mitochondrial proton/calcium exchanger protein precursor [Homo sapiens - Protein

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Bi-allelic LETM1 variants perturb mitochondrial ion homeostasis leading to a clinical spectrum with predominant nervous system involvement. [Am J Hum Genet. 2022]
Bi-allelic LETM1 variants perturb mitochondrial ion homeostasis leading to a clinical spectrum with predominant nervous system involvement.
Kaiyrzhanov R, Mohammed SEM, Maroofian R, Husain RA, Catania A, Torraco A, Alahmad A, Dutra-Clarke M, Grønborg S, Sudarsanam A, et al. Am J Hum Genet. 2022 Sep 1; 109(9):1692-1712.
The leucine zipper EF-hand containing transmembrane protein-1 EF-hand is a tripartite calcium, temperature, and pH sensor. [Protein Sci. 2021]
The leucine zipper EF-hand containing transmembrane protein-1 EF-hand is a tripartite calcium, temperature, and pH sensor.
Lin QT, Lee R, Feng AL, Kim MS, Stathopulos PB. Protein Sci. 2021 Apr; 30(4):855-872. Epub 2021 Mar 2.
Suppression of LETM1 inhibits the proliferation and stemness of colorectal cancer cells through reactive oxygen species-induced autophagy. [J Cell Mol Med. 2021]
Suppression of LETM1 inhibits the proliferation and stemness of colorectal cancer cells through reactive oxygen species-induced autophagy.
Che N, Yang Z, Liu X, Li M, Feng Y, Zhang C, Li C, Cui Y, Xuan Y. J Cell Mol Med. 2021 Feb; 25(4):2110-2120. Epub 2020 Dec 13.

RefSeq genomic sequence
See the genomic reference sequence for the LETM1 gene (NG_013063.1).
RefSeq mRNA
See reference mRNA sequence for the LETM1 gene (NM_012318.3).
RefSeq protein isoforms
See 6 reference sequence protein isoforms for the LETM1 gene.

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NP_036450 [Domain Mapping of Disease Mut...]
NP_036450
Domain Mapping of Disease Mutations
Ensembl [Ensembl]
Ensembl
GlyGen glycoinformatics resource [GlyGen glycoinformatics resou...]
GlyGen glycoinformatics resource
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
OncoMX cancer biomarker resource [OncoMX cancer biomarker resou...]
OncoMX cancer biomarker resource
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
Find Quality Antibodies [GeneTex Inc]
Find Quality Antibodies
GeneTex Inc

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