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coronin-6 isoform 7 [Homo sapiens]

NCBI Reference Sequence: NP_001375367.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001375367             397 aa            linear   PRI 22-SEP-2024
DEFINITION  coronin-6 isoform 7 [Homo sapiens].
ACCESSION   NP_001375367
VERSION     NP_001375367.1
DBSOURCE    REFSEQ: accession NM_001388438.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 397)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (residues 1 to 397)
  AUTHORS   Cardinali,B., Cappella,M., Provenzano,C., Garcia-Manteiga,J.M.,
            Lazarevic,D., Cittaro,D., Martelli,F. and Falcone,G.
  TITLE     MicroRNA-222 regulates muscle alternative splicing through Rbm24
            during differentiation of skeletal muscle cells
  JOURNAL   Cell Death Dis 7 (2), e2086 (2016)
   PUBMED   26844700
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 397)
  AUTHORS   Morris,M.R., Ricketts,C.J., Gentle,D., McRonald,F., Carli,N.,
            Khalili,H., Brown,M., Kishida,T., Yao,M., Banks,R.E., Clarke,N.,
            Latif,F. and Maher,E.R.
  TITLE     Genome-wide methylation analysis identifies epigenetically
            inactivated candidate tumour suppressor genes in renal cell
            carcinoma
  JOURNAL   Oncogene 30 (12), 1390-1401 (2011)
   PUBMED   21132003
REFERENCE   4  (residues 1 to 397)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104564.11.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..397
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     Protein         1..397
                     /product="coronin-6 isoform 7"
                     /note="coronin, actin binding protein 6; clipin-E;
                     coronin-like protein E"
                     /calculated_mol_wt=44265
     Region          9..379
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          37..79
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          85..129
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          134..171
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          179..211
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..397
                     /gene="CORO6"
                     /gene_synonym="ClipinE"
                     /coded_by="NM_001388438.1:289..1482"
                     /note="isoform 7 is encoded by transcript variant 10"
                     /db_xref="GeneID:84940"
                     /db_xref="HGNC:HGNC:21356"
ORIGIN      
        1 msrrvvrqsk frhvfgqaak adqayedirv skvtwdssfc avnpkflaii veaggggafi
       61 vlplaktgrv dknyplvtgh tapvldidwc phndnviasa sddttimvwq ipdytpmrni
      121 tepiitlegh skrvgilswh ptarnvllsa ggdnviiiwn vgtgevllsl ddmhpdvihs
      181 vcwnsngsll attckdktlr iidprkgqvv agdssiryfe itdeppfvhy lntfsskepq
      241 rgmgfmpkrg ldvskceiar fyklherkce piimtvprks dlfqddlypd tpgpepalea
      301 dewlsgqdae pvlislrdgy vppkhrelrv tkrnildvrp psgprrsqsa sdaplsqqht
      361 letlleeika lrervqaqeq ritalenmlc elvdgtd
//
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