A PH domain in the Arf GTPase-activating protein (GAP) ARAP1 binds phosphatidylinositol 3,4,5-trisphosphate and regulates Arf GAP activity independently of recruitment to the plasma membranes.
Campa F, Yoon HY, Ha VL, Szentpetery Z, Balla T, Randazzo PA. J Biol Chem. 2009 Oct 9; 284(41):28069-28083. Epub 2009 Aug 7.