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mitogen-activated protein kinase 12 isoform 1 [Homo sapiens]

NCBI Reference Sequence: NP_002960.2

Identical Proteins FASTA Graphics 

LOCUS       NP_002960                367 aa            linear   PRI 03-SEP-2024
DEFINITION  mitogen-activated protein kinase 12 isoform 1 [Homo sapiens].
ACCESSION   NP_002960 XP_003403794
VERSION     NP_002960.2
DBSOURCE    REFSEQ: accession NM_002969.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 367)
  AUTHORS   Zang,Y., Li,J., Wan,B., Tai,Y., Liu,H., Li,Q., Ji,Y. and Wang,G.
  TITLE     LOC730101 transmitted by exosomes facilitates laryngeal squamous
            cell carcinoma tumorigenesis via regulation of p38 MAPK gamma
  JOURNAL   Cell Signal 122, 111336 (2024)
   PUBMED   39121975
  REMARK    GeneRIF: LOC730101 transmitted by exosomes facilitates laryngeal
            squamous cell carcinoma tumorigenesis via regulation of p38 MAPK
            gamma.
REFERENCE   2  (residues 1 to 367)
  AUTHORS   Sengupta,P., Dutta,A., Suseela,Y.V., Roychowdhury,T., Banerjee,N.,
            Dutta,A., Halder,S., Jana,K., Mukherjee,G., Chattopadhyay,S.,
            Govindaraju,T. and Chatterjee,S.
  TITLE     G-quadruplex structural dynamics at MAPK12 promoter dictates
            transcriptional switch to determine stemness in breast cancer
  JOURNAL   Cell Mol Life Sci 81 (1), 33 (2024)
   PUBMED   38214819
  REMARK    GeneRIF: G-quadruplex structural dynamics at MAPK12 promoter
            dictates transcriptional switch to determine stemness in breast
            cancer.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 367)
  AUTHORS   Yin,D.P., Zheng,Y.F., Sun,P., Yao,M.Y., Xie,L.X., Dou,X.W., Tian,Y.
            and Liu,J.S.
  TITLE     The pro-tumorigenic activity of p38gamma overexpression in
            nasopharyngeal carcinoma
  JOURNAL   Cell Death Dis 13 (3), 210 (2022)
   PUBMED   35246508
  REMARK    GeneRIF: The pro-tumorigenic activity of p38gamma overexpression in
            nasopharyngeal carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 367)
  AUTHORS   Vallabhaneni,S., Liu,J., Morel,M., Wang,J., DeMayo,F.J. and Long,W.
  TITLE     Conditional ERK3 overexpression cooperates with PTEN deletion to
            promote lung adenocarcinoma formation in mice
  JOURNAL   Mol Oncol 16 (5), 1184-1199 (2022)
   PUBMED   34719109
  REMARK    GeneRIF: Conditional ERK3 overexpression cooperates with PTEN
            deletion to promote lung adenocarcinoma formation in mice.
REFERENCE   5  (residues 1 to 367)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (residues 1 to 367)
  AUTHORS   Goedert,M., Hasegawa,M., Jakes,R., Lawler,S., Cuenda,A. and
            Cohen,P.
  TITLE     Phosphorylation of microtubule-associated protein tau by
            stress-activated protein kinases
  JOURNAL   FEBS Lett 409 (1), 57-62 (1997)
   PUBMED   9199504
REFERENCE   7  (residues 1 to 367)
  AUTHORS   Goedert,M., Hasegawa,J., Craxton,M., Leversha,M.A. and Clegg,S.
  TITLE     Assignment of the human stress-activated protein kinase-3 gene
            (SAPK3) to chromosome 22q13.3 by fluorescence in situ hybridization
  JOURNAL   Genomics 41 (3), 501-502 (1997)
   PUBMED   9169156
REFERENCE   8  (residues 1 to 367)
  AUTHORS   Li,Z., Jiang,Y., Ulevitch,R.J. and Han,J.
  TITLE     The primary structure of p38 gamma: a new member of p38 group of
            MAP kinases
  JOURNAL   Biochem Biophys Res Commun 228 (2), 334-340 (1996)
   PUBMED   8920915
REFERENCE   9  (residues 1 to 367)
  AUTHORS   Lechner,C., Zahalka,M.A., Giot,J.F., Moller,N.P. and Ullrich,A.
  TITLE     ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 93 (9), 4355-4359 (1996)
   PUBMED   8633070
REFERENCE   10 (residues 1 to 367)
  AUTHORS   Saleem,A., Datta,R., Yuan,Z.M., Kharbanda,S. and Kufe,D.
  TITLE     Involvement of stress-activated protein kinase in the cellular
            response to 1-beta-D-arabinofuranosylcytosine and other
            DNA-damaging agents
  JOURNAL   Cell Growth Differ 6 (12), 1651-1658 (1995)
   PUBMED   9019171
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U66243.2, CB123561.1, Y10487.1,
            BC015741.1 and N94360.1.
            
