LOCUS       NP_001021346            1419 aa            linear   INV 04-DEC-2024
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta
            egl-8 [Caenorhabditis elegans].
ACCESSION   NP_001021346
VERSION     NP_001021346.1
DBLINK      BioProject: PRJNA158
DBSOURCE    REFSEQ: accession NM_001026175.5
KEYWORDS    RefSeq.
SOURCE      Caenorhabditis elegans
  ORGANISM  Caenorhabditis elegans
            Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
            Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
            Caenorhabditis.
REFERENCE   1  (residues 1 to 1419)
  AUTHORS   Sulson,J.E. and Waterston,R.
  CONSRTM   Caenorhabditis elegans Sequencing Consortium
  TITLE     Genome sequence of the nematode C. elegans: a platform for
            investigating biology
  JOURNAL   Science 282 (5396), 2012-2018 (1998)
   PUBMED   9851916
  REMARK    Erratum:[Science 1999 Jan 1;283(5398):35]
REFERENCE   2  (residues 1 to 1419)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (04-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 1419)
  AUTHORS   WormBase.
  CONSRTM   WormBase Consortium
  TITLE     Direct Submission
  JOURNAL   Submitted (17-OCT-2024) WormBase Group, European Bioinformatics
            Institute, Cambridge, CB10 1SA, UK. Email: help@wormbase.org
REFERENCE   4  (residues 1 to 1419)
  AUTHORS   Sulson,J.E. and Waterston,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAR-2003) Nematode Sequencing Project: Sanger
            Institute, Hinxton, Cambridge CB10 1SA, UK and The Genome Institute
            at Washington University, St. Louis, MO 63110, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by WormBase. The
            reference sequence is identical to CCD61782.
FEATURES             Location/Qualifiers
     source          1..1419
                     /organism="Caenorhabditis elegans"
                     /strain="Bristol N2"
                     /db_xref="taxon:6239"
                     /chromosome="V"
     Protein         1..1419
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta egl-8"
                     /calculated_mol_wt=159365
     Region          17..142
                     /region_name="PH_PLC_beta"
                     /note="Phospholipase C-beta (PLC-beta) pleckstrin homology
                     (PH) domain; cd13361"
                     /db_xref="CDD:270167"
     Site            order(22,24,36,53,116)
                     /site_type="other"
                     /note="Rac1 binding site [polypeptide binding]"
                     /db_xref="CDD:270167"
     Site            order(25,27,33,35,37,52..53)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270167"
     Region          147..327
                     /region_name="EFh_PI-PLCbeta"
                     /note="EF-hand motif found in metazoan
                     phosphoinositide-specific phospholipase C (PI-PLC)-beta
                     isozymes; cd16200"
                     /db_xref="CDD:320030"
     Region          147..176
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320030"
     Region          182..240
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320030"
     Region          249..277
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320030"
     Region          294..327
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320030"
     Region          339..>495
                     /region_name="PI-PLCc_beta"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta; cd08591"
                     /db_xref="CDD:176533"
     Site            order(355,403)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176533"
     Site            order(356,385,387,437)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176533"
     Region          <528..>668
                     /region_name="Herpes_BLLF1"
                     /note="Herpes virus major outer envelope glycoprotein
                     (BLLF1); pfam05109"
                     /db_xref="CDD:282904"
     Region          <758..861
                     /region_name="PI-PLCc_GDPD_SF"
                     /note="Catalytic domain of phosphoinositide-specific
                     phospholipase C-like phosphodiesterases superfamily;
                     cl14615"
                     /db_xref="CDD:472694"
     Region          895..1015
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(912,938,969,971,975)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     Region          1120..1164
                     /region_name="DUF1154"
                     /note="Protein of unknown function (DUF1154); pfam06631"
                     /db_xref="CDD:461969"
     Region          1279..1418
                     /region_name="PLC-beta_C"
                     /note="PLC-beta C terminal; pfam08703"
                     /db_xref="CDD:462571"
     CDS             1..1419
                     /gene="egl-8"
                     /locus_tag="CELE_B0348.4"
                     /standard_name="B0348.4a"
                     /coded_by="NM_001026175.5:183..4442"
                     /note="Confirmed by transcript evidence"
                     /db_xref="GeneID:178537"
                     /db_xref="WormBase:WBGene00001177"
ORIGIN      
        1 makefqfnwk ptiipellhg svfdryddes tclelnaqvr idengfflrw liegkdavvl
       61 dmgqiweart gglpkdgrim feleqrgase tiaertiwit hgqdlvnvqs fflvaesvel
      121 aktcragind ilkssrirhv cpttqlmkyh twltmnvner rkipikliik tfssgkpekm
      181 vqkclndlgl ggdkytparv inrsmgkkfr nfykcsrgrk rkereeldvd iltfekfqrl
      241 ynkicprtev qelfvklsgq keyltkerli nflneeqrdp rlneilfpff dsqrivallk
      301 khendikyqe dgkmsgdgfl rflmsdenpp vfldriemfm dmdqplchyy insshntylt
      361 grqyggksss eiyrqvllsg crcieldcwd gtgenkgepi ithgkamctd vffkdvlvqi
      421 rdtafarsdf pvvlsfenhc sksnqlkmak ycmdifgdml lskpfedapl dpgvslpspn
      481 rlrkkilikn krlktdierh qldqflregk ldeedelnet pevvgedsvs prsggsggtg
      541 apeevdddts dddddpsvqt slnvmrtipt vnttsnngsn rsarssldtp spsggslmvp
      601 dratstatsi knavlarspn fsslrqklsf krrqsplagd qrahpeveqp vsssspatps
      661 isgpppcats sgstssitit ttgcstsssg pskhilggem pakendeahp elkqnfiakn
      721 lkgfgfskkq pvltkeeeer ifaeyhytga ttnihpllss lvnythpvkf sgfdvaeann
      781 lhfhmssfse stglgylkqs apefvnynkr qssriypkga rvdssnflpq ifwnagcqmv
      841 slnfqtpdvy mqlnmgkfey nggsgyllkp dflrrpdrtf dpfsespvdg viaahcsvrv
      901 isgqflsdrk igtyvevemy glptdtirke hktkvipgng lnpvynedpf vfrkvvlpel
      961 avlrfavyde ngkqlgqril pldglqagyr hislrsdtnq sfilspvlfv qiviktyvpd
     1021 elsglvdala dpraflseqk krqealahmg vddsdipdvp ntrnmalrhv kqpprqngss
     1081 adllanngqt gsargdqtss masstirspn eqpqpvavdk fkvdpievdd lrrdkafakl
     1141 lkrfqkeldd lrkkhqkqrd siqkqqqtnv dklitnnrrs tkkekgsrrs ltasvssgcg
     1201 sasgtvtvsv cspsgascsg ystggpstpv acnsdgtgsp atigspvpqd lvnndrvrsl
     1261 vntqtgewsa mvrrhdeeef elkkvqlkeq fdllrklmse aqknqmlalk lrleaegkdl
     1321 kqtqtkksme dakviqldkg iktkaerdrr vkelneknlk mfveerkrla mkaqkheeql
     1381 tkrhldqleq ldkdfhkald aevgnykeeq laaqptsvv
//