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AMP-activated serine/threonine-protein kinase regulatory subunit SNF4 [Saccharomyces cerevisiae S288C]

NCBI Reference Sequence: NP_011400.1

Identical Proteins FASTA Graphics 

LOCUS       NP_011400                322 aa            linear   PLN 17-DEC-2024
DEFINITION  AMP-activated serine/threonine-protein kinase regulatory subunit
            SNF4 [Saccharomyces cerevisiae S288C].
ACCESSION   NP_011400
VERSION     NP_011400.1
DBLINK      BioProject: PRJNA128
DBSOURCE    REFSEQ: accession NM_001180980.1
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (residues 1 to 322)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (residues 1 to 322)
  AUTHORS   Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M.,
            Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J.,
            Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E.,
            Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E.,
            Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B.,
            Kleine,K. et al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome VII
  JOURNAL   Nature 387 (6632 SUPPL), 81-84 (1997)
   PUBMED   9169869
REFERENCE   3  (residues 1 to 322)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (residues 1 to 322)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 322)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (residues 1 to 322)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (residues 1 to 322)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   8  (residues 1 to 322)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. The reference
            sequence is identical to DAA07993.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..322
                     /organism="Saccharomyces cerevisiae S288C"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="VII"
     Protein         1..322
                     /product="AMP-activated serine/threonine-protein kinase
                     regulatory subunit SNF4"
                     /calculated_mol_wt=36270
     Region          30..172
                     /region_name="CBS_euAMPK_gamma-like_repeat1"
                     /note="Two tandem repeats of the cystathionine
                     beta-synthase (CBS pair) domains found in AMP-activated
                     protein kinase gamma-like proteins, repeat 1; cd04618"
                     /db_xref="CDD:341388"
     Site            order(38,40..42,64..66,146,164,166,168..169,172)
                     /site_type="other"
                     /note="ligand binding site II [chemical binding]"
                     /db_xref="CDD:341388"
     Region          38..110
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341388"
     Site            order(64,78,82..83,86,124,146..148,168)
                     /site_type="other"
                     /note="ligand binding site I [chemical binding]"
                     /db_xref="CDD:341388"
     Region          124..172
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341388"
     Region          195..318
                     /region_name="CBS_euAMPK_gamma-like_repeat2"
                     /note="CBS pair domain found in 5'-AMP (adenosine
                     monophosphate)-activated protein kinase; cd04641"
                     /db_xref="CDD:341399"
     Site            order(196,198..200,222..224,294,307,309,311..312,315)
                     /site_type="other"
                     /note="ligand binding site II [chemical binding]"
                     /db_xref="CDD:341399"
     Region          196..261
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341399"
     Site            order(222,235,239..240,243,272,294..296,311)
                     /site_type="other"
                     /note="ligand binding site I [chemical binding]"
                     /db_xref="CDD:341399"
     Region          272..315
                     /region_name="CBS repeat"
                     /note="CBS repeat [structural motif]"
                     /db_xref="CDD:341399"
     CDS             1..322
                     /gene="SNF4"
                     /locus_tag="YGL115W"
                     /gene_synonym="CAT3; SCI1"
                     /coded_by="NM_001180980.1:1..969"
                     /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
                     [PMID:2481228|PMID:17237508]"
                     /experiment="EXISTENCE:direct assay:GO:0005641 nuclear
                     envelope lumen [PMID:17237508]"
                     /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
                     [PMID:2481228|PMID:17237508]"
                     /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
                     [PMID:26928762]"
                     /experiment="EXISTENCE:direct assay:GO:0005886 plasma
                     membrane [PMID:12562756]"
                     /experiment="EXISTENCE:direct assay:GO:0031588
                     nucleotide-activated protein kinase complex
                     [PMID:12393914|PMID:2481228]"
                     /experiment="EXISTENCE:genetic interaction:GO:0004679
                     AMP-activated protein kinase activity [PMID:2557546]"
                     /experiment="EXISTENCE:genetic interaction:GO:0006357
                     regulation of transcription by RNA polymerase II
                     [PMID:2557546]"
                     /experiment="EXISTENCE:genetic interaction:GO:0043539
                     protein serine/threonine kinase activator activity
                     [PMID:2557546]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0004679
                     AMP-activated protein kinase activity
                     [PMID:2557546|PMID:11486005|PMID:7913470]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006914
                     autophagy [PMID:31962153]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0007031
                     peroxisome organization [PMID:1355328]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0043539 protein
                     serine/threonine kinase activator activity
                     [PMID:11486005|PMID:2557546]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0045722
                     positive regulation of gluconeogenesis [PMID:2481228]"
                     /experiment="EXISTENCE:physical interaction:GO:0031588
                     nucleotide-activated protein kinase complex
                     [PMID:9121458|PMID:2481228]"
                     /experiment="EXISTENCE:physical interaction:GO:0045722
                     positive regulation of gluconeogenesis [PMID:2481228]"
                     /note="Activating gamma subunit of the AMP-activated Snf1p
                     kinase complex; additional subunits of the complex are
                     Snf1p and a Sip1p/Sip2p/Gal83p family member; activates
                     glucose-repressed genes, represses glucose-induced genes;
                     role in sporulation, and peroxisome biogenesis; protein
                     abundance increases in response to DNA replication stress"
                     /db_xref="GeneID:852763"
                     /db_xref="SGD:S000003083"
ORIGIN      
        1 mkptqdsqek vsieqqlave sirkflnskt sydvlpvsyr livldtsllv kkslnvllqn
       61 sivsaplwds ktsrfagllt ttdfinviqy yfsnpdkfel vdklqldglk dieralgvdq
      121 ldtasihpsr plfeaclkml esrsgripli dqdeethrei vvsvltqyri lkfvalncre
      181 thflkipigd lniitqdnmk scqmttpvid viqmltqgrv ssvpiideng ylinvyeayd
      241 vlglikggiy ndlslsvgea lmrrsddfeg vytctkndkl stimdnirka rvhrffvvdd
      301 vgrlvgvltl sdilkyillg sn
//
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Protein 3D Structure

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Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the SNF4 gene (NM_001180980.1).

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