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sialidase-2 [Mus musculus]

NCBI Reference Sequence: NP_001153637.2

Identical Proteins FASTA Graphics 

LOCUS       NP_001153637             379 aa            linear   ROD 14-JUN-2024
DEFINITION  sialidase-2 [Mus musculus].
ACCESSION   NP_001153637
VERSION     NP_001153637.2
DBSOURCE    REFSEQ: accession NM_001160165.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 379)
  AUTHORS   Dai,W., Wu,G., Liu,K., Chen,Q., Tao,J., Liu,H. and Shen,M.
  TITLE     Lactate promotes myogenesis via activating H3K9
            lactylation-dependent up-regulation of Neu2 expression
  JOURNAL   J Cachexia Sarcopenia Muscle 14 (6), 2851-2865 (2023)
   PUBMED   37919243
  REMARK    GeneRIF: Lactate promotes myogenesis via activating H3K9
            lactylation-dependent up-regulation of Neu2 expression.
REFERENCE   2  (residues 1 to 379)
  AUTHORS   Zizioli,D., Codenotti,S., Benaglia,G., Manzoni,M., Massardi,E.,
            Fanzani,A., Borsani,G. and Monti,E.
  TITLE     Downregulation of Zebrafish Cytosolic Sialidase Neu3.2 Affects
            Skeletal Muscle Development
  JOURNAL   Int J Mol Sci 24 (17), 13578 (2023)
   PUBMED   37686385
  REMARK    GeneRIF: Downregulation of Zebrafish Cytosolic Sialidase Neu3.2
            Affects Skeletal Muscle Development.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 379)
  AUTHORS   Oh,M., Ha,D.I., Son,C., Kang,J.G., Hwang,H., Moon,S.B., Kim,M.,
            Nam,J., Kim,J.S., Song,S.Y., Kim,Y.S., Park,S., Yoo,J.S., Ko,J.H.
            and Park,K.
  TITLE     Defect in cytosolic Neu2 sialidase abrogates lipid metabolism and
            impairs muscle function in vivo
  JOURNAL   Sci Rep 12 (1), 3216 (2022)
   PUBMED   35217678
  REMARK    GeneRIF: Defect in cytosolic Neu2 sialidase abrogates lipid
            metabolism and impairs muscle function in vivo.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 379)
  AUTHORS   Kijimoto-Ochiai,S., Doi,N., Fujii,M., Go,S., Kabayama,K.,
            Moriya,S., Miyagi,T. and Koda,T.
  TITLE     Possible association of Neu2 with plasma membrane fraction from
            mouse thymus exhibited sialidase activity with fetuin at pH 7.0 but
            not at pH 4.5
  JOURNAL   Microbiol Immunol 57 (8), 569-582 (2013)
   PUBMED   23750721
  REMARK    GeneRIF: Neu2 from thymus exhibited sialidase activity with fetuin
            at pH 7.0.
REFERENCE   5  (residues 1 to 379)
  AUTHORS   Kakani,S., Yardeni,T., Poling,J., Ciccone,C., Niethamer,T.,
            Klootwijk,E.D., Manoli,I., Darvish,D., Hoogstraten-Miller,S.,
            Zerfas,P., Tian,E., Ten Hagen,K.G., Kopp,J.B., Gahl,W.A. and
            Huizing,M.
  TITLE     The Gne M712T mouse as a model for human glomerulopathy
  JOURNAL   Am J Pathol 180 (4), 1431-1440 (2012)
   PUBMED   22322304
REFERENCE   6  (residues 1 to 379)
  AUTHORS   Fanzani,A., Colombo,F., Giuliani,R., Preti,A. and Marchesini,S.
  TITLE     Insulin-like growth factor 1 signaling regulates cytosolic
            sialidase Neu2 expression during myoblast differentiation and
            hypertrophy
  JOURNAL   FEBS J 273 (16), 3709-3721 (2006)
   PUBMED   16869890
  REMARK    GeneRIF: Our data demonstrate that IGF-1-induced myoblast
            differentiation and hypertrophy are driven, at least in part, by
            Neu2 upregulation and further support the significant role of
            cytosolic sialidase in myoblasts.
REFERENCE   7  (residues 1 to 379)
  AUTHORS   Vyas,A., Saha,B., Lai,E. and Tole,S.
  TITLE     Paleocortex is specified in mice in which dorsal telencephalic
            patterning is severely disrupted
  JOURNAL   J Comp Neurol 466 (4), 545-553 (2003)
   PUBMED   14566948
REFERENCE   8  (residues 1 to 379)
  AUTHORS   Kotani,K., Kuroiwa,A., Saito,T., Matsuda,Y., Koda,T. and
            Kijimoto-Ochiai,S.
  TITLE     Cloning, chromosomal mapping, and characteristic 5'-UTR sequence of
            murine cytosolic sialidase
  JOURNAL   Biochem Biophys Res Commun 286 (2), 250-258 (2001)
   PUBMED   11500029
REFERENCE   9  (residues 1 to 379)
  AUTHORS   Hasegawa,T., Yamaguchi,K., Wada,T., Takeda,A., Itoyama,Y. and
            Miyagi,T.
  TITLE     Molecular cloning of mouse ganglioside sialidase and its increased
            expression in Neuro2a cell differentiation
  JOURNAL   J Biol Chem 275 (11), 8007-8015 (2000)
   PUBMED   10713120
  REMARK    Erratum:[J Biol Chem 2000 May 12;275(19):14778]
REFERENCE   10 (residues 1 to 379)
  AUTHORS   Fronda,C.L., Zeng,G., Gao,L. and Yu,R.K.
  TITLE     Molecular cloning and expression of mouse brain sialidase
  JOURNAL   Biochem Biophys Res Commun 258 (3), 727-731 (1999)
   PUBMED   10329453
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102564.7.
            
