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cyclin-dependent kinase 7 isoform 3 [Homo sapiens]

NCBI Reference Sequence: NP_001310999.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001310999             289 aa            linear   PRI 15-OCT-2024
DEFINITION  cyclin-dependent kinase 7 isoform 3 [Homo sapiens].
ACCESSION   NP_001310999 XP_011541395 XP_011545246
VERSION     NP_001310999.1
DBSOURCE    REFSEQ: accession NM_001324070.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 289)
  AUTHORS   Shirasawa,M., Nakajima,R., Zhou,Y., Zhao,L., Fikriyanti,M.,
            Iwanaga,R., Bradford,A.P., Kurayoshi,K., Araki,K. and Ohtani,K.
  TITLE     Activation of the CDK7 Gene, Coding for the Catalytic Subunit of
            the Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) and
            General Transcription Factor II H, by the Trans-Activator Protein
            Tax of Human T-Cell Leukemia Virus Type-1
  JOURNAL   Genes (Basel) 15 (8), 1080 (2024)
   PUBMED   39202439
  REMARK    GeneRIF: Activation of the CDK7 Gene, Coding for the Catalytic
            Subunit of the Cyclin-Dependent Kinase (CDK)-Activating Kinase
            (CAK) and General Transcription Factor II H, by the Trans-Activator
            Protein Tax of Human T-Cell Leukemia Virus Type-1.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 289)
  AUTHORS   Duster,R., Anand,K., Binder,S.C., Schmitz,M., Gatterdam,K.,
            Fisher,R.P. and Geyer,M.
  TITLE     Structural basis of Cdk7 activation by dual T-loop phosphorylation
  JOURNAL   Nat Commun 15 (1), 6597 (2024)
   PUBMED   39097586
  REMARK    GeneRIF: Structural basis of Cdk7 activation by dual T-loop
            phosphorylation.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 289)
  AUTHORS   Velychko,T., Mohammad,E., Ferrer-Vicens,I., Parfentev,I.,
            Werner,M., Studniarek,C., Schwalb,B., Urlaub,H., Murphy,S.,
            Cramer,P. and Lidschreiber,M.
  TITLE     CDK7 kinase activity promotes RNA polymerase II promoter escape by
            facilitating initiation factor release
  JOURNAL   Mol Cell 84 (12), 2287-2303 (2024)
   PUBMED   38821049
  REMARK    GeneRIF: CDK7 kinase activity promotes RNA polymerase II promoter
            escape by facilitating initiation factor release.
REFERENCE   4  (residues 1 to 289)
  AUTHORS   Gong,Y. and Li,H.
  TITLE     CDK7 in breast cancer: mechanisms of action and therapeutic
            potential
  JOURNAL   Cell Commun Signal 22 (1), 226 (2024)
   PUBMED   38605321
  REMARK    GeneRIF: CDK7 in breast cancer: mechanisms of action and
            therapeutic potential.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 289)
  AUTHORS   Schutz,M., Wangen,C., Sommerer,M., Kogler,M., Eickhoff,J.,
            Degenhart,C., Klebl,B., Naing,Z., Egilmezer,E., Hamilton,S.T.,
            Rawlinson,W.D., Sticht,H. and Marschall,M.
  TITLE     Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97
            undergoes regulatory interaction with human cyclin H and CDK7 to
            codetermine viral replication efficiency
  JOURNAL   Virus Res 335, 199200 (2023)
   PUBMED   37591314
  REMARK    GeneRIF: Cytomegalovirus cyclin-dependent kinase ortholog
            vCDK/pUL97 undergoes regulatory interaction with human cyclin H and
            CDK7 to codetermine viral replication efficiency.
REFERENCE   6  (residues 1 to 289)
  AUTHORS   Aprelikova,O., Xiong,Y. and Liu,E.T.
  TITLE     Both p16 and p21 families of cyclin-dependent kinase (CDK)
            inhibitors block the phosphorylation of cyclin-dependent kinases by
            the CDK-activating kinase
  JOURNAL   J Biol Chem 270 (31), 18195-18197 (1995)
   PUBMED   7629134
REFERENCE   7  (residues 1 to 289)
  AUTHORS   Shiekhattar,R., Mermelstein,F., Fisher,R.P., Drapkin,R.,
            Dynlacht,B., Wessling,H.C., Morgan,D.O. and Reinberg,D.
  TITLE     Cdk-activating kinase complex is a component of human transcription
            factor TFIIH
  JOURNAL   Nature 374 (6519), 283-287 (1995)
   PUBMED   7533895
REFERENCE   8  (residues 1 to 289)
  AUTHORS   Desai,D., Wessling,H.C., Fisher,R.P. and Morgan,D.O.
  TITLE     Effects of phosphorylation by CAK on cyclin binding by CDC2 and
            CDK2
  JOURNAL   Mol Cell Biol 15 (1), 345-350 (1995)
   PUBMED   7799941
REFERENCE   9  (residues 1 to 289)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   10 (residues 1 to 289)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J Biol Chem 263 (6), 2962-2968 (1988)
   PUBMED   2449431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK308493.1, BC000834.2 and CA437275.1.
            
