LOCUS NP_005997 673 aa linear PRI 01-JUL-2024
DEFINITION zinc finger and BTB domain-containing protein 16 isoform 1 [Homo
sapiens].
ACCESSION NP_005997
VERSION NP_005997.2
DBSOURCE REFSEQ: accession NM_006006.6
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 673)
AUTHORS Wang,K., Guo,D., Yan,T., Sun,S., Wang,Y., Zheng,H., Wang,G. and
Du,J.
TITLE ZBTB16 inhibits DNA replication and induces cell cycle arrest by
targeting WDHD1 transcription in lung adenocarcinoma
JOURNAL Oncogene 43 (23), 1796-1810 (2024)
PUBMED 38654107
REMARK GeneRIF: ZBTB16 inhibits DNA replication and induces cell cycle
arrest by targeting WDHD1 transcription in lung adenocarcinoma.
REFERENCE 2 (residues 1 to 673)
AUTHORS Mao,Y., Su,X., Guo,Q., Yao,X., Zhao,Q., Guo,Y., Wang,Y., Li,X. and
Lu,Y.
TITLE Long non-coding RNA LINC00930 targeting miR-6792-3p/ZBTB16
regulates the proliferation and EMT of pancreatic cancer
JOURNAL BMC Cancer 24 (1), 638 (2024)
PUBMED 38789960
REMARK GeneRIF: Long non-coding RNA LINC00930 targeting miR-6792-3p/ZBTB16
regulates the proliferation and EMT of pancreatic cancer.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 673)
AUTHORS Krontira,A.C., Cruceanu,C., Dony,L., Kyrousi,C., Link,M.H., Rek,N.,
Pohlchen,D., Raimundo,C., Penner-Goeke,S., Schowe,A., Czamara,D.,
Lahti-Pulkkinen,M., Sammallahti,S., Wolford,E., Heinonen,K.,
Roeh,S., Sportelli,V., Wolfel,B., Kodel,M., Sauer,S.,
Rex-Haffner,M., Raikkonen,K., Labeur,M., Cappello,S. and
Binder,E.B.
TITLE Human cortical neurogenesis is altered via glucocorticoid-mediated
regulation of ZBTB16 expression
JOURNAL Neuron 112 (9), 1426-1443 (2024)
PUBMED 38442714
REMARK GeneRIF: Human cortical neurogenesis is altered via
glucocorticoid-mediated regulation of ZBTB16 expression.
REFERENCE 4 (residues 1 to 673)
AUTHORS Liu,T.M., Lee,E.H., Lim,B. and Shyh-Chang,N.
TITLE Concise Review: Balancing Stem Cell Self-Renewal and
Differentiation with PLZF
JOURNAL Stem Cells 34 (2), 277-287 (2016)
PUBMED 26676652
REMARK GeneRIF: Emerging evidence shows that PLZF regulates the balance of
self-renewal and differentiation in stem cells.
Review article
REFERENCE 5 (residues 1 to 673)
AUTHORS Song,G., Wang,L., Bi,K. and Jiang,G.
TITLE Regulation of the C/EBPalpha signaling pathway in acute myeloid
leukemia (Review)
JOURNAL Oncol Rep 33 (5), 2099-2106 (2015)
PUBMED 25760953
REMARK Review article
REFERENCE 6 (residues 1 to 673)
AUTHORS Zhang,T., Xiong,H., Kan,L.X., Zhang,C.K., Jiao,X.F., Fu,G.,
Zhang,Q.H., Lu,L., Tong,J.H., Gu,B.W., Yu,M., Liu,J.X., Licht,J.,
Waxman,S., Zelent,A., Chen,E. and Chen,S.J.
TITLE Genomic sequence, structural organization, molecular evolution, and
aberrant rearrangement of promyelocytic leukemia zinc finger gene
JOURNAL Proc Natl Acad Sci U S A 96 (20), 11422-11427 (1999)
PUBMED 10500192
REFERENCE 7 (residues 1 to 673)
AUTHORS van Schothorst,E.M., Prins,D.E., Baysal,B.E., Beekman,M.,
Licht,J.D., Waxman,S., Zelent,A., Cornelisse,C.J., van Ommen,G.J.,
Richard,C.W. 3rd and Devilee,P.
TITLE Genomic structure of the human PLZF gene
JOURNAL Gene 236 (1), 21-24 (1999)
PUBMED 10433962
REFERENCE 8 (residues 1 to 673)
AUTHORS Reid,A., Gould,A., Brand,N., Cook,M., Strutt,P., Li,J., Licht,J.,
Waxman,S., Krumlauf,R. and Zelent,A.
TITLE Leukemia translocation gene, PLZF, is expressed with a speckled
nuclear pattern in early hematopoietic progenitors
JOURNAL Blood 86 (12), 4544-4552 (1995)
PUBMED 8541544
REFERENCE 9 (residues 1 to 673)
AUTHORS Chen,S.J., Zelent,A., Tong,J.H., Yu,H.Q., Wang,Z.Y., Derre,J.,
Berger,R., Waxman,S. and Chen,Z.
TITLE Rearrangements of the retinoic acid receptor alpha and
promyelocytic leukemia zinc finger genes resulting from
t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia
JOURNAL J Clin Invest 91 (5), 2260-2267 (1993)
PUBMED 8387545
REFERENCE 10 (residues 1 to 673)
AUTHORS Chen,Z., Brand,N.J., Chen,A., Chen,S.J., Tong,J.H., Wang,Z.Y.,
Waxman,S. and Zelent,A.
TITLE Fusion between a novel Kruppel-like zinc finger gene and the
retinoic acid receptor-alpha locus due to a variant t(11;17)
translocation associated with acute promyelocytic leukaemia
JOURNAL EMBO J 12 (3), 1161-1167 (1993)
PUBMED 8384553
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BX648973.1, BC029812.1,
BM969145.1 and AP002518.3.
