Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice.
Stevenson WS, Hyland CD, Zhang JG, Morgan PO, Willson TA, Gill A, Hilton AA, Viney EM, Bahlo M, Masters SL, et al. Proc Natl Acad Sci U S A. 2010 Sep 21; 107(38):16625-30. Epub 2010 Sep 7.