            On or before Apr 26, 2016 this sequence version replaced
            XP_011541395.1, XP_011545246.1.
            
            Summary: The protein encoded by this gene is a member of the
            cyclin-dependent protein kinase (CDK) family. CDK family members
            are highly similar to the gene products of Saccharomyces cerevisiae
            cdc28, and Schizosaccharomyces pombe cdc2, and are known to be
            important regulators of cell cycle progression. This protein forms
            a trimeric complex with cyclin H and MAT1, which functions as a
            Cdk-activating kinase (CAK). It is an essential component of the
            transcription factor TFIIH, that is involved in transcription
            initiation and DNA repair. This protein is thought to serve as a
            direct link between the regulation of transcription and the cell
            cycle. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.60414.1,
                                           SRR1163658.91962.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     Protein         1..289
                     /product="cyclin-dependent kinase 7 isoform 3"
                     /EC_number="2.7.11.23"
                     /EC_number="2.7.11.22"
                     /note="cyclin-dependent kinase 7 (MO15 homolog, Xenopus
                     laevis, cdk-activating kinase); serine/threonine kinase
                     stk1; serine/threonine protein kinase 1; serine/threonine
                     protein kinase MO15; homolog of Xenopus MO15
                     Cdk-activating kinase; kinase subunit of CAK; 39 KDa
                     protein kinase; cell division protein kinase 7; TFIIH
                     basal transcription factor complex kinase subunit;
                     CDK-activating kinase 1"
                     /calculated_mol_wt=32480
     Region          11..251
                     /region_name="STKc_CDK7"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Cyclin-Dependent protein Kinase 7; cd07841"
                     /db_xref="CDD:270833"
     Site            order(80,82,101,113,115..118,120,158..159)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270833"
     Site            order(97..108,110..120)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270833"
     CDS             1..289
                     /gene="CDK7"
                     /gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
                     STK1"
                     /coded_by="NM_001324070.2:91..960"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:1022"
                     /db_xref="HGNC:HGNC:1778"
                     /db_xref="MIM:601955"
ORIGIN      
        1 maldvksrak ryekldflge gqfatvykar dkntnqivai kkviikdnsl vltpshikay
       61 mlmtlqgley lhqhwilhrd lkpnnlllde ngvlkladfg laksfgspnr aythqvvtrw
      121 yrapellfga rmygvgvdmw avgcilaell lrvpflpgds dldqltrife tlgtpteeqw
      181 pdmcslpdyv tfksfpgipl hhifsaagdd lldliqglfl fnpcaritat qalkmkyfsn
      241 rpgptpgcql prpncpvetl keqsnpalai krkrtealeq gglpkklif
//
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