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DNA primase subunit PRI1 [Saccharomyces cerevisiae S288C]

NCBI Reference Sequence: NP_012273.1

Identical Proteins FASTA Graphics 

LOCUS       NP_012273                409 aa            linear   PLN 17-DEC-2024
DEFINITION  DNA primase subunit PRI1 [Saccharomyces cerevisiae S288C].
ACCESSION   NP_012273
VERSION     NP_012273.1
DBLINK      BioProject: PRJNA128
DBSOURCE    REFSEQ: accession NM_001179530.1
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (residues 1 to 409)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (residues 1 to 409)
  AUTHORS   Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D.,
            Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N.,
            Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G.,
            Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N.,
            Skelton,J., Smith,V., Barrell,B. et al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome IX
  JOURNAL   Nature 387 (6632 SUPPL), 84-87 (1997)
   PUBMED   9169870
REFERENCE   3  (residues 1 to 409)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (residues 1 to 409)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 409)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (residues 1 to 409)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   7  (residues 1 to 409)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. The reference
            sequence is identical to DAA08554.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Saccharomyces cerevisiae S288C"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="IX"
     Protein         1..409
                     /product="DNA primase subunit PRI1"
                     /calculated_mol_wt=47559
     Region          13..362
                     /region_name="primase_sml"
                     /note="DNA primase, eukaryotic-type, small subunit,
                     putative; TIGR00335"
                     /db_xref="CDD:273020"
     Site            order(111,113,115,162,165..166,168,314,323..324,326,332)
                     /site_type="other"
                     /note="nucleotide binding site [chemical binding]"
                     /db_xref="CDD:240130"
     Site            order(130,133)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:240130"
     Site            order(150..152,190,195,210,213)
                     /site_type="other"
                     /note="subunit interface [polypeptide binding]"
                     /db_xref="CDD:240130"
     CDS             1..409
                     /gene="PRI1"
                     /locus_tag="YIR008C"
                     /coded_by="NM_001179530.1:1..1230"
                     /experiment="EXISTENCE:direct assay:GO:0003697
                     single-stranded DNA binding [PMID:20404922]"
                     /experiment="EXISTENCE:direct assay:GO:0003896 DNA primase
                     activity [PMID:3888995|PMID:3061469|PMID:2644256]"
                     /experiment="EXISTENCE:direct assay:GO:0005658 alpha DNA
                     polymerase:primase complex [PMID:3888995|PMID:22593576]"
                     /experiment="EXISTENCE:direct assay:GO:0006269 DNA
                     replication, synthesis of primer [PMID:2644256]"
                     /experiment="EXISTENCE:direct assay:GO:0043596 nuclear
                     replication fork [PMID:16103218]"
                     /experiment="EXISTENCE:genetic interaction:GO:0003896 DNA
                     primase activity [PMID:8436268]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0003896 DNA
                     primase activity [PMID:8436268]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA
                     replication [PMID:2023935]"
                     /note="Subunit of DNA primase; DNA primase is required for
                     DNA synthesis and double-strand break repair"
                     /db_xref="GeneID:854825"
                     /db_xref="SGD:S000001447"
ORIGIN      
        1 mtnsvktngp sssdmeyyyk slypfkhifn wlnhspkpsr dminrefama frsgaykryn
       61 sfnsvqdfka qiekanpdrf eigaiynkpp rerdtllkse lkalekelvf didmddydaf
      121 rtccsgaqvc skcwkfisla mkitntalre dfgykdfiwv fsgrrgahcw vsdkraralt
      181 dvqrrnvldy vnvirdrntd krlalkrpyh phlarsleql kpffvsimle eqnpweddqh
      241 aiqtllpaly dkqlidslkk ywldnprrss kekwndidqi atslfkgpkq dshiiklrec
      301 kedlvlmtly pkldvevtkq tihllkapfc ihpatgnvcv pidesfapek apklidlqte
      361 meknndvslt alqpfinqfq ayvssllkne lgsvkrered ddepasldf
//
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