mitogen-activated protein kinase kinase kinase 12 [Mus musculus]

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A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS. [Ann Clin Transl Neurol. 2022]
A Phase 1 study of GDC-0134, a dual leucine zipper kinase inhibitor, in ALS.
Katz JS, Rothstein JD, Cudkowicz ME, Genge A, Oskarsson B, Hains AB, Chen C, Galanter J, Burgess BL, Cho W, et al. Ann Clin Transl Neurol. 2022 Jan; 9(1):50-66. Epub 2022 Jan 10.
High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity. [Acta Neuropathol Commun. 2019]
High-throughput microscopy exposes a pharmacological window in which dual leucine zipper kinase inhibition preserves neuronal network connectivity.
Verschuuren M, Verstraelen P, García-Díaz Barriga G, Cilissen I, Coninx E, Verslegers M, Larsen PH, Nuydens R, De Vos WH. Acta Neuropathol Commun. 2019 Jun 4; 7(1):93. Epub 2019 Jun 4.
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. [Sci Transl Med. 2017]
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.
Le Pichon CE, Meilandt WJ, Dominguez S, Solanoy H, Lin H, Ngu H, Gogineni A, Sengupta Ghosh A, Jiang Z, Lee SH, et al. Sci Transl Med. 2017 Aug 16; 9(403).

RefSeq mRNA
See reference mRNA sequence for the Map3k12 gene (NM_001358844.2).
RefSeq protein isoforms
See 10 reference sequence protein isoforms for the Map3k12 gene.

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