LOCUS NP_001003714 55 aa linear PRI 21-SEP-2024
DEFINITION ATP synthase subunit f, mitochondrial isoform 2c [Homo sapiens].
ACCESSION NP_001003714
VERSION NP_001003714.1
DBSOURCE REFSEQ: accession NM_001003714.4
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 55)
AUTHORS Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
Warscheid,B.
TITLE Quantitative high-confidence human mitochondrial proteome and its
dynamics in cellular context
JOURNAL Cell Metab 33 (12), 2464-2483 (2021)
PUBMED 34800366
REFERENCE 2 (residues 1 to 55)
AUTHORS Solaini,G., Sgarbi,G. and Baracca,A.
TITLE The F1Fo-ATPase inhibitor, IF1, is a critical regulator of energy
metabolism in cancer cells
JOURNAL Biochem Soc Trans 49 (2), 815-827 (2021)
PUBMED 33929490
REMARK GeneRIF: The F1Fo-ATPase inhibitor, IF1, is a critical regulator of
energy metabolism in cancer cells.
Review article
REFERENCE 3 (residues 1 to 55)
AUTHORS Mnatsakanyan,N. and Jonas,E.A.
TITLE The new role of F1Fo ATP synthase in mitochondria-mediated
neurodegeneration and neuroprotection
JOURNAL Exp Neurol 332, 113400 (2020)
PUBMED 32653453
REMARK GeneRIF: The new role of F1Fo ATP synthase in mitochondria-mediated
neurodegeneration and neuroprotection.
Review article
REFERENCE 4 (residues 1 to 55)
AUTHORS Fujikawa,M., Sugawara,K., Tanabe,T. and Yoshida,M.
TITLE Assembly of human mitochondrial ATP synthase through two separate
intermediates, F1-c-ring and b-e-g complex
JOURNAL FEBS Lett 589 (19 Pt B), 2707-2712 (2015)
PUBMED 26297831
REFERENCE 5 (residues 1 to 55)
AUTHORS de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
TITLE Proteomic characterization of the human sperm nucleus
JOURNAL Proteomics 11 (13), 2714-2726 (2011)
PUBMED 21630459
REFERENCE 6 (residues 1 to 55)
AUTHORS Aggeler,R., Coons,J., Taylor,S.W., Ghosh,S.S., Garcia,J.J.,
Capaldi,R.A. and Marusich,M.F.
TITLE A functionally active human F1F0 ATPase can be purified by
immunocapture from heart tissue and fibroblast cell lines. Subunit
structure and activity studies
JOURNAL J Biol Chem 277 (37), 33906-33912 (2002)
PUBMED 12110673
REFERENCE 7 (residues 1 to 55)
AUTHORS Bosetti,F., Brizzi,F., Barogi,S., Mancuso,M., Siciliano,G.,
Tendi,E.A., Murri,L., Rapoport,S.I. and Solaini,G.
TITLE Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase)
activities in platelets and brain from patients with Alzheimer's
disease
JOURNAL Neurobiol Aging 23 (3), 371-376 (2002)
PUBMED 11959398
REFERENCE 8 (residues 1 to 55)
AUTHORS Wang,H. and Oster,G.
TITLE Energy transduction in the F1 motor of ATP synthase
JOURNAL Nature 396 (6708), 279-282 (1998)
PUBMED 9834036
REFERENCE 9 (residues 1 to 55)
AUTHORS Elston,T., Wang,H. and Oster,G.
TITLE Energy transduction in ATP synthase
JOURNAL Nature 391 (6666), 510-513 (1998)
PUBMED 9461222
REFERENCE 10 (residues 1 to 55)
AUTHORS Boyer,P.D., Cross,R.L. and Momsen,W.
TITLE A new concept for energy coupling in oxidative phosphorylation
based on a molecular explanation of the oxygen exchange reactions
JOURNAL Proc Natl Acad Sci U S A 70 (10), 2837-2839 (1973)
PUBMED 4517936
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CB110074.1.
Summary: Mitochondrial ATP synthase catalyzes ATP synthesis,
utilizing an electrochemical gradient of protons across the inner
membrane during oxidative phosphorylation. It is composed of two
linked multi-subunit complexes: the soluble catalytic core, F1, and
the membrane-spanning component, Fo, which comprises the proton
channel. The catalytic portion of mitochondrial ATP synthase
consists of five different subunits (alpha, beta, gamma, delta, and
epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and
single representatives of the gamma, delta, and epsilon subunits.
The proton channel likely has nine subunits (a, b, c, d, e, f, g,
F6 and 8). This gene encodes the f subunit of the Fo complex.
Alternatively spliced transcript variants encoding different
isoforms have been identified for this gene. This gene has multiple
pseudogenes. Naturally occurring read-through transcription also
exists between this gene and the downstream pentatricopeptide
repeat domain 1 (PTCD1) gene. [provided by RefSeq, Nov 2010].
Transcript Variant: This variant (3) lacks an alternate in-frame
exon in the 3' coding region, compared to variant 1. It encodes a
shorter isoform (2c) that is missing an internal segment when
compared to isoform 2a.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: CB119143.1, CB110074.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1966682,
SAMEA1968189 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: reported by MitoCarta
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..55
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q22.1"
Protein 1..55
/product="ATP synthase subunit f, mitochondrial isoform
2c"
/EC_number="3.6.1.14"
/note="F1Fo-ATPase synthase f subunit; ATP synthase, H+
transporting, mitochondrial F0 complex, subunit f; ATP
synthase f chain, mitochondrial; F1Fo-ATP synthase complex
Fo membrane domain f subunit; F1F0-type ATPase subunit f;
ATP synthase, H+ transporting, mitochondrial Fo complex
subunit F2"
/calculated_mol_wt=6164
Region <14..>50
/region_name="WRW"
/note="Mitochondrial F1F0-ATP synthase, subunit f;
pfam10206"
/db_xref="CDD:431134"
CDS 1..55
/gene="ATP5MF"
/gene_synonym="ATP5J2; ATP5JL"
/coded_by="NM_001003714.4:27..194"
/note="isoform 2c is encoded by transcript variant 3"
/db_xref="CCDS:CCDS34692.1"
/db_xref="GeneID:9551"
/db_xref="HGNC:HGNC:848"
/db_xref="MIM:619792"
ORIGIN
1 masvgecpap vpvkdkklle vklgelpswi lmrdfspsgi fgafqreher lrkyh
//