LOCUS NP_001380533 331 aa linear PRI 22-SEP-2024
DEFINITION apolipoprotein L3 isoform 2 [Homo sapiens].
ACCESSION NP_001380533
VERSION NP_001380533.1
DBSOURCE REFSEQ: accession NM_001393604.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 331)
AUTHORS Lv,Y., Tang,W., Xu,Y., Chang,W., Zhang,Z., Lin,Q., Ji,M., Feng,Q.,
He,G. and Xu,J.
TITLE Apolipoprotein L3 enhances CD8+ T cell antitumor immunity of
colorectal cancer by promoting LDHA-mediated ferroptosis
JOURNAL Int J Biol Sci 19 (4), 1284-1298 (2023)
PUBMED 36923931
REMARK GeneRIF: Apolipoprotein L3 enhances CD8+ T cell antitumor immunity
of colorectal cancer by promoting LDHA-mediated ferroptosis.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 331)
AUTHORS Gaudet,R.G., Zhu,S., Halder,A., Kim,B.H., Bradfield,C.J., Huang,S.,
Xu,D., Maminska,A., Nguyen,T.N., Lazarou,M., Karatekin,E., Gupta,K.
and MacMicking,J.D.
TITLE A human apolipoprotein L with detergent-like activity kills
intracellular pathogens
JOURNAL Science 373 (6552) (2021)
PUBMED 34437126
REMARK GeneRIF: A human apolipoprotein L with detergent-like activity
kills intracellular pathogens.
REFERENCE 3 (residues 1 to 331)
AUTHORS Pays,E.
TITLE The function of apolipoproteins L (APOLs): relevance for kidney
disease, neurotransmission disorders, cancer and viral infection
JOURNAL FEBS J 288 (2), 360-381 (2021)
PUBMED 32530132
REMARK GeneRIF: The function of apolipoproteins L (APOLs): relevance for
kidney disease, neurotransmission disorders, cancer and viral
infection.
Review article
REFERENCE 4 (residues 1 to 331)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 5 (residues 1 to 331)
AUTHORS Uzureau,S., Lecordier,L., Uzureau,P., Hennig,D., Graversen,J.H.,
Homble,F., Mfutu,P.E., Oliveira Arcolino,F., Ramos,A.R., La
Rovere,R.M., Luyten,T., Vermeersch,M., Tebabi,P., Dieu,M.,
Cuypers,B., Deborggraeve,S., Rabant,M., Legendre,C., Moestrup,S.K.,
Levtchenko,E., Bultynck,G., Erneux,C., Perez-Morga,D. and Pays,E.
TITLE APOL1 C-Terminal Variants May Trigger Kidney Disease through
Interference with APOL3 Control of Actomyosin
JOURNAL Cell Rep 30 (11), 3821-3836 (2020)
PUBMED 32187552
REMARK GeneRIF: APOL1 C-Terminal Variants May Trigger Kidney Disease
through Interference with APOL3 Control of Actomyosin.
REFERENCE 6 (residues 1 to 331)
AUTHORS Mimmack,M.L., Ryan,M., Baba,H., Navarro-Ruiz,J., Iritani,S.,
Faull,R.L., McKenna,P.J., Jones,P.B., Arai,H., Starkey,M.,
Emson,P.C. and Bahn,S.
TITLE Gene expression analysis in schizophrenia: reproducible
up-regulation of several members of the apolipoprotein L family
located in a high-susceptibility locus for schizophrenia on
chromosome 22
JOURNAL Proc Natl Acad Sci U S A 99 (7), 4680-4685 (2002)
PUBMED 11930015
REFERENCE 7 (residues 1 to 331)
AUTHORS Monajemi,H., Fontijn,R.D., Pannekoek,H. and Horrevoets,A.J.
TITLE The apolipoprotein L gene cluster has emerged recently in evolution
and is expressed in human vascular tissue
JOURNAL Genomics 79 (4), 539-546 (2002)
PUBMED 11944986
REMARK GeneRIF: APOL3 has been found only in humans and African green
monkeys
REFERENCE 8 (residues 1 to 331)
AUTHORS Page,N.M., Butlin,D.J., Lomthaisong,K. and Lowry,P.J.
TITLE The human apolipoprotein L gene cluster: identification,
classification, and sites of distribution
JOURNAL Genomics 74 (1), 71-78 (2001)
PUBMED 11374903
REFERENCE 9 (residues 1 to 331)
AUTHORS Duchateau,P.N., Pullinger,C.R., Cho,M.H., Eng,C. and Kane,J.P.
TITLE Apolipoprotein L gene family: tissue-specific expression, splicing,
promoter regions; discovery of a new gene
JOURNAL J Lipid Res 42 (4), 620-630 (2001)
PUBMED 11290834
REFERENCE 10 (residues 1 to 331)
AUTHORS Horrevoets,A.J., Fontijn,R.D., van Zonneveld,A.J., de Vries,C.J.,
ten Cate,J.W. and Pannekoek,H.
TITLE Vascular endothelial genes that are responsive to tumor necrosis
factor-alpha in vitro are expressed in atherosclerotic lesions,
including inhibitor of apoptosis protein-1, stannin, and two novel
genes
JOURNAL Blood 93 (10), 3418-3431 (1999)
PUBMED 10233894
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from Z95114.19.
Summary: This gene is a member of the apolipoprotein L gene family,
and it is present in a cluster with other family members on
chromosome 22. The encoded protein is found in the cytoplasm, where
it may affect the movement of lipids, including cholesterol, and/or
allow the binding of lipids to organelles. In addition, expression
of this gene is up-regulated by tumor necrosis factor-alpha in
endothelial cells lining the normal and atherosclerotic iliac
artery and aorta. Alternative splicing results in multiple
transcript variants. [provided by RefSeq, Mar 2015].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: CR979109.1 [ECO:0000331]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..331
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="22"
/map="22q12.3"
Protein 1..331
/product="apolipoprotein L3 isoform 2"
/note="TNF-inducible protein CG12-1; apolipoprotein L, 3;
apolipoprotein L-III"
/calculated_mol_wt=36414
Region 29..320
/region_name="ApoL"
/note="Apolipoprotein L; pfam05461"
/db_xref="CDD:461657"
CDS 1..331
/gene="APOL3"
/gene_synonym="apoL-III; APOLIII; CG121; CG12_1"
/coded_by="NM_001393604.1:427..1422"
/note="isoform 2 is encoded by transcript variant 23"
/db_xref="CCDS:CCDS13923.1"
/db_xref="GeneID:80833"
/db_xref="HGNC:HGNC:14868"
/db_xref="MIM:607253"
ORIGIN
1 mdsekkrfte eatkyfrerv spvhlqillt nneawkrfvt aaelprdead alyealkklr
61 tyaaiedeyv qqkdeqfrew flkefpqvkr kiqesieklr alangieevh rgctisnvvs
121 sstgaasgim slaglvlapf tagtslalta agvglgaasa vtgittsive hsytssaeae
181 asrltatsid rlkvfkevmr ditpnllsll nnyyeatqti gseirairqa rararlpvtt
241 wrisagsggq aertiagttr avsrgarils attsgiflal dvvnlvyesk hlhegaksas
301 aeelrrqaqe leenlmeltq iyqrlnpcht h
//