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isoleucine biosynthesis protein MMF1 [Saccharomyces cerevisiae S288C]

NCBI Reference Sequence: NP_012213.3

Identical Proteins FASTA Graphics 

LOCUS       NP_012213                145 aa            linear   PLN 17-DEC-2024
DEFINITION  isoleucine biosynthesis protein MMF1 [Saccharomyces cerevisiae
            S288C].
ACCESSION   NP_012213
VERSION     NP_012213.3
DBLINK      BioProject: PRJNA128
DBSOURCE    REFSEQ: accession NM_001179401.3
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (residues 1 to 145)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (residues 1 to 145)
  AUTHORS   Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D.,
            Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N.,
            Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G.,
            Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N.,
            Skelton,J., Smith,V., Barrell,B. et al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome IX
  JOURNAL   Nature 387 (6632 SUPPL), 84-87 (1997)
   PUBMED   9169870
REFERENCE   3  (residues 1 to 145)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (residues 1 to 145)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 145)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (residues 1 to 145)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   7  (residues 1 to 145)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. The reference
            sequence is identical to DAA08496.
            
            On Jul 30, 2012 this sequence version replaced NP_012213.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..145
                     /organism="Saccharomyces cerevisiae S288C"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="IX"
     Protein         1..145
                     /product="isoleucine biosynthesis protein MMF1"
                     /calculated_mol_wt=15777
     Region          21..143
                     /region_name="TIGR00004"
                     /note="reactive intermediate/imine deaminase"
                     /db_xref="CDD:129116"
     Site            order(36..37,40,42,45,47,49..50,89,91..92,94,96,107,110,
                     119..126,136,138,140)
                     /site_type="other"
                     /note="homotrimer interaction site [polypeptide binding]"
                     /db_xref="CDD:100004"
     Site            order(36,103,107,121,136)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:100004"
     CDS             1..145
                     /gene="MMF1"
                     /locus_tag="YIL051C"
                     /gene_synonym="IBM1"
                     /coded_by="NM_001179401.3:1..438"
                     /experiment="EXISTENCE:direct assay:GO:0005739
                     mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
                     /experiment="EXISTENCE:direct assay:GO:0005759
                     mitochondrial matrix [PMID:11003673]"
                     /experiment="EXISTENCE:genetic interaction:GO:0032543
                     mitochondrial translation [PMID:15164357]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0009097
                     isoleucine biosynthetic process [PMID:11442631]"
                     /note="Mitochondrial protein required for transamination
                     of isoleucine; but not of valine or leucine; may regulate
                     specificity of branched-chain transaminases Bat1p and
                     Bat2p; induction of expression in response to stress is
                     mediated by a Hog1p-regulated antisense RNA and gene
                     looping; interacts genetically with mitochondrial
                     ribosomal protein genes; MMF1 has a paralog, HMF1, that
                     arose from the whole genome duplication"
                     /db_xref="GeneID:854760"
                     /db_xref="SGD:S000001313"
ORIGIN      
        1 mflrnsvlrt apvlrrgitt ltpvstklap paaasysqam kannfvyvsg qipytpdnkp
       61 vqgsisekae qvfqnvknil aesnssldni vkvnvfladm knfaefnsvy akhfhthkpa
      121 rscvgvaslp lnvdlemevi avekn
//
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Protein 3D Structure

Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the MMF1 gene (NM_001179401.3).

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