U.S. flag

An official website of the United States government

alkaline phosphatase PHO8 [Saccharomyces cerevisiae S288C]

NCBI Reference Sequence: NP_010769.3

Identical Proteins FASTA Graphics 

LOCUS       NP_010769                566 aa            linear   PLN 17-DEC-2024
DEFINITION  alkaline phosphatase PHO8 [Saccharomyces cerevisiae S288C].
ACCESSION   NP_010769
VERSION     NP_010769.3
DBLINK      BioProject: PRJNA128
DBSOURCE    REFSEQ: accession NM_001180789.3
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (residues 1 to 566)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (residues 1 to 566)
  AUTHORS   Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P.,
            Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C.,
            Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F.,
            Delaveau,T., del Rey,F., Dujon,B., Eide,L.G.,
            Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et
            al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome IV
  JOURNAL   Nature 387 (6632 SUPPL), 75-78 (1997)
   PUBMED   9169867
REFERENCE   3  (residues 1 to 566)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (residues 1 to 566)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 566)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (residues 1 to 566)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (06-FEB-2013) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (residues 1 to 566)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   8  (residues 1 to 566)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   9  (residues 1 to 566)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. The reference
            sequence is identical to DAA12314.
            
            On Jul 30, 2012 this sequence version replaced NP_010769.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..566
                     /organism="Saccharomyces cerevisiae S288C"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="IV"
     Protein         1..566
                     /product="alkaline phosphatase PHO8"
                     /EC_number="3.1.3.1"
                     /EC_number="3.1.3.54"
                     /EC_number="3.1.7.6"
                     /calculated_mol_wt=62873
     Region          66..527
                     /region_name="Alk_phosphatase"
                     /note="Alkaline phosphatase; pfam00245"
                     /db_xref="CDD:395188"
     Site            order(75,122..123,176,187,325,330,334,373..374)
                     /site_type="active"
                     /db_xref="CDD:293736"
     Site            order(75,122..123,187,330,334,374)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:293736"
     CDS             1..566
                     /gene="PHO8"
                     /locus_tag="YDR481C"
                     /coded_by="NM_001180789.3:1..1701"
                     /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
                     vacuole membrane [PMID:26928762|PMID:2676517]"
                     /experiment="EXISTENCE:direct assay:GO:0004035 alkaline
                     phosphatase activity [PMID:8499492]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0009166
                     nucleotide catabolic process [PMID:25468960]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0046496
                     nicotinamide nucleotide metabolic process [PMID:21349851]"
                     /note="Repressible vacuolar alkaline phosphatase; controls
                     polyphosphate content; regulated by levels of Pi and by
                     Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates
                     phosphotyrosyl peptides; contributes to NAD+ metabolism by
                     producing nicotinamide riboside from NMN"
                     /db_xref="GeneID:852092"
                     /db_xref="SGD:S000002889"
ORIGIN      
        1 mmthtlpseq trlvpgsdss srpkkrrisk rskiivstvv ciglllvlvq lafpssfalr
       61 sashkkknvi ffvtdgmgpa slsmarsfnq hvndlpiddi ltldehfigs srtrssdslv
      121 tdsaagataf acalksynga igvdphhrpc gtvleaakla gyltglvvtt ritdatpasf
      181 sshvdyrwqe dliathqlge yplgrvvdll mgggrshfyp qgekaspygh hgarkdgrdl
      241 ideaqsngwq yvgdrknfds llkshgenvt lpflglfadn dipfeidrde keypslkeqv
      301 kvalgaleka snedkdsngf flmvegsrid haghqndpas qvrevlafde afqyvlefae
      361 nsdtetvlvs tsdhetgglv tsrqvtasyp qyvwypqvla nathsgeflk rklvdfvheh
      421 kgasskienf ikheilekdl giydytdsdl etlihlddna naiqdklndm vsfraqigwt
      481 thghsavdvn iyayankkat wsyvlnnlqg nhentevgqf lenflelnln evtdlirdtk
      541 htsdfdatei asevqhydey yheltn
//
Feature
Display: FASTA GenBank Help
Details

Supplemental Content

Change region shown

Customize view

Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the PHO8 gene (NM_001180789.3).

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
External link. Please review our privacy policy.