LOCUS NP_009694 2368 aa linear PLN 17-DEC-2024
DEFINITION protein kinase MEC1 [Saccharomyces cerevisiae S288C].
ACCESSION NP_009694
VERSION NP_009694.3
DBLINK BioProject: PRJNA128
DBSOURCE REFSEQ: accession NM_001178484.3
KEYWORDS RefSeq.
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (residues 1 to 2368)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 2 (residues 1 to 2368)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 3 (residues 1 to 2368)
AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C.,
Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al.
TITLE Complete DNA sequence of yeast chromosome II
JOURNAL EMBO J. 13 (24), 5795-5809 (1994)
PUBMED 7813418
REFERENCE 4 (residues 1 to 2368)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (17-DEC-2024) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 5 (residues 1 to 2368)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 6 (residues 1 to 2368)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 7 (residues 1 to 2368)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
COMMENT REVIEWED REFSEQ: This record has been curated by SGD. The reference
sequence is identical to DAA07252.
On Jul 30, 2012 this sequence version replaced NP_009694.2.
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..2368
/organism="Saccharomyces cerevisiae S288C"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="II"
Protein 1..2368
/product="protein kinase MEC1"
/EC_number="2.7.11.1"
/calculated_mol_wt=273212
Region 194..2368
/region_name="TEL1"
/note="Phosphatidylinositol kinase or protein kinase, PI-3
family [Signal transduction mechanisms]; COG5032"
/db_xref="CDD:227365"
CDS 1..2368
/gene="MEC1"
/locus_tag="YBR136W"
/gene_synonym="ESR1; RAD31; SAD3"
/coded_by="NM_001178484.3:1..7107"
/experiment="EXISTENCE:direct assay:GO:0000723 telomere
maintenance [PMID:15721260]"
/experiment="EXISTENCE:direct assay:GO:0004672 protein
kinase activity [PMID:11095737]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:23934994]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:14576278]"
/experiment="EXISTENCE:genetic interaction:GO:0000722
telomere maintenance via recombination [PMID:17202155]"
/experiment="EXISTENCE:genetic interaction:GO:0004672
protein kinase activity [PMID:21841787]"
/experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA
replication [PMID:10511542]"
/experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA
recombination [PMID:10511543]"
/experiment="EXISTENCE:mutant phenotype:GO:0007131
reciprocal meiotic recombination [PMID:10511543]"
/experiment="EXISTENCE:mutant phenotype:GO:0042770 signal
transduction in response to DNA damage [PMID:17693258]"
/experiment="EXISTENCE:mutant phenotype:GO:2000105
positive regulation of DNA-templated DNA replication
[PMID:23307868]"
/note="Genome integrity checkpoint protein and PI kinase
superfamily member; Mec1p and Dun1p function in same
pathway to regulate dNTP pools and telomere length; signal
transducer required for cell cycle arrest and
transcriptional responses to damaged or unreplicated DNA;
