LOCUS NP_001269956 137 aa linear PRI 19-SEP-2024
DEFINITION protein N-terminal glutamine amidohydrolase isoform 3 [Homo
sapiens].
ACCESSION NP_001269956 XP_005251055
VERSION NP_001269956.1
DBSOURCE REFSEQ: accession NM_001283027.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 137)
AUTHORS Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
TITLE A comprehensive SARS-CoV-2-human protein-protein interactome
reveals COVID-19 pathobiology and potential host therapeutic
targets
JOURNAL Nat Biotechnol 41 (1), 128-139 (2023)
PUBMED 36217030
REFERENCE 2 (residues 1 to 137)
AUTHORS Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
Falter-Braun,P.
TITLE A proteome-scale map of the SARS-CoV-2-human contactome
JOURNAL Nat Biotechnol 41 (1), 140-149 (2023)
PUBMED 36217029
REFERENCE 3 (residues 1 to 137)
AUTHORS Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
Harper,J.W. and Gygi,S.P.
TITLE Dual proteome-scale networks reveal cell-specific remodeling of the
human interactome
JOURNAL Cell 184 (11), 3022-3040 (2021)
PUBMED 33961781
REFERENCE 4 (residues 1 to 137)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 5 (residues 1 to 137)
AUTHORS Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
Clark,A.G. and Yu,H.
TITLE Extensive disruption of protein interactions by genetic variants
across the allele frequency spectrum in human populations
JOURNAL Nat Commun 10 (1), 4141 (2019)
PUBMED 31515488
REMARK Publication Status: Online-Only
REFERENCE 6 (residues 1 to 137)
AUTHORS Park,M.S., Bitto,E., Kim,K.R., Bingman,C.A., Miller,M.D., Kim,H.J.,
Han,B.W. and Phillips,G.N. Jr.
TITLE Crystal structure of human protein N-terminal glutamine
amidohydrolase, an initial component of the N-end rule pathway
JOURNAL PLoS One 9 (10), e111142 (2014)
PUBMED 25356641
REMARK GeneRIF: the peptide backbone recognition patch of hNtaq1 forms
nonspecific interactions with N-terminal peptides of substrate
proteins
Publication Status: Online-Only
REFERENCE 7 (residues 1 to 137)
AUTHORS Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
Roth,F.P., Braun,P. and Vidal,M.
TITLE Next-generation sequencing to generate interactome datasets
JOURNAL Nat Methods 8 (6), 478-480 (2011)
PUBMED 21516116
REFERENCE 8 (residues 1 to 137)
AUTHORS Wang,H., Piatkov,K.I., Brower,C.S. and Varshavsky,A.
TITLE Glutamine-specific N-terminal amidase, a component of the N-end
rule pathway
JOURNAL Mol Cell 34 (6), 686-695 (2009)
PUBMED 19560421
REFERENCE 9 (residues 1 to 137)
AUTHORS Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
Wanker,E.E., Barabasi,A.L. and Vidal,M.
TITLE An empirical framework for binary interactome mapping
JOURNAL Nat Methods 6 (1), 83-90 (2009)
PUBMED 19060904
REFERENCE 10 (residues 1 to 137)
AUTHORS Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
and Zoghbi,H.Y.
TITLE A protein-protein interaction network for human inherited ataxias
and disorders of Purkinje cell degeneration
JOURNAL Cell 125 (4), 801-814 (2006)
PUBMED 16713569
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC021305.9, BG528966.1 and AU119047.1.
On Sep 25, 2013 this sequence version replaced XP_005251055.1.
Transcript Variant: This variant (3) uses an alternate splice site
in the 5' UTR and has an alternate internal exon compared to
variant 1. These differences cause translation initiation at a
alternate start codon compared to variant 1. The encoded isoform
(3) is shorter and has a disntinct N-teminus compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1163658.517135.1,
SRR1163658.461621.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..137
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q24.13"
Protein 1..137
/product="protein N-terminal glutamine amidohydrolase
isoform 3"
/EC_number="3.5.1.122"
/note="protein N-terminal glutamine amidohydrolase;
nt(Q)-amidase; N-terminal Gln amidase; WDYHV
motif-containing protein 1; protein NH2-terminal glutamine
deamidase; WDYHV motif containing 1"
/calculated_mol_wt=15632
Region <11..132
/region_name="Nt_Gln_amidase"
/note="N-terminal glutamine amidase; pfam09764"
/db_xref="CDD:462887"
CDS 1..137
/gene="NTAQ1"
/gene_synonym="C8orf32; WDYHV1"
/coded_by="NM_001283027.1:355..768"
/note="isoform 3 is encoded by transcript variant 3"
/db_xref="GeneID:55093"
/db_xref="HGNC:HGNC:25490"
/db_xref="MIM:620846"
ORIGIN
1 mhanvllnah dyhvvllhvs sggqnfiydl dtvlpfpclf dtyvedafks dddihpqfrr
61 kfrviradsy lknfasdrsh mkdssgnwre ppppypciet gdskmnlndf ismdpkvgwg
121 avytlsefth rfgsknc
//