            On or before Aug 3, 2011 this sequence version replaced
            XP_003403794.1, NP_002960.1.
            
            Summary: Activation of members of the mitogen-activated protein
            kinase family is a major mechanism for transduction of
            extracellular signals. Stress-activated protein kinases are one
            subclass of MAP kinases. The protein encoded by this gene functions
            as a signal transducer during differentiation of myoblasts to
            myotubes. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y10487.1, SRR1163655.92310.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215659.13/ ENSP00000215659.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..367
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     Protein         1..367
                     /product="mitogen-activated protein kinase 12 isoform 1"
                     /EC_number="2.7.11.24"
                     /note="mitogen-activated protein kinase 3;
                     stress-activated protein kinase 3; MAP kinase 12; MAP
                     kinase p38 gamma; extracellular signal-regulated kinase 6;
                     mitogen-activated protein kinase p38 gamma"
                     /calculated_mol_wt=41809
     Region          11..353
                     /region_name="STKc_p38gamma"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     p38gamma Mitogen-Activated Protein Kinase (also called
                     MAPK12); cd07880"
                     /db_xref="CDD:143385"
     Site            order(33..36,38,40..41,54,56,73,78,87,89,107,109..112,115,
                     117..118,153,155,157..158,160,170..171,173..174,183,
                     185..188,190,228)
                     /site_type="active"
                     /db_xref="CDD:143385"
     Site            order(33..34,38,40..41,54,56,78,87,89,107,109..112,115,
                     153,155,157..158,170..171,173)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:143385"
     Site            order(73,117,153,155,174,183,185..188,190,228)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:143385"
     Site            order(114,119,128..129,132,161..165,314)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:143385"
     Site            170..190
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:143385"
     Region          183..185
                     /region_name="TXY"
                     /note="propagated from UniProtKB/Swiss-Prot (P53778.3)"
     Site            183
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAP2K3 and MAP2K6.
                     /evidence=ECO:0000250|UniProtKB:Q63538; propagated from
                     UniProtKB/Swiss-Prot (P53778.3)"
     Site            185
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P53778.3)"
     Site            order(194..195,198,200,202..204,239,245,249,252,262,
                     294..297)
                     /site_type="lipid-binding"
                     /note="lipid binding site [chemical binding]"
                     /db_xref="CDD:143385"
     CDS             1..367
                     /gene="MAPK12"
                     /gene_synonym="ERK-6; ERK3; ERK6; MAPK 12; P38GAMMA;
                     PRKM12; SAPK-3; SAPK3"
                     /coded_by="NM_002969.6:175..1278"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS14089.1"
                     /db_xref="GeneID:6300"
                     /db_xref="HGNC:HGNC:6874"
                     /db_xref="MIM:602399"
ORIGIN      
        1 mssppparsg fyrqevtkta wevravyrdl qpvgsgayga vcsavdgrtg akvaikklyr
       61 pfqselfakr ayrelrllkh mrhenvigll dvftpdetld dftdfylvmp fmgtdlgklm
      121 kheklgedri qflvyqmlkg lryihaagii hrdlkpgnla vnedcelkil dfglarqads
      181 emtgyvvtrw yrapevilnw mrytqtvdiw svgcimaemi tgktlfkgsd hldqlkeimk
      241 vtgtppaefv qrlqsdeakn ymkglpelek kdfasiltna splavnllek mlvldaeqrv
      301 tagealahpy feslhdtede pqvqkyddsf ddvdrtldew krvtykevls fkpprqlgar
      361 vsketpl
//
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Protein 3D Structure

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Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the MAPK12 gene (NM_002969.6).
  • RefSeq protein isoforms
    See the other reference sequence protein isoform for the MAPK12 gene (NP_001290181.1).

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