LOCUS NP_001153637 379 aa linear ROD 14-JUN-2024
DEFINITION sialidase-2 [Mus musculus].
ACCESSION NP_001153637
VERSION NP_001153637.2
DBSOURCE REFSEQ: accession NM_001160165.2
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 379)
AUTHORS Dai,W., Wu,G., Liu,K., Chen,Q., Tao,J., Liu,H. and Shen,M.
TITLE Lactate promotes myogenesis via activating H3K9
lactylation-dependent up-regulation of Neu2 expression
JOURNAL J Cachexia Sarcopenia Muscle 14 (6), 2851-2865 (2023)
PUBMED 37919243
REMARK GeneRIF: Lactate promotes myogenesis via activating H3K9
lactylation-dependent up-regulation of Neu2 expression.
REFERENCE 2 (residues 1 to 379)
AUTHORS Zizioli,D., Codenotti,S., Benaglia,G., Manzoni,M., Massardi,E.,
Fanzani,A., Borsani,G. and Monti,E.
TITLE Downregulation of Zebrafish Cytosolic Sialidase Neu3.2 Affects
Skeletal Muscle Development
JOURNAL Int J Mol Sci 24 (17), 13578 (2023)
PUBMED 37686385
REMARK GeneRIF: Downregulation of Zebrafish Cytosolic Sialidase Neu3.2
Affects Skeletal Muscle Development.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 379)
AUTHORS Oh,M., Ha,D.I., Son,C., Kang,J.G., Hwang,H., Moon,S.B., Kim,M.,
Nam,J., Kim,J.S., Song,S.Y., Kim,Y.S., Park,S., Yoo,J.S., Ko,J.H.
and Park,K.
TITLE Defect in cytosolic Neu2 sialidase abrogates lipid metabolism and
impairs muscle function in vivo
JOURNAL Sci Rep 12 (1), 3216 (2022)
PUBMED 35217678
REMARK GeneRIF: Defect in cytosolic Neu2 sialidase abrogates lipid
metabolism and impairs muscle function in vivo.
Publication Status: Online-Only
REFERENCE 4 (residues 1 to 379)
AUTHORS Kijimoto-Ochiai,S., Doi,N., Fujii,M., Go,S., Kabayama,K.,
Moriya,S., Miyagi,T. and Koda,T.
TITLE Possible association of Neu2 with plasma membrane fraction from
mouse thymus exhibited sialidase activity with fetuin at pH 7.0 but
not at pH 4.5
JOURNAL Microbiol Immunol 57 (8), 569-582 (2013)
PUBMED 23750721
REMARK GeneRIF: Neu2 from thymus exhibited sialidase activity with fetuin
at pH 7.0.
REFERENCE 5 (residues 1 to 379)
AUTHORS Kakani,S., Yardeni,T., Poling,J., Ciccone,C., Niethamer,T.,
Klootwijk,E.D., Manoli,I., Darvish,D., Hoogstraten-Miller,S.,
Zerfas,P., Tian,E., Ten Hagen,K.G., Kopp,J.B., Gahl,W.A. and
Huizing,M.
TITLE The Gne M712T mouse as a model for human glomerulopathy
JOURNAL Am J Pathol 180 (4), 1431-1440 (2012)
PUBMED 22322304
REFERENCE 6 (residues 1 to 379)
AUTHORS Fanzani,A., Colombo,F., Giuliani,R., Preti,A. and Marchesini,S.
TITLE Insulin-like growth factor 1 signaling regulates cytosolic
sialidase Neu2 expression during myoblast differentiation and
hypertrophy
JOURNAL FEBS J 273 (16), 3709-3721 (2006)
PUBMED 16869890
REMARK GeneRIF: Our data demonstrate that IGF-1-induced myoblast
differentiation and hypertrophy are driven, at least in part, by
Neu2 upregulation and further support the significant role of
cytosolic sialidase in myoblasts.
REFERENCE 7 (residues 1 to 379)
AUTHORS Vyas,A., Saha,B., Lai,E. and Tole,S.
TITLE Paleocortex is specified in mice in which dorsal telencephalic
patterning is severely disrupted
JOURNAL J Comp Neurol 466 (4), 545-553 (2003)
PUBMED 14566948
REFERENCE 8 (residues 1 to 379)
AUTHORS Kotani,K., Kuroiwa,A., Saito,T., Matsuda,Y., Koda,T. and
Kijimoto-Ochiai,S.
