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RecName: Full=Nuclear distribution protein nudF 1; AltName: Full=Lissencephaly-1 homolog 1; Short=LIS-1 1

UniProtKB/Swiss-Prot: B6QC56.1

Identical Proteins FASTA Graphics 

LOCUS       LIS11_TALMQ              459 aa            linear   PLN 27-NOV-2024
DEFINITION  RecName: Full=Nuclear distribution protein nudF 1; AltName:
            Full=Lissencephaly-1 homolog 1; Short=LIS-1 1.
ACCESSION   B6QC56
VERSION     B6QC56.1
DBSOURCE    UniProtKB: locus LIS11_TALMQ, accession B6QC56;
            class: standard.
            created: Feb 8, 2011.
            sequence updated: Dec 16, 2008.
            annotation updated: Nov 27, 2024.
            xrefs: DS995900.1, EEA25550.1, XP_002146097.1
            xrefs (non-sequence databases): AlphaFoldDB:B6QC56, SMR:B6QC56,
            STRING:441960.B6QC56, VEuPathDB:FungiDB:PMAA_066550,
            HOGENOM:CLU_000288_57_15_1, OrthoDB:1798470at2759,
            PhylomeDB:B6QC56, Proteomes:UP000001294, GO:0005881, GO:0000776,
            GO:0005875, GO:0005635, GO:0000922, GO:0070840, GO:0051010,
            GO:0051301, GO:0000132, GO:0031023, GO:0051012, GO:0007097,
            GO:0047496, CDD:cd00200, FunFam:2.130.10.10:FF:000342,
            FunFam:1.20.960.30:FF:000002, Gene3D:1.20.960.30,
            Gene3D:2.130.10.10, HAMAP:MF_03141, InterPro:IPR017252,
            InterPro:IPR020472, InterPro:IPR037190, InterPro:IPR006594,
            InterPro:IPR015943, InterPro:IPR019775, InterPro:IPR036322,
            InterPro:IPR001680, InterPro:IPR050349, PANTHER:PTHR44129:SF1,
            PANTHER:PTHR44129, Pfam:PF00400, PIRSF:PIRSF037647, PRINTS:PR00320,
            SMART:SM00320, SUPFAM:SSF109925, SUPFAM:SSF50978, PROSITE:PS50896,
            PROSITE:PS00678, PROSITE:PS50082, PROSITE:PS50294
KEYWORDS    Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
            Microtubule; Mitosis; Reference proteome; Repeat; Transport; WD
            repeat.
SOURCE      Talaromyces marneffei ATCC 18224 (Penicillium marneffei ATCC 18224)
  ORGANISM  Talaromyces marneffei ATCC 18224
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae;
            Talaromyces; Talaromyces sect. Talaromyces.
REFERENCE   1  (residues 1 to 459)
  AUTHORS   Nierman,W.C., Fedorova-Abrams,N.D. and Andrianopoulos,A.
  TITLE     Genome Sequence of the AIDS-Associated Pathogen Penicillium
            marneffei (ATCC18224) and Its Near Taxonomic Relative Talaromyces
            stipitatus (ATCC10500)
  JOURNAL   Genome Announc 3 (1), e01559-14 (2015)
   PUBMED   25676766
  REMARK    NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
            STRAIN=ATCC 18224 / CBS 334.59 / QM 7333
            Publication Status: Online-Only
COMMENT     [FUNCTION] Positively regulates the activity of the minus-end
            directed microtubule motor protein dynein. May enhance
            dynein-mediated microtubule sliding by targeting dynein to the
            microtubule plus end. Required for nuclear migration during
            vegetative growth as well as development. Required for retrograde
            early endosome (EE) transport from the hyphal tip. Required for
            localization of dynein to the mitotic spindle poles. Recruits
            additional proteins to the dynein complex at SPBs.
            {ECO:0000255|HAMAP-Rule:MF_03141}.
            [SUBUNIT] Self-associates. Interacts with nudE and dynein.
            {ECO:0000255|HAMAP-Rule:MF_03141}.
            [SUBCELLULAR LOCATION] Cytoplasm, cytoskeleton
            {ECO:0000255|HAMAP-Rule:MF_03141}. Cytoplasm, cytoskeleton, spindle
            pole {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the plus
            ends of microtubules at the hyphal tip and the mitotic spindle
            poles. {ECO:0000255|HAMAP-Rule:MF_03141}.
