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immunoglobulin heavy chain constant region, partial [Homo sapiens]

GenBank: CAC12842.1

Identical Proteins FASTA Graphics 

LOCUS       CAC12842                 326 aa            linear   PRI 14-JUL-2016
DEFINITION  immunoglobulin heavy chain constant region, partial [Homo sapiens].
ACCESSION   CAC12842
VERSION     CAC12842.1
DBSOURCE    embl accession AJ250170.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Ellison,J. and Hood,L.
  TITLE     Linkage and sequence homology of two human immunoglobulin gamma
            heavy chain constant region genes
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 79 (6), 1984-1988 (1982)
   PUBMED   6804948
REFERENCE   2
  AUTHORS   Hougs,L., Svejgaard,A. and Barington,T.
  TITLE     The first constant-domain (CH1) exon of human IGHG2 is polymorphic
            and in strong linkage disequilibrium with the CH2 exon polymorphism
            encoding the G2m(n+) allotype in Caucasians
  JOURNAL   Immunogenetics 52 (3-4), 242-248 (2001)
   PUBMED   11220626
REFERENCE   3  (residues 1 to 326)
  AUTHORS   Hougs,L.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-OCT-1999) Hougs L., Dept. of Clinical Immunology,
            sect. 7631, National University Hospital, Rigshospitalet, Tagensvej
            20, DK-2200 Copenhagen N., DENMARK
COMMENT     Related sequences Z49801 and Z49802.
FEATURES             Location/Qualifiers
     source          1..326
                     /organism="Homo sapiens"
                     /strain="Caucasian"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.3"
                     /clone="pIgG2n+1"
                     /haplotype="G2m(n+)"
                     /sex="female"
                     /cell_type="lymphocytes"
                     /tissue_type="blood"
                     /geo_loc_name="Denmark"
     Protein         <1..326
                     /product="immunoglobulin heavy chain constant region"
     Region          5..98
                     /region_name="IgC1_CH1_IgEG"
                     /note="CH1 domain (first constant Ig domain of the heavy
                     chain) in immunoglobulin heavy epsilon and gamma chain;
                     member of the C1-set of Ig superfamily (IgSF) domains;
                     cd21817"
                     /db_xref="CDD:409622"
     Region          5..12
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409622"
     Site            order(9..11,24,28,30,51,53,56..57,64..66,68,96)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:409622"
     Region          23..30
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409622"
     Region          36..42
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409622"
     Region          44..45
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409622"
     Region          51..57
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409622"
     Region          63..71
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409622"
     Region          80..87
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409622"
     Region          92..97
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409622"
     Region          118..216
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          136..140
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409493"
     Region          153..157
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409493"
     Region          183..187
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409493"
     Region          197..202
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409493"
     Region          212..215
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409493"
     Region          225..326
                     /region_name="IgC1_CH3_IgAGD_CH4_IgAEM"
                     /note="CH3 domain (third constant Ig domain of the heavy
                     chain) in immunoglobulin heavy alpha, gamma, and delta
                     chains, and CH4 domain (fourth constant Ig domain of the
                     heavy chain) in immunoglobulin heavy alpha, epsilon, and
                     mu chains; member of the C1-set of I; cd05768"
                     /db_xref="CDD:409425"
     Region          225..231
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:409425"
     Site            order(230,245,249,286,290)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:409425"
     Region          242..250
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409425"
     Region          255..261
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409425"
     Site            order(261,305,311..312,314..315,317)
                     /site_type="other"
                     /note="receptor binding site [polypeptide binding]"
                     /db_xref="CDD:409425"
     Region          270..276
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409425"
     Region          283..291
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409425"
     Region          301..308
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409425"
     Region          314..321
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409425"
     CDS             1..326
                     /gene="IgG2"
                     /coded_by="join(AJ250170.1:<216..509,AJ250170.1:902..937,
                     AJ250170.1:1056..1382,AJ250170.1:1480..1803)"
                     /citation=[1]
                     /citation=[2]
ORIGIN      
        1 astkgpsvfp lapcsrstse staalgclvk dyfpepvtvs wnsgaltsgv htfpavlqss
       61 glyslssvvt vtssnfgtqt ytcnvdhkps ntkvdktver kccvecppcp appvagpsvf
      121 lfppkpkdtl misrtpevtc vvvdvshedp evqfnwyvdg mevhnaktkp reeqfnstfr
      181 vvsvltvvhq dwlngkeykc kvsnkglpap iektisktkg qprepqvytl ppsreemtkn
      241 qvsltclvkg fypsdiavew esngqpenny kttppmldsd gsfflysklt vdksrwqqgn
      301 vfscsvmhea lhnhytqksl slspgk
//
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