LOCUS NP_001371544 892 aa linear PRI 03-SEP-2024
DEFINITION dipeptidyl peptidase 9 isoform 1 [Homo sapiens].
ACCESSION NP_001371544
VERSION NP_001371544.1
DBSOURCE REFSEQ: accession NM_001384615.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 892)
AUTHORS Zhou,Y., Chen,Y., Xuan,C., Li,X., Tan,Y., Yang,M., Cao,M., Chen,C.,
Huang,X. and Hu,R.
TITLE DPP9 regulates NQO1 and ROS to promote resistance to chemotherapy
in liver cancer cells
JOURNAL Redox Biol 75, 103292 (2024)
PUBMED 39094401
REMARK GeneRIF: DPP9 regulates NQO1 and ROS to promote resistance to
chemotherapy in liver cancer cells.
REFERENCE 2 (residues 1 to 892)
AUTHORS Hess,L., Aliar,K., Grunwald,B.T., Griffin,R., Lozan,A., Knoller,M.,
Khokha,R., Brummer,T. and Reinheckel,T.
TITLE Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and
metastasis in breast cancer
JOURNAL Biochim Biophys Acta Mol Basis Dis 1870 (5), 167133 (2024)
PUBMED 38531482
REMARK GeneRIF: Dipeptidyl-peptidase 9 regulates the dynamics of
tumorigenesis and metastasis in breast cancer.
REFERENCE 3 (residues 1 to 892)
AUTHORS Li,K., Zhang,Y., Zhao,W., Wang,R., Li,Y., Wei,L., Wang,L., Chen,X.,
Chen,Z., Liu,P., Nie,N., Tian,X. and Fu,R.
TITLE DPP8/9 inhibition attenuates the TGF-beta1-induced excessive
deposition of extracellular matrix (ECM) in human mesangial cells
via Smad and Akt signaling pathways
JOURNAL Toxicol Lett 395, 1-10 (2024)
PUBMED 38458339
REMARK GeneRIF: DPP8/9 inhibition attenuates the TGF-beta1-induced
excessive deposition of extracellular matrix (ECM) in human
mesangial cells via Smad and Akt signaling pathways.
REFERENCE 4 (residues 1 to 892)
AUTHORS Chang,K., Chen,Y., Zhang,X., Zhang,W., Xu,N., Zeng,B., Wang,Y.,
Feng,T., Dai,B., Xu,F., Ye,D. and Wang,C.
TITLE DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib
Resistance in Clear Cell Renal Cell Carcinoma
JOURNAL Cancer Res 83 (23), 3940-3955 (2023)
PUBMED 37713596
REMARK GeneRIF: DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce
Sorafenib Resistance in Clear Cell Renal Cell Carcinoma.
REFERENCE 5 (residues 1 to 892)
AUTHORS Wolf,C., Fischer,H., Kuhl,J.S., Koss,S., Jamra,R.A., Starke,S.,
Schultz,J., Ehl,S., Neumann,K., Schuetz,C., Huber,R., Hornung,V.
and Lee-Kirsch,M.A.
TITLE Hemophagocytic lymphohistiocytosis-like hyperinflammation due to a
de novo mutation in DPP9
JOURNAL J Allergy Clin Immunol 152 (5), 1336-1344 (2023)
PUBMED 37544411
REMARK GeneRIF: Hemophagocytic lymphohistiocytosis-like hyperinflammation
due to a de novo mutation in DPP9.
REFERENCE 6 (residues 1 to 892)
AUTHORS Ogasawara,W., Tanaka,C., Suzuki,M., Kobayashi,G., Ogawa,Y.,
Okada,H. and Morikawa,Y.
TITLE Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24:
role of the signal sequence and overexpression in Escherichia coli
JOURNAL Protein Expr Purif 41 (2), 241-251 (2005)
PUBMED 15866709
REFERENCE 7 (residues 1 to 892)
AUTHORS Ajami,K., Abbott,C.A., McCaughan,G.W. and Gorrell,M.D.
TITLE Dipeptidyl peptidase 9 has two forms, a broad tissue distribution,
cytoplasmic localization and DPIV-like peptidase activity
JOURNAL Biochim Biophys Acta 1679 (1), 18-28 (2004)
PUBMED 15245913
REMARK GeneRIF: identification of two forms, their tissue distribution,
cytoplasmic localization
REFERENCE 8 (residues 1 to 892)
AUTHORS Qi,S.Y., Riviere,P.J., Trojnar,J., Junien,J.L. and Akinsanya,K.O.
TITLE Cloning and characterization of dipeptidyl peptidase 10, a new
member of an emerging subgroup of serine proteases
JOURNAL Biochem J 373 (Pt 1), 179-189 (2003)
PUBMED 12662155
REFERENCE 9 (residues 1 to 892)
AUTHORS Ajami,K., Abbott,C.A., Obradovic,M., Gysbers,V., Kahne,T.,
McCaughan,G.W. and Gorrell,M.D.
