LOCUS NP_011400 322 aa linear PLN 17-DEC-2024
DEFINITION AMP-activated serine/threonine-protein kinase regulatory subunit
SNF4 [Saccharomyces cerevisiae S288C].
ACCESSION NP_011400
VERSION NP_011400.1
DBLINK BioProject: PRJNA128
DBSOURCE REFSEQ: accession NM_001180980.1
KEYWORDS RefSeq.
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (residues 1 to 322)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 2 (residues 1 to 322)
AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M.,
Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J.,
Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E.,
Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E.,
Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B.,
Kleine,K. et al.
TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII
JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997)
PUBMED 9169869
REFERENCE 3 (residues 1 to 322)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 4 (residues 1 to 322)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (17-DEC-2024) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 5 (residues 1 to 322)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 6 (residues 1 to 322)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 7 (residues 1 to 322)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 8 (residues 1 to 322)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
COMMENT REVIEWED REFSEQ: This record has been curated by SGD. The reference
sequence is identical to DAA07993.
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..322
/organism="Saccharomyces cerevisiae S288C"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="VII"
Protein 1..322
/product="AMP-activated serine/threonine-protein kinase
regulatory subunit SNF4"
/calculated_mol_wt=36270
Region 30..172
/region_name="CBS_euAMPK_gamma-like_repeat1"
/note="Two tandem repeats of the cystathionine
beta-synthase (CBS pair) domains found in AMP-activated
protein kinase gamma-like proteins, repeat 1; cd04618"
/db_xref="CDD:341388"
Site order(38,40..42,64..66,146,164,166,168..169,172)
/site_type="other"
/note="ligand binding site II [chemical binding]"
/db_xref="CDD:341388"
Region 38..110
/region_name="CBS repeat"
/note="CBS repeat [structural motif]"
/db_xref="CDD:341388"
Site order(64,78,82..83,86,124,146..148,168)
/site_type="other"
/note="ligand binding site I [chemical binding]"
/db_xref="CDD:341388"
Region 124..172
/region_name="CBS repeat"
/note="CBS repeat [structural motif]"
/db_xref="CDD:341388"
Region 195..318
/region_name="CBS_euAMPK_gamma-like_repeat2"
/note="CBS pair domain found in 5'-AMP (adenosine
monophosphate)-activated protein kinase; cd04641"
/db_xref="CDD:341399"
Site order(196,198..200,222..224,294,307,309,311..312,315)
/site_type="other"
/note="ligand binding site II [chemical binding]"
/db_xref="CDD:341399"
Region 196..261
/region_name="CBS repeat"
/note="CBS repeat [structural motif]"
/db_xref="CDD:341399"
Site order(222,235,239..240,243,272,294..296,311)
/site_type="other"
/note="ligand binding site I [chemical binding]"
/db_xref="CDD:341399"
Region 272..315
/region_name="CBS repeat"
/note="CBS repeat [structural motif]"
/db_xref="CDD:341399"
CDS 1..322
/gene="SNF4"
/locus_tag="YGL115W"
/gene_synonym="CAT3; SCI1"
/coded_by="NM_001180980.1:1..969"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:2481228|PMID:17237508]"
/experiment="EXISTENCE:direct assay:GO:0005641 nuclear
envelope lumen [PMID:17237508]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:2481228|PMID:17237508]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:12562756]"
/experiment="EXISTENCE:direct assay:GO:0031588
nucleotide-activated protein kinase complex
[PMID:12393914|PMID:2481228]"
/experiment="EXISTENCE:genetic interaction:GO:0004679
AMP-activated protein kinase activity [PMID:2557546]"
/experiment="EXISTENCE:genetic interaction:GO:0006357
regulation of transcription by RNA polymerase II
[PMID:2557546]"
/experiment="EXISTENCE:genetic interaction:GO:0043539
protein serine/threonine kinase activator activity
[PMID:2557546]"
/experiment="EXISTENCE:mutant phenotype:GO:0004679
AMP-activated protein kinase activity
[PMID:2557546|PMID:11486005|PMID:7913470]"
/experiment="EXISTENCE:mutant phenotype:GO:0006914
autophagy [PMID:31962153]"
/experiment="EXISTENCE:mutant phenotype:GO:0007031
peroxisome organization [PMID:1355328]"
/experiment="EXISTENCE:mutant phenotype:GO:0043539 protein
serine/threonine kinase activator activity
[PMID:11486005|PMID:2557546]"
/experiment="EXISTENCE:mutant phenotype:GO:0045722
positive regulation of gluconeogenesis [PMID:2481228]"
/experiment="EXISTENCE:physical interaction:GO:0031588
nucleotide-activated protein kinase complex
[PMID:9121458|PMID:2481228]"
/experiment="EXISTENCE:physical interaction:GO:0045722
positive regulation of gluconeogenesis [PMID:2481228]"
/note="Activating gamma subunit of the AMP-activated Snf1p
kinase complex; additional subunits of the complex are
Snf1p and a Sip1p/Sip2p/Gal83p family member; activates
glucose-repressed genes, represses glucose-induced genes;
role in sporulation, and peroxisome biogenesis; protein
abundance increases in response to DNA replication stress"
/db_xref="GeneID:852763"
/db_xref="SGD:S000003083"
ORIGIN
1 mkptqdsqek vsieqqlave sirkflnskt sydvlpvsyr livldtsllv kkslnvllqn
61 sivsaplwds ktsrfagllt ttdfinviqy yfsnpdkfel vdklqldglk dieralgvdq
121 ldtasihpsr plfeaclkml esrsgripli dqdeethrei vvsvltqyri lkfvalncre
181 thflkipigd lniitqdnmk scqmttpvid viqmltqgrv ssvpiideng ylinvyeayd
241 vlglikggiy ndlslsvgea lmrrsddfeg vytctkndkl stimdnirka rvhrffvvdd
301 vgrlvgvltl sdilkyillg sn
//