LOCUS NP_001290035 349 aa linear PRI 22-SEP-2024
DEFINITION coiled-coil domain-containing protein 138 isoform 3 [Homo sapiens].
ACCESSION NP_001290035 XP_005263952
VERSION NP_001290035.1
DBSOURCE REFSEQ: accession NM_001303106.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 349)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 2 (residues 1 to 349)
AUTHORS Drew,K., Lee,C., Huizar,R.L., Tu,F., Borgeson,B., McWhite,C.D.,
Ma,Y., Wallingford,J.B. and Marcotte,E.M.
TITLE Integration of over 9,000 mass spectrometry experiments builds a
global map of human protein complexes
JOURNAL Mol Syst Biol 13 (6), 932 (2017)
PUBMED 28596423
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 349)
AUTHORS Volik,S., Raphael,B.J., Huang,G., Stratton,M.R., Bignel,G.,
Murnane,J., Brebner,J.H., Bajsarowicz,K., Paris,P.L., Tao,Q.,
Kowbel,D., Lapuk,A., Shagin,D.A., Shagina,I.A., Gray,J.W.,
Cheng,J.F., de Jong,P.J., Pevzner,P. and Collins,C.
TITLE Decoding the fine-scale structure of a breast cancer genome and
transcriptome
JOURNAL Genome Res 16 (3), 394-404 (2006)
PUBMED 16461635
REFERENCE 4 (residues 1 to 349)
AUTHORS Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
Offenbacher,J., Danzig,J. and Ducar,M.
TITLE Creation of genome-wide protein expression libraries using random
activation of gene expression
JOURNAL Nat Biotechnol 19 (5), 440-445 (2001)
PUBMED 11329013
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC010095.6 and AC073415.6.
On Dec 17, 2014 this sequence version replaced XP_005263952.1.
Transcript Variant: This variant (3) uses an alternate splice site
in its 5' UTR which results in the use of a downstream in-frame
start codon, compared to variant 1. The encoded isoform (3) has a
shorter N-terminus, compared to variant 1. Variants 3 and 16 both
encode the same isoform (3).
##Evidence-Data-START##
Transcript exon combination :: SRR14038197.1795585.1, BC038421.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1968540
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..349
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q13"
Protein 1..349
/product="coiled-coil domain-containing protein 138
isoform 3"
/note="coiled-coil domain-containing protein 138"
/calculated_mol_wt=39487
CDS 1..349
/gene="CCDC138"
/coded_by="NM_001303106.2:996..2045"
/note="isoform 3 is encoded by transcript variant 3"
/db_xref="GeneID:165055"
/db_xref="HGNC:HGNC:26531"
ORIGIN
1 mtiqrlkgss havhemkslk qekapvskty kvplngqvye lltvfmdwis dhhlskvkhe
61 esgmdgkkpq lkfasqrndi qekcvkllpl mteqlqwmpf vniklhepfv kfiywslrql
121 dagaqhstmt stlrrlgedi fkgvvtkgiq dnspqhsven kpktaaffks snlplrflst
181 livlktvtqa dylaqafdsl cldlkteegk tlfleyqavp vilshlriss kgllsnvids
241 llqmtvesks lqpfleacsn slffrtcsvl lrapkldlqi leklsiilqk lskiksnkkl
301 felftihlml qeiqrttnpe haflcinlns tlfnlgltkc nslvssasp
//