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protein kinase MEC1 [Saccharomyces cerevisiae S288C]

NCBI Reference Sequence: NP_009694.3

Identical Proteins FASTA Graphics 

LOCUS       NP_009694               2368 aa            linear   PLN 17-DEC-2024
DEFINITION  protein kinase MEC1 [Saccharomyces cerevisiae S288C].
ACCESSION   NP_009694
VERSION     NP_009694.3
DBLINK      BioProject: PRJNA128
DBSOURCE    REFSEQ: accession NM_001178484.3
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (residues 1 to 2368)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (residues 1 to 2368)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   3  (residues 1 to 2368)
  AUTHORS   Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C.,
            Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al.
  TITLE     Complete DNA sequence of yeast chromosome II
  JOURNAL   EMBO J. 13 (24), 5795-5809 (1994)
   PUBMED   7813418
REFERENCE   4  (residues 1 to 2368)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 2368)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (residues 1 to 2368)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   7  (residues 1 to 2368)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. The reference
            sequence is identical to DAA07252.
            
            On Jul 30, 2012 this sequence version replaced NP_009694.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..2368
                     /organism="Saccharomyces cerevisiae S288C"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="II"
     Protein         1..2368
                     /product="protein kinase MEC1"
                     /EC_number="2.7.11.1"
                     /calculated_mol_wt=273212
     Region          194..2368
                     /region_name="TEL1"
                     /note="Phosphatidylinositol kinase or protein kinase, PI-3
                     family [Signal transduction mechanisms]; COG5032"
                     /db_xref="CDD:227365"
     CDS             1..2368
                     /gene="MEC1"
                     /locus_tag="YBR136W"
                     /gene_synonym="ESR1; RAD31; SAD3"
                     /coded_by="NM_001178484.3:1..7107"
                     /experiment="EXISTENCE:direct assay:GO:0000723 telomere
                     maintenance [PMID:15721260]"
                     /experiment="EXISTENCE:direct assay:GO:0004672 protein
                     kinase activity [PMID:11095737]"
                     /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
                     [PMID:23934994]"
                     /experiment="EXISTENCE:direct assay:GO:0005739
                     mitochondrion [PMID:16823961|PMID:14576278]"
                     /experiment="EXISTENCE:genetic interaction:GO:0000722
                     telomere maintenance via recombination [PMID:17202155]"
                     /experiment="EXISTENCE:genetic interaction:GO:0004672
                     protein kinase activity [PMID:21841787]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA
                     replication [PMID:10511542]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA
                     recombination [PMID:10511543]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0007131
                     reciprocal meiotic recombination [PMID:10511543]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0042770 signal
                     transduction in response to DNA damage [PMID:17693258]"
                     /experiment="EXISTENCE:mutant phenotype:GO:2000105
                     positive regulation of DNA-templated DNA replication
                     [PMID:23307868]"
                     /note="Genome integrity checkpoint protein and PI kinase
                     superfamily member; Mec1p and Dun1p function in same
