LOCUS NP_001240630 1367 aa linear PRI 17-MAR-2024
DEFINITION erbin isoform 9 [Homo sapiens].
ACCESSION NP_001240630
VERSION NP_001240630.1
DBSOURCE REFSEQ: accession NM_001253701.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 1367)
AUTHORS Zhang,Z., Xu,X., Zhang,D., Zhao,S., Wang,C., Zhang,G., Chen,W.,
Liu,J., Gong,H., Rixiati,Y., Li,S., Shen,T. and Li,J.
TITLE Targeting Erbin-mitochondria axis in platelets/megakaryocytes
promotes B cell-mediated antitumor immunity
JOURNAL Cell Metab 36 (3), 541-556 (2024)
PUBMED 38232736
REMARK GeneRIF: Targeting Erbin-mitochondria axis in
platelets/megakaryocytes promotes B cell-mediated antitumor
immunity.
REFERENCE 2 (residues 1 to 1367)
AUTHORS Peng,X., Zhao,L., Yao,L., Dong,J., Wu,W. and Luo,T.
TITLE Exosomal ERBB2IP contributes to tumor growth via elevating PSAT1
expression in non-small cell lung carcinoma
JOURNAL Thorac Cancer 14 (19), 1812-1823 (2023)
PUBMED 37192746
REMARK GeneRIF: Exosomal ERBB2IP contributes to tumor growth via elevating
PSAT1 expression in non-small cell lung carcinoma.
REFERENCE 3 (residues 1 to 1367)
AUTHORS Shen,T., Liu,J.L., Wang,C.Y., Rixiati,Y., Li,S., Cai,L.D.,
Zhao,Y.Y. and Li,J.M.
TITLE Targeting Erbin in B cells for therapy of lung metastasis of
colorectal cancer
JOURNAL Signal Transduct Target Ther 6 (1), 115 (2021)
PUBMED 33707428
REMARK GeneRIF: Targeting Erbin in B cells for therapy of lung metastasis
of colorectal cancer.
Publication Status: Online-Only
REFERENCE 4 (residues 1 to 1367)
AUTHORS Jang,H., Stevens,P., Gao,T. and Galperin,E.
TITLE The leucine-rich repeat signaling scaffolds Shoc2 and Erbin:
cellular mechanism and role in disease
JOURNAL FEBS J 288 (3), 721-739 (2021)
PUBMED 32558243
REMARK GeneRIF: The leucine-rich repeat signaling scaffolds Shoc2 and
Erbin: cellular mechanism and role in disease.
Review article
REFERENCE 5 (residues 1 to 1367)
AUTHORS Jaulin-Bastard,F., Arsanto,J.P., Le Bivic,A., Navarro,C., Vely,F.,
Saito,H., Marchetto,S., Hatzfeld,M., Santoni,M.J., Birnbaum,D. and
Borg,J.P.
TITLE Interaction between Erbin and a Catenin-related protein in
epithelial cells
JOURNAL J Biol Chem 277 (4), 2869-2875 (2002)
PUBMED 11711544
REFERENCE 6 (residues 1 to 1367)
AUTHORS Favre,B., Fontao,L., Koster,J., Shafaatian,R., Jaunin,F.,
Saurat,J.H., Sonnenberg,A. and Borradori,L.
TITLE The hemidesmosomal protein bullous pemphigoid antigen 1 and the
integrin beta 4 subunit bind to ERBIN. Molecular cloning of
multiple alternative splice variants of ERBIN and analysis of their
tissue expression
JOURNAL J Biol Chem 276 (35), 32427-32436 (2001)
PUBMED 11375975
REFERENCE 7 (residues 1 to 1367)
AUTHORS Saito,H., Santoni,M.J., Arsanto,J.P., Jaulin-Bastard,F., Le
Bivic,A., Marchetto,S., Audebert,S., Isnardon,D., Adelaide,J.,
Birnbaum,D. and Borg,J.P.
TITLE Lano, a novel LAP protein directly connected to MAGUK proteins in
epithelial cells
JOURNAL J Biol Chem 276 (34), 32051-32055 (2001)
PUBMED 11440998
REFERENCE 8 (residues 1 to 1367)
AUTHORS Huang,Y.Z., Wang,Q., Xiong,W.C. and Mei,L.
TITLE Erbin is a protein concentrated at postsynaptic membranes that
interacts with PSD-95
JOURNAL J Biol Chem 276 (22), 19318-19326 (2001)
PUBMED 11279080
REFERENCE 9 (residues 1 to 1367)
AUTHORS Jaulin-Bastard,F., Saito,H., Le Bivic,A., Ollendorff,V.,
Marchetto,S., Birnbaum,D. and Borg,J.P.
TITLE The ERBB2/HER2 receptor differentially interacts with ERBIN and
PICK1 PSD-95/DLG/ZO-1 domain proteins
JOURNAL J Biol Chem 276 (18), 15256-15263 (2001)
PUBMED 11278603
REFERENCE 10 (residues 1 to 1367)
AUTHORS Borg,J.P., Marchetto,S., Le Bivic,A., Ollendorff,V.,
Jaulin-Bastard,F., Saito,H., Fournier,E., Adelaide,J., Margolis,B.
and Birnbaum,D.