            [DOMAIN] Dimerization mediated by the LisH domain may be required
            to activate dynein. {ECO:0000255|HAMAP-Rule:MF_03141}.
            [SIMILARITY] Belongs to the WD repeat LIS1/nudF family.
            {ECO:0000255|HAMAP-Rule:MF_03141}.
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Talaromyces marneffei ATCC 18224"
                     /db_xref="taxon:441960"
     gene            1..459
                     /gene="nudF-1"
                     /locus_tag="PMAA_066550"
                     /gene_synonym="lis1-1"
     Protein         1..459
                     /product="Nuclear distribution protein nudF 1"
                     /note="Lissencephaly-1 homolog 1; LIS-1 1"
                     /UniProtKB_evidence="Inferred from homology"
     Region          1..459
                     /region_name="Mature chain"
                     /note="Nuclear distribution protein nudF 1.
                     /id=PRO_0000405090."
     Region          9..41
                     /region_name="Domain"
                     /note="LisH. /evidence=ECO:0000255|HAMAP-Rule:MF_03141."
     Region          61..88
                     /region_name="Coiled-coil region"
                     /note="/evidence=ECO:0000255|HAMAP-Rule:MF_03141."
     Region          112..408
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cd00200"
                     /db_xref="CDD:238121"
     Region          114..155
                     /region_name="Repetitive region"
                     /note="WD 1."
     Site            order(115,133,137,143..144,156..157,177,181,187..188,
                     201..202,219,224,230..231,244,261,266,272..273,288..289,
                     329,333,339..340,351..352,369,374,380..381,395..396)
                     /site_type="active"
                     /note="structural tetrad [active]"
                     /db_xref="CDD:238121"
     Region          119..156
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          157..197
                     /region_name="Repetitive region"
                     /note="WD 2."
     Region          162..201
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          201..240
                     /region_name="Repetitive region"
                     /note="WD 3."
     Region          206..242
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          243..282
                     /region_name="Repetitive region"
                     /note="WD 4."
     Region          249..286
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          288..349
                     /region_name="Repetitive region"
                     /note="WD 5."
     Region          293..350
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          351..390
                     /region_name="Repetitive region"
                     /note="WD 6."
     Region          356..393
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          395..440
                     /region_name="Repetitive region"
                     /note="WD 7."
     Region          442..459
                     /region_name="Repetitive region"
                     /note="WD 8."
ORIGIN      
        1 msrlltirqa eelhksiiay lsannlsnaa salrgelgls eevfdtgtmv kyetllekkw
       61 tsivrlqkki mdlearcgal qtelnnatpt slskrnqdpa swlpkvpary sleshrntin
      121 clafhpkfss iasgsddcmi kiwdwelgel ettlkghtra vldvdygntq sgvllascss
      181 dlsikiwnpl edyknirtll ghehsvsavr fipgrnllts asrdkdlriw dvttgfcvkt
      241 iqghsgwvrd vcpsfdgnyl fsagddvtar lwditnisnp eakltmvghd hvieccavap
      301 qtsyqylapm aglkkealsk msaveftatg srdktikvwd rrgsclmtlv ghdnwvraiv
      361 fhpggkylls asddksircw dlsqdgkcvk tlsdahgrfv tclrwapsvv kevapsaesa
      421 ngqtdtndll kskdnqpqvq ircvvasggv dqklnifan
//
Feature
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