TITLE Cloning, chromosomal mapping, and characteristic 5'-UTR sequence of
murine cytosolic sialidase
JOURNAL Biochem Biophys Res Commun 286 (2), 250-258 (2001)
PUBMED 11500029
REFERENCE 9 (residues 1 to 379)
AUTHORS Hasegawa,T., Yamaguchi,K., Wada,T., Takeda,A., Itoyama,Y. and
Miyagi,T.
TITLE Molecular cloning of mouse ganglioside sialidase and its increased
expression in Neuro2a cell differentiation
JOURNAL J Biol Chem 275 (11), 8007-8015 (2000)
PUBMED 10713120
REMARK Erratum:[J Biol Chem 2000 May 12;275(19):14778]
REFERENCE 10 (residues 1 to 379)
AUTHORS Fronda,C.L., Zeng,G., Gao,L. and Yu,R.K.
TITLE Molecular cloning and expression of mouse brain sialidase
JOURNAL Biochem Biophys Res Commun 258 (3), 727-731 (1999)
PUBMED 10329453
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC102564.7.
On May 3, 2023 this sequence version replaced NP_001153637.1.
Sequence Note:.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB048604.1, AF139059.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849375, SAMN00849383
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
is not conserved
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..379
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="1"
/map="1 44.44 cM"
Protein 1..379
/product="sialidase-2"
/EC_number="3.2.1.18"
/note="cytosolic sialidase; murine thymic sialidase;
N-acetyl-alpha-neuraminidase 2; skeletal muscle sialidase;
brain sialidase; cystolic sialidase"
/calculated_mol_wt=42272
Region 10..367
/region_name="Sialidase_non-viral"
/note="Non-viral sialidases; cd15482"
/db_xref="CDD:271234"
Region 20..74
/region_name="Sialidase propeller 1"
/note="Sialidase propeller 1 [structural motif]"
/db_xref="CDD:271234"
Region 20..23
/region_name="FRIP motif"
/note="propagated from UniProtKB/Swiss-Prot (Q9JMH3.1)"
Site order(21,47,218,237,303,333,354)
/site_type="active"
/note="catalytic site [active]"
/db_xref="CDD:271234"
Region 84..142
/region_name="Sialidase propeller 2"
/note="Sialidase propeller 2 [structural motif]"
/db_xref="CDD:271234"
Region 127..138
/region_name="BNR 1"
/note="propagated from UniProtKB/Swiss-Prot (Q9JMH3.1)"
Region 156..211
/region_name="Sialidase propeller 3"
/note="Sialidase propeller 3 [structural motif]"
/db_xref="CDD:271234"
Region 197..208
/region_name="BNR 2"
/note="propagated from UniProtKB/Swiss-Prot (Q9JMH3.1)"
Region 217..258
/region_name="Sialidase propeller 4"
/note="Sialidase propeller 4 [structural motif]"
/db_xref="CDD:271234"
Region 270..326
/region_name="Sialidase propeller 5"
/note="Sialidase propeller 5 [structural motif]"
/db_xref="CDD:271234"
Region 332..367
/region_name="Sialidase propeller 6"
/note="Sialidase propeller 6 [structural motif]"
/db_xref="CDD:271234"
CDS 1..379
/gene="Neu2"
/gene_synonym="MBS; MSS; MTS"
/coded_by="NM_001160165.2:269..1408"
/db_xref="CCDS:CCDS48309.1"
/db_xref="GeneID:23956"
/db_xref="MGI:MGI:1344417"
ORIGIN
1 matcpvlqke tlfrtgvhay ripallylkk qktllafaek rasktdehae livlrrgsyn
61 eatnrvkwqp eevvtqaqle ghrsmnpcpl ydkqtktlfl ffiavpgrvs ehhqlhtkvn
121 vtrlccvsst dhgrtwspiq dltettigst hqewatfavg pghclqlrnp agsllvpaya
181 yrklhpaqkp tpfafcfisl dhghtwklgn fvaenslecq vaevgtgaqr mvylnarsfl
241 garvqaqspn dgldfqdnrv vsklvepphg chgsvvafhn piskphaldt wllythptds
301 rnrtnlgvyl nqmpldptaw septllamgi caysdlqnmg qgpdgspqfg clyesgnyee
361 iifliftlkq afptvfdaq
//