LOCUS DAA11684 530 aa linear PLN 16-DEC-2024
DEFINITION TPA_inf: D-lactate dehydrogenase [Saccharomyces cerevisiae S288C].
ACCESSION DAA11684
VERSION DAA11684.1
DBLINK BioProject: PRJNA43747
DBSOURCE accession BK006938.2
KEYWORDS Third Party Data; TPA.
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (residues 1 to 530)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 2 (residues 1 to 530)
AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P.,
Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C.,
Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F.,
Delaveau,T., del Rey,F., Dujon,B., Eide,L.G.,
Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et
al.
TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV
JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997)
PUBMED 9169867
REFERENCE 3 (residues 1 to 530)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 4 (residues 1 to 530)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REFERENCE 5 (residues 1 to 530)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 6 (residues 1 to 530)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 7 (residues 1 to 530)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 8 (residues 1 to 530)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
COMMENT Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..530
/organism="Saccharomyces cerevisiae S288C"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="IV"
Protein 1..530
/product="D-lactate dehydrogenase"
/EC_number="1.1.2.4"
/EC_number="1.1.99.40"
Region 61..528
/region_name="GlcD"
/note="FAD/FMN-containing lactate dehydrogenase/glycolate
oxidase [Energy production and conversion]; COG0277"
/db_xref="CDD:440046"
CDS 1..530
/gene="DLD2"
/locus_tag="YDL178W"
/gene_synonym="AIP2"
/coded_by="BK006938.2:139522..141114"
/experiment="EXISTENCE:direct assay:GO:0004458 D-lactate
dehydrogenase (cytochrome) activity [PMID:10509019]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005759
mitochondrial matrix [PMID:10509019]"
/experiment="EXISTENCE:direct assay:GO:0051990
(R)-2-hydroxyglutarate dehydrogenase activity
[PMID:26774271]"
/experiment="EXISTENCE:direct assay:GO:0071949 FAD binding
[PMID:26774271]"
/experiment="EXISTENCE:mutant phenotype:GO:0003779 actin
binding [PMID:15158445]"
/experiment="EXISTENCE:mutant phenotype:GO:1903457 lactate
catabolic process [PMID:26774271]"
/note="D-2-hydroxyglutarate dehydrogenase, and minor
D-lactate dehydrogenase; mitochondrial matrix protein that
oxidizes D-2-hydroxyglutarate (D-2HG), an oncometabolite,
to alpha-ketoglutarate with a minor role in lactate
catabolism; located in the mitochondrial matrix"
/db_xref="SGD:S000002337"
ORIGIN
1 mlrnilvrst gsnfkfagry mkssallgyy rrvnyystki qtrltsenyp dvhrdprfkk
61 ltsddlnyfk silseqeilr asesedlsfy nedwmrkykg qsklvlrpks vekvslilny
121 cndekiavvp qggntglvgg svpifdelil slanlnkird fdpvsgilkc dagvilenan
181 nyvmeqnymf pldlgakgsc hvggvvatna gglrllrygs lhgsvlglev vmpngqivns
241 mhsmrkdntg ydlkqlfigs egtigiitgv siltvpkpka fnvsylsves fedvqkvfvr
301 arqelseils afefmdaksq vlaksqlkda afpledehpf yilietsgsn kdhddsklet
361 flenvmeegi vtdgvvaqde telqnlwkwr emipeasqan ggvykydvsl plkdlyslve
421 atnarlseae lvgdspkpvv gaigyghvgd gnlhlnvavr eynkniektl epfvyefvss
481 khgsvsaehg lgfqkknyig yskspeevkm mkdlkvhydp ngilnpykyi
//