LOCUS NP_001152825 134 aa linear PRI 04-APR-2024
DEFINITION regenerating islet-derived protein 4 isoform 2 precursor [Homo
sapiens].
ACCESSION NP_001152825
VERSION NP_001152825.1
DBSOURCE REFSEQ: accession NM_001159353.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 134)
AUTHORS Zhang,C.Y., Zhang,R., Zhang,L., Wang,Z.M., Sun,H.Z., Cui,Z.G. and
Zheng,H.C.
TITLE Regenerating gene 4 promotes chemoresistance of colorectal cancer
by affecting lipid droplet synthesis and assembly
JOURNAL World J Gastroenterol 29 (35), 5104-5124 (2023)
PUBMED 37744296
REMARK GeneRIF: Regenerating gene 4 promotes chemoresistance of colorectal
cancer by affecting lipid droplet synthesis and assembly.
REFERENCE 2 (residues 1 to 134)
AUTHORS Xiang,L.W., Xue,H., Ha,M.W., Yu,D.Y., Xiao,L.J. and Zheng,H.C.
TITLE The effects of REG4 expression on chemoresistance of ovarian cancer
JOURNAL J Obstet Gynaecol 42 (7), 3149-3157 (2022)
PUBMED 35929918
REMARK GeneRIF: The effects of REG4 expression on chemoresistance of
ovarian cancer.
REFERENCE 3 (residues 1 to 134)
AUTHORS Takasawa,S., Tsuchida,C., Sakuramoto-Tsuchida,S., Uchiyama,T.,
Makino,M., Yamauchi,A. and Itaya-Hironaka,A.
TITLE Upregulation of REG IV gene in human intestinal epithelial cells by
lipopolysaccharide via downregulation of microRNA-24
JOURNAL J Cell Mol Med 26 (17), 4710-4720 (2022)
PUBMED 35946046
REMARK GeneRIF: Upregulation of REG IV gene in human intestinal epithelial
cells by lipopolysaccharide via downregulation of microRNA-24.
REFERENCE 4 (residues 1 to 134)
AUTHORS Bishnupuri,K.S., Sainathan,S.K., Ciorba,M.A., Houchen,C.W. and
Dieckgraefe,B.K.
TITLE Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of
Colorectal and Pancreatic Cancer Cells
JOURNAL Mol Cancer Res 20 (3), 387-399 (2022)
PUBMED 34753802
REMARK GeneRIF: Reg4 Interacts with CD44 to Regulate Proliferation and
Stemness of Colorectal and Pancreatic Cancer Cells.
REFERENCE 5 (residues 1 to 134)
AUTHORS Kang,G., Oh,I., Pyo,J., Kang,D. and Son,B.
TITLE Clinicopathological Significance and Prognostic Implications of
REG4 Immunohistochemical Expression in Colorectal Cancer
JOURNAL Medicina (Kaunas) 57 (9), 938 (2021)
PUBMED 34577861
REMARK GeneRIF: Clinicopathological Significance and Prognostic
Implications of REG4 Immunohistochemical Expression in Colorectal
Cancer.
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 134)
AUTHORS Zhang,Z. and Henzel,W.J.
TITLE Signal peptide prediction based on analysis of experimentally
verified cleavage sites
JOURNAL Protein Sci 13 (10), 2819-2824 (2004)
PUBMED 15340161
REFERENCE 7 (residues 1 to 134)
AUTHORS Zhang,Y., Lai,M., Lv,B., Gu,X., Wang,H., Zhu,Y., Zhu,Y., Shao,L.
and Wang,G.
TITLE Overexpression of Reg IV in colorectal adenoma
JOURNAL Cancer Lett 200 (1), 69-76 (2003)
PUBMED 14550954
REMARK GeneRIF: overexpression of Reg IV may be an early event in
colorectal carcinogenesis.
REFERENCE 8 (residues 1 to 134)
AUTHORS Kamarainen,M., Heiskala,K., Knuutila,S., Heiskala,M., Winqvist,O.
and Andersson,L.C.
TITLE RELP, a novel human REG-like protein with up-regulated expression
in inflammatory and metaplastic gastrointestinal mucosa
JOURNAL Am J Pathol 163 (1), 11-20 (2003)
PUBMED 12819006
REMARK GeneRIF: Results suggest that RELP might be involved in
inflammatory and metaplastic responses of the gastrointestinal
epithelium.
REFERENCE 9 (residues 1 to 134)
AUTHORS Violette,S., Festor,E., Pandrea-Vasile,I., Mitchell,V., Adida,C.,
Dussaulx,E., Lacorte,J.M., Chambaz,J., Lacasa,M. and Lesuffleur,T.
TITLE Reg IV, a new member of the regenerating gene family, is
overexpressed in colorectal carcinomas
JOURNAL Int J Cancer 103 (2), 185-193 (2003)
PUBMED 12455032
REFERENCE 10 (residues 1 to 134)
AUTHORS Hartupee,J.C., Zhang,H., Bonaldo,M.F., Soares,M.B. and
Dieckgraefe,B.K.
TITLE Isolation and characterization of a cDNA encoding a novel member of
the human regenerating protein family: Reg IV
JOURNAL Biochim Biophys Acta 1518 (3), 287-293 (2001)
PUBMED 11311942
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AY126672.1 and AL359752.11.
Transcript Variant: This variant (3) lacks several 3' exons but has
an alternate 3' end, as compared to variant 1. The resulting
isoform (2) has a shorter and different C-terminus, as compared to
isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AY126672.1, DB010408.1 [ECO:0000332]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..134
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p12"
Protein 1..134
/product="regenerating islet-derived protein 4 isoform 2
precursor"
/note="regenerating gene type IV; gastrointestinal
secretory protein; regenerating islet-derived protein 4;
REG-4; reg IV; REG-like protein; regenerating
islet-derived protein IV; regenerating islet-derived
family, member 4"
/calculated_mol_wt=12677
sig_peptide 1..22
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
/calculated_mol_wt=2334
Region 30..>55
/region_name="CLECT"
/note="C-type lectin (CTL)/C-type lectin-like (CTLD)
domain; cl02432"
/db_xref="CDD:470576"
Site 50
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9BYZ8.1)"
CDS 1..134
/gene="REG4"
/gene_synonym="GISP; REG-IV; RELP"
/coded_by="NM_001159353.2:147..551"
/note="isoform 2 precursor is encoded by transcript
variant 3"
/db_xref="CCDS:CCDS53354.1"
/db_xref="GeneID:83998"
/db_xref="HGNC:HGNC:22977"
/db_xref="MIM:609846"
ORIGIN
1 masrsmrlll llsclaktgv lgdiimrpsc apgwfyhksn cygyfrklrn wsdaevrnll
61 pawpglsrak dqpepqisfd sgssvlpghy eekplwlvkw reegcvfnsf nsvsiaeaga
121 vcqtldglqa htdt
//