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perilipin-3 isoform 1 [Homo sapiens]

NCBI Reference Sequence: NP_005808.3

Identical Proteins FASTA Graphics 

LOCUS       NP_005808                434 aa            linear   PRI 20-SEP-2024
DEFINITION  perilipin-3 isoform 1 [Homo sapiens].
ACCESSION   NP_005808
VERSION     NP_005808.3
DBSOURCE    REFSEQ: accession NM_005817.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 434)
  AUTHORS   Liang,W., Zhou,Z., Gao,Q., Zhu,Z., Zhu,J., Lin,J., Wen,Y., Qian,F.,
            Wang,L., Zhai,Y., Lv,J., Zhang,H., Zhong,F. and Du,H.
  TITLE     Tumor-derived Prevotella intermedia aggravates gastric cancer by
            enhancing Perilipin 3 expression
  JOURNAL   Cancer Sci 115 (4), 1141-1153 (2024)
   PUBMED   38287724
  REMARK    GeneRIF: Tumor-derived Prevotella intermedia aggravates gastric
            cancer by enhancing Perilipin 3 expression.
REFERENCE   2  (residues 1 to 434)
  AUTHORS   He,Y., Liu,L., Dong,Y., Zhang,X., Song,Y., Jing,Y., Ni,Y., Wang,Y.,
            Wang,Z. and Ding,L.
  TITLE     Lipid droplets-related Perilipin-3: potential immune checkpoint and
            oncogene in oral squamous cell carcinoma
  JOURNAL   Cancer Immunol Immunother 73 (5), 78 (2024)
   PUBMED   38554152
  REMARK    GeneRIF: Lipid droplets-related Perilipin-3: potential immune
            checkpoint and oncogene in oral squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 434)
  AUTHORS   Stribny,J. and Schneiter,R.
  TITLE     Binding of perilipin 3 to membranes containing diacylglycerol is
            mediated by conserved residues within its PAT domain
  JOURNAL   J Biol Chem 299 (12), 105384 (2023)
   PUBMED   37898398
  REMARK    GeneRIF: Binding of perilipin 3 to membranes containing
            diacylglycerol is mediated by conserved residues within its PAT
            domain.
REFERENCE   4  (residues 1 to 434)
  AUTHORS   Men,X. and Zhu,W.
  TITLE     Silencing of Perilipin 3 Inhibits Lung Adenocarcinoma Cell Immune
            Resistance by Regulating the Transcription of PD-L1 Through c-Myc
  JOURNAL   Immunol Invest 52 (7), 815-831 (2023)
   PUBMED   37578465
  REMARK    GeneRIF: Silencing of Perilipin 3 Inhibits Lung Adenocarcinoma Cell
            Immune Resistance by Regulating the Transcription of PD-L1 Through
            c-Myc.
REFERENCE   5  (residues 1 to 434)
  AUTHORS   Chung,J., Park,J., Lai,Z.W., Lambert,T.J., Richards,R.C., Zhang,J.,
            Walther,T.C. and Farese,R.V. Jr.
  TITLE     The Troyer syndrome protein spartin mediates selective autophagy of
            lipid droplets
  JOURNAL   Nat Cell Biol 25 (8), 1101-1110 (2023)
   PUBMED   37443287
REFERENCE   6  (residues 1 to 434)
  AUTHORS   Krise,J.P., Sincock,P.M., Orsel,J.G. and Pfeffer,S.R.
  TITLE     Quantitative analysis of TIP47-receptor cytoplasmic domain
            interactions: implications for endosome-to-trans Golgi network
            trafficking
  JOURNAL   J Biol Chem 275 (33), 25188-25193 (2000)
   PUBMED   10829017
REFERENCE   7  (residues 1 to 434)
  AUTHORS   Than,N.G., Sumegi,B., Than,G.N., Kispal,G. and Bohn,H.
  TITLE     Cloning and sequencing of human oncodevelopmental soluble placental
            tissue protein 17 (PP17): homology with adipophilin and the mouse
            adipose differentiation-related protein
  JOURNAL   Tumour Biol 20 (4), 184-192 (1999)
   PUBMED   10393528
REFERENCE   8  (residues 1 to 434)
  AUTHORS   Than,N.G., Sumegi,B., Than,G.N., Kispal,G. and Bohn,H.
  TITLE     Cloning and sequence analysis of cDNAs encoding human placental
            tissue protein 17 (PP17) variants
  JOURNAL   Eur J Biochem 258 (2), 752-757 (1998)
   PUBMED   9874244
REFERENCE   9  (residues 1 to 434)
  AUTHORS   Diaz,E. and Pfeffer,S.R.
  TITLE     TIP47: a cargo selection device for mannose 6-phosphate receptor
            trafficking
  JOURNAL   Cell 93 (3), 433-443 (1998)
   PUBMED   9590177
REFERENCE   10 (residues 1 to 434)
  AUTHORS   Bohn,H., Kraus,W. and Winckler,W.
  TITLE     Purification and characterization of two new soluble placental
            tissue proteins (PP13 and PP17)
  JOURNAL   Oncodev Biol Med 4 (5), 343-350 (1983)
   PUBMED   6856484
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312740.1, BQ057849.1,
            AK225045.1 and BC019278.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 14, 2009 this sequence version replaced NP_005808.2.
            
