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zinc finger and BTB domain-containing protein 16 isoform 1 [Homo sapiens]

NCBI Reference Sequence: NP_005997.2

Identical Proteins FASTA Graphics 

LOCUS       NP_005997                673 aa            linear   PRI 01-JUL-2024
DEFINITION  zinc finger and BTB domain-containing protein 16 isoform 1 [Homo
            sapiens].
ACCESSION   NP_005997
VERSION     NP_005997.2
DBSOURCE    REFSEQ: accession NM_006006.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 673)
  AUTHORS   Wang,K., Guo,D., Yan,T., Sun,S., Wang,Y., Zheng,H., Wang,G. and
            Du,J.
  TITLE     ZBTB16 inhibits DNA replication and induces cell cycle arrest by
            targeting WDHD1 transcription in lung adenocarcinoma
  JOURNAL   Oncogene 43 (23), 1796-1810 (2024)
   PUBMED   38654107
  REMARK    GeneRIF: ZBTB16 inhibits DNA replication and induces cell cycle
            arrest by targeting WDHD1 transcription in lung adenocarcinoma.
REFERENCE   2  (residues 1 to 673)
  AUTHORS   Mao,Y., Su,X., Guo,Q., Yao,X., Zhao,Q., Guo,Y., Wang,Y., Li,X. and
            Lu,Y.
  TITLE     Long non-coding RNA LINC00930 targeting miR-6792-3p/ZBTB16
            regulates the proliferation and EMT of pancreatic cancer
  JOURNAL   BMC Cancer 24 (1), 638 (2024)
   PUBMED   38789960
  REMARK    GeneRIF: Long non-coding RNA LINC00930 targeting miR-6792-3p/ZBTB16
            regulates the proliferation and EMT of pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 673)
  AUTHORS   Krontira,A.C., Cruceanu,C., Dony,L., Kyrousi,C., Link,M.H., Rek,N.,
            Pohlchen,D., Raimundo,C., Penner-Goeke,S., Schowe,A., Czamara,D.,
            Lahti-Pulkkinen,M., Sammallahti,S., Wolford,E., Heinonen,K.,
            Roeh,S., Sportelli,V., Wolfel,B., Kodel,M., Sauer,S.,
            Rex-Haffner,M., Raikkonen,K., Labeur,M., Cappello,S. and
            Binder,E.B.
  TITLE     Human cortical neurogenesis is altered via glucocorticoid-mediated
            regulation of ZBTB16 expression
  JOURNAL   Neuron 112 (9), 1426-1443 (2024)
   PUBMED   38442714
  REMARK    GeneRIF: Human cortical neurogenesis is altered via
            glucocorticoid-mediated regulation of ZBTB16 expression.
REFERENCE   4  (residues 1 to 673)
  AUTHORS   Liu,T.M., Lee,E.H., Lim,B. and Shyh-Chang,N.
  TITLE     Concise Review: Balancing Stem Cell Self-Renewal and
            Differentiation with PLZF
  JOURNAL   Stem Cells 34 (2), 277-287 (2016)
   PUBMED   26676652
  REMARK    GeneRIF: Emerging evidence shows that PLZF regulates the balance of
            self-renewal and differentiation in stem cells.
            Review article
REFERENCE   5  (residues 1 to 673)
  AUTHORS   Song,G., Wang,L., Bi,K. and Jiang,G.
  TITLE     Regulation of the C/EBPalpha signaling pathway in acute myeloid
            leukemia (Review)
  JOURNAL   Oncol Rep 33 (5), 2099-2106 (2015)
   PUBMED   25760953
  REMARK    Review article
REFERENCE   6  (residues 1 to 673)
  AUTHORS   Zhang,T., Xiong,H., Kan,L.X., Zhang,C.K., Jiao,X.F., Fu,G.,
            Zhang,Q.H., Lu,L., Tong,J.H., Gu,B.W., Yu,M., Liu,J.X., Licht,J.,
            Waxman,S., Zelent,A., Chen,E. and Chen,S.J.
  TITLE     Genomic sequence, structural organization, molecular evolution, and
            aberrant rearrangement of promyelocytic leukemia zinc finger gene
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11422-11427 (1999)
   PUBMED   10500192
REFERENCE   7  (residues 1 to 673)
  AUTHORS   van Schothorst,E.M., Prins,D.E., Baysal,B.E., Beekman,M.,
            Licht,J.D., Waxman,S., Zelent,A., Cornelisse,C.J., van Ommen,G.J.,
            Richard,C.W. 3rd and Devilee,P.
  TITLE     Genomic structure of the human PLZF gene
  JOURNAL   Gene 236 (1), 21-24 (1999)
   PUBMED   10433962
REFERENCE   8  (residues 1 to 673)
  AUTHORS   Reid,A., Gould,A., Brand,N., Cook,M., Strutt,P., Li,J., Licht,J.,
            Waxman,S., Krumlauf,R. and Zelent,A.
  TITLE     Leukemia translocation gene, PLZF, is expressed with a speckled
            nuclear pattern in early hematopoietic progenitors
  JOURNAL   Blood 86 (12), 4544-4552 (1995)
   PUBMED   8541544
REFERENCE   9  (residues 1 to 673)
  AUTHORS   Chen,S.J., Zelent,A., Tong,J.H., Yu,H.Q., Wang,Z.Y., Derre,J.,
            Berger,R., Waxman,S. and Chen,Z.
  TITLE     Rearrangements of the retinoic acid receptor alpha and
            promyelocytic leukemia zinc finger genes resulting from
            t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia
  JOURNAL   J Clin Invest 91 (5), 2260-2267 (1993)
   PUBMED   8387545
REFERENCE   10 (residues 1 to 673)
  AUTHORS   Chen,Z., Brand,N.J., Chen,A., Chen,S.J., Tong,J.H., Wang,Z.Y.,
            Waxman,S. and Zelent,A.
  TITLE     Fusion between a novel Kruppel-like zinc finger gene and the
            retinoic acid receptor-alpha locus due to a variant t(11;17)
            translocation associated with acute promyelocytic leukaemia
  JOURNAL   EMBO J 12 (3), 1161-1167 (1993)
   PUBMED   8384553
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX648973.1, BC029812.1,
            BM969145.1 and AP002518.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 9, 2002 this sequence version replaced NP_005997.1.
            