facilitates replication fork progression and regulates
P-body formation under replication stress; promotes
interhomolog recombination by phosphorylating Hop1p;
associates with shortened, dysfunctional telomeres"
/db_xref="GeneID:852433"
/db_xref="SGD:S000000340"
ORIGIN
1 meshvkylde lilaikdlns gvdskvqikk vptdpsssqe yakslkilnt lirnlkdqrr
61 nnimkndtif sktvsalall leynpfllvm kdsngnfeiq rliddflnis vlnydnyhri
121 wfmrrklgsw ckacvefygk pakfqltahf entmnlyeqa ltevllgkte llkfydtlkg
181 lyillywfts eystfgnsia fldsslgftk fdfnfqrlir ivlyvfdsce laaleyaeiq
241 lkyislvvdy vcnrtistal dapalvcceq lkfvlttmhh fldnkyglld ndptmakgil
301 rlyslcisnd fskcfvdhfp idqwadfsqs ehfpftqltn kalsivyfdl krrslpveal
361 kydnkfniwv yqsepdsslk nvtspfddry kqleklrllv lkkfnkterg tllkyrvnql
421 spgffqragn dfklilneas vsiqtcfktn nitrltswtv ilgrlacles ekfsgtlpns
481 tkdmdnwyvc hlcdiektgn pfvrinpnrp eaagkseifr ilhsnflshp nidefsesll
541 sgilfslhri fshfqppklt dgngqinksf klvqkcfmns nrylrllstr iiplfnisds
601 hnsedehtat likflqsqkl pvvkenlvia wtqltlttsn dvfdtlllkl idifnsddys
661 lrimmtlqik nmakilkktp yqllspilpv llrqlgknlv erkvgfqnli ellgysskti
721 ldifqryiip yaiiqyksdv lseiakimcd gdtslinqmk vnllkknsrq ifavalvkhg
781 lfsldiletl flnraptfdk gyitaylpdy ktlaeitkly knsvtkdasd senanmilcs
841 lrflitnfek dkrhgskykn innwtddqeq afqkklqdni lgifqvfssd ihdvegrtty
901 yeklrvingi sfliiyapkk siisalaqis iclqtglglk evryeafrcw hllvrhlnde
961 elstvidsli afilqkwsef ngklrnivys ildtlikeks dlilklkpyt tlalvgkpel
1021 gilardgqfa rmvnkirstt dlipifannl kssnkyvinq nlddievylr rkqtersidf
1081 tpkkvgqtsd itlvlgalld tshkfrnldk dlcekcakci smigvldvtk hefkrttyse
1141 nevydlndsv qtikfliwvi ndilvpafwq senpskqlfv alviqeslky cglsseswdm
1201 nhkelypnea klwekfnsvs kttiypllss lylaqswkey vplkypsnnf kegykiwvkr
1261 ftldllktgt tenhplhvfs slireddgsl snfllpyisl diiikaekgt pyadilngii
1321 iefdsiftcn legmnnlqvd slrmcyesif rvfeyckkwa tefkqnyskl hgtfiikdtk
1381 ttnmllride flrttpsdll aqrsletdsf ersalyleqc yrqnphdknq ngqllknlqi
1441 tyeeigdids ldgvlrtfat gnlvskieel qysenwklaq dcfnvlgkfs ddpktttrml
1501 ksmydhqlys qiisnssfhs sdgkislspd vkewysigle aanlegnvqt lknwveqies
1561 lrniddrevl lqyniakali aisnedplrt qkyihnsfrl igtnfitssk ettllkkqnl
1621 lmklhslydl sflssakdkf eyksnttild yrmerigadf vpnhyilsmr ksfdqlkmne
1681 qadadlgktf ftlaqlarnn arldiasesl mhclerrlpq aelefaeilw kqgendralk
1741 ivqeihekyq enssvnardr aavllkftew ldlsnnsase qiikqyqdif qidskwdkpy
1801 ysiglyysrl lerkkaegyi tngrfeyrai syfllafekn takvrenlpk vitfwldiaa
1861 asiseapgnr kemlskated icshveealq hcptyiwyfv ltqllsrllh shqssaqiim
1921 hillslavey pshilwyita lvnsnsskrv lrgkhileky rqhsqnphdl vssaldltka
1981 ltrvclqdvk sitsrsgksl ekdfkfdmnv apsamvvpvr knldiisple snsmrgyqpf
2041 rpvvsiirfg ssykvfsslk kpkqlniigs dgniygimck kedvrqdnqy mqfattmdfl
2101 lskdiasrkr slginiysvl slredcgile mvpnvvtlrs ilstkyeslk ikyslkslhd
2161 rwqhtavdgk lefymeqvdk fppilyqwfl enfpdpinwf narntyarsy avmamvghil
2221 glgdrhceni lldiqtgkvl hvdfdclfek gkrlpvpeiv pfrltpnlld algiigtegt
2281 fkkssevtla lmrknevalm nvietimydr nmdhsiqkal kvlrnkirgi dpqdglvlsv
2341 agqtetliqe atsednlskm yigwlpfw
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