This sequence is a reference standard in the RefSeqGene project.
On Jun 9, 2002 this sequence version replaced NP_005997.1.
Summary: This gene is a member of the Krueppel C2H2-type
zinc-finger protein family and encodes a zinc finger transcription
factor that contains nine Kruppel-type zinc finger domains at the
carboxyl terminus. This protein is located in the nucleus, is
involved in cell cycle progression, and interacts with a histone
deacetylase. Specific instances of aberrant gene rearrangement at
this locus have been associated with acute promyelocytic leukemia
(APL). Alternate transcriptional splice variants have been
characterized. [provided by RefSeq, Jul 2008].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803611.89400.1,
DRR138518.289817.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000335953.9/ ENSP00000338157.4
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..673
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q23.2"
Protein 1..673
/product="zinc finger and BTB domain-containing protein 16
isoform 1"
/note="zinc finger protein 145 (Kruppel-like, expressed in
promyelocytic leukemia); promyelocytic leukaemia zinc
finger; zinc finger and BTB domain-containing protein 16;
zinc finger protein PLZF"
/calculated_mol_wt=74143
Region 16..122
/region_name="BTB_POZ_ZBTB16_PLZF"
/note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
(poxvirus and zinc finger) domain found in zinc finger and
BTB domain-containing protein 16 (ZBTB16); cd18205"
/db_xref="CDD:349514"
Site 76
/site_type="phosphorylation"
/note="Phosphoserine, by PDPK1. /evidence=ECO:0000255;
propagated from UniProtKB/Swiss-Prot (Q05516.2)"
Region 177..>327
/region_name="PHA03307"
/note="transcriptional regulator ICP4; Provisional"
/db_xref="CDD:223039"
Site 184
/site_type="phosphorylation"
/note="Phosphoserine, by PDPK1. /evidence=ECO:0000255;
propagated from UniProtKB/Swiss-Prot (Q05516.2)"
Site 197
/site_type="phosphorylation"
/note="Phosphoserine, by PDPK1. /evidence=ECO:0000255;
propagated from UniProtKB/Swiss-Prot (Q05516.2)"
Region 200..300
/region_name="Interaction with RUNX1T1.
/evidence=ECO:0000269|PubMed:10688654"
/note="propagated from UniProtKB/Swiss-Prot (Q05516.2)"
Region 215..236
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q05516.2)"
Region 249..332
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q05516.2)"
Site 256
/site_type="phosphorylation"
/note="Phosphoserine, by PDPK1. /evidence=ECO:0000255;
propagated from UniProtKB/Swiss-Prot (Q05516.2)"
Site 282
/site_type="phosphorylation"
/note="Phosphothreonine, by PDPK1. /evidence=ECO:0000255;
propagated from UniProtKB/Swiss-Prot (Q05516.2)"
Site 394..395
/site_type="other"
/note="Breakpoint for translocation to form PLZF-RAR-alpha
oncogene; propagated from UniProtKB/Swiss-Prot (Q05516.2)"
Region 406..426
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 434..454
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region <448..622
/region_name="COG5048"
/note="FOG: Zn-finger [General function prediction only]"
/db_xref="CDD:227381"
Region 463..483
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 492..512
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 520..540
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site order(525,527,529,531..532,535..536,539,553,555,559..560,
563..564,567,581,583,585,587..588,591..592,595)
/site_type="other"
/note="putative nucleic acid binding site [nucleotide
binding]"
/db_xref="CDD:275368"
Region 548..568
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 576..596
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Region 604..624
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
Site 628
/site_type="phosphorylation"
/note="Phosphoserine, by PDPK1. /evidence=ECO:0000255;
propagated from UniProtKB/Swiss-Prot (Q05516.2)"
Region 632..652
/region_name="C2H2 Zn finger"
/note="C2H2 Zn finger [structural motif]"
/db_xref="CDD:275368"
CDS 1..673
/gene="ZBTB16"
/gene_synonym="PLZF; ZNF145"
/coded_by="NM_006006.6:263..2284"
/note="isoform 1 is encoded by transcript variant 1"
/db_xref="CCDS:CCDS8367.1"
/db_xref="GeneID:7704"
/db_xref="HGNC:HGNC:12930"
/db_xref="MIM:176797"
ORIGIN
1 mdltkmgmiq lqnpshptgl lckanqmrla gtlcdvvimv dsqefhahrt vlactskmfe
61 ilfhrnsqhy tldflspktf qqileyayta tlqakaedld dllyaaeile ieyleeqclk
121 mletiqasdd ndteatmadg gaeeeedrka rylknifisk hsseesgyas vagqslpgpm
181 vdqspsvsts fglsamsptk aavdslmtig qsllqgtlqp pagpeeptla gggrhpgvae
241 vktemmqvde vpsqdspgaa essisggmgd kveergkegp gtptrssvit sarelhygre
301 esaeqvpppa eagqaptgrp ehpapppekh lgiysvlpnh kadavlsmps svtsglhvqp
361 alavsmdfst yggllpqgfi qrelfsklge lavgmksesr tigeqcsvcg velpdneave
421 qhrklhsgmk tygcelcgkr fldslrlrmh llahsagaka fvcdqcgaqf skedalethr
481 qthtgtdmav fcllcgkrfq aqsalqqhme vhagvrsyic secnrtfpsh talkrhlrsh
541 tgdhpyecef cgscfrdest lkshkrihtg ekpyecngcg kkfslkhqle thyrvhtgek
601 pfecklchqr srdysamikh lrthngaspy qcticteycp slssmqkhmk ghkpeeippd
661 wriektylyl cyv
//