TITLE ERBIN: a basolateral PDZ protein that interacts with the mammalian
ERBB2/HER2 receptor
JOURNAL Nat Cell Biol 2 (7), 407-414 (2000)
PUBMED 10878805
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DR000131.1, BC050692.1,
BC144075.1, AB033051.2, BP342103.1, N67861.1 and AC025442.6.
Summary: This gene is a member of the leucine-rich repeat and PDZ
domain (LAP) family. The encoded protein contains 17 leucine-rich
repeats and one PDZ domain. It binds to the unphosphorylated form
of the ERBB2 protein and regulates ERBB2 function and localization.
It has also been shown to affect the Ras signaling pathway by
disrupting Ras-Raf interaction. Alternatively spliced transcript
variants encoding multiple isoforms have been observed for this
gene. [provided by RefSeq, Nov 2011].
Transcript Variant: This variant (9) uses an alternate splice site
and lacks an exon in the 3' coding region, but maintains the
reading frame, compared to variant 1. The encoded isoform (9) is
shorter than isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: single sample supports all introns SAMEA1965299,
SAMEA1966682 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..1367
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q12.3"
Protein 1..1367
/product="erbin isoform 9"
/note="densin-180-like protein; protein LAP2; epididymis
secretory protein Li 78"
/calculated_mol_wt=153412
Region 24..47
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 48..70
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 67..419
/region_name="LRR"
/note="Leucine-rich repeat (LRR) protein [Transcription];
COG4886"
/db_xref="CDD:443914"
Region 71..93
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 94..116
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 117..139
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 140..162
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 163..185
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 186..208
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 209..231
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 255..277
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 278..300
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 301..323
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 347..369
/region_name="leucine-rich repeat"
/note="leucine-rich repeat [structural motif]"
/db_xref="CDD:275380"
Region 1277..1363
/region_name="PDZ_densin_erbin-like"
/note="PDZ domain of densin, erbin, and related domains;
cd06749"
/db_xref="CDD:467231"
Site order(1286..1292,1312,1315,1343,1347,1350..1351)
/site_type="other"
/note="peptide binding site [polypeptide binding]"
/db_xref="CDD:467231"
CDS 1..1367
/gene="ERBIN"
/gene_synonym="ERBB2IP; HEL-S-78; LAP2"
/coded_by="NM_001253701.2:290..4393"
/note="isoform 9 is encoded by transcript variant 9"
/db_xref="CCDS:CCDS58951.1"
/db_xref="GeneID:55914"
/db_xref="HGNC:HGNC:15842"
/db_xref="MIM:606944"
ORIGIN
1 mttkrslfvr lvpcrclrge eetvttldys hcsleqvpke iftfektlee lyldanqiee
61 lpkqlfncqs lhklslpdnd lttlpasian linlreldvs kngiqefpen iknckvltiv
121 easvnpiskl pdgfsqllnl tqlylndafl eflpanfgrl tklqilelre nqlkmlpktm
181 nrltqlerld lgsneftevp evleqlsglk efwmdanrlt fipgfigslk qltyldvskn
241 niemveegis tcenlqdlll ssnslqqlpe tigslknitt lkidenqlmy lpdsigglis
301 veeldcsfne vealpssigq ltnlrtfaad hnylqqlppe igswknitvl flhsnkletl
361 peemgdmqkl kvinlsdnrl knlpfsftkl qqltamwlsd nqskpliplq ketdsetqkm
421 vltnymfpqq prtedvmfis dnesfnpslw eeqrkqraqv afecdedkde reappregnl
481 kryptpypde lknmvktvqt ivhrlkdeet nedsgrdlkp hedqqdinkd tsestttvks
541 kvderekymi gnsvqkisep eaeispgslp vtanmkasen lkhivnhddv feeseelssd
601 eemkmaemrp plietsinqp kvvalsnnkk ddtketdsls devthnsnqn nsncsspsrm
661 sdsvslntds sqdtslcspv kqthidinsk irqedenfns llqngdilns steekfkahd
721 kkdfnlpeyd lnveerlvli eksvdstata ddthkldhin mnlnklitnd tfqpeimers
781 ktqdivlgts flsinskeet ehlengnkyp nlesvnkvng hseetsqspn rtephdsdcs
841 vdlgiskste dlspqksgpv gsvvkshsit nmeigglkiy dilsdngpqq psttvkitsa
901 vdgknivrsk satllydqpl qvftgsssss dlisgtkaif kfdsnhnpee pniirgptsg
961 pqsapqiygp pqyniqysss aavkdtlwhs kqnpqidhas fppqllprse stenqsyakh
1021 sanmnfsnhn nvrantayhl hqrlgparhg emwaispndr lipavtrsti qrqssvssta
1081 svnlgdpgst rraqipegdy lsyrefhsag rtppmmpgsq rplsartysi dgpnasrpqs
1141 arpsineipe rtmsvsdfny srtspskrpn arvgsehsll dppgkskvpr dwreqvlrhi
1201 eakklekmpl sngqmgqplr pqanysqihh ppqasvarhp sreqlidylm lkvahqppyt
1261 qphcsprqgh elakqeirvr vekdpelgfs isggvggrgn pfrpdddgif vtrvqpegpa
1321 skllqpgdki iqangysfin iehgqavsll ktfqntveli ivrevss
//