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putative carboxylic ester hydrolase [Saccharomyces cerevisiae S288C]

NCBI Reference Sequence: NP_014665.1

Identical Proteins FASTA Graphics 

LOCUS       NP_014665                715 aa            linear   PLN 17-DEC-2024
DEFINITION  putative carboxylic ester hydrolase [Saccharomyces cerevisiae
            S288C].
ACCESSION   NP_014665
VERSION     NP_014665.1
DBLINK      BioProject: PRJNA128
DBSOURCE    REFSEQ: accession NM_001183441.1
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (residues 1 to 715)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (residues 1 to 715)
  AUTHORS   Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W.,
            Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R.,
            Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G.,
            Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H.,
            Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome XV
  JOURNAL   Nature 387 (6632 SUPPL), 98-102 (1997)
   PUBMED   9169874
REFERENCE   3  (residues 1 to 715)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (residues 1 to 715)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 715)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (residues 1 to 715)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (residues 1 to 715)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   8  (residues 1 to 715)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (27-MAY-2010) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   9  (residues 1 to 715)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. The reference
            sequence is identical to DAA10805.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..715
                     /organism="Saccharomyces cerevisiae S288C"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="XV"
     Protein         1..715
                     /product="putative carboxylic ester hydrolase"
                     /calculated_mol_wt=81638
     Region          519..699
                     /region_name="DDHD"
                     /note="DDHD domain; pfam02862"
                     /db_xref="CDD:460725"
     CDS             1..715
                     /gene="DDL1"
                     /locus_tag="YOR022C"
                     /coded_by="NM_001183441.1:1..2148"
                     /experiment="EXISTENCE:direct assay:GO:0004620
                     phospholipase activity [PMID:27746179|PMID:27402848]"
                     /experiment="EXISTENCE:direct assay:GO:0005739
                     mitochondrion [PMID:16823961|PMID:24769239|PMID:14562095]"
                     /experiment="EXISTENCE:direct assay:GO:0005759
                     mitochondrial matrix [PMID:27746179]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0004620
                     phospholipase activity [PMID:27402848]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006644
                     phospholipid metabolic process [PMID:27402848]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0032048
                     cardiolipin metabolic process [PMID:27402848]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0046337
                     phosphatidylethanolamine metabolic process
                     [PMID:27402848]"
                     /note="DDHD domain-containing phospholipase A1;
                     mitochondrial matrix enzyme with sn-1-specific activity,
                     hydrolyzing cardiolipin, PE, PC, PG and PA; implicated in
                     remodeling of mitochondrial phospholipids;
                     antagonistically regulated by Aft1p and Aft2p; in humans,
                     mutations in DDHD1 and DDHD2 genes cause specific types of
                     hereditary spastic paraplegia, while DDL1-defective yeast
                     share similar phenotypes such as mitochondrial dysfunction
                     and defects in lipid metabolism"
                     /db_xref="GeneID:854187"
                     /db_xref="SGD:S000005548"
ORIGIN      
        1 mlrfthrglp sstrfrnifv rlnhiyvpwf yaidvpnskp ylptyqtlhs pkkfkpfsvd
       61 dsnrlekask rqerrpvlvn edylfkvdls hmelsptywe gptyqvrrgv wfdssnqpls
      121 sdltseiegl ykqlkfddsn ddptttppae sqdifrlkgk ypvdkenege qkngssnkde
      181 nestfkfilf ankqtaflls dldggklqla flrsnlaqsl pinatmitrs ykysssattk
      241 qtstsfkaak tpqtevadgs nssksrsiet klekkvsnlf nlsdflqlfn gnaskdqdda
      301 qslekqmetd ynnadnsqga nasskiedgk nsgasdrqir snrrdvdnli lcvhgigqtl
      361 gkkyeyvnfa htvnllrsnm kkiynnsekl qslntapdyk sncnvqvlpi twrhsisfqt
      421 dakeenienp dlptlsqvtv ngvlplrkll adglldilly vepyyqdmil qqvtsqlnkt
      481 yrifkefnpe fdgkvhlvgh slgsmilfdi lskqkkyele fqvdnlffig spigllkliq
      541 rtkigdrpef pndlerkltv qrpqckdiyn vyhvcdpisy rmeplvskem ahyeqtylph
      601 cseaygltsk vlefgeniwk dlpgtdennl qskktspekk evklsenltr mltglnytgr
      661 ldyamspsll evdfisaiks hvsyfeepdi aafilkeils khenaseiyv krktg
//
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Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the DDL1 gene (NM_001183441.1).

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