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coiled-coil domain-containing protein 138 isoform 3 [Homo sapiens]

NCBI Reference Sequence: NP_001290035.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001290035             349 aa            linear   PRI 22-SEP-2024
DEFINITION  coiled-coil domain-containing protein 138 isoform 3 [Homo sapiens].
ACCESSION   NP_001290035 XP_005263952
VERSION     NP_001290035.1
DBSOURCE    REFSEQ: accession NM_001303106.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 349)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 349)
  AUTHORS   Drew,K., Lee,C., Huizar,R.L., Tu,F., Borgeson,B., McWhite,C.D.,
            Ma,Y., Wallingford,J.B. and Marcotte,E.M.
  TITLE     Integration of over 9,000 mass spectrometry experiments builds a
            global map of human protein complexes
  JOURNAL   Mol Syst Biol 13 (6), 932 (2017)
   PUBMED   28596423
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 349)
  AUTHORS   Volik,S., Raphael,B.J., Huang,G., Stratton,M.R., Bignel,G.,
            Murnane,J., Brebner,J.H., Bajsarowicz,K., Paris,P.L., Tao,Q.,
            Kowbel,D., Lapuk,A., Shagin,D.A., Shagina,I.A., Gray,J.W.,
            Cheng,J.F., de Jong,P.J., Pevzner,P. and Collins,C.
  TITLE     Decoding the fine-scale structure of a breast cancer genome and
            transcriptome
  JOURNAL   Genome Res 16 (3), 394-404 (2006)
   PUBMED   16461635
REFERENCE   4  (residues 1 to 349)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010095.6 and AC073415.6.
            
            On Dec 17, 2014 this sequence version replaced XP_005263952.1.
            
            Transcript Variant: This variant (3) uses an alternate splice site
            in its 5' UTR which results in the use of a downstream in-frame
            start codon, compared to variant 1. The encoded isoform (3) has a
            shorter N-terminus, compared to variant 1. Variants 3 and 16 both
            encode the same isoform (3).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1795585.1, BC038421.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..349
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q13"
     Protein         1..349
                     /product="coiled-coil domain-containing protein 138
                     isoform 3"
                     /note="coiled-coil domain-containing protein 138"
                     /calculated_mol_wt=39487
     CDS             1..349
                     /gene="CCDC138"
                     /coded_by="NM_001303106.2:996..2045"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:165055"
                     /db_xref="HGNC:HGNC:26531"
ORIGIN      
        1 mtiqrlkgss havhemkslk qekapvskty kvplngqvye lltvfmdwis dhhlskvkhe
       61 esgmdgkkpq lkfasqrndi qekcvkllpl mteqlqwmpf vniklhepfv kfiywslrql
      121 dagaqhstmt stlrrlgedi fkgvvtkgiq dnspqhsven kpktaaffks snlplrflst
      181 livlktvtqa dylaqafdsl cldlkteegk tlfleyqavp vilshlriss kgllsnvids
      241 llqmtvesks lqpfleacsn slffrtcsvl lrapkldlqi leklsiilqk lskiksnkkl
      301 felftihlml qeiqrttnpe haflcinlns tlfnlgltkc nslvssasp
//
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