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GenBank: CAC12842.1
Identical Proteins FASTA Graphics
LOCUS CAC12842 326 aa linear PRI 14-JUL-2016 DEFINITION immunoglobulin heavy chain constant region, partial [Homo sapiens]. ACCESSION CAC12842 VERSION CAC12842.1 DBSOURCE embl accession AJ250170.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 AUTHORS Ellison,J. and Hood,L. TITLE Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes JOURNAL Proc. Natl. Acad. Sci. U.S.A. 79 (6), 1984-1988 (1982) PUBMED 6804948 REFERENCE 2 AUTHORS Hougs,L., Svejgaard,A. and Barington,T. TITLE The first constant-domain (CH1) exon of human IGHG2 is polymorphic and in strong linkage disequilibrium with the CH2 exon polymorphism encoding the G2m(n+) allotype in Caucasians JOURNAL Immunogenetics 52 (3-4), 242-248 (2001) PUBMED 11220626 REFERENCE 3 (residues 1 to 326) AUTHORS Hougs,L. TITLE Direct Submission JOURNAL Submitted (07-OCT-1999) Hougs L., Dept. of Clinical Immunology, sect. 7631, National University Hospital, Rigshospitalet, Tagensvej 20, DK-2200 Copenhagen N., DENMARK COMMENT Related sequences Z49801 and Z49802. FEATURES Location/Qualifiers source 1..326 /organism="Homo sapiens" /strain="Caucasian" /db_xref="taxon:9606" /chromosome="14" /map="14q32.3" /clone="pIgG2n+1" /haplotype="G2m(n+)" /sex="female" /cell_type="lymphocytes" /tissue_type="blood" /geo_loc_name="Denmark" Protein <1..326 /product="immunoglobulin heavy chain constant region" Region 5..98 /region_name="IgC1_CH1_IgEG" /note="CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy epsilon and gamma chain; member of the C1-set of Ig superfamily (IgSF) domains; cd21817" /db_xref="CDD:409622" Region 5..12 /region_name="Ig strand A" /note="Ig strand A [structural motif]" /db_xref="CDD:409622" Site order(9..11,24,28,30,51,53,56..57,64..66,68,96) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:409622" Region 23..30 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409622" Region 36..42 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409622" Region 44..45 /region_name="Ig strand C'" /note="Ig strand C' [structural motif]" /db_xref="CDD:409622" Region 51..57 /region_name="Ig strand D" /note="Ig strand D [structural motif]" /db_xref="CDD:409622" Region 63..71 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409622" Region 80..87 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409622" Region 92..97 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409622" Region 118..216 /region_name="Ig" /note="Immunoglobulin domain; cl11960" /db_xref="CDD:472250" Region 136..140 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409493" Region 153..157 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409493" Region 183..187 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409493" Region 197..202 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409493" Region 212..215 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409493" Region 225..326 /region_name="IgC1_CH3_IgAGD_CH4_IgAEM" /note="CH3 domain (third constant Ig domain of the heavy chain) in immunoglobulin heavy alpha, gamma, and delta chains, and CH4 domain (fourth constant Ig domain of the heavy chain) in immunoglobulin heavy alpha, epsilon, and mu chains; member of the C1-set of I; cd05768" /db_xref="CDD:409425" Region 225..231 /region_name="Ig strand A" /note="Ig strand A [structural motif]" /db_xref="CDD:409425" Site order(230,245,249,286,290) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:409425" Region 242..250 /region_name="Ig strand B" /note="Ig strand B [structural motif]" /db_xref="CDD:409425" Region 255..261 /region_name="Ig strand C" /note="Ig strand C [structural motif]" /db_xref="CDD:409425" Site order(261,305,311..312,314..315,317) /site_type="other" /note="receptor binding site [polypeptide binding]" /db_xref="CDD:409425" Region 270..276 /region_name="Ig strand D" /note="Ig strand D [structural motif]" /db_xref="CDD:409425" Region 283..291 /region_name="Ig strand E" /note="Ig strand E [structural motif]" /db_xref="CDD:409425" Region 301..308 /region_name="Ig strand F" /note="Ig strand F [structural motif]" /db_xref="CDD:409425" Region 314..321 /region_name="Ig strand G" /note="Ig strand G [structural motif]" /db_xref="CDD:409425" CDS 1..326 /gene="IgG2" /coded_by="join(AJ250170.1:<216..509,AJ250170.1:902..937, AJ250170.1:1056..1382,AJ250170.1:1480..1803)" /citation=[1] /citation=[2] ORIGIN 1 astkgpsvfp lapcsrstse staalgclvk dyfpepvtvs wnsgaltsgv htfpavlqss 61 glyslssvvt vtssnfgtqt ytcnvdhkps ntkvdktver kccvecppcp appvagpsvf 121 lfppkpkdtl misrtpevtc vvvdvshedp evqfnwyvdg mevhnaktkp reeqfnstfr 181 vvsvltvvhq dwlngkeykc kvsnkglpap iektisktkg qprepqvytl ppsreemtkn 241 qvsltclvkg fypsdiavew esngqpenny kttppmldsd gsfflysklt vdksrwqqgn 301 vfscsvmhea lhnhytqksl slspgk //
Whole sequence Selected region from: to:
Conserved Domains
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