LOCUS NP_001310999 289 aa linear PRI 15-OCT-2024
DEFINITION cyclin-dependent kinase 7 isoform 3 [Homo sapiens].
ACCESSION NP_001310999 XP_011541395 XP_011545246
VERSION NP_001310999.1
DBSOURCE REFSEQ: accession NM_001324070.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 289)
AUTHORS Shirasawa,M., Nakajima,R., Zhou,Y., Zhao,L., Fikriyanti,M.,
Iwanaga,R., Bradford,A.P., Kurayoshi,K., Araki,K. and Ohtani,K.
TITLE Activation of the CDK7 Gene, Coding for the Catalytic Subunit of
the Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) and
General Transcription Factor II H, by the Trans-Activator Protein
Tax of Human T-Cell Leukemia Virus Type-1
JOURNAL Genes (Basel) 15 (8), 1080 (2024)
PUBMED 39202439
REMARK GeneRIF: Activation of the CDK7 Gene, Coding for the Catalytic
Subunit of the Cyclin-Dependent Kinase (CDK)-Activating Kinase
(CAK) and General Transcription Factor II H, by the Trans-Activator
Protein Tax of Human T-Cell Leukemia Virus Type-1.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 289)
AUTHORS Duster,R., Anand,K., Binder,S.C., Schmitz,M., Gatterdam,K.,
Fisher,R.P. and Geyer,M.
TITLE Structural basis of Cdk7 activation by dual T-loop phosphorylation
JOURNAL Nat Commun 15 (1), 6597 (2024)
PUBMED 39097586
REMARK GeneRIF: Structural basis of Cdk7 activation by dual T-loop
phosphorylation.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 289)
AUTHORS Velychko,T., Mohammad,E., Ferrer-Vicens,I., Parfentev,I.,
Werner,M., Studniarek,C., Schwalb,B., Urlaub,H., Murphy,S.,
Cramer,P. and Lidschreiber,M.
TITLE CDK7 kinase activity promotes RNA polymerase II promoter escape by
facilitating initiation factor release
JOURNAL Mol Cell 84 (12), 2287-2303 (2024)
PUBMED 38821049
REMARK GeneRIF: CDK7 kinase activity promotes RNA polymerase II promoter
escape by facilitating initiation factor release.
REFERENCE 4 (residues 1 to 289)
AUTHORS Gong,Y. and Li,H.
TITLE CDK7 in breast cancer: mechanisms of action and therapeutic
potential
JOURNAL Cell Commun Signal 22 (1), 226 (2024)
PUBMED 38605321
REMARK GeneRIF: CDK7 in breast cancer: mechanisms of action and
therapeutic potential.
Review article
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 289)
AUTHORS Schutz,M., Wangen,C., Sommerer,M., Kogler,M., Eickhoff,J.,
Degenhart,C., Klebl,B., Naing,Z., Egilmezer,E., Hamilton,S.T.,
Rawlinson,W.D., Sticht,H. and Marschall,M.
TITLE Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97
undergoes regulatory interaction with human cyclin H and CDK7 to
codetermine viral replication efficiency
JOURNAL Virus Res 335, 199200 (2023)
PUBMED 37591314
REMARK GeneRIF: Cytomegalovirus cyclin-dependent kinase ortholog
vCDK/pUL97 undergoes regulatory interaction with human cyclin H and
CDK7 to codetermine viral replication efficiency.
REFERENCE 6 (residues 1 to 289)
AUTHORS Aprelikova,O., Xiong,Y. and Liu,E.T.
TITLE Both p16 and p21 families of cyclin-dependent kinase (CDK)
inhibitors block the phosphorylation of cyclin-dependent kinases by
the CDK-activating kinase
JOURNAL J Biol Chem 270 (31), 18195-18197 (1995)
PUBMED 7629134
REFERENCE 7 (residues 1 to 289)
AUTHORS Shiekhattar,R., Mermelstein,F., Fisher,R.P., Drapkin,R.,
Dynlacht,B., Wessling,H.C., Morgan,D.O. and Reinberg,D.
