LOCUS LIS11_TALMQ 459 aa linear PLN 27-NOV-2024
DEFINITION RecName: Full=Nuclear distribution protein nudF 1; AltName:
Full=Lissencephaly-1 homolog 1; Short=LIS-1 1.
ACCESSION B6QC56
VERSION B6QC56.1
DBSOURCE UniProtKB: locus LIS11_TALMQ, accession B6QC56;
class: standard.
created: Feb 8, 2011.
sequence updated: Dec 16, 2008.
annotation updated: Nov 27, 2024.
xrefs: DS995900.1, EEA25550.1, XP_002146097.1
xrefs (non-sequence databases): AlphaFoldDB:B6QC56, SMR:B6QC56,
STRING:441960.B6QC56, VEuPathDB:FungiDB:PMAA_066550,
HOGENOM:CLU_000288_57_15_1, OrthoDB:1798470at2759,
PhylomeDB:B6QC56, Proteomes:UP000001294, GO:0005881, GO:0000776,
GO:0005875, GO:0005635, GO:0000922, GO:0070840, GO:0051010,
GO:0051301, GO:0000132, GO:0031023, GO:0051012, GO:0007097,
GO:0047496, CDD:cd00200, FunFam:2.130.10.10:FF:000342,
FunFam:1.20.960.30:FF:000002, Gene3D:1.20.960.30,
Gene3D:2.130.10.10, HAMAP:MF_03141, InterPro:IPR017252,
InterPro:IPR020472, InterPro:IPR037190, InterPro:IPR006594,
InterPro:IPR015943, InterPro:IPR019775, InterPro:IPR036322,
InterPro:IPR001680, InterPro:IPR050349, PANTHER:PTHR44129:SF1,
PANTHER:PTHR44129, Pfam:PF00400, PIRSF:PIRSF037647, PRINTS:PR00320,
SMART:SM00320, SUPFAM:SSF109925, SUPFAM:SSF50978, PROSITE:PS50896,
PROSITE:PS00678, PROSITE:PS50082, PROSITE:PS50294
KEYWORDS Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
Microtubule; Mitosis; Reference proteome; Repeat; Transport; WD
repeat.
SOURCE Talaromyces marneffei ATCC 18224 (Penicillium marneffei ATCC 18224)
ORGANISM Talaromyces marneffei ATCC 18224
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae;
Talaromyces; Talaromyces sect. Talaromyces.
REFERENCE 1 (residues 1 to 459)
AUTHORS Nierman,W.C., Fedorova-Abrams,N.D. and Andrianopoulos,A.
TITLE Genome Sequence of the AIDS-Associated Pathogen Penicillium
marneffei (ATCC18224) and Its Near Taxonomic Relative Talaromyces
stipitatus (ATCC10500)
JOURNAL Genome Announc 3 (1), e01559-14 (2015)
PUBMED 25676766
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
STRAIN=ATCC 18224 / CBS 334.59 / QM 7333
Publication Status: Online-Only
COMMENT [FUNCTION] Positively regulates the activity of the minus-end
directed microtubule motor protein dynein. May enhance
dynein-mediated microtubule sliding by targeting dynein to the
microtubule plus end. Required for nuclear migration during
vegetative growth as well as development. Required for retrograde
early endosome (EE) transport from the hyphal tip. Required for
localization of dynein to the mitotic spindle poles. Recruits
additional proteins to the dynein complex at SPBs.
{ECO:0000255|HAMAP-Rule:MF_03141}.
[SUBUNIT] Self-associates. Interacts with nudE and dynein.
{ECO:0000255|HAMAP-Rule:MF_03141}.
[SUBCELLULAR LOCATION] Cytoplasm, cytoskeleton
{ECO:0000255|HAMAP-Rule:MF_03141}. Cytoplasm, cytoskeleton, spindle
pole {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the plus
ends of microtubules at the hyphal tip and the mitotic spindle
poles. {ECO:0000255|HAMAP-Rule:MF_03141}.
[DOMAIN] Dimerization mediated by the LisH domain may be required
to activate dynein. {ECO:0000255|HAMAP-Rule:MF_03141}.
[SIMILARITY] Belongs to the WD repeat LIS1/nudF family.
{ECO:0000255|HAMAP-Rule:MF_03141}.
FEATURES Location/Qualifiers
source 1..459
/organism="Talaromyces marneffei ATCC 18224"
/db_xref="taxon:441960"
gene 1..459
/gene="nudF-1"
/locus_tag="PMAA_066550"
/gene_synonym="lis1-1"
Protein 1..459
/product="Nuclear distribution protein nudF 1"
/note="Lissencephaly-1 homolog 1; LIS-1 1"
/UniProtKB_evidence="Inferred from homology"
Region 1..459
/region_name="Mature chain"
/note="Nuclear distribution protein nudF 1.
/id=PRO_0000405090."
Region 9..41
/region_name="Domain"
/note="LisH. /evidence=ECO:0000255|HAMAP-Rule:MF_03141."
Region 61..88
/region_name="Coiled-coil region"
/note="/evidence=ECO:0000255|HAMAP-Rule:MF_03141."
Region 112..408
/region_name="WD40"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; cd00200"
/db_xref="CDD:238121"
Region 114..155
/region_name="Repetitive region"
/note="WD 1."
Site order(115,133,137,143..144,156..157,177,181,187..188,
201..202,219,224,230..231,244,261,266,272..273,288..289,
329,333,339..340,351..352,369,374,380..381,395..396)
/site_type="active"
/note="structural tetrad [active]"
/db_xref="CDD:238121"
Region 119..156
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 157..197
/region_name="Repetitive region"
/note="WD 2."
Region 162..201
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 201..240
/region_name="Repetitive region"
/note="WD 3."
Region 206..242
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 243..282
/region_name="Repetitive region"
/note="WD 4."
Region 249..286
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 288..349
/region_name="Repetitive region"
/note="WD 5."
Region 293..350
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 351..390
/region_name="Repetitive region"
/note="WD 6."
Region 356..393
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 395..440
/region_name="Repetitive region"
/note="WD 7."
Region 442..459
/region_name="Repetitive region"
/note="WD 8."
ORIGIN
1 msrlltirqa eelhksiiay lsannlsnaa salrgelgls eevfdtgtmv kyetllekkw
61 tsivrlqkki mdlearcgal qtelnnatpt slskrnqdpa swlpkvpary sleshrntin
121 clafhpkfss iasgsddcmi kiwdwelgel ettlkghtra vldvdygntq sgvllascss
181 dlsikiwnpl edyknirtll ghehsvsavr fipgrnllts asrdkdlriw dvttgfcvkt
241 iqghsgwvrd vcpsfdgnyl fsagddvtar lwditnisnp eakltmvghd hvieccavap
301 qtsyqylapm aglkkealsk msaveftatg srdktikvwd rrgsclmtlv ghdnwvraiv
361 fhpggkylls asddksircw dlsqdgkcvk tlsdahgrfv tclrwapsvv kevapsaesa
421 ngqtdtndll kskdnqpqvq ircvvasggv dqklnifan
//