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regenerating islet-derived protein 4 isoform 2 precursor [Homo sapiens]

NCBI Reference Sequence: NP_001152825.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001152825             134 aa            linear   PRI 04-APR-2024
DEFINITION  regenerating islet-derived protein 4 isoform 2 precursor [Homo
            sapiens].
ACCESSION   NP_001152825
VERSION     NP_001152825.1
DBSOURCE    REFSEQ: accession NM_001159353.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 134)
  AUTHORS   Zhang,C.Y., Zhang,R., Zhang,L., Wang,Z.M., Sun,H.Z., Cui,Z.G. and
            Zheng,H.C.
  TITLE     Regenerating gene 4 promotes chemoresistance of colorectal cancer
            by affecting lipid droplet synthesis and assembly
  JOURNAL   World J Gastroenterol 29 (35), 5104-5124 (2023)
   PUBMED   37744296
  REMARK    GeneRIF: Regenerating gene 4 promotes chemoresistance of colorectal
            cancer by affecting lipid droplet synthesis and assembly.
REFERENCE   2  (residues 1 to 134)
  AUTHORS   Xiang,L.W., Xue,H., Ha,M.W., Yu,D.Y., Xiao,L.J. and Zheng,H.C.
  TITLE     The effects of REG4 expression on chemoresistance of ovarian cancer
  JOURNAL   J Obstet Gynaecol 42 (7), 3149-3157 (2022)
   PUBMED   35929918
  REMARK    GeneRIF: The effects of REG4 expression on chemoresistance of
            ovarian cancer.
REFERENCE   3  (residues 1 to 134)
  AUTHORS   Takasawa,S., Tsuchida,C., Sakuramoto-Tsuchida,S., Uchiyama,T.,
            Makino,M., Yamauchi,A. and Itaya-Hironaka,A.
  TITLE     Upregulation of REG IV gene in human intestinal epithelial cells by
            lipopolysaccharide via downregulation of microRNA-24
  JOURNAL   J Cell Mol Med 26 (17), 4710-4720 (2022)
   PUBMED   35946046
  REMARK    GeneRIF: Upregulation of REG IV gene in human intestinal epithelial
            cells by lipopolysaccharide via downregulation of microRNA-24.
REFERENCE   4  (residues 1 to 134)
  AUTHORS   Bishnupuri,K.S., Sainathan,S.K., Ciorba,M.A., Houchen,C.W. and
            Dieckgraefe,B.K.
  TITLE     Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of
            Colorectal and Pancreatic Cancer Cells
  JOURNAL   Mol Cancer Res 20 (3), 387-399 (2022)
   PUBMED   34753802
  REMARK    GeneRIF: Reg4 Interacts with CD44 to Regulate Proliferation and
            Stemness of Colorectal and Pancreatic Cancer Cells.
REFERENCE   5  (residues 1 to 134)
  AUTHORS   Kang,G., Oh,I., Pyo,J., Kang,D. and Son,B.
  TITLE     Clinicopathological Significance and Prognostic Implications of
            REG4 Immunohistochemical Expression in Colorectal Cancer
  JOURNAL   Medicina (Kaunas) 57 (9), 938 (2021)
   PUBMED   34577861
  REMARK    GeneRIF: Clinicopathological Significance and Prognostic
            Implications of REG4 Immunohistochemical Expression in Colorectal
            Cancer.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 134)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   7  (residues 1 to 134)
  AUTHORS   Zhang,Y., Lai,M., Lv,B., Gu,X., Wang,H., Zhu,Y., Zhu,Y., Shao,L.
            and Wang,G.
  TITLE     Overexpression of Reg IV in colorectal adenoma
  JOURNAL   Cancer Lett 200 (1), 69-76 (2003)
   PUBMED   14550954
  REMARK    GeneRIF: overexpression of Reg IV may be an early event in
            colorectal carcinogenesis.
REFERENCE   8  (residues 1 to 134)
  AUTHORS   Kamarainen,M., Heiskala,K., Knuutila,S., Heiskala,M., Winqvist,O.
            and Andersson,L.C.
  TITLE     RELP, a novel human REG-like protein with up-regulated expression
            in inflammatory and metaplastic gastrointestinal mucosa
  JOURNAL   Am J Pathol 163 (1), 11-20 (2003)
   PUBMED   12819006
  REMARK    GeneRIF: Results suggest that RELP might be involved in
            inflammatory and metaplastic responses of the gastrointestinal
            epithelium.
REFERENCE   9  (residues 1 to 134)
  AUTHORS   Violette,S., Festor,E., Pandrea-Vasile,I., Mitchell,V., Adida,C.,
            Dussaulx,E., Lacorte,J.M., Chambaz,J., Lacasa,M. and Lesuffleur,T.
  TITLE     Reg IV, a new member of the regenerating gene family, is
            overexpressed in colorectal carcinomas
  JOURNAL   Int J Cancer 103 (2), 185-193 (2003)
   PUBMED   12455032
REFERENCE   10 (residues 1 to 134)
  AUTHORS   Hartupee,J.C., Zhang,H., Bonaldo,M.F., Soares,M.B. and
            Dieckgraefe,B.K.
  TITLE     Isolation and characterization of a cDNA encoding a novel member of
            the human regenerating protein family: Reg IV
  JOURNAL   Biochim Biophys Acta 1518 (3), 287-293 (2001)
   PUBMED   11311942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY126672.1 and AL359752.11.
            
            Transcript Variant: This variant (3) lacks several 3' exons but has
            an alternate 3' end, as compared to variant 1. The resulting
            isoform (2) has a shorter and different C-terminus, as compared to
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY126672.1, DB010408.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..134
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p12"
     Protein         1..134
                     /product="regenerating islet-derived protein 4 isoform 2
                     precursor"
                     /note="regenerating gene type IV; gastrointestinal
                     secretory protein; regenerating islet-derived protein 4;
                     REG-4; reg IV; REG-like protein; regenerating
                     islet-derived protein IV; regenerating islet-derived
                     family, member 4"
                     /calculated_mol_wt=12677
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2334
     Region          30..>55
                     /region_name="CLECT"
                     /note="C-type lectin (CTL)/C-type lectin-like (CTLD)
                     domain; cl02432"
                     /db_xref="CDD:470576"
     Site            50
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9BYZ8.1)"
     CDS             1..134
                     /gene="REG4"
                     /gene_synonym="GISP; REG-IV; RELP"
                     /coded_by="NM_001159353.2:147..551"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 3"
                     /db_xref="CCDS:CCDS53354.1"
                     /db_xref="GeneID:83998"
                     /db_xref="HGNC:HGNC:22977"
                     /db_xref="MIM:609846"
ORIGIN      
        1 masrsmrlll llsclaktgv lgdiimrpsc apgwfyhksn cygyfrklrn wsdaevrnll
       61 pawpglsrak dqpepqisfd sgssvlpghy eekplwlvkw reegcvfnsf nsvsiaeaga
      121 vcqtldglqa htdt
//
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