LOCUS NP_001277701 802 aa linear ROD 07-AUG-2023
DEFINITION trophinin isoform 5 [Mus musculus].
ACCESSION NP_001277701
VERSION NP_001277701.1
DBSOURCE REFSEQ: accession NM_001290772.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 802)
AUTHORS Park SK, Yoon J, Wang L, Shibata TK, Motamedchaboki K, Shim KJ,
Chang MS, Lee SH, Tamura N, Hatakeyama S, Nadano D, Sugihara K and
Fukuda MN.
TITLE Enhancement of mouse sperm motility by trophinin-binding peptide
JOURNAL Reprod Biol Endocrinol 10, 101 (2012)
PUBMED 23194061
REMARK GeneRIF: The expression of trophinin in the mouse sperm tail causes
a significant increase in sperm motility.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 802)
AUTHORS Shaut CA, Keene DR, Sorensen LK, Li DY and Stadler HS.
TITLE HOXA13 Is essential for placental vascular patterning and labyrinth
endothelial specification
JOURNAL PLoS Genet 4 (5), e1000073 (2008)
PUBMED 18483557
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 802)
AUTHORS Miyamoto-Sato E, Ishizaka M, Horisawa K, Tateyama S, Takashima H,
Fuse S, Sue K, Hirai N, Masuoka K and Yanagawa H.
TITLE Cell-free cotranslation and selection using in vitro virus for
high-throughput analysis of protein-protein interactions and
complexes
JOURNAL Genome Res 15 (5), 710-717 (2005)
PUBMED 15867431
REFERENCE 4 (residues 1 to 802)
AUTHORS Bertrand M, Huijbers I, Chomez P and De Backer O.
TITLE Comparative expression analysis of the MAGED genes during
embryogenesis and brain development
JOURNAL Dev Dyn 230 (2), 325-334 (2004)
PUBMED 15162511
REMARK GeneRIF: Maged3 expression is restricted to the central nervous
system where it was mostly detected in postmitotic neurons
REFERENCE 5 (residues 1 to 802)
AUTHORS Nadano D, Sugihara K, Paria BC, Saburi S, Copeland NG, Gilbert DJ,
Jenkins NA, Nakayama J and Fukuda MN.
TITLE Significant differences between mouse and human trophinins are
revealed by their expression patterns and targeted disruption of
mouse trophinin gene
JOURNAL Biol Reprod 66 (2), 313-321 (2002)
PUBMED 11804944
REMARK GeneRIF: Targeted disruption of the trophinin gene in the mouse
showed a partial embryonic lethality in a 129/SvJ background
REFERENCE 6 (residues 1 to 802)
AUTHORS Saburi S, Nadano D, Akama TO, Hirama K, Yamanouchi K, Naito K, Tojo
H, Tachi C and Fukuda MN.
TITLE The trophinin gene encodes a novel group of MAGE proteins,
magphinins, and regulates cell proliferation during gametogenesis
in the mouse
JOURNAL J Biol Chem 276 (52), 49378-49389 (2001)
PUBMED 11590179
REFERENCE 7 (residues 1 to 802)
AUTHORS Chomez P, De Backer O, Bertrand M, De Plaen E, Boon T and Lucas S.
TITLE An overview of the MAGE gene family with the identification of all
human members of the family
JOURNAL Cancer Res 61 (14), 5544-5551 (2001)
PUBMED 11454705
REFERENCE 8 (residues 1 to 802)
AUTHORS Suzuki N, Nadano D, Paria BC, Kupriyanov S, Sugihara K and Fukuda
MN.
TITLE Trophinin expression in the mouse uterus coincides with
implantation and is hormonally regulated but not induced by
implanting blastocysts
JOURNAL Endocrinology 141 (11), 4247-4254 (2000)
PUBMED 11089559
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL672150.19.
Transcript Variant: This variant (6) lacks an alternate exon in the
3' coding region, which results in a frameshift, compared to
variant 1. The encoded isoform (5) has a distinct C-terminus and is
shorter than isoform 1.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##Evidence-Data-START##
Transcript exon combination :: AF288606.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN01164138 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..802
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="X"
/map="X 68.46 cM"
Protein 1..802
/product="trophinin isoform 5"
/note="melanoma antigen, family D, 3; trophinin-2; necdin
and trophinin like"
/calculated_mol_wt=87178
Region <20..>243
/region_name="Herpes_BLLF1"
/note="Herpes virus major outer envelope glycoprotein
(BLLF1); pfam05109"
/db_xref="CDD:282904"
Region 272..>490
/region_name="MSCRAMM_ClfA"
/note="MSCRAMM family adhesin clumping factor ClfA;
NF033609"
/db_xref="CDD:468110"
Region 596..756
/region_name="MAGE"
/note="MAGE homology domain; pfam01454"
/db_xref="CDD:426270"
CDS 1..802
/gene="Tro"
/gene_synonym="Maged3; Maged3l; magphinin; Tnn; Trol"
/coded_by="NM_001290772.1:118..2526"
/note="isoform 5 is encoded by transcript variant 6"
/db_xref="CCDS:CCDS81183.1"
/db_xref="GeneID:56191"
/db_xref="MGI:MGI:1928994"
ORIGIN
1 mdrrndhghr vptfqgplpp agslglpfsp dvqsettekd ppiasrskkn knkknsikpm
61 dkttpapppv psandnasnk pkvtlqalnl pmftqisqas atteapniqa svtsqtqkak
121 tmrvtpkvsl tgsedattql kpplqalnlp vttptiqtpv anesanslas tavnkskkas
181 tannaanktv psaaeislas aathtvttqg qaaketgsiq tiaatarskk nskgkrtpak
241 ttntdneyve asnaieassr qigasgrqte asnrqieass rqteasnrqt eassrqteas
301 srqtetsnrq igasnrqima snrqigasnr qieasnrqig asnrqtevss rqieasnrqi
361 gasnrqteas nrqigasnrq teasnrqiga snrqtdasnr qtdasnrqte assrqteass
421 rqteassrqt eassrqieas aaavrpkkpr gkkgnnkgsn sasepseapp aiqtvtnhal
481 svtvrirrgs rarkaanknr atesqaqiae qgaqaseasi saletqvaaa vqaladdyla
541 qlslepttrt rgkrnrkskh pngeertgnn yrripwgrrl ppprdvailq eranklvkyl
601 lvkdqtkipi krsdmlkdvi qeyedyfpei ierasyalek mfrvnlkeid kqnnlyilis
661 tqessagimg ttkdtpklgl lmvilsvifm ngnkaseavi wevlrklglh pgvkhslfge
721 vkklitdefv kqkyleykrv pnsrppeyef fwglrsyhet skmkvlkfac kacspclqit
781 ltatilpmep mcsfgivvha aa
//