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apolipoprotein L3 isoform 2 [Homo sapiens]

NCBI Reference Sequence: NP_001380533.1

Identical Proteins FASTA Graphics 

LOCUS       NP_001380533             331 aa            linear   PRI 22-SEP-2024
DEFINITION  apolipoprotein L3 isoform 2 [Homo sapiens].
ACCESSION   NP_001380533
VERSION     NP_001380533.1
DBSOURCE    REFSEQ: accession NM_001393604.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 331)
  AUTHORS   Lv,Y., Tang,W., Xu,Y., Chang,W., Zhang,Z., Lin,Q., Ji,M., Feng,Q.,
            He,G. and Xu,J.
  TITLE     Apolipoprotein L3 enhances CD8+ T cell antitumor immunity of
            colorectal cancer by promoting LDHA-mediated ferroptosis
  JOURNAL   Int J Biol Sci 19 (4), 1284-1298 (2023)
   PUBMED   36923931
  REMARK    GeneRIF: Apolipoprotein L3 enhances CD8+ T cell antitumor immunity
            of colorectal cancer by promoting LDHA-mediated ferroptosis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 331)
  AUTHORS   Gaudet,R.G., Zhu,S., Halder,A., Kim,B.H., Bradfield,C.J., Huang,S.,
            Xu,D., Maminska,A., Nguyen,T.N., Lazarou,M., Karatekin,E., Gupta,K.
            and MacMicking,J.D.
  TITLE     A human apolipoprotein L with detergent-like activity kills
            intracellular pathogens
  JOURNAL   Science 373 (6552) (2021)
   PUBMED   34437126
  REMARK    GeneRIF: A human apolipoprotein L with detergent-like activity
            kills intracellular pathogens.
REFERENCE   3  (residues 1 to 331)
  AUTHORS   Pays,E.
  TITLE     The function of apolipoproteins L (APOLs): relevance for kidney
            disease, neurotransmission disorders, cancer and viral infection
  JOURNAL   FEBS J 288 (2), 360-381 (2021)
   PUBMED   32530132
  REMARK    GeneRIF: The function of apolipoproteins L (APOLs): relevance for
            kidney disease, neurotransmission disorders, cancer and viral
            infection.
            Review article
REFERENCE   4  (residues 1 to 331)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (residues 1 to 331)
  AUTHORS   Uzureau,S., Lecordier,L., Uzureau,P., Hennig,D., Graversen,J.H.,
            Homble,F., Mfutu,P.E., Oliveira Arcolino,F., Ramos,A.R., La
            Rovere,R.M., Luyten,T., Vermeersch,M., Tebabi,P., Dieu,M.,
            Cuypers,B., Deborggraeve,S., Rabant,M., Legendre,C., Moestrup,S.K.,
            Levtchenko,E., Bultynck,G., Erneux,C., Perez-Morga,D. and Pays,E.
  TITLE     APOL1 C-Terminal Variants May Trigger Kidney Disease through
            Interference with APOL3 Control of Actomyosin
  JOURNAL   Cell Rep 30 (11), 3821-3836 (2020)
   PUBMED   32187552
  REMARK    GeneRIF: APOL1 C-Terminal Variants May Trigger Kidney Disease
            through Interference with APOL3 Control of Actomyosin.
REFERENCE   6  (residues 1 to 331)
  AUTHORS   Mimmack,M.L., Ryan,M., Baba,H., Navarro-Ruiz,J., Iritani,S.,
            Faull,R.L., McKenna,P.J., Jones,P.B., Arai,H., Starkey,M.,
            Emson,P.C. and Bahn,S.
  TITLE     Gene expression analysis in schizophrenia: reproducible
            up-regulation of several members of the apolipoprotein L family
            located in a high-susceptibility locus for schizophrenia on
            chromosome 22
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4680-4685 (2002)
   PUBMED   11930015
REFERENCE   7  (residues 1 to 331)
  AUTHORS   Monajemi,H., Fontijn,R.D., Pannekoek,H. and Horrevoets,A.J.
  TITLE     The apolipoprotein L gene cluster has emerged recently in evolution
            and is expressed in human vascular tissue
  JOURNAL   Genomics 79 (4), 539-546 (2002)
   PUBMED   11944986
  REMARK    GeneRIF: APOL3 has been found only in humans and African green
            monkeys
REFERENCE   8  (residues 1 to 331)
  AUTHORS   Page,N.M., Butlin,D.J., Lomthaisong,K. and Lowry,P.J.
  TITLE     The human apolipoprotein L gene cluster: identification,
            classification, and sites of distribution
  JOURNAL   Genomics 74 (1), 71-78 (2001)
   PUBMED   11374903
REFERENCE   9  (residues 1 to 331)
  AUTHORS   Duchateau,P.N., Pullinger,C.R., Cho,M.H., Eng,C. and Kane,J.P.
  TITLE     Apolipoprotein L gene family: tissue-specific expression, splicing,
            promoter regions; discovery of a new gene
  JOURNAL   J Lipid Res 42 (4), 620-630 (2001)
   PUBMED   11290834
REFERENCE   10 (residues 1 to 331)
  AUTHORS   Horrevoets,A.J., Fontijn,R.D., van Zonneveld,A.J., de Vries,C.J.,
            ten Cate,J.W. and Pannekoek,H.
  TITLE     Vascular endothelial genes that are responsive to tumor necrosis
            factor-alpha in vitro are expressed in atherosclerotic lesions,
            including inhibitor of apoptosis protein-1, stannin, and two novel
            genes
  JOURNAL   Blood 93 (10), 3418-3431 (1999)
   PUBMED   10233894
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z95114.19.
            
            Summary: This gene is a member of the apolipoprotein L gene family,
            and it is present in a cluster with other family members on
            chromosome 22. The encoded protein is found in the cytoplasm, where
            it may affect the movement of lipids, including cholesterol, and/or
            allow the binding of lipids to organelles. In addition, expression
            of this gene is up-regulated by tumor necrosis factor-alpha in
            endothelial cells lining the normal and atherosclerotic iliac
            artery and aorta. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Mar 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: CR979109.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     Protein         1..331
                     /product="apolipoprotein L3 isoform 2"
                     /note="TNF-inducible protein CG12-1; apolipoprotein L, 3;
                     apolipoprotein L-III"
                     /calculated_mol_wt=36414
     Region          29..320
                     /region_name="ApoL"
                     /note="Apolipoprotein L; pfam05461"
                     /db_xref="CDD:461657"
     CDS             1..331
                     /gene="APOL3"
                     /gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
                     /coded_by="NM_001393604.1:427..1422"
                     /note="isoform 2 is encoded by transcript variant 23"
                     /db_xref="CCDS:CCDS13923.1"
                     /db_xref="GeneID:80833"
                     /db_xref="HGNC:HGNC:14868"
                     /db_xref="MIM:607253"
ORIGIN      
        1 mdsekkrfte eatkyfrerv spvhlqillt nneawkrfvt aaelprdead alyealkklr
       61 tyaaiedeyv qqkdeqfrew flkefpqvkr kiqesieklr alangieevh rgctisnvvs
      121 sstgaasgim slaglvlapf tagtslalta agvglgaasa vtgittsive hsytssaeae
      181 asrltatsid rlkvfkevmr ditpnllsll nnyyeatqti gseirairqa rararlpvtt
      241 wrisagsggq aertiagttr avsrgarils attsgiflal dvvnlvyesk hlhegaksas
      301 aeelrrqaqe leenlmeltq iyqrlnpcht h
//
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