TITLE Cdk-activating kinase complex is a component of human transcription
factor TFIIH
JOURNAL Nature 374 (6519), 283-287 (1995)
PUBMED 7533895
REFERENCE 8 (residues 1 to 289)
AUTHORS Desai,D., Wessling,H.C., Fisher,R.P. and Morgan,D.O.
TITLE Effects of phosphorylation by CAK on cyclin binding by CDC2 and
CDK2
JOURNAL Mol Cell Biol 15 (1), 345-350 (1995)
PUBMED 7799941
REFERENCE 9 (residues 1 to 289)
AUTHORS Jacob,G.A., Luse,S.W. and Luse,D.S.
TITLE Abortive initiation is increased only for the weakest members of a
set of down mutants of the adenovirus 2 major late promoter
JOURNAL J Biol Chem 266 (33), 22537-22544 (1991)
PUBMED 1939271
REFERENCE 10 (residues 1 to 289)
AUTHORS Conaway,R.C. and Conaway,J.W.
TITLE ATP activates transcription initiation from promoters by RNA
polymerase II in a reversible step prior to RNA synthesis
JOURNAL J Biol Chem 263 (6), 2962-2968 (1988)
PUBMED 2449431
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK308493.1, BC000834.2 and CA437275.1.
On or before Apr 26, 2016 this sequence version replaced
XP_011541395.1, XP_011545246.1.
Summary: The protein encoded by this gene is a member of the
cyclin-dependent protein kinase (CDK) family. CDK family members
are highly similar to the gene products of Saccharomyces cerevisiae
cdc28, and Schizosaccharomyces pombe cdc2, and are known to be
important regulators of cell cycle progression. This protein forms
a trimeric complex with cyclin H and MAT1, which functions as a
Cdk-activating kinase (CAK). It is an essential component of the
transcription factor TFIIH, that is involved in transcription
initiation and DNA repair. This protein is thought to serve as a
direct link between the regulation of transcription and the cell
cycle. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1163658.60414.1,
SRR1163658.91962.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1968189
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..289
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="5"
/map="5q13.2"
Protein 1..289
/product="cyclin-dependent kinase 7 isoform 3"
/EC_number="2.7.11.23"
/EC_number="2.7.11.22"
/note="cyclin-dependent kinase 7 (MO15 homolog, Xenopus
laevis, cdk-activating kinase); serine/threonine kinase
stk1; serine/threonine protein kinase 1; serine/threonine
protein kinase MO15; homolog of Xenopus MO15
Cdk-activating kinase; kinase subunit of CAK; 39 KDa
protein kinase; cell division protein kinase 7; TFIIH
basal transcription factor complex kinase subunit;
CDK-activating kinase 1"
/calculated_mol_wt=32480
Region 11..251
/region_name="STKc_CDK7"
/note="Catalytic domain of the Serine/Threonine Kinase,
Cyclin-Dependent protein Kinase 7; cd07841"
/db_xref="CDD:270833"
Site order(80,82,101,113,115..118,120,158..159)
/site_type="other"
/note="polypeptide substrate binding site [polypeptide
binding]"
/db_xref="CDD:270833"
Site order(97..108,110..120)
/site_type="other"
/note="activation loop (A-loop)"
/db_xref="CDD:270833"
CDS 1..289
/gene="CDK7"
/gene_synonym="CAK; CAK1; CDKN7; HCAK; MO15; p39MO15;
STK1"
/coded_by="NM_001324070.2:91..960"
/note="isoform 3 is encoded by transcript variant 3"
/db_xref="GeneID:1022"
/db_xref="HGNC:HGNC:1778"
/db_xref="MIM:601955"
ORIGIN
1 maldvksrak ryekldflge gqfatvykar dkntnqivai kkviikdnsl vltpshikay
61 mlmtlqgley lhqhwilhrd lkpnnlllde ngvlkladfg laksfgspnr aythqvvtrw
121 yrapellfga rmygvgvdmw avgcilaell lrvpflpgds dldqltrife tlgtpteeqw
181 pdmcslpdyv tfksfpgipl hhifsaagdd lldliqglfl fnpcaritat qalkmkyfsn
241 rpgptpgcql prpncpvetl keqsnpalai krkrtealeq gglpkklif
//