BIG1, a brefeldin A-inhibited guanine nucleotide-exchange factor, is required for GABA-gated Cl⁻ influx through regulation of GABAA receptor trafficking.
Li C, Chen S, Yu Y, Zhou C, Wang Y, Le K, Li D, Shao W, Lu L, You Y, et al. Mol Neurobiol. 2014 Apr; 49(2):808-19. Epub 2013 Oct 3.