LOCUS NP_001375367 397 aa linear PRI 22-SEP-2024
DEFINITION coronin-6 isoform 7 [Homo sapiens].
ACCESSION NP_001375367
VERSION NP_001375367.1
DBSOURCE REFSEQ: accession NM_001388438.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 397)
AUTHORS Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
TITLE Interactome Mapping Provides a Network of Neurodegenerative Disease
Proteins and Uncovers Widespread Protein Aggregation in Affected
Brains
JOURNAL Cell Rep 32 (7), 108050 (2020)
PUBMED 32814053
REFERENCE 2 (residues 1 to 397)
AUTHORS Cardinali,B., Cappella,M., Provenzano,C., Garcia-Manteiga,J.M.,
Lazarevic,D., Cittaro,D., Martelli,F. and Falcone,G.
TITLE MicroRNA-222 regulates muscle alternative splicing through Rbm24
during differentiation of skeletal muscle cells
JOURNAL Cell Death Dis 7 (2), e2086 (2016)
PUBMED 26844700
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 397)
AUTHORS Morris,M.R., Ricketts,C.J., Gentle,D., McRonald,F., Carli,N.,
Khalili,H., Brown,M., Kishida,T., Yao,M., Banks,R.E., Clarke,N.,
Latif,F. and Maher,E.R.
TITLE Genome-wide methylation analysis identifies epigenetically
inactivated candidate tumour suppressor genes in renal cell
carcinoma
JOURNAL Oncogene 30 (12), 1390-1401 (2011)
PUBMED 21132003
REFERENCE 4 (residues 1 to 397)
AUTHORS Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
TITLE DNA sequence of human chromosome 17 and analysis of rearrangement
in the human lineage
JOURNAL Nature 440 (7087), 1045-1049 (2006)
PUBMED 16625196
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC104564.11.
##Evidence-Data-START##
RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
[ECO:0006172]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..397
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q11.2"
Protein 1..397
/product="coronin-6 isoform 7"
/note="coronin, actin binding protein 6; clipin-E;
coronin-like protein E"
/calculated_mol_wt=44265
Region 9..379
/region_name="WD40"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; cl29593"
/db_xref="CDD:475233"
Region 37..79
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 85..129
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 134..171
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
Region 179..211
/region_name="WD40 repeat"
/note="WD40 repeat [structural motif]"
/db_xref="CDD:293791"
CDS 1..397
/gene="CORO6"
/gene_synonym="ClipinE"
/coded_by="NM_001388438.1:289..1482"
/note="isoform 7 is encoded by transcript variant 10"
/db_xref="GeneID:84940"
/db_xref="HGNC:HGNC:21356"
ORIGIN
1 msrrvvrqsk frhvfgqaak adqayedirv skvtwdssfc avnpkflaii veaggggafi
61 vlplaktgrv dknyplvtgh tapvldidwc phndnviasa sddttimvwq ipdytpmrni
121 tepiitlegh skrvgilswh ptarnvllsa ggdnviiiwn vgtgevllsl ddmhpdvihs
181 vcwnsngsll attckdktlr iidprkgqvv agdssiryfe itdeppfvhy lntfsskepq
241 rgmgfmpkrg ldvskceiar fyklherkce piimtvprks dlfqddlypd tpgpepalea
301 dewlsgqdae pvlislrdgy vppkhrelrv tkrnildvrp psgprrsqsa sdaplsqqht
361 letlleeika lrervqaqeq ritalenmlc elvdgtd
//