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erbin isoform 9 [Homo sapiens]

NCBI Reference Sequence: NP_001240630.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001240630            1367 aa            linear   PRI 17-MAR-2024
DEFINITION  erbin isoform 9 [Homo sapiens].
ACCESSION   NP_001240630
VERSION     NP_001240630.1
DBSOURCE    REFSEQ: accession NM_001253701.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1367)
  AUTHORS   Zhang,Z., Xu,X., Zhang,D., Zhao,S., Wang,C., Zhang,G., Chen,W.,
            Liu,J., Gong,H., Rixiati,Y., Li,S., Shen,T. and Li,J.
  TITLE     Targeting Erbin-mitochondria axis in platelets/megakaryocytes
            promotes B cell-mediated antitumor immunity
  JOURNAL   Cell Metab 36 (3), 541-556 (2024)
   PUBMED   38232736
  REMARK    GeneRIF: Targeting Erbin-mitochondria axis in
            platelets/megakaryocytes promotes B cell-mediated antitumor
            immunity.
REFERENCE   2  (residues 1 to 1367)
  AUTHORS   Peng,X., Zhao,L., Yao,L., Dong,J., Wu,W. and Luo,T.
  TITLE     Exosomal ERBB2IP contributes to tumor growth via elevating PSAT1
            expression in non-small cell lung carcinoma
  JOURNAL   Thorac Cancer 14 (19), 1812-1823 (2023)
   PUBMED   37192746
  REMARK    GeneRIF: Exosomal ERBB2IP contributes to tumor growth via elevating
            PSAT1 expression in non-small cell lung carcinoma.
REFERENCE   3  (residues 1 to 1367)
  AUTHORS   Shen,T., Liu,J.L., Wang,C.Y., Rixiati,Y., Li,S., Cai,L.D.,
            Zhao,Y.Y. and Li,J.M.
  TITLE     Targeting Erbin in B cells for therapy of lung metastasis of
            colorectal cancer
  JOURNAL   Signal Transduct Target Ther 6 (1), 115 (2021)
   PUBMED   33707428
  REMARK    GeneRIF: Targeting Erbin in B cells for therapy of lung metastasis
            of colorectal cancer.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1367)
  AUTHORS   Jang,H., Stevens,P., Gao,T. and Galperin,E.
  TITLE     The leucine-rich repeat signaling scaffolds Shoc2 and Erbin:
            cellular mechanism and role in disease
  JOURNAL   FEBS J 288 (3), 721-739 (2021)
   PUBMED   32558243
  REMARK    GeneRIF: The leucine-rich repeat signaling scaffolds Shoc2 and
            Erbin: cellular mechanism and role in disease.
            Review article
REFERENCE   5  (residues 1 to 1367)
  AUTHORS   Jaulin-Bastard,F., Arsanto,J.P., Le Bivic,A., Navarro,C., Vely,F.,
            Saito,H., Marchetto,S., Hatzfeld,M., Santoni,M.J., Birnbaum,D. and
            Borg,J.P.
  TITLE     Interaction between Erbin and a Catenin-related protein in
            epithelial cells
  JOURNAL   J Biol Chem 277 (4), 2869-2875 (2002)
   PUBMED   11711544
REFERENCE   6  (residues 1 to 1367)
  AUTHORS   Favre,B., Fontao,L., Koster,J., Shafaatian,R., Jaunin,F.,
            Saurat,J.H., Sonnenberg,A. and Borradori,L.
  TITLE     The hemidesmosomal protein bullous pemphigoid antigen 1 and the
            integrin beta 4 subunit bind to ERBIN. Molecular cloning of
            multiple alternative splice variants of ERBIN and analysis of their
            tissue expression
  JOURNAL   J Biol Chem 276 (35), 32427-32436 (2001)
   PUBMED   11375975
REFERENCE   7  (residues 1 to 1367)
  AUTHORS   Saito,H., Santoni,M.J., Arsanto,J.P., Jaulin-Bastard,F., Le
            Bivic,A., Marchetto,S., Audebert,S., Isnardon,D., Adelaide,J.,
            Birnbaum,D. and Borg,J.P.
  TITLE     Lano, a novel LAP protein directly connected to MAGUK proteins in
            epithelial cells
  JOURNAL   J Biol Chem 276 (34), 32051-32055 (2001)
   PUBMED   11440998
REFERENCE   8  (residues 1 to 1367)
  AUTHORS   Huang,Y.Z., Wang,Q., Xiong,W.C. and Mei,L.
  TITLE     Erbin is a protein concentrated at postsynaptic membranes that
            interacts with PSD-95
  JOURNAL   J Biol Chem 276 (22), 19318-19326 (2001)
   PUBMED   11279080
REFERENCE   9  (residues 1 to 1367)
  AUTHORS   Jaulin-Bastard,F., Saito,H., Le Bivic,A., Ollendorff,V.,
            Marchetto,S., Birnbaum,D. and Borg,J.P.
