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NCBI Reference Sequence: NP_001021348.1
Identical Proteins FASTA Graphics
LOCUS NP_001021348 592 aa linear INV 04-DEC-2024 DEFINITION 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 [Caenorhabditis elegans]. ACCESSION NP_001021348 VERSION NP_001021348.1 DBLINK BioProject: PRJNA158 DBSOURCE REFSEQ: accession NM_001026177.6 KEYWORDS RefSeq. SOURCE Caenorhabditis elegans ORGANISM Caenorhabditis elegans Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis. REFERENCE 1 (residues 1 to 592) AUTHORS Sulson,J.E. and Waterston,R. CONSRTM Caenorhabditis elegans Sequencing Consortium TITLE Genome sequence of the nematode C. elegans: a platform for investigating biology JOURNAL Science 282 (5396), 2012-2018 (1998) PUBMED 9851916 REMARK Erratum:[Science 1999 Jan 1;283(5398):35] REFERENCE 2 (residues 1 to 592) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (04-DEC-2024) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 592) AUTHORS WormBase. CONSRTM WormBase Consortium TITLE Direct Submission JOURNAL Submitted (17-OCT-2024) WormBase Group, European Bioinformatics Institute, Cambridge, CB10 1SA, UK. Email: help@wormbase.org REFERENCE 4 (residues 1 to 592) AUTHORS Sulson,J.E. and Waterston,R. TITLE Direct Submission JOURNAL Submitted (03-MAR-2003) Nematode Sequencing Project: Sanger Institute, Hinxton, Cambridge CB10 1SA, UK and The Genome Institute at Washington University, St. Louis, MO 63110, USA COMMENT REVIEWED REFSEQ: This record has been curated by WormBase. The reference sequence is identical to CCD61784. FEATURES Location/Qualifiers source 1..592 /organism="Caenorhabditis elegans" /strain="Bristol N2" /db_xref="taxon:6239" /chromosome="V" Protein 1..592 /product="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8" /calculated_mol_wt=68574 Region 17..142 /region_name="PH_PLC_beta" /note="Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain; cd13361" /db_xref="CDD:270167" Site order(22,24,36,53,116) /site_type="other" /note="Rac1 binding site [polypeptide binding]" /db_xref="CDD:270167" Site order(25,27,33,35,37,52..53) /site_type="other" /note="putative phosphoinositide binding site [chemical binding]" /db_xref="CDD:270167" Region 147..327 /region_name="EFh_PI-PLCbeta" /note="EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes; cd16200" /db_xref="CDD:320030" Region 147..176 /region_name="EF-hand motif" /note="EF-hand motif [structural motif]" /db_xref="CDD:320030" Region 182..240 /region_name="EF-hand motif" /note="EF-hand motif [structural motif]" /db_xref="CDD:320030" Region 249..277 /region_name="EF-hand motif" /note="EF-hand motif [structural motif]" /db_xref="CDD:320030" Region 294..327 /region_name="EF-hand motif" /note="EF-hand motif [structural motif]" /db_xref="CDD:320030" Region 339..>495 /region_name="PI-PLCc_beta" /note="Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta; cd08591" /db_xref="CDD:176533" Site order(355,403) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:176533" Site order(356,385,387,437) /site_type="other" /note="Ca binding site [ion binding]" /db_xref="CDD:176533" CDS 1..592 /gene="egl-8" /locus_tag="CELE_B0348.4" /standard_name="B0348.4c" /coded_by="NM_001026177.6:189..1967" /note="Confirmed by transcript evidence" /db_xref="GeneID:178537" /db_xref="WormBase:WBGene00001177" ORIGIN 1 makefqfnwk ptiipellhg svfdryddes tclelnaqvr idengfflrw liegkdavvl 61 dmgqiweart gglpkdgrim feleqrgase tiaertiwit hgqdlvnvqs fflvaesvel 121 aktcragind ilkssrirhv cpttqlmkyh twltmnvner rkipikliik tfssgkpekm 181 vqkclndlgl ggdkytparv inrsmgkkfr nfykcsrgrk rkereeldvd iltfekfqrl 241 ynkicprtev qelfvklsgq keyltkerli nflneeqrdp rlneilfpff dsqrivallk 301 khendikyqe dgkmsgdgfl rflmsdenpp vfldriemfm dmdqplchyy insshntylt 361 grqyggksss eiyrqvllsg crcieldcwd gtgenkgepi ithgkamctd vffkdvlvqi 421 rdtafarsdf pvvlsfenhc sksnqlkmak ycmdifgdml lskpfedapl dpgvslpspn 481 rlrkkilikn krlktdierh qldqflregk ldeedelnet pevvgedsvs prempakend 541 eahpelkqnf iaknlkgfgf skkqetnkis nfnivfkgfl fllilillsq ip //
Whole sequence Selected region from: to:
Conserved Domains
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