LOCUS NP_006691 582 aa linear PRI 04-APR-2024
DEFINITION TRAF-type zinc finger domain-containing protein 1 [Homo sapiens].
ACCESSION NP_006691
VERSION NP_006691.1
DBSOURCE REFSEQ: accession NM_006700.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 582)
AUTHORS Gupta,S., Singh,P., Tasneem,A., Almatroudi,A., Rahmani,A.H.,
Dohare,R. and Parveen,S.
TITLE Integrative Multiomics and Regulatory Network Analyses Uncovers the
Role of OAS3, TRAFD1, miR-222-3p, and miR-125b-5p in Hepatitis E
Virus Infection
JOURNAL Genes (Basel) 14 (1), 42 (2022)
PUBMED 36672782
REMARK GeneRIF: Integrative Multiomics and Regulatory Network Analyses
Uncovers the Role of OAS3, TRAFD1, miR-222-3p, and miR-125b-5p in
Hepatitis E Virus Infection.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 582)
AUTHORS Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
TITLE Differential CFTR-Interactome Proximity Labeling Procedures
Identify Enrichment in Multiple SLC Transporters
JOURNAL Int J Mol Sci 23 (16), 8937 (2022)
PUBMED 36012204
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 582)
AUTHORS Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
TITLE CFTR interactome mapping using the mammalian membrane two-hybrid
high-throughput screening system
JOURNAL Mol Syst Biol 18 (2), e10629 (2022)
PUBMED 35156780
REFERENCE 4 (residues 1 to 582)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 5 (residues 1 to 582)
AUTHORS Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
Clark,A.G. and Yu,H.
TITLE Extensive disruption of protein interactions by genetic variants
across the allele frequency spectrum in human populations
JOURNAL Nat Commun 10 (1), 4141 (2019)
PUBMED 31515488
REMARK Publication Status: Online-Only
REFERENCE 6 (residues 1 to 582)
AUTHORS Kaltenbach,L.S., Romero,E., Becklin,R.R., Chettier,R., Bell,R.,
Phansalkar,A., Strand,A., Torcassi,C., Savage,J., Hurlburt,A.,
Cha,G.H., Ukani,L., Chepanoske,C.L., Zhen,Y., Sahasrabudhe,S.,
Olson,J., Kurschner,C., Ellerby,L.M., Peltier,J.M., Botas,J. and
Hughes,R.E.
TITLE Huntingtin interacting proteins are genetic modifiers of
neurodegeneration
JOURNAL PLoS Genet 3 (5), e82 (2007)
PUBMED 17500595
REFERENCE 7 (residues 1 to 582)
AUTHORS Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
TITLE A probability-based approach for high-throughput protein
phosphorylation analysis and site localization
JOURNAL Nat Biotechnol 24 (10), 1285-1292 (2006)
PUBMED 16964243
REFERENCE 8 (residues 1 to 582)
AUTHORS Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
TITLE Phosphoproteome analysis of the human mitotic spindle
JOURNAL Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
PUBMED 16565220
REFERENCE 9 (residues 1 to 582)
AUTHORS Mashima,R., Saeki,K., Aki,D., Minoda,Y., Takaki,H., Sanada,T.,
Kobayashi,T., Aburatani,H., Yamanashi,Y. and Yoshimura,A.
TITLE FLN29, a novel interferon- and LPS-inducible gene acting as a
negative regulator of toll-like receptor signaling
JOURNAL J Biol Chem 280 (50), 41289-41297 (2005)
PUBMED 16221674
REMARK GeneRIF: FLN29 is a new negative feedback regulator of TLR
signaling
REFERENCE 10 (residues 1 to 582)
AUTHORS Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
TITLE Large-scale characterization of HeLa cell nuclear phosphoproteins
JOURNAL Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
PUBMED 15302935
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK312601.1, BC003553.2 and CA314188.1.
Summary: The innate immune system confers host defense against
viral and microbial infection, and TRAFD1 is a negative feedback
regulator that controls excessive immune responses (Sanada et al.,
2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009].
Transcript Variant: This variant (2) differs in the 5' UTR compared
to variant 1. Variants 1 and 2 both encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803616.46222.1,
SRR3476690.536433.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000412615.7/ ENSP00000396526.2
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..582
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q24.13"
Protein 1..582
/product="TRAF-type zinc finger domain-containing protein
1"
/note="FLN29 gene product"
/calculated_mol_wt=64710
Site 2
/site_type="acetylation"
/note="N-acetylalanine.
/evidence=ECO:0007744|PubMed:22814378; propagated from
UniProtKB/Swiss-Prot (O14545.1)"
Region <7..131
/region_name="PLN03086"
/note="PRLI-interacting factor K; Provisional"
/db_xref="CDD:178635"
Site 191
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (O14545.1)"
Region 217..236
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (O14545.1)"
Site 278
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (O14545.1)"
Site 320
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:24275569; propagated from
UniProtKB/Swiss-Prot (O14545.1)"
Site 326
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:21406692; propagated from
UniProtKB/Swiss-Prot (O14545.1)"
Site 327
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:18669648,
ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569;
propagated from UniProtKB/Swiss-Prot (O14545.1)"
Region 401..582
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (O14545.1)"
Region <406..543
/region_name="PHA03247"
/note="large tegument protein UL36; Provisional"
/db_xref="CDD:223021"
Site 409
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:23186163,
ECO:0007744|PubMed:24275569; propagated from
UniProtKB/Swiss-Prot (O14545.1)"
Site 415
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:16964243,
ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332,
ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569;
propagated from UniProtKB/Swiss-Prot (O14545.1)"
Site 430
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:23186163; propagated from
UniProtKB/Swiss-Prot (O14545.1)"
Site 470
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:18669648; propagated from
UniProtKB/Swiss-Prot (O14545.1)"
CDS 1..582
/gene="TRAFD1"
/gene_synonym="FLN29"
/coded_by="NM_006700.3:72..1820"
/db_xref="CCDS:CCDS9160.1"
/db_xref="GeneID:10906"
/db_xref="HGNC:HGNC:24808"
/db_xref="MIM:613197"
ORIGIN
1 maeflddqet rlcdnckkei pvfnftihei hcqrnigmcp tckepfpksd methmaaehc
61 qvtckcnkkl ekrllkkhee tecplrlavc qhcdlelsil klkehedycg artelcgncg
121 rnvlvkdlkt hpevcgrege ekrnevaipp naydeswgqd giwiasqllr qiealdppmr
181 lprrplrafe sdvfhnrttn qrnitaqvsi qnnlfeeqer qernrgqqpp keggeesanl
241 dfmlalslqn egqassvaeq dfwravcead qshggprsls dikgaadeim lpcefceely
301 peellidhqt scnpsralps lntgsssprg veepdvifqn flqqaasnql dslmglsnsh
361 pveesiiipc efcgvqleee vlfhhqdqcd qrpatatnhv tegiprldsq pqetspelpr
421 rrvrhqgdls sgylddtkqe tangptsclp psrpinnmta tynqlsrsts gprpgcqpss
481 pcvpklsnsd sqdiqgrnrd sqngaiapgh vsvirppqnl ypenivpsfs pgpsgrygas
541 grseggrnsr vtpaaanyrs rtakakpskq qgagdaeeee ee
//