:P46379"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
     Region          1026..1068
                     /region_name="Nuclear localization site.
                     /evidence=ECO:0000250|UniProtKB:P46379"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
     Region          1036..1146
                     /region_name="Sufficient for the delivery of client
                     proteins to the endoplasmic reticulum.
                     /evidence=ECO:0000250|UniProtKB:P46379"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
     Site            1067
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P46379; propagated from
                     UniProtKB/Swiss-Prot (Q6MG49.2)"
     Region          1072..1129
                     /region_name="BAG-similar domain, required and sufficient
                     for interaction with UBL4A.
                     /evidence=ECO:0000250|UniProtKB:P46379"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6MG49.2)"
     Site            1095
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q6MG49.2)"
     Site            1131
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P46379; propagated from
                     UniProtKB/Swiss-Prot (Q6MG49.2)"
     CDS             1..1146
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /coded_by="NM_001033968.2:114..3554"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:94342"
                     /db_xref="RGD:71064"
ORIGIN      
        1 mepsdststa meepdslevl vktldsqtrt fivgaqmnvk efkehiaasv sipsekqrli
       61 yqgrvlqddk klqdynvggk vihlverapp qtqlpsgass gtgsasathg ggplpgtrgp
      121 gasghdrnan syvmvgtfnl psdgsavdvh inmeqapiqs eprvrlvmaq hmirdiqtll
      181 srmecrggtq aqasqpppqt ptvasetval nsqtsepves eapprepmes eemeerpptq
      241 tpelppsgpa pagpapapet napnhpspae hvevlqelqr lqrrlqpflq rycevlgaaa
      301 ttdynnnheg reedqrlinl vgeslrllgn tfvalsdlrc nlacapprhl hvvrpmshyt
      361 tpmvlqqaai piqinvgttv tmtgngarpp papgaeaasp gsgqasslpp ssatvdsste
      421 gapppgpapp patshprvir ishqsvepvv mmhmniqdsg aqpggvpsap tgplgppghg
      481 qslgqqvpgf ptaptrvvia rptppqarps hpggppvsga lqgaglgtnt slaqmvsglv
      541 gqllmqpvlv aqgtpgmapa sasapataqa qapapapapa papatasasa gttntattag
      601 papggpaqpp ppqpsaadlq fsqllgnllg pagpgaggps lasptitvav pgvpaflqgm
      661 teflqasqaa pppppppppp ppapeqqttp ppgspsggta spgglgpesl ppefftsvvq
      721 gvlssllgsl garagssesi aafiqrlsgs snifepgadg algffgalls llcqnfsmvd
      781 vvmllhghfq plqrlqpqlr sffhqhylgg qeptssnirm athtlitgle eyvresfslv
      841 qvqpgvdiir tnleflqeqf nsiaahvlhc tdsgfgarll elcnqglfec lalnlhclgg
      901 qqmelaavin grirrmsrgv npslvswltt mmglrlqvvl ehmpvgpdai lryvrrigdp
      961 pqalpeepme vqgaertspe pqredaspap gttaeeamsr gpppapeggs rdeqdgasad
     1021 aepwaaavpp ewvpiiqqdi qsqrkvkpqp plsdaylsgm pakrrktmqg egpqlllsea
     1081 vsraakaaga rpltspesls rdleapevqe syrqqlrsdi qkrlqedpny spqrfpnahr
     1141 afaddp
//
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