            Summary: This gene is a member of the Krueppel C2H2-type
            zinc-finger protein family and encodes a zinc finger transcription
            factor that contains nine Kruppel-type zinc finger domains at the
            carboxyl terminus. This protein is located in the nucleus, is
            involved in cell cycle progression, and interacts with a histone
            deacetylase. Specific instances of aberrant gene rearrangement at
            this locus have been associated with acute promyelocytic leukemia
            (APL). Alternate transcriptional splice variants have been
            characterized. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.89400.1,
                                           DRR138518.289817.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335953.9/ ENSP00000338157.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..673
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.2"
     Protein         1..673
                     /product="zinc finger and BTB domain-containing protein 16
                     isoform 1"
                     /note="zinc finger protein 145 (Kruppel-like, expressed in
                     promyelocytic leukemia); promyelocytic leukaemia zinc
                     finger; zinc finger and BTB domain-containing protein 16;
                     zinc finger protein PLZF"
                     /calculated_mol_wt=74143
     Region          16..122
                     /region_name="BTB_POZ_ZBTB16_PLZF"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in zinc finger and
                     BTB domain-containing protein 16 (ZBTB16); cd18205"
                     /db_xref="CDD:349514"
     Site            76
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PDPK1. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (Q05516.2)"
     Region          177..>327
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Site            184
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PDPK1. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (Q05516.2)"
     Site            197
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PDPK1. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (Q05516.2)"
     Region          200..300
                     /region_name="Interaction with RUNX1T1.
                     /evidence=ECO:0000269|PubMed:10688654"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05516.2)"
     Region          215..236
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05516.2)"
     Region          249..332
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05516.2)"
     Site            256
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PDPK1. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (Q05516.2)"
     Site            282
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PDPK1. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (Q05516.2)"
     Site            394..395
                     /site_type="other"
                     /note="Breakpoint for translocation to form PLZF-RAR-alpha
                     oncogene; propagated from UniProtKB/Swiss-Prot (Q05516.2)"
     Region          406..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          434..454
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <448..622
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          463..483
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          492..512
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          520..540
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(525,527,529,531..532,535..536,539,553,555,559..560,
                     563..564,567,581,583,585,587..588,591..592,595)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          548..568
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          576..596
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          604..624
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            628
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PDPK1. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (Q05516.2)"
     Region          632..652
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..673
                     /gene="ZBTB16"
                     /gene_synonym="PLZF; ZNF145"
                     /coded_by="NM_006006.6:263..2284"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS8367.1"
                     /db_xref="GeneID:7704"
                     /db_xref="HGNC:HGNC:12930"
                     /db_xref="MIM:176797"
ORIGIN      
        1 mdltkmgmiq lqnpshptgl lckanqmrla gtlcdvvimv dsqefhahrt vlactskmfe
       61 ilfhrnsqhy tldflspktf qqileyayta tlqakaedld dllyaaeile ieyleeqclk
      121 mletiqasdd ndteatmadg gaeeeedrka rylknifisk hsseesgyas vagqslpgpm
      181 vdqspsvsts fglsamsptk aavdslmtig qsllqgtlqp pagpeeptla gggrhpgvae
      241 vktemmqvde vpsqdspgaa essisggmgd kveergkegp gtptrssvit sarelhygre
      301 esaeqvpppa eagqaptgrp ehpapppekh lgiysvlpnh kadavlsmps svtsglhvqp
      361 alavsmdfst yggllpqgfi qrelfsklge lavgmksesr tigeqcsvcg velpdneave
      421 qhrklhsgmk tygcelcgkr fldslrlrmh llahsagaka fvcdqcgaqf skedalethr
      481 qthtgtdmav fcllcgkrfq aqsalqqhme vhagvrsyic secnrtfpsh talkrhlrsh
      541 tgdhpyecef cgscfrdest lkshkrihtg ekpyecngcg kkfslkhqle thyrvhtgek
      601 pfecklchqr srdysamikh lrthngaspy qcticteycp slssmqkhmk ghkpeeippd
      661 wriektylyl cyv
//
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