LOCUS SYK_PROM4 503 aa linear BCT 27-NOV-2024
DEFINITION RecName: Full=Lysine--tRNA ligase; AltName: Full=Lysyl-tRNA
synthetase; Short=LysRS.
ACCESSION A9BD62
VERSION A9BD62.1
DBSOURCE UniProtKB: locus SYK_PROM4, accession A9BD62;
class: standard.
created: Mar 24, 2009.
sequence updated: Jan 15, 2008.
annotation updated: Nov 27, 2024.
xrefs: CP000878.1, ABX09675.1, WP_012196295.1
xrefs (non-sequence databases): AlphaFoldDB:A9BD62, SMR:A9BD62,
STRING:93059.P9211_17441, KEGG:pmj:P9211_17441, eggNOG:COG1190,
HOGENOM:CLU_008255_6_0_3, OrthoDB:9802326at2,
Proteomes:UP000000788, GO:0005829, GO:0005524, GO:0004824,
GO:0000287, GO:0000049, GO:0006430, CDD:cd00775, CDD:cd04322,
FunFam:3.30.930.10:FF:000238, Gene3D:2.40.50.140, HAMAP:MF_00252,
InterPro:IPR004364, InterPro:IPR006195, InterPro:IPR045864,
InterPro:IPR002313, InterPro:IPR044136, InterPro:IPR018149,
InterPro:IPR012340, InterPro:IPR004365, NCBIfam:TIGR00499,
PANTHER:PTHR42918:SF9, PANTHER:PTHR42918, Pfam:PF00152,
Pfam:PF01336, PRINTS:PR00982, SUPFAM:SSF55681, SUPFAM:SSF50249,
PROSITE:PS50862
KEYWORDS Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
Magnesium; Metal-binding; Nucleotide-binding; Protein biosynthesis;
Reference proteome.
SOURCE Prochlorococcus marinus str. MIT 9211
ORGANISM Prochlorococcus marinus str. MIT 9211
Bacteria; Bacillati; Cyanobacteriota; Cyanophyceae;
Synechococcales; Prochlorococcaceae; Prochlorococcus.
REFERENCE 1 (residues 1 to 503)
AUTHORS Kettler,G.C., Martiny,A.C., Huang,K., Zucker,J., Coleman,M.L.,
Rodrigue,S., Chen,F., Lapidus,A., Ferriera,S., Johnson,J.,
Steglich,C., Church,G.M., Richardson,P. and Chisholm,S.W.
TITLE Patterns and implications of gene gain and loss in the evolution of
Prochlorococcus
JOURNAL PLoS Genet 3 (12), e231 (2007)
PUBMED 18159947
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
STRAIN=MIT 9211
COMMENT [CATALYTIC ACTIVITY] Reaction=tRNA(Lys) + L-lysine + ATP =
L-lysyl-tRNA(Lys) + AMP + diphosphate; Xref=Rhea:RHEA:20792,
Rhea:RHEA-COMP:9696, Rhea:RHEA-COMP:9697, ChEBI:CHEBI:30616,
ChEBI:CHEBI:32551, ChEBI:CHEBI:33019, ChEBI:CHEBI:78442,
ChEBI:CHEBI:78529, ChEBI:CHEBI:456215; EC=6.1.1.6;
Evidence={ECO:0000255|HAMAP-Rule:MF_00252}.
[COFACTOR] Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000255|HAMAP-Rule:MF_00252}; Note=Binds 3 Mg(2+)
ions per subunit. {ECO:0000255|HAMAP-Rule:MF_00252}.
[SUBUNIT] Homodimer. {ECO:0000255|HAMAP-Rule:MF_00252}.
[SUBCELLULAR LOCATION] Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00252}.
[SIMILARITY] Belongs to the class-II aminoacyl-tRNA synthetase
family. {ECO:0000255|HAMAP-Rule:MF_00252}.
FEATURES Location/Qualifiers
source 1..503
/organism="Prochlorococcus marinus str. MIT 9211"
/strain="MIT 9211"
/db_xref="taxon:93059"
gene 1..503
/gene="lysS"
/locus_tag="P9211_17441"
Protein 1..503
/product="Lysine--tRNA ligase"
/EC_number="6.1.1.6"
/note="Lysyl-tRNA synthetase; LysRS"
/UniProtKB_evidence="Inferred from homology"
Region 1..503
/region_name="Mature chain"
/note="Lysine--tRNA ligase. /id=PRO_1000101134."
Region 1..500
/region_name="lysS"
/note="lysyl-tRNA synthetase; Reviewed; PRK00484"
/db_xref="CDD:234778"
Site 203..207
/site_type="other"
/note="motif 1"
/db_xref="CDD:238398"
Site order(235,257,259,265,269,410,417,420,424,476)
/site_type="active"
/db_xref="CDD:238398"
Site 256..259
/site_type="other"
/note="motif 2"
/db_xref="CDD:238398"
Site 473..476
/site_type="other"
/note="motif 3"
/db_xref="CDD:238398"
ORIGIN
1 msdlketrle kaqvlkklgn gpygirfevt hkaavlqveh qdlangqerq levcvagrvi
61 srrvmgklaf ftlsdesgsi qlflekatle ehsdldqesp gsfsqltdlv dsgdwigvng
121 ilrrtdrgel sikvfswtml ckslqplpdk whglsdvekr yrqryvdliv npqsrktfrs
181 ralmvsairr wlderdflei etpvlqseag gaearpfith hntldlslyl riatelhlkr
241 lvvggfervy elgrifrneg istrhnpeft tveiyqafad ytdmmdltee misfvcsqic
301 gsttiqyqgk evdltppwrr itmhelvles tgldfyefgq diskastamq svglnvpdha
361 dsvgrlmnea feqavegdlf qptfvmdypi eisplarkhr skpgiverfe lfiagretan
421 afselidpvd qkerlllqqs rrqagdleah videdfvnal evgmpptggl gigidrlvml
481 ltdspsirdv iafpllkpes gsq
//