LOCUS NP_010769 566 aa linear PLN 17-DEC-2024
DEFINITION alkaline phosphatase PHO8 [Saccharomyces cerevisiae S288C].
ACCESSION NP_010769
VERSION NP_010769.3
DBLINK BioProject: PRJNA128
DBSOURCE REFSEQ: accession NM_001180789.3
KEYWORDS RefSeq.
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (residues 1 to 566)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 2 (residues 1 to 566)
AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P.,
Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C.,
Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F.,
Delaveau,T., del Rey,F., Dujon,B., Eide,L.G.,
Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et
al.
TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV
JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997)
PUBMED 9169867
REFERENCE 3 (residues 1 to 566)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 4 (residues 1 to 566)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (17-DEC-2024) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 5 (residues 1 to 566)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 6 (residues 1 to 566)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 7 (residues 1 to 566)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 8 (residues 1 to 566)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 9 (residues 1 to 566)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
COMMENT REVIEWED REFSEQ: This record has been curated by SGD. The reference
sequence is identical to DAA12314.
On Jul 30, 2012 this sequence version replaced NP_010769.2.
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..566
/organism="Saccharomyces cerevisiae S288C"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="IV"
Protein 1..566
/product="alkaline phosphatase PHO8"
/EC_number="3.1.3.1"
/EC_number="3.1.3.54"
/EC_number="3.1.7.6"
/calculated_mol_wt=62873
Region 66..527
/region_name="Alk_phosphatase"
/note="Alkaline phosphatase; pfam00245"
/db_xref="CDD:395188"
Site order(75,122..123,176,187,325,330,334,373..374)
/site_type="active"
/db_xref="CDD:293736"
Site order(75,122..123,187,330,334,374)
/site_type="other"
/note="substrate binding site [chemical binding]"
/db_xref="CDD:293736"
CDS 1..566
/gene="PHO8"
/locus_tag="YDR481C"
/coded_by="NM_001180789.3:1..1701"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane [PMID:26928762|PMID:2676517]"
/experiment="EXISTENCE:direct assay:GO:0004035 alkaline
phosphatase activity [PMID:8499492]"
/experiment="EXISTENCE:mutant phenotype:GO:0009166
nucleotide catabolic process [PMID:25468960]"
/experiment="EXISTENCE:mutant phenotype:GO:0046496
nicotinamide nucleotide metabolic process [PMID:21349851]"
/note="Repressible vacuolar alkaline phosphatase; controls
polyphosphate content; regulated by levels of Pi and by
Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates
phosphotyrosyl peptides; contributes to NAD+ metabolism by
producing nicotinamide riboside from NMN"
/db_xref="GeneID:852092"
/db_xref="SGD:S000002889"
ORIGIN
1 mmthtlpseq trlvpgsdss srpkkrrisk rskiivstvv ciglllvlvq lafpssfalr
61 sashkkknvi ffvtdgmgpa slsmarsfnq hvndlpiddi ltldehfigs srtrssdslv
121 tdsaagataf acalksynga igvdphhrpc gtvleaakla gyltglvvtt ritdatpasf
181 sshvdyrwqe dliathqlge yplgrvvdll mgggrshfyp qgekaspygh hgarkdgrdl
241 ideaqsngwq yvgdrknfds llkshgenvt lpflglfadn dipfeidrde keypslkeqv
301 kvalgaleka snedkdsngf flmvegsrid haghqndpas qvrevlafde afqyvlefae
361 nsdtetvlvs tsdhetgglv tsrqvtasyp qyvwypqvla nathsgeflk rklvdfvheh
421 kgasskienf ikheilekdl giydytdsdl etlihlddna naiqdklndm vsfraqigwt
481 thghsavdvn iyayankkat wsyvlnnlqg nhentevgqf lenflelnln evtdlirdtk
541 htsdfdatei asevqhydey yheltn
//