                     pathway to regulate dNTP pools and telomere length; signal
                     transducer required for cell cycle arrest and
                     transcriptional responses to damaged or unreplicated DNA;
                     facilitates replication fork progression and regulates
                     P-body formation under replication stress; promotes
                     interhomolog recombination by phosphorylating Hop1p;
                     associates with shortened, dysfunctional telomeres"
                     /db_xref="GeneID:852433"
                     /db_xref="SGD:S000000340"
ORIGIN      
        1 meshvkylde lilaikdlns gvdskvqikk vptdpsssqe yakslkilnt lirnlkdqrr
       61 nnimkndtif sktvsalall leynpfllvm kdsngnfeiq rliddflnis vlnydnyhri
      121 wfmrrklgsw ckacvefygk pakfqltahf entmnlyeqa ltevllgkte llkfydtlkg
      181 lyillywfts eystfgnsia fldsslgftk fdfnfqrlir ivlyvfdsce laaleyaeiq
      241 lkyislvvdy vcnrtistal dapalvcceq lkfvlttmhh fldnkyglld ndptmakgil
      301 rlyslcisnd fskcfvdhfp idqwadfsqs ehfpftqltn kalsivyfdl krrslpveal
      361 kydnkfniwv yqsepdsslk nvtspfddry kqleklrllv lkkfnkterg tllkyrvnql
      421 spgffqragn dfklilneas vsiqtcfktn nitrltswtv ilgrlacles ekfsgtlpns
      481 tkdmdnwyvc hlcdiektgn pfvrinpnrp eaagkseifr ilhsnflshp nidefsesll
      541 sgilfslhri fshfqppklt dgngqinksf klvqkcfmns nrylrllstr iiplfnisds
      601 hnsedehtat likflqsqkl pvvkenlvia wtqltlttsn dvfdtlllkl idifnsddys
      661 lrimmtlqik nmakilkktp yqllspilpv llrqlgknlv erkvgfqnli ellgysskti
      721 ldifqryiip yaiiqyksdv lseiakimcd gdtslinqmk vnllkknsrq ifavalvkhg
      781 lfsldiletl flnraptfdk gyitaylpdy ktlaeitkly knsvtkdasd senanmilcs
      841 lrflitnfek dkrhgskykn innwtddqeq afqkklqdni lgifqvfssd ihdvegrtty
      901 yeklrvingi sfliiyapkk siisalaqis iclqtglglk evryeafrcw hllvrhlnde
      961 elstvidsli afilqkwsef ngklrnivys ildtlikeks dlilklkpyt tlalvgkpel
     1021 gilardgqfa rmvnkirstt dlipifannl kssnkyvinq nlddievylr rkqtersidf
     1081 tpkkvgqtsd itlvlgalld tshkfrnldk dlcekcakci smigvldvtk hefkrttyse
     1141 nevydlndsv qtikfliwvi ndilvpafwq senpskqlfv alviqeslky cglsseswdm
     1201 nhkelypnea klwekfnsvs kttiypllss lylaqswkey vplkypsnnf kegykiwvkr
     1261 ftldllktgt tenhplhvfs slireddgsl snfllpyisl diiikaekgt pyadilngii
     1321 iefdsiftcn legmnnlqvd slrmcyesif rvfeyckkwa tefkqnyskl hgtfiikdtk
     1381 ttnmllride flrttpsdll aqrsletdsf ersalyleqc yrqnphdknq ngqllknlqi
     1441 tyeeigdids ldgvlrtfat gnlvskieel qysenwklaq dcfnvlgkfs ddpktttrml
     1501 ksmydhqlys qiisnssfhs sdgkislspd vkewysigle aanlegnvqt lknwveqies
     1561 lrniddrevl lqyniakali aisnedplrt qkyihnsfrl igtnfitssk ettllkkqnl
     1621 lmklhslydl sflssakdkf eyksnttild yrmerigadf vpnhyilsmr ksfdqlkmne
     1681 qadadlgktf ftlaqlarnn arldiasesl mhclerrlpq aelefaeilw kqgendralk
     1741 ivqeihekyq enssvnardr aavllkftew ldlsnnsase qiikqyqdif qidskwdkpy
     1801 ysiglyysrl lerkkaegyi tngrfeyrai syfllafekn takvrenlpk vitfwldiaa
     1861 asiseapgnr kemlskated icshveealq hcptyiwyfv ltqllsrllh shqssaqiim
     1921 hillslavey pshilwyita lvnsnsskrv lrgkhileky rqhsqnphdl vssaldltka
     1981 ltrvclqdvk sitsrsgksl ekdfkfdmnv apsamvvpvr knldiisple snsmrgyqpf
     2041 rpvvsiirfg ssykvfsslk kpkqlniigs dgniygimck kedvrqdnqy mqfattmdfl
     2101 lskdiasrkr slginiysvl slredcgile mvpnvvtlrs ilstkyeslk ikyslkslhd
     2161 rwqhtavdgk lefymeqvdk fppilyqwfl enfpdpinwf narntyarsy avmamvghil
     2221 glgdrhceni lldiqtgkvl hvdfdclfek gkrlpvpeiv pfrltpnlld algiigtegt
     2281 fkkssevtla lmrknevalm nvietimydr nmdhsiqkal kvlrnkirgi dpqdglvlsv
     2341 agqtetliqe atsednlskm yigwlpfw
//
Feature
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Protein 3D Structure

See all 4 structures...

Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the MEC1 gene (NM_001178484.3).

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