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beta-crystallin A4 [Rattus norvegicus]

NCBI Reference Sequence: NP_113877.1

Identical Proteins FASTA Graphics 

LOCUS       NP_113877                196 aa            linear   ROD 30-JUL-2024
DEFINITION  beta-crystallin A4 [Rattus norvegicus].
ACCESSION   NP_113877
VERSION     NP_113877.1
DBSOURCE    REFSEQ: accession NM_031689.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 196)
  AUTHORS   Li,W., Ji,Q., Wei,Z., Chen,Y.L., Zhang,Z., Yin,X., Aghmiuni,S.K.,
            Liu,M., Chen,W., Shi,L., Chen,Q., Du,X., Yu,L., Cao,M.J., Wang,Z.,
            Huang,S., Jin,T. and Wang,Q.
  TITLE     Biochemical characterization of G64W mutant of acidic
            beta-crystallin 4
  JOURNAL   Exp Eye Res 186, 107712 (2019)
   PUBMED   31254514
REFERENCE   2  (residues 1 to 196)
  AUTHORS   Billingsley,G., Santhiya,S.T., Paterson,A.D., Ogata,K., Wodak,S.,
            Hosseini,S.M., Manisastry,S.M., Vijayalakshmi,P., Gopinath,P.M.,
            Graw,J. and Heon,E.
  TITLE     CRYBA4, a novel human cataract gene, is also involved in
            microphthalmia
  JOURNAL   Am J Hum Genet 79 (4), 702-709 (2006)
   PUBMED   16960806
REFERENCE   3  (residues 1 to 196)
  AUTHORS   Lampi,K.J., Shih,M., Ueda,Y., Shearer,T.R. and David,L.L.
  TITLE     Lens proteomics: analysis of rat crystallin sequences and
            two-dimensional electrophoresis map
  JOURNAL   Invest Ophthalmol Vis Sci 43 (1), 216-224 (2002)
   PUBMED   11773034
REFERENCE   4  (residues 1 to 196)
  AUTHORS   Takeuchi,N. and Kamei,A.
  TITLE     Crystallin proteins in lenses of hereditary cataractous rat, ICR/f
  JOURNAL   Biol Pharm Bull 23 (3), 283-290 (2000)
   PUBMED   10726880
REFERENCE   5  (residues 1 to 196)
  AUTHORS   David,L.L. and Shearer,T.R.
  TITLE     Beta-crystallins insolubilized by calpain II in vitro contain
            cleavage sites similar to beta-crystallins insolubilized during
            cataract
  JOURNAL   FEBS Lett 324 (3), 265-270 (1993)
   PUBMED   8405363
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF013247.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF013247.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093047 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..196
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     Protein         1..196
                     /product="beta-crystallin A4"
                     /note="beta-A4 crystallin"
                     /calculated_mol_wt=22251
     Region          2..11
                     /region_name="N-terminal arm"
                     /note="propagated from UniProtKB/Swiss-Prot (P56374.2)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylthreonine.
                     /evidence=ECO:0000269|PubMed:11773034; propagated from
                     UniProtKB/Swiss-Prot (P56374.2)"
     Region          13..97
                     /region_name="Crystall"
                     /note="Beta/Gamma crystallin; pfam00030"
                     /db_xref="CDD:459639"
     Region          99..104
                     /region_name="Connecting peptide"
                     /note="propagated from UniProtKB/Swiss-Prot (P56374.2)"
     Region          106..194
                     /region_name="Crystall"
                     /note="Beta/Gamma crystallin; pfam00030"
                     /db_xref="CDD:459639"
     CDS             1..196
                     /gene="Cryba4"
                     /coded_by="NM_031689.1:36..626"
                     /db_xref="GeneID:64348"
                     /db_xref="RGD:61962"
ORIGIN      
        1 mtlqctksag hwrvvvwdee gfqgrrheft aecpsvldlg fetvrslkvl sgawvgfeha
       61 gfqgqqyvle rgdypgwdaw ggntaypaer ltsfrpvaca nhrdsrltif eqenflgrkg
      121 elsddypslq amgwdgtevg sfhvqsgawv csqfpgyrgf qyvlesdhhs gdykhfrewg
      181 shahtfqvqs vrriqq
//
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