LOCUS NP_014665 715 aa linear PLN 17-DEC-2024
DEFINITION putative carboxylic ester hydrolase [Saccharomyces cerevisiae
S288C].
ACCESSION NP_014665
VERSION NP_014665.1
DBLINK BioProject: PRJNA128
DBSOURCE REFSEQ: accession NM_001183441.1
KEYWORDS RefSeq.
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (residues 1 to 715)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 2 (residues 1 to 715)
AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W.,
Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R.,
Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G.,
Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H.,
Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al.
TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV
JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997)
PUBMED 9169874
REFERENCE 3 (residues 1 to 715)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 4 (residues 1 to 715)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (17-DEC-2024) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 5 (residues 1 to 715)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 6 (residues 1 to 715)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 7 (residues 1 to 715)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 8 (residues 1 to 715)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 9 (residues 1 to 715)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
COMMENT REVIEWED REFSEQ: This record has been curated by SGD. The reference
sequence is identical to DAA10805.
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..715
/organism="Saccharomyces cerevisiae S288C"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="XV"
Protein 1..715
/product="putative carboxylic ester hydrolase"
/calculated_mol_wt=81638
Region 519..699
/region_name="DDHD"
/note="DDHD domain; pfam02862"
/db_xref="CDD:460725"
CDS 1..715
/gene="DDL1"
/locus_tag="YOR022C"
/coded_by="NM_001183441.1:1..2148"
/experiment="EXISTENCE:direct assay:GO:0004620
phospholipase activity [PMID:27746179|PMID:27402848]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239|PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005759
mitochondrial matrix [PMID:27746179]"
/experiment="EXISTENCE:mutant phenotype:GO:0004620
phospholipase activity [PMID:27402848]"
/experiment="EXISTENCE:mutant phenotype:GO:0006644
phospholipid metabolic process [PMID:27402848]"
/experiment="EXISTENCE:mutant phenotype:GO:0032048
cardiolipin metabolic process [PMID:27402848]"
/experiment="EXISTENCE:mutant phenotype:GO:0046337
phosphatidylethanolamine metabolic process
[PMID:27402848]"
/note="DDHD domain-containing phospholipase A1;
mitochondrial matrix enzyme with sn-1-specific activity,
hydrolyzing cardiolipin, PE, PC, PG and PA; implicated in
remodeling of mitochondrial phospholipids;
antagonistically regulated by Aft1p and Aft2p; in humans,
mutations in DDHD1 and DDHD2 genes cause specific types of
hereditary spastic paraplegia, while DDL1-defective yeast
share similar phenotypes such as mitochondrial dysfunction
and defects in lipid metabolism"
/db_xref="GeneID:854187"
/db_xref="SGD:S000005548"
ORIGIN
1 mlrfthrglp sstrfrnifv rlnhiyvpwf yaidvpnskp ylptyqtlhs pkkfkpfsvd
61 dsnrlekask rqerrpvlvn edylfkvdls hmelsptywe gptyqvrrgv wfdssnqpls
121 sdltseiegl ykqlkfddsn ddptttppae sqdifrlkgk ypvdkenege qkngssnkde
181 nestfkfilf ankqtaflls dldggklqla flrsnlaqsl pinatmitrs ykysssattk
241 qtstsfkaak tpqtevadgs nssksrsiet klekkvsnlf nlsdflqlfn gnaskdqdda
301 qslekqmetd ynnadnsqga nasskiedgk nsgasdrqir snrrdvdnli lcvhgigqtl
361 gkkyeyvnfa htvnllrsnm kkiynnsekl qslntapdyk sncnvqvlpi twrhsisfqt
421 dakeenienp dlptlsqvtv ngvlplrkll adglldilly vepyyqdmil qqvtsqlnkt
481 yrifkefnpe fdgkvhlvgh slgsmilfdi lskqkkyele fqvdnlffig spigllkliq
541 rtkigdrpef pndlerkltv qrpqckdiyn vyhvcdpisy rmeplvskem ahyeqtylph
601 cseaygltsk vlefgeniwk dlpgtdennl qskktspekk evklsenltr mltglnytgr
661 ldyamspsll evdfisaiks hvsyfeepdi aafilkeils khenaseiyv krktg
//