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RecName: Full=Lysine--tRNA ligase; AltName: Full=Lysyl-tRNA synthetase; Short=LysRS

UniProtKB/Swiss-Prot: A9BD62.1

Identical Proteins FASTA Graphics 

LOCUS       SYK_PROM4                503 aa            linear   BCT 27-NOV-2024
DEFINITION  RecName: Full=Lysine--tRNA ligase; AltName: Full=Lysyl-tRNA
            synthetase; Short=LysRS.
ACCESSION   A9BD62
VERSION     A9BD62.1
DBSOURCE    UniProtKB: locus SYK_PROM4, accession A9BD62;
            class: standard.
            created: Mar 24, 2009.
            sequence updated: Jan 15, 2008.
            annotation updated: Nov 27, 2024.
            xrefs: CP000878.1, ABX09675.1, WP_012196295.1
            xrefs (non-sequence databases): AlphaFoldDB:A9BD62, SMR:A9BD62,
            STRING:93059.P9211_17441, KEGG:pmj:P9211_17441, eggNOG:COG1190,
            HOGENOM:CLU_008255_6_0_3, OrthoDB:9802326at2,
            Proteomes:UP000000788, GO:0005829, GO:0005524, GO:0004824,
            GO:0000287, GO:0000049, GO:0006430, CDD:cd00775, CDD:cd04322,
            FunFam:3.30.930.10:FF:000238, Gene3D:2.40.50.140, HAMAP:MF_00252,
            InterPro:IPR004364, InterPro:IPR006195, InterPro:IPR045864,
            InterPro:IPR002313, InterPro:IPR044136, InterPro:IPR018149,
            InterPro:IPR012340, InterPro:IPR004365, NCBIfam:TIGR00499,
            PANTHER:PTHR42918:SF9, PANTHER:PTHR42918, Pfam:PF00152,
            Pfam:PF01336, PRINTS:PR00982, SUPFAM:SSF55681, SUPFAM:SSF50249,
            PROSITE:PS50862
KEYWORDS    Aminoacyl-tRNA synthetase; ATP-binding; Cytoplasm; Ligase;
            Magnesium; Metal-binding; Nucleotide-binding; Protein biosynthesis;
            Reference proteome.
SOURCE      Prochlorococcus marinus str. MIT 9211
  ORGANISM  Prochlorococcus marinus str. MIT 9211
            Bacteria; Bacillati; Cyanobacteriota; Cyanophyceae;
            Synechococcales; Prochlorococcaceae; Prochlorococcus.
REFERENCE   1  (residues 1 to 503)
  AUTHORS   Kettler,G.C., Martiny,A.C., Huang,K., Zucker,J., Coleman,M.L.,
            Rodrigue,S., Chen,F., Lapidus,A., Ferriera,S., Johnson,J.,
            Steglich,C., Church,G.M., Richardson,P. and Chisholm,S.W.
  TITLE     Patterns and implications of gene gain and loss in the evolution of
            Prochlorococcus
  JOURNAL   PLoS Genet 3 (12), e231 (2007)
   PUBMED   18159947
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=MIT 9211
COMMENT     [CATALYTIC ACTIVITY] Reaction=tRNA(Lys) + L-lysine + ATP =
            L-lysyl-tRNA(Lys) + AMP + diphosphate; Xref=Rhea:RHEA:20792,
            Rhea:RHEA-COMP:9696, Rhea:RHEA-COMP:9697, ChEBI:CHEBI:30616,
            ChEBI:CHEBI:32551, ChEBI:CHEBI:33019, ChEBI:CHEBI:78442,
            ChEBI:CHEBI:78529, ChEBI:CHEBI:456215; EC=6.1.1.6;
            Evidence={ECO:0000255|HAMAP-Rule:MF_00252}.
            [COFACTOR] Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
            Evidence={ECO:0000255|HAMAP-Rule:MF_00252}; Note=Binds 3 Mg(2+)
            ions per subunit. {ECO:0000255|HAMAP-Rule:MF_00252}.
            [SUBUNIT] Homodimer. {ECO:0000255|HAMAP-Rule:MF_00252}.
            [SUBCELLULAR LOCATION] Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00252}.
            [SIMILARITY] Belongs to the class-II aminoacyl-tRNA synthetase
            family. {ECO:0000255|HAMAP-Rule:MF_00252}.
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Prochlorococcus marinus str. MIT 9211"
                     /strain="MIT 9211"
                     /db_xref="taxon:93059"
     gene            1..503
                     /gene="lysS"
                     /locus_tag="P9211_17441"
     Protein         1..503
                     /product="Lysine--tRNA ligase"
                     /EC_number="6.1.1.6"
                     /note="Lysyl-tRNA synthetase; LysRS"
                     /UniProtKB_evidence="Inferred from homology"
     Region          1..503
                     /region_name="Mature chain"
                     /note="Lysine--tRNA ligase. /id=PRO_1000101134."
     Region          1..500
                     /region_name="lysS"
                     /note="lysyl-tRNA synthetase; Reviewed; PRK00484"
                     /db_xref="CDD:234778"
     Site            203..207
                     /site_type="other"
                     /note="motif 1"
                     /db_xref="CDD:238398"
     Site            order(235,257,259,265,269,410,417,420,424,476)
                     /site_type="active"
                     /db_xref="CDD:238398"
     Site            256..259
                     /site_type="other"
                     /note="motif 2"
                     /db_xref="CDD:238398"
     Site            473..476
                     /site_type="other"
                     /note="motif 3"
                     /db_xref="CDD:238398"
ORIGIN      
        1 msdlketrle kaqvlkklgn gpygirfevt hkaavlqveh qdlangqerq levcvagrvi
       61 srrvmgklaf ftlsdesgsi qlflekatle ehsdldqesp gsfsqltdlv dsgdwigvng
      121 ilrrtdrgel sikvfswtml ckslqplpdk whglsdvekr yrqryvdliv npqsrktfrs
      181 ralmvsairr wlderdflei etpvlqseag gaearpfith hntldlslyl riatelhlkr
      241 lvvggfervy elgrifrneg istrhnpeft tveiyqafad ytdmmdltee misfvcsqic
      301 gsttiqyqgk evdltppwrr itmhelvles tgldfyefgq diskastamq svglnvpdha
      361 dsvgrlmnea feqavegdlf qptfvmdypi eisplarkhr skpgiverfe lfiagretan
      421 afselidpvd qkerlllqqs rrqagdleah videdfvnal evgmpptggl gigidrlvml
      481 ltdspsirdv iafpllkpes gsq
//
Feature
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