A stable liver-specific urate oxidase gene knockout hyperuricemia mouse model finds activated hepatic de novo purine biosynthesis and urate nephropathy.
Pang L, Liang N, Li C, Merriman TR, Zhang H, Yan F, Sun W, Li R, Xue X, Liu Z, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Mar; 1870(3):167009. Epub 2024 Jan 17.