  TITLE     The ERBB2/HER2 receptor differentially interacts with ERBIN and
            PICK1 PSD-95/DLG/ZO-1 domain proteins
  JOURNAL   J Biol Chem 276 (18), 15256-15263 (2001)
   PUBMED   11278603
REFERENCE   10 (residues 1 to 1367)
  AUTHORS   Borg,J.P., Marchetto,S., Le Bivic,A., Ollendorff,V.,
            Jaulin-Bastard,F., Saito,H., Fournier,E., Adelaide,J., Margolis,B.
            and Birnbaum,D.
  TITLE     ERBIN: a basolateral PDZ protein that interacts with the mammalian
            ERBB2/HER2 receptor
  JOURNAL   Nat Cell Biol 2 (7), 407-414 (2000)
   PUBMED   10878805
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR000131.1, BC050692.1,
            BC144075.1, AB033051.2, BP342103.1, N67861.1 and AC025442.6.
            
            Summary: This gene is a member of the leucine-rich repeat and PDZ
            domain (LAP) family. The encoded protein contains 17 leucine-rich
            repeats and one PDZ domain. It binds to the unphosphorylated form
            of the ERBB2 protein and regulates ERBB2 function and localization.
            It has also been shown to affect the Ras signaling pathway by
            disrupting Ras-Raf interaction. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (9) uses an alternate splice site
            and lacks an exon in the 3' coding region, but maintains the
            reading frame, compared to variant 1. The encoded isoform (9) is
            shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1367
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.3"
     Protein         1..1367
                     /product="erbin isoform 9"
                     /note="densin-180-like protein; protein LAP2; epididymis
                     secretory protein Li 78"
                     /calculated_mol_wt=153412
     Region          24..47
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          48..70
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          67..419
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          71..93
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          94..116
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          117..139
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          140..162
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          163..185
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          186..208
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          209..231
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          255..277
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          278..300
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          301..323
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          347..369
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1277..1363
                     /region_name="PDZ_densin_erbin-like"
                     /note="PDZ domain of densin, erbin, and related domains;
                     cd06749"
                     /db_xref="CDD:467231"
     Site            order(1286..1292,1312,1315,1343,1347,1350..1351)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467231"
     CDS             1..1367
                     /gene="ERBIN"
                     /gene_synonym="ERBB2IP; HEL-S-78; LAP2"
                     /coded_by="NM_001253701.2:290..4393"
                     /note="isoform 9 is encoded by transcript variant 9"
                     /db_xref="CCDS:CCDS58951.1"
                     /db_xref="GeneID:55914"
                     /db_xref="HGNC:HGNC:15842"
                     /db_xref="MIM:606944"
ORIGIN      
        1 mttkrslfvr lvpcrclrge eetvttldys hcsleqvpke iftfektlee lyldanqiee
       61 lpkqlfncqs lhklslpdnd lttlpasian linlreldvs kngiqefpen iknckvltiv
      121 easvnpiskl pdgfsqllnl tqlylndafl eflpanfgrl tklqilelre nqlkmlpktm
      181 nrltqlerld lgsneftevp evleqlsglk efwmdanrlt fipgfigslk qltyldvskn
      241 niemveegis tcenlqdlll ssnslqqlpe tigslknitt lkidenqlmy lpdsigglis
      301 veeldcsfne vealpssigq ltnlrtfaad hnylqqlppe igswknitvl flhsnkletl
      361 peemgdmqkl kvinlsdnrl knlpfsftkl qqltamwlsd nqskpliplq ketdsetqkm
      421 vltnymfpqq prtedvmfis dnesfnpslw eeqrkqraqv afecdedkde reappregnl
      481 kryptpypde lknmvktvqt ivhrlkdeet nedsgrdlkp hedqqdinkd tsestttvks
      541 kvderekymi gnsvqkisep eaeispgslp vtanmkasen lkhivnhddv feeseelssd
      601 eemkmaemrp plietsinqp kvvalsnnkk ddtketdsls devthnsnqn nsncsspsrm
      661 sdsvslntds sqdtslcspv kqthidinsk irqedenfns llqngdilns steekfkahd
      721 kkdfnlpeyd lnveerlvli eksvdstata ddthkldhin mnlnklitnd tfqpeimers
      781 ktqdivlgts flsinskeet ehlengnkyp nlesvnkvng hseetsqspn rtephdsdcs
      841 vdlgiskste dlspqksgpv gsvvkshsit nmeigglkiy dilsdngpqq psttvkitsa
      901 vdgknivrsk satllydqpl qvftgsssss dlisgtkaif kfdsnhnpee pniirgptsg
      961 pqsapqiygp pqyniqysss aavkdtlwhs kqnpqidhas fppqllprse stenqsyakh
     1021 sanmnfsnhn nvrantayhl hqrlgparhg emwaispndr lipavtrsti qrqssvssta
     1081 svnlgdpgst rraqipegdy lsyrefhsag rtppmmpgsq rplsartysi dgpnasrpqs
     1141 arpsineipe rtmsvsdfny srtspskrpn arvgsehsll dppgkskvpr dwreqvlrhi
     1201 eakklekmpl sngqmgqplr pqanysqihh ppqasvarhp sreqlidylm lkvahqppyt
     1261 qphcsprqgh elakqeirvr vekdpelgfs isggvggrgn pfrpdddgif vtrvqpegpa
     1321 skllqpgdki iqangysfin iehgqavsll ktfqntveli ivrevss
//
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