E3 ubiquitin-protein ligase Itchy homolog isoform 2 [Homo sapiens]

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Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity. [mBio. 2024]
Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity.
Wang Y, Hollingsworth LR, Sangaré LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ. mBio. 2024 Mar 13; 15(3):e0330223. Epub 2024 Feb 20.
H5N1 infection impairs the alveolar epithelial barrier through intercellular junction proteins via Itch-mediated proteasomal degradation. [Commun Biol. 2022]
H5N1 infection impairs the alveolar epithelial barrier through intercellular junction proteins via Itch-mediated proteasomal degradation.
Ruan T, Sun Y, Zhang J, Sun J, Liu W, Prinz RA, Peng D, Liu X, Xu X. Commun Biol. 2022 Mar 1; 5(1):186. Epub 2022 Mar 1.
Molecular Interactions between Two LMP2A PY Motifs of EBV and WW Domains of E3 Ubiquitin Ligase AIP4. [Life (Basel). 2021]
Molecular Interactions between Two LMP2A PY Motifs of EBV and WW Domains of E3 Ubiquitin Ligase AIP4.
Seo MD, Seok SH, Kim JH, Choi JW, Park SJ, Lee BJ. Life (Basel). 2021 Apr 22; 11(5). Epub 2021 Apr 22.

RefSeq genomic sequence
See the genomic reference sequence for the ITCH gene (NG_023206.1).
RefSeq mRNA
See reference mRNA sequence for the ITCH gene (NM_031483.7).
RefSeq protein isoforms
See 25 reference sequence protein isoforms for the ITCH gene.

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NP_113671
Domain Mapping of Disease Mutations
Ensembl [Ensembl]
Ensembl
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
OncoMX cancer biomarker resource [OncoMX cancer biomarker resou...]
OncoMX cancer biomarker resource
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reagents
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