LOCUS NP_001185685 69 aa linear PRI 03-APR-2024
DEFINITION guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
[Homo sapiens].
ACCESSION NP_001185685
VERSION NP_001185685.1
DBSOURCE REFSEQ: accession NM_001198756.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 69)
AUTHORS Khater,M., Bryant,C.N. and Wu,G.
TITLE Gbetagamma translocation to the Golgi apparatus activates ARF1 to
spatiotemporally regulate G protein-coupled receptor signaling to
MAPK
JOURNAL J Biol Chem 296, 100805 (2021)
PUBMED 34022220
REMARK GeneRIF: Gbetagamma translocation to the Golgi apparatus activates
ARF1 to spatiotemporally regulate G protein-coupled receptor
signaling to MAPK.
REFERENCE 2 (residues 1 to 69)
AUTHORS Dong,Z., Ma,Y., Zhou,H., Shi,L., Ye,G., Yang,L., Liu,P. and Zhou,L.
TITLE Integrated genomics analysis highlights important SNPs and genes
implicated in moderate-to-severe asthma based on GWAS and eQTL
datasets
JOURNAL BMC Pulm Med 20 (1), 270 (2020)
PUBMED 33066754
REMARK GeneRIF: Integrated genomics analysis highlights important SNPs and
genes implicated in moderate-to-severe asthma based on GWAS and
eQTL datasets.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 69)
AUTHORS Liu,G.M., Ji,X., Lu,T.C., Duan,L.W., Jia,W.Y., Liu,Y., Sun,M.L. and
Luo,Y.G.
TITLE Comprehensive multi-omics analysis identified core molecular
processes in esophageal cancer and revealed GNGT2 as a potential
prognostic marker
JOURNAL World J Gastroenterol 25 (48), 6890-6901 (2019)
PUBMED 31908393
REMARK GeneRIF: Survival analysis showed that G protein subunit gamma
transducin 2 (GNGT2) was closely related to survival of esophageal
cancer. Expression of GNGT2 was evaluated by quantitative real time
polymerase chain reaction, and the results showed that GNGT2
expression was significantly upregulated in esophageal cancer
patient samples and cell lines, and that GNGT2 could promote the
proliferation of esophageal cancer cell lines.
REFERENCE 4 (residues 1 to 69)
AUTHORS Blanquart,S., Borowiec,A.S., Delcourt,P., Figeac,M., Emerling,C.A.,
Meseguer,A.S., Roudbaraki,M., Prevarskaya,N. and Bidaux,G.
TITLE Evolution of the human cold/menthol receptor, TRPM8
JOURNAL Mol Phylogenet Evol 136, 104-118 (2019)
PUBMED 30980935
REFERENCE 5 (residues 1 to 69)
AUTHORS Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
and Easton,D.F.
CONSRTM COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
Study Collaborators/British Association of Urological Surgeons'
Section of Oncology; UK ProtecT (Prostate testing for cancer and
Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
Association Group to Investigate Cancer-Associated Alterations in
the Genome) Consortium
TITLE Identification of 23 new prostate cancer susceptibility loci using
the iCOGS custom genotyping array
JOURNAL Nat Genet 45 (4), 385-391 (2013)
PUBMED 23535732
REFERENCE 6 (residues 1 to 69)
AUTHORS Yang,M., He,R.L., Benovic,J.L. and Ye,R.D.
TITLE beta-Arrestin1 interacts with the G-protein subunits beta1gamma2
and promotes beta1gamma2-dependent Akt signalling for NF-kappaB
activation
JOURNAL Biochem J 417 (1), 287-296 (2009)
PUBMED 18729826
REMARK GeneRIF: Results identify novel functions of beta-arrestin1 in
binding to the beta1gamma2 subunits of heterotrimeric G-proteins
and promoting G(betagamma)-mediated Akt signalling for NF-kappaB
activation.
REFERENCE 7 (residues 1 to 69)
AUTHORS Huang,L., Shanker,Y.G., Dubauskaite,J., Zheng,J.Z., Yan,W.,
Rosenzweig,S., Spielman,A.I., Max,M. and Margolskee,R.F.
TITLE Ggamma13 colocalizes with gustducin in taste receptor cells and
mediates IP3 responses to bitter denatonium
JOURNAL Nat Neurosci 2 (12), 1055-1062 (1999)
PUBMED 10570481
REFERENCE 8 (residues 1 to 69)
AUTHORS Ong,O.C., Hu,K., Rong,H., Lee,R.H. and Fung,B.K.
TITLE Gene structure and chromosome localization of the G gamma c subunit
of human cone G-protein (GNGT2)
JOURNAL Genomics 44 (1), 101-109 (1997)
PUBMED 9286705
REFERENCE 9 (residues 1 to 69)
AUTHORS Huang,C.L., Jan,Y.N. and Jan,L.Y.
TITLE Binding of the G protein betagamma subunit to multiple regions of G
protein-gated inward-rectifying K+ channels
JOURNAL FEBS Lett 405 (3), 291-298 (1997)
PUBMED 9108307
REFERENCE 10 (residues 1 to 69)
AUTHORS Cohen,N.A., Sha,Q., Makhina,E.N., Lopatin,A.N., Linder,M.E.,
Snyder,S.H. and Nichols,C.G.
TITLE Inhibition of an inward rectifier potassium channel (Kir2.3) by
G-protein betagamma subunits
JOURNAL J Biol Chem 271 (50), 32301-32305 (1996)
PUBMED 8943291
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BM723861.1, AC069454.22 and
BU742490.1.
Summary: Phototransduction in rod and cone photoreceptors is
regulated by groups of signaling proteins. The encoded protein is
thought to play a crucial role in cone phototransduction. It
belongs to the G protein gamma family and localized specifically in
cones. Several transcript variants encoding the same protein have
been found for this gene. [provided by RefSeq, Nov 2010].
Transcript Variant: This variant (4) differs in the 5' UTR compared
to variant 1. All four variants encode the same protein.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BM723861.1, SRR1803614.236879.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..69
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21.32"
Protein 1..69
/product="guanine nucleotide-binding protein
G(I)/G(S)/G(O) subunit gamma-T2"
/note="gamma-T2 subunit; G protein cone gamma 8 subunit;
guanine nucleotide binding protein gamma 9; G-gamma-9; g
gamma-C; guanine nucleotide binding protein gamma
transducing activity polypeptide 2; guanine nucleotide
binding protein (G protein), gamma transducing activity
polypeptide 2; heterotrimeric guanine nucleotide-binding
protein 3I"
/calculated_mol_wt=7616
Region 8..69
/region_name="GGL"
/note="G protein gamma subunit-like motifs; smart00224"
/db_xref="CDD:128520"
Site order(8,11,15,18,22,27,29,32..33,36..37,40,49..50,60)
/site_type="other"
/note="beta subunit binding site [polypeptide binding]"
/db_xref="CDD:238024"
Site 66
/site_type="methylation"
/note="Cysteine methyl ester. /evidence=ECO:0000255;
propagated from UniProtKB/Swiss-Prot (O14610.1)"
CDS 1..69
/gene="GNGT2"
/gene_synonym="G-GAMMA-8; G-GAMMA-C; GNG9; GNGT8; HG3I"
/coded_by="NM_001198756.1:181..390"
/db_xref="CCDS:CCDS11545.1"
/db_xref="GeneID:2793"
/db_xref="HGNC:HGNC:4412"
/db_xref="MIM:139391"
ORIGIN
1 maqdlsekdl lkmeveqlkk evkntripis kagkeikeyv eaqagndpfl kgipedknpf
61 kekggclis
//