LOCUS NP_012213 145 aa linear PLN 17-DEC-2024
DEFINITION isoleucine biosynthesis protein MMF1 [Saccharomyces cerevisiae
S288C].
ACCESSION NP_012213
VERSION NP_012213.3
DBLINK BioProject: PRJNA128
DBSOURCE REFSEQ: accession NM_001179401.3
KEYWORDS RefSeq.
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (residues 1 to 145)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 2 (residues 1 to 145)
AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D.,
Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N.,
Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G.,
Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N.,
Skelton,J., Smith,V., Barrell,B. et al.
TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX
JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997)
PUBMED 9169870
REFERENCE 3 (residues 1 to 145)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 4 (residues 1 to 145)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (17-DEC-2024) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 5 (residues 1 to 145)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 6 (residues 1 to 145)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 7 (residues 1 to 145)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
COMMENT REVIEWED REFSEQ: This record has been curated by SGD. The reference
sequence is identical to DAA08496.
On Jul 30, 2012 this sequence version replaced NP_012213.2.
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..145
/organism="Saccharomyces cerevisiae S288C"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="IX"
Protein 1..145
/product="isoleucine biosynthesis protein MMF1"
/calculated_mol_wt=15777
Region 21..143
/region_name="TIGR00004"
/note="reactive intermediate/imine deaminase"
/db_xref="CDD:129116"
Site order(36..37,40,42,45,47,49..50,89,91..92,94,96,107,110,
119..126,136,138,140)
/site_type="other"
/note="homotrimer interaction site [polypeptide binding]"
/db_xref="CDD:100004"
Site order(36,103,107,121,136)
/site_type="active"
/note="putative active site [active]"
/db_xref="CDD:100004"
CDS 1..145
/gene="MMF1"
/locus_tag="YIL051C"
/gene_synonym="IBM1"
/coded_by="NM_001179401.3:1..438"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005759
mitochondrial matrix [PMID:11003673]"
/experiment="EXISTENCE:genetic interaction:GO:0032543
mitochondrial translation [PMID:15164357]"
/experiment="EXISTENCE:mutant phenotype:GO:0009097
isoleucine biosynthetic process [PMID:11442631]"
/note="Mitochondrial protein required for transamination
of isoleucine; but not of valine or leucine; may regulate
specificity of branched-chain transaminases Bat1p and
Bat2p; induction of expression in response to stress is
mediated by a Hog1p-regulated antisense RNA and gene
looping; interacts genetically with mitochondrial
ribosomal protein genes; MMF1 has a paralog, HMF1, that
arose from the whole genome duplication"
/db_xref="GeneID:854760"
/db_xref="SGD:S000001313"
ORIGIN
1 mflrnsvlrt apvlrrgitt ltpvstklap paaasysqam kannfvyvsg qipytpdnkp
61 vqgsisekae qvfqnvknil aesnssldni vkvnvfladm knfaefnsvy akhfhthkpa
121 rscvgvaslp lnvdlemevi avekn
//