LOCUS NP_113877 196 aa linear ROD 30-JUL-2024
DEFINITION beta-crystallin A4 [Rattus norvegicus].
ACCESSION NP_113877
VERSION NP_113877.1
DBSOURCE REFSEQ: accession NM_031689.1
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 196)
AUTHORS Li,W., Ji,Q., Wei,Z., Chen,Y.L., Zhang,Z., Yin,X., Aghmiuni,S.K.,
Liu,M., Chen,W., Shi,L., Chen,Q., Du,X., Yu,L., Cao,M.J., Wang,Z.,
Huang,S., Jin,T. and Wang,Q.
TITLE Biochemical characterization of G64W mutant of acidic
beta-crystallin 4
JOURNAL Exp Eye Res 186, 107712 (2019)
PUBMED 31254514
REFERENCE 2 (residues 1 to 196)
AUTHORS Billingsley,G., Santhiya,S.T., Paterson,A.D., Ogata,K., Wodak,S.,
Hosseini,S.M., Manisastry,S.M., Vijayalakshmi,P., Gopinath,P.M.,
Graw,J. and Heon,E.
TITLE CRYBA4, a novel human cataract gene, is also involved in
microphthalmia
JOURNAL Am J Hum Genet 79 (4), 702-709 (2006)
PUBMED 16960806
REFERENCE 3 (residues 1 to 196)
AUTHORS Lampi,K.J., Shih,M., Ueda,Y., Shearer,T.R. and David,L.L.
TITLE Lens proteomics: analysis of rat crystallin sequences and
two-dimensional electrophoresis map
JOURNAL Invest Ophthalmol Vis Sci 43 (1), 216-224 (2002)
PUBMED 11773034
REFERENCE 4 (residues 1 to 196)
AUTHORS Takeuchi,N. and Kamei,A.
TITLE Crystallin proteins in lenses of hereditary cataractous rat, ICR/f
JOURNAL Biol Pharm Bull 23 (3), 283-290 (2000)
PUBMED 10726880
REFERENCE 5 (residues 1 to 196)
AUTHORS David,L.L. and Shearer,T.R.
TITLE Beta-crystallins insolubilized by calpain II in vitro contain
cleavage sites similar to beta-crystallins insolubilized during
cataract
JOURNAL FEBS Lett 324 (3), 265-270 (1993)
PUBMED 8405363
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AF013247.1.
##Evidence-Data-START##
Transcript exon combination :: AF013247.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN16093047 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..196
/organism="Rattus norvegicus"
/strain="Sprague-Dawley"
/db_xref="taxon:10116"
/chromosome="12"
/map="12q16"
Protein 1..196
/product="beta-crystallin A4"
/note="beta-A4 crystallin"
/calculated_mol_wt=22251
Region 2..11
/region_name="N-terminal arm"
/note="propagated from UniProtKB/Swiss-Prot (P56374.2)"
Site 2
/site_type="acetylation"
/note="N-acetylthreonine.
/evidence=ECO:0000269|PubMed:11773034; propagated from
UniProtKB/Swiss-Prot (P56374.2)"
Region 13..97
/region_name="Crystall"
/note="Beta/Gamma crystallin; pfam00030"
/db_xref="CDD:459639"
Region 99..104
/region_name="Connecting peptide"
/note="propagated from UniProtKB/Swiss-Prot (P56374.2)"
Region 106..194
/region_name="Crystall"
/note="Beta/Gamma crystallin; pfam00030"
/db_xref="CDD:459639"
CDS 1..196
/gene="Cryba4"
/coded_by="NM_031689.1:36..626"
/db_xref="GeneID:64348"
/db_xref="RGD:61962"
ORIGIN
1 mtlqctksag hwrvvvwdee gfqgrrheft aecpsvldlg fetvrslkvl sgawvgfeha
61 gfqgqqyvle rgdypgwdaw ggntaypaer ltsfrpvaca nhrdsrltif eqenflgrkg
121 elsddypslq amgwdgtevg sfhvqsgawv csqfpgyrgf qyvlesdhhs gdykhfrewg
181 shahtfqvqs vrriqq
//