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1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 [Caenorhabditis elegans]

NCBI Reference Sequence: NP_001021348.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001021348             592 aa            linear   INV 04-DEC-2024
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta
            egl-8 [Caenorhabditis elegans].
ACCESSION   NP_001021348
VERSION     NP_001021348.1
DBLINK      BioProject: PRJNA158
DBSOURCE    REFSEQ: accession NM_001026177.6
KEYWORDS    RefSeq.
SOURCE      Caenorhabditis elegans
  ORGANISM  Caenorhabditis elegans
            Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
            Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
            Caenorhabditis.
REFERENCE   1  (residues 1 to 592)
  AUTHORS   Sulson,J.E. and Waterston,R.
  CONSRTM   Caenorhabditis elegans Sequencing Consortium
  TITLE     Genome sequence of the nematode C. elegans: a platform for
            investigating biology
  JOURNAL   Science 282 (5396), 2012-2018 (1998)
   PUBMED   9851916
  REMARK    Erratum:[Science 1999 Jan 1;283(5398):35]
REFERENCE   2  (residues 1 to 592)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (04-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 592)
  AUTHORS   WormBase.
  CONSRTM   WormBase Consortium
  TITLE     Direct Submission
  JOURNAL   Submitted (17-OCT-2024) WormBase Group, European Bioinformatics
            Institute, Cambridge, CB10 1SA, UK. Email: help@wormbase.org
REFERENCE   4  (residues 1 to 592)
  AUTHORS   Sulson,J.E. and Waterston,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAR-2003) Nematode Sequencing Project: Sanger
            Institute, Hinxton, Cambridge CB10 1SA, UK and The Genome Institute
            at Washington University, St. Louis, MO 63110, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by WormBase. The
            reference sequence is identical to CCD61784.
FEATURES             Location/Qualifiers
     source          1..592
                     /organism="Caenorhabditis elegans"
                     /strain="Bristol N2"
                     /db_xref="taxon:6239"
                     /chromosome="V"
     Protein         1..592
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta egl-8"
                     /calculated_mol_wt=68574
     Region          17..142
                     /region_name="PH_PLC_beta"
                     /note="Phospholipase C-beta (PLC-beta) pleckstrin homology
                     (PH) domain; cd13361"
                     /db_xref="CDD:270167"
     Site            order(22,24,36,53,116)
                     /site_type="other"
                     /note="Rac1 binding site [polypeptide binding]"
                     /db_xref="CDD:270167"
     Site            order(25,27,33,35,37,52..53)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270167"
     Region          147..327
                     /region_name="EFh_PI-PLCbeta"
                     /note="EF-hand motif found in metazoan
                     phosphoinositide-specific phospholipase C (PI-PLC)-beta
                     isozymes; cd16200"
                     /db_xref="CDD:320030"
     Region          147..176
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320030"
     Region          182..240
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320030"
     Region          249..277
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320030"
     Region          294..327
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320030"
     Region          339..>495
                     /region_name="PI-PLCc_beta"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-beta; cd08591"
                     /db_xref="CDD:176533"
     Site            order(355,403)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176533"
     Site            order(356,385,387,437)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:176533"
     CDS             1..592
                     /gene="egl-8"
                     /locus_tag="CELE_B0348.4"
                     /standard_name="B0348.4c"
                     /coded_by="NM_001026177.6:189..1967"
                     /note="Confirmed by transcript evidence"
                     /db_xref="GeneID:178537"
                     /db_xref="WormBase:WBGene00001177"
ORIGIN      
        1 makefqfnwk ptiipellhg svfdryddes tclelnaqvr idengfflrw liegkdavvl
       61 dmgqiweart gglpkdgrim feleqrgase tiaertiwit hgqdlvnvqs fflvaesvel
      121 aktcragind ilkssrirhv cpttqlmkyh twltmnvner rkipikliik tfssgkpekm
      181 vqkclndlgl ggdkytparv inrsmgkkfr nfykcsrgrk rkereeldvd iltfekfqrl
      241 ynkicprtev qelfvklsgq keyltkerli nflneeqrdp rlneilfpff dsqrivallk
      301 khendikyqe dgkmsgdgfl rflmsdenpp vfldriemfm dmdqplchyy insshntylt
      361 grqyggksss eiyrqvllsg crcieldcwd gtgenkgepi ithgkamctd vffkdvlvqi
      421 rdtafarsdf pvvlsfenhc sksnqlkmak ycmdifgdml lskpfedapl dpgvslpspn
      481 rlrkkilikn krlktdierh qldqflregk ldeedelnet pevvgedsvs prempakend
      541 eahpelkqnf iaknlkgfgf skkqetnkis nfnivfkgfl fllilillsq ip
//
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