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leucine-rich repeat-containing protein 43 isoform 2 [Mus musculus]

NCBI Reference Sequence: NP_001276750.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001276750             660 aa            linear   ROD 01-AUG-2024
DEFINITION  leucine-rich repeat-containing protein 43 isoform 2 [Mus musculus].
ACCESSION   NP_001276750 XP_006530460
VERSION     NP_001276750.1
DBSOURCE    REFSEQ: accession NM_001289821.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 660)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133051.1, AK167729.1 and DV646947.1.
            
            On Jan 31, 2014 this sequence version replaced XP_006530460.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. It
            encodes isoform 2, which is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167318.1, AK167729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..660
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.01 cM"
     Protein         1..660
                     /product="leucine-rich repeat-containing protein 43
                     isoform 2"
                     /note="leucine-rich repeat-containing protein 43"
                     /calculated_mol_wt=74026
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3V0L5.1)"
     Region          148..169
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3V0L5.1)"
     Region          154..291
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          170..191
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3V0L5.1)"
     Region          171..194
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          194..213
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3V0L5.1)"
     Region          195..221
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          221..242
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3V0L5.1)"
     Region          222..247
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          248..259
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          374..407
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3V0L5.1)"
     Region          526..563
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3V0L5.1)"
     Region          609..633
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3V0L5.1)"
     CDS             1..660
                     /gene="Lrrc43"
                     /gene_synonym="Gm1061"
                     /coded_by="NM_001289821.1:6..1988"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS71662.1"
                     /db_xref="GeneID:381741"
                     /db_xref="MGI:MGI:2685907"
ORIGIN      
        1 metsesstsd yrqtegegeg vpgtlstavc ehlrklclre fpcgigswnk srflpqkcrv
       61 wrelvpkeee tlvpeeetve allglvrsnh spwamlkdas aedrflrela iqnplmikdt
      121 ffysyfrslr vvnkgvslvd kdllkflkle elvlsankie eidannlppt lkvlelygnl
      181 iasmeclcsa ppprlqhlgl ghnkllgple slyvtshnwp qlvsldlgfn nltdlqnmil
      241 glstlrhlrl lvlqgnplsl vpyyrgftid slahlcvldd itvspnekhq frglnihgdl
      301 lareaqfvvt ignvrgvlds sildpepgpd gpfisysyyv tydfvededm ernvsglvea
      361 thhdsvldei dkhfsgtdee dqqedpldgr hrhrgrqrfh pgsteemske lsefiakems
      421 qmaegsvesg itevdwsets isihsaplpq sidsseelak lrpkidiqlc pspgtvlfnt
      481 vhkpwsdvip ctyemkhtlk elirvkafll agttilswpv vptpvesplp akkgkdnnkk
      541 kepakdkvhk kkkepprelr qdppvltvlg sglvylepll ageavvstvc nfgvvrtlet
      601 drlthardsk kvkkslkkdr sktvpptmes gyqpeplsve vqiqlhqyrs veeaflslid
//
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