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ferric-chelate reductase [Saccharomyces cerevisiae S288C]

NCBI Reference Sequence: NP_015026.1

Identical Proteins FASTA Graphics 

LOCUS       NP_015026                711 aa            linear   PLN 17-DEC-2024
DEFINITION  ferric-chelate reductase [Saccharomyces cerevisiae S288C].
ACCESSION   NP_015026
VERSION     NP_015026.1
DBLINK      BioProject: PRJNA128
DBSOURCE    REFSEQ: accession NM_001183801.1
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (residues 1 to 711)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (residues 1 to 711)
  AUTHORS   Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W.,
            Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R.,
            Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G.,
            Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H.,
            Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome XV
  JOURNAL   Nature 387 (6632 SUPPL), 98-102 (1997)
   PUBMED   9169874
REFERENCE   3  (residues 1 to 711)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (residues 1 to 711)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 711)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (residues 1 to 711)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (residues 1 to 711)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   8  (residues 1 to 711)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (27-MAY-2010) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   9  (residues 1 to 711)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. The reference
            sequence is identical to DAA11139.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Saccharomyces cerevisiae S288C"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="XV"
     Protein         1..711
                     /product="ferric-chelate reductase"
                     /EC_number="1.16.1.9"
                     /calculated_mol_wt=80458
     Region          280..397
                     /region_name="Ferric_reduct"
                     /note="Ferric reductase like transmembrane component;
                     pfam01794"
                     /db_xref="CDD:426438"
     Region          435..709
                     /region_name="NOX_Duox_like_FAD_NADP"
                     /note="NADPH oxidase (NOX) catalyzes the generation of
                     reactive oxygen species (ROS) such as superoxide and
                     hydrogen peroxide. ROS were originally identified as
                     bactericidal agents in phagocytes, but are now also
                     implicated in cell signaling and metabolism. NOX...;
                     cd06186"
                     /db_xref="CDD:99783"
     Site            order(464,479..482,496..498,502..505,547)
                     /site_type="other"
                     /note="FAD binding pocket [chemical binding]"
                     /db_xref="CDD:99783"
     Site            order(479,481..482)
                     /site_type="other"
                     /note="FAD binding motif [chemical binding]"
                     /db_xref="CDD:99783"
     Site            542..552
                     /site_type="other"
                     /note="NAD pyrophosphate binding region [chemical
                     binding]"
                     /db_xref="CDD:99783"
     Site            order(542,546..549,551)
                     /site_type="other"
                     /note="beta-alpha-beta stucture motif"
                     /db_xref="CDD:99783"
     Site            order(547..548,576..578,678..679)
                     /site_type="other"
                     /note="NAD binding pocket [chemical binding]"
                     /db_xref="CDD:99783"
     Site            order(574..575,578)
                     /site_type="other"
                     /note="NADP ribose binding motif [chemical binding]"
                     /db_xref="CDD:99783"
     CDS             1..711
                     /gene="FRE3"
                     /locus_tag="YOR381W"
                     /coded_by="NM_001183801.1:1..2136"
                     /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
                     vacuole [PMID:26928762]"
                     /experiment="EXISTENCE:direct assay:GO:0005886 plasma
                     membrane [PMID:11120744]"
                     /experiment="EXISTENCE:genetic interaction:GO:0000293
                     ferric-chelate reductase activity [PMID:11120744]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006879
                     intracellular iron ion homeostasis
                     [PMID:10341420|PMID:9726978]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0015891
                     siderophore transport [PMID:9726978]"
                     /note="Ferric reductase; reduces siderophore-bound iron
                     prior to uptake by transporters; expression induced by low
                     iron levels"
                     /db_xref="GeneID:854563"
                     /db_xref="SGD:S000005908"
ORIGIN      
        1 mywvllcgsi llcclsgasa spaktkmygk lplvltdacm gvlgevtwey ssddlysspa
       61 ctyepalqsm lyciyeslne kgysnrtfek tfaaikedca yytdnlqnmt nadfynmlnn
      121 gttyiiqyse gsanltypie mdaqvrenyy ysyhgfyany dightyggii cayfvgvmil
      181 asilhylsyt pfktalfkqr lvryvrrylt iptiwgkhas sfsylkiftg flptrsegvi
      241 ilgylvlhtv flaygyqydp ynlifdsrre qiaryvadrs gvlafahfpl ialfagrnnf
      301 lefisgvkyt sfimfhkwlg rmmfldavih gaaytsysvf ykdwaaskee tywqfgvaal
      361 civgvmvffs lamfrkffye aflflhivlg alffytcweh vvelsgiewi yaaiaiwtid
      421 rlirivrvsy fgfpkaslql vgddiirvtv krpvrlwkak pgqyvfvsfl hhlyfwqshp
      481 ftvldsiikd geltiilkek kgvtklvkky vccnggkasm rlaiegpygs sspvnnydnv
      541 llltggtglp gpiahaiklg ktsaatgkqf iklviavrgf nvleaykpel mcledlnvql
      601 hiyntmevpa ltpndsleis qqdekadgkg vvmattleqs pnpvefdgtv fhhgrpnvek
      661 llhevgdlng slavvccgpp vfvdevrdqt anlvlekpak aieyfeeyqs w
//
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Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the FRE3 gene (NM_001183801.1).

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