            On May 3, 2023 this sequence version replaced NP_001153637.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB048604.1, AF139059.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..379
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.44 cM"
     Protein         1..379
                     /product="sialidase-2"
                     /EC_number="3.2.1.18"
                     /note="cytosolic sialidase; murine thymic sialidase;
                     N-acetyl-alpha-neuraminidase 2; skeletal muscle sialidase;
                     brain sialidase; cystolic sialidase"
                     /calculated_mol_wt=42272
     Region          10..367
                     /region_name="Sialidase_non-viral"
                     /note="Non-viral sialidases; cd15482"
                     /db_xref="CDD:271234"
     Region          20..74
                     /region_name="Sialidase propeller 1"
                     /note="Sialidase propeller 1 [structural motif]"
                     /db_xref="CDD:271234"
     Region          20..23
                     /region_name="FRIP motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMH3.1)"
     Site            order(21,47,218,237,303,333,354)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:271234"
     Region          84..142
                     /region_name="Sialidase propeller 2"
                     /note="Sialidase propeller 2 [structural motif]"
                     /db_xref="CDD:271234"
     Region          127..138
                     /region_name="BNR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMH3.1)"
     Region          156..211
                     /region_name="Sialidase propeller 3"
                     /note="Sialidase propeller 3 [structural motif]"
                     /db_xref="CDD:271234"
     Region          197..208
                     /region_name="BNR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JMH3.1)"
     Region          217..258
                     /region_name="Sialidase propeller 4"
                     /note="Sialidase propeller 4 [structural motif]"
                     /db_xref="CDD:271234"
     Region          270..326
                     /region_name="Sialidase propeller 5"
                     /note="Sialidase propeller 5 [structural motif]"
                     /db_xref="CDD:271234"
     Region          332..367
                     /region_name="Sialidase propeller 6"
                     /note="Sialidase propeller 6 [structural motif]"
                     /db_xref="CDD:271234"
     CDS             1..379
                     /gene="Neu2"
                     /gene_synonym="MBS; MSS; MTS"
                     /coded_by="NM_001160165.2:269..1408"
                     /db_xref="CCDS:CCDS48309.1"
                     /db_xref="GeneID:23956"
                     /db_xref="MGI:MGI:1344417"
ORIGIN      
        1 matcpvlqke tlfrtgvhay ripallylkk qktllafaek rasktdehae livlrrgsyn
       61 eatnrvkwqp eevvtqaqle ghrsmnpcpl ydkqtktlfl ffiavpgrvs ehhqlhtkvn
      121 vtrlccvsst dhgrtwspiq dltettigst hqewatfavg pghclqlrnp agsllvpaya
      181 yrklhpaqkp tpfafcfisl dhghtwklgn fvaenslecq vaevgtgaqr mvylnarsfl
      241 garvqaqspn dgldfqdnrv vsklvepphg chgsvvafhn piskphaldt wllythptds
      301 rnrtnlgvyl nqmpldptaw septllamgi caysdlqnmg qgpdgspqfg clyesgnyee
      361 iifliftlkq afptvfdaq
//
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