TITLE Structural requirements for catalysis, expression, and dimerization
in the CD26/DPIV gene family
JOURNAL Biochemistry 42 (3), 694-701 (2003)
PUBMED 12534281
REFERENCE 10 (residues 1 to 892)
AUTHORS Olsen,C. and Wagtmann,N.
TITLE Identification and characterization of human DPP9, a novel
homologue of dipeptidyl peptidase IV
JOURNAL Gene 299 (1-2), 185-193 (2002)
PUBMED 12459266
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC005783.1 and AC005594.1.
Summary: This gene encodes a protein that is a member of the S9B
family in clan SC of the serine proteases. The protein has been
shown to have post-proline dipeptidyl aminopeptidase activity,
cleaving Xaa-Pro dipeptides from the N-termini of proteins.
Although the activity of this protein is similar to that of
dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane
bound. In general, dipeptidyl peptidases appear to be involved in
the regulation of the activity of their substrates and have been
linked to a variety of diseases including type 2 diabetes, obesity
and cancer. Several transcript variants of this gene have been
described but not fully characterized. [provided by RefSeq, Jul
2008].
Transcript Variant: This variant (8) differs in the 5' UTR compared
to variant 1. Variants 1 and 4-8 all encode the same isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR14038193.4555417.1,
SRR14038192.2384027.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
coronavirus related :: locus in the vicinity of disease-associated
variant(s)
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..892
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="19"
/map="19p13.3"
Protein 1..892
/product="dipeptidyl peptidase 9 isoform 1"
/EC_number="3.4.14.5"
/note="dipeptidyl peptidase IV-related protein-2;
dipeptidyl peptidase IX; dipeptidyl peptidase-like protein
9"
/calculated_mol_wt=101539
Region <53..164
/region_name="Dpp_8_9_N"
/note="Dipeptidyl peptidase 8 and 9 N-terminal; pfam19520"
/db_xref="CDD:466112"
Region 175..599
/region_name="DPPIV_N"
/note="Dipeptidyl peptidase IV (DPP IV) N-terminal region;
pfam00930"
/db_xref="CDD:395744"
Region 691..892
/region_name="Peptidase_S9"
/note="Prolyl oligopeptidase family; pfam00326"
/db_xref="CDD:459761"
CDS 1..892
/gene="DPP9"
/gene_synonym="DP9; DPLP9; DPP IX; DPRP-2; DPRP2; HATIS;
IMD111"
/coded_by="NM_001384615.1:205..2883"
/note="isoform 1 is encoded by transcript variant 8"
/db_xref="CCDS:CCDS45928.1"
/db_xref="GeneID:91039"
/db_xref="HGNC:HGNC:18648"
/db_xref="MIM:608258"
ORIGIN
1 mrkvkklrld kentgswrsf slnsegaerm attgtptadr gdaaatddpa arfqvqkhsw
61 dglrsiihgs rkysglivnk aphdfqfvqk tdesgphshr lyylgmpygs rensllysei
121 pkkvrkeall llswkqmldh fqatphhgvy sreeellrer krlgvfgits ydfhsesglf
181 lfqasnslfh crdggkngfm vspmkpleik tqcsgprmdp kicpadpaff sfinnsdlwv
241 anietgeerr ltfchqglsn vlddpksagv atfviqeefd rftgywwcpt aswegseglk
301 tlrilyeevd esevevihvp spaleerktd syryprtgsk npkialklae fqtdsqgkiv
361 stqekelvqp fsslfpkvey iaragwtrdg kyawamfldr pqqwlqlvll ppalfipste
421 neeqrlasar avprnvqpyv vyeevtnvwi nvhdifypfp qsegedelcf lranecktgf
481 chlykvtavl ksqgydwsep fspgedefkc pikeeialts gewevlarhg skiwvneetk
541 lvyfqgtkdt plehhlyvvs yeaageivrl ttpgfshscs msqnfdmfvs hyssvstppc
601 vhvyklsgpd ddplhkqprf wasmmeaasc ppdyvppeif hfhtrsdvrl ygmiykphal
661 qpgkkhptvl fvyggpqvql vnnsfkgiky lrlntlaslg yavvvidgrg scqrglrfeg
721 alknqmgqve iedqveglqf vaekygfidl srvaihgwsy ggflslmgli hkpqvfkvai
781 agapvtvwma ydtgyterym dvpennqhgy eagsvalhve klpnepnrll ilhgfldenv
841 hffhtnflvs qliragkpyq lqiypnerhs ircpesgehy evtllhflqe yl
//