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TPA: D-lactate dehydrogenase [Saccharomyces cerevisiae S288C]

GenBank: DAA11684.1

Identical Proteins FASTA Graphics 

LOCUS       DAA11684                 530 aa            linear   PLN 16-DEC-2024
DEFINITION  TPA_inf: D-lactate dehydrogenase [Saccharomyces cerevisiae S288C].
ACCESSION   DAA11684
VERSION     DAA11684.1
DBLINK      BioProject: PRJNA43747
DBSOURCE    accession BK006938.2
KEYWORDS    Third Party Data; TPA.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (residues 1 to 530)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   2  (residues 1 to 530)
  AUTHORS   Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P.,
            Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C.,
            Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F.,
            Delaveau,T., del Rey,F., Dujon,B., Eide,L.G.,
            Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et
            al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome IV
  JOURNAL   Nature 387 (6632 SUPPL), 75-78 (1997)
   PUBMED   9169867
REFERENCE   3  (residues 1 to 530)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   4  (residues 1 to 530)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
REFERENCE   5  (residues 1 to 530)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   6  (residues 1 to 530)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (residues 1 to 530)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (06-FEB-2013) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   8  (residues 1 to 530)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
COMMENT     Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..530
                     /organism="Saccharomyces cerevisiae S288C"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="IV"
     Protein         1..530
                     /product="D-lactate dehydrogenase"
                     /EC_number="1.1.2.4"
                     /EC_number="1.1.99.40"
     Region          61..528
                     /region_name="GlcD"
                     /note="FAD/FMN-containing lactate dehydrogenase/glycolate
                     oxidase [Energy production and conversion]; COG0277"
                     /db_xref="CDD:440046"
     CDS             1..530
                     /gene="DLD2"
                     /locus_tag="YDL178W"
                     /gene_synonym="AIP2"
                     /coded_by="BK006938.2:139522..141114"
                     /experiment="EXISTENCE:direct assay:GO:0004458 D-lactate
                     dehydrogenase (cytochrome) activity [PMID:10509019]"
                     /experiment="EXISTENCE:direct assay:GO:0005739
                     mitochondrion [PMID:16823961|PMID:24769239]"
                     /experiment="EXISTENCE:direct assay:GO:0005759
                     mitochondrial matrix [PMID:10509019]"
                     /experiment="EXISTENCE:direct assay:GO:0051990
                     (R)-2-hydroxyglutarate dehydrogenase activity
                     [PMID:26774271]"
                     /experiment="EXISTENCE:direct assay:GO:0071949 FAD binding
                     [PMID:26774271]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0003779 actin
                     binding [PMID:15158445]"
                     /experiment="EXISTENCE:mutant phenotype:GO:1903457 lactate
                     catabolic process [PMID:26774271]"
                     /note="D-2-hydroxyglutarate dehydrogenase, and minor
                     D-lactate dehydrogenase; mitochondrial matrix protein that
                     oxidizes D-2-hydroxyglutarate (D-2HG), an oncometabolite,
                     to alpha-ketoglutarate with a minor role in lactate
                     catabolism; located in the mitochondrial matrix"
                     /db_xref="SGD:S000002337"
ORIGIN      
        1 mlrnilvrst gsnfkfagry mkssallgyy rrvnyystki qtrltsenyp dvhrdprfkk
       61 ltsddlnyfk silseqeilr asesedlsfy nedwmrkykg qsklvlrpks vekvslilny
      121 cndekiavvp qggntglvgg svpifdelil slanlnkird fdpvsgilkc dagvilenan
      181 nyvmeqnymf pldlgakgsc hvggvvatna gglrllrygs lhgsvlglev vmpngqivns
      241 mhsmrkdntg ydlkqlfigs egtigiitgv siltvpkpka fnvsylsves fedvqkvfvr
      301 arqelseils afefmdaksq vlaksqlkda afpledehpf yilietsgsn kdhddsklet
      361 flenvmeegi vtdgvvaqde telqnlwkwr emipeasqan ggvykydvsl plkdlyslve
      421 atnarlseae lvgdspkpvv gaigyghvgd gnlhlnvavr eynkniektl epfvyefvss
      481 khgsvsaehg lgfqkknyig yskspeevkm mkdlkvhydp ngilnpykyi
//
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Reference sequence information

  • RefSeq protein
    See the reference protein sequence for D-lactate dehydrogenase (NP_010103.1).

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