            Summary: Mannose 6-phophate receptors (MPRs) deliver lysosomal
            hydrolase from the Golgi to endosomes and then return to the Golgi
            complex. The protein encoded by this gene interacts with the
            cytoplasmic domains of both cation-independent and cation-dependent
            MPRs, and is required for endosome-to-Golgi transport. This protein
            also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS
            oncogene family. The interaction with RAB9 has been shown to
            increase the affinity of this protein for its cargo. Multiple
            transcript variants encoding different isoforms have been found for
            this gene.[provided by RefSeq, Aug 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019278.1, AK226088.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221957.9/ ENSP00000221957.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..434
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     Protein         1..434
                     /product="perilipin-3 isoform 1"
                     /note="tail-interacting protein, 47 kD; testicular tissue
                     protein Li 114; cargo selection protein TIP47; placental
                     protein 17; 47 kDa MPR-binding protein;
                     mannose-6-phosphate receptor-binding protein 1"
                     /calculated_mol_wt=46944
     Region          1..22
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O60664.3)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0007744|PubMed:19413330,
                     ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378;
                     propagated from UniProtKB/Swiss-Prot (O60664.3)"
     Region          18..425
                     /region_name="Perilipin"
                     /note="Perilipin family; pfam03036"
                     /db_xref="CDD:460784"
     Site            31
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O60664.3)"
     Site            65
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (O60664.3)"
     Site            91
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O60664.3)"
     Site            130
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (O60664.3)"
     Site            148
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O60664.3)"
     Site            170
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (O60664.3)"
     Site            175
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (O60664.3)"
     Site            179
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648; propagated from
                     UniProtKB/Swiss-Prot (O60664.3)"
     Site            216
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O60664.3)"
     Site            217
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O60664.3)"
     Site            241
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O60664.3)"
     Site            251
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:34077757; propagated from
                     UniProtKB/Swiss-Prot (O60664.3)"
     CDS             1..434
                     /gene="PLIN3"
                     /gene_synonym="M6PRBP1; PP17; TIP47"
                     /coded_by="NM_005817.5:77..1381"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS12137.1"
                     /db_xref="GeneID:10226"
                     /db_xref="HGNC:HGNC:16893"
                     /db_xref="MIM:602702"
ORIGIN      
        1 msadgaeadg stqvtveepv qqpsvvdrva smplisstcd mvsaayastk esyphiktvc
       61 daaekgvrtl taaavsgaqp ilsklepqia saseyahrgl dkleenlpil qqptekvlad
      121 tkelvsskvs gaqemvssak dtvatqlsea vdatrgavqs gvdktksvvt ggvqsvmgsr
      181 lgqmvlsgvd tvlgkseewa dnhlpltdae lariatsldg fdvasvqqqr qeqsyfvrlg
      241 slserlrqha yehslgklra tkqraqeall qlsqvlslme tvkqgvdqkl vegqeklhqm
      301 wlswnqkqlq gpekeppkpe qvesraltmf rdiaqqlqat ctslgssiqg lptnvkdqvq
      361 qarrqvedlq atfssihsfq dlsssilaqs rervasarea ldhmveyvaq ntpvtwlvgp
      421 fapgitekap eekk
//
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