LOCUS NP_015026 711 aa linear PLN 17-DEC-2024
DEFINITION ferric-chelate reductase [Saccharomyces cerevisiae S288C].
ACCESSION NP_015026
VERSION NP_015026.1
DBLINK BioProject: PRJNA128
DBSOURCE REFSEQ: accession NM_001183801.1
KEYWORDS RefSeq.
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (residues 1 to 711)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 2 (residues 1 to 711)
AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W.,
Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R.,
Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G.,
Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H.,
Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al.
TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV
JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997)
PUBMED 9169874
REFERENCE 3 (residues 1 to 711)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 4 (residues 1 to 711)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (17-DEC-2024) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 5 (residues 1 to 711)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 6 (residues 1 to 711)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 7 (residues 1 to 711)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 8 (residues 1 to 711)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 9 (residues 1 to 711)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
COMMENT REVIEWED REFSEQ: This record has been curated by SGD. The reference
sequence is identical to DAA11139.
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..711
/organism="Saccharomyces cerevisiae S288C"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="XV"
Protein 1..711
/product="ferric-chelate reductase"
/EC_number="1.16.1.9"
/calculated_mol_wt=80458
Region 280..397
/region_name="Ferric_reduct"
/note="Ferric reductase like transmembrane component;
pfam01794"
/db_xref="CDD:426438"
Region 435..709
/region_name="NOX_Duox_like_FAD_NADP"
/note="NADPH oxidase (NOX) catalyzes the generation of
reactive oxygen species (ROS) such as superoxide and
hydrogen peroxide. ROS were originally identified as
bactericidal agents in phagocytes, but are now also
implicated in cell signaling and metabolism. NOX...;
cd06186"
/db_xref="CDD:99783"
Site order(464,479..482,496..498,502..505,547)
/site_type="other"
/note="FAD binding pocket [chemical binding]"
/db_xref="CDD:99783"
Site order(479,481..482)
/site_type="other"
/note="FAD binding motif [chemical binding]"
/db_xref="CDD:99783"
Site 542..552
/site_type="other"
/note="NAD pyrophosphate binding region [chemical
binding]"
/db_xref="CDD:99783"
Site order(542,546..549,551)
/site_type="other"
/note="beta-alpha-beta stucture motif"
/db_xref="CDD:99783"
Site order(547..548,576..578,678..679)
/site_type="other"
/note="NAD binding pocket [chemical binding]"
/db_xref="CDD:99783"
Site order(574..575,578)
/site_type="other"
/note="NADP ribose binding motif [chemical binding]"
/db_xref="CDD:99783"
CDS 1..711
/gene="FRE3"
/locus_tag="YOR381W"
/coded_by="NM_001183801.1:1..2136"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:11120744]"
/experiment="EXISTENCE:genetic interaction:GO:0000293
ferric-chelate reductase activity [PMID:11120744]"
/experiment="EXISTENCE:mutant phenotype:GO:0006879
intracellular iron ion homeostasis
[PMID:10341420|PMID:9726978]"
/experiment="EXISTENCE:mutant phenotype:GO:0015891
siderophore transport [PMID:9726978]"
/note="Ferric reductase; reduces siderophore-bound iron
prior to uptake by transporters; expression induced by low
iron levels"
/db_xref="GeneID:854563"
/db_xref="SGD:S000005908"
ORIGIN
1 mywvllcgsi llcclsgasa spaktkmygk lplvltdacm gvlgevtwey ssddlysspa
61 ctyepalqsm lyciyeslne kgysnrtfek tfaaikedca yytdnlqnmt nadfynmlnn
121 gttyiiqyse gsanltypie mdaqvrenyy ysyhgfyany dightyggii cayfvgvmil
181 asilhylsyt pfktalfkqr lvryvrrylt iptiwgkhas sfsylkiftg flptrsegvi
241 ilgylvlhtv flaygyqydp ynlifdsrre qiaryvadrs gvlafahfpl ialfagrnnf
301 lefisgvkyt sfimfhkwlg rmmfldavih gaaytsysvf ykdwaaskee tywqfgvaal
361 civgvmvffs lamfrkffye aflflhivlg alffytcweh vvelsgiewi yaaiaiwtid
421 rlirivrvsy fgfpkaslql vgddiirvtv krpvrlwkak pgqyvfvsfl hhlyfwqshp
481 ftvldsiikd geltiilkek kgvtklvkky vccnggkasm rlaiegpygs sspvnnydnv
541 llltggtglp gpiahaiklg ktsaatgkqf iklviavrgf nvleaykpel mcledlnvql
601 hiyntmevpa ltpndsleis qqdekadgkg vvmattleqs pnpvefdgtv fhhgrpnvek
661 llhevgdlng slavvccgpp vfvdevrdqt anlvlekpak aieyfeeyqs w
//