mitogen-activated protein kinase kinase kinase 9 isoform 1 [Homo sapie - Protein

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Protein 3D Structure

Structure of MLK1 kinase domain with leucine zipper 1

PDB: 4UY9

Source: Homo sapiens

Method: X-ray Diffraction

Resolution: 2.81 Å

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Articles about the MAP3K9 gene

Elevation of miR-125b-5p is related to improved prognosis in laryngeal squamous cell carcinoma and inhibits the malignancy and glycometabolic disorder by targeting MAP3K9. [Neoplasma. 2022]
Elevation of miR-125b-5p is related to improved prognosis in laryngeal squamous cell carcinoma and inhibits the malignancy and glycometabolic disorder by targeting MAP3K9.
Chen F, Lao Z, Zhang HY, Wang J, Wang SZ. Neoplasma. 2022 May; 69(3):550-559. Epub 2022 Feb 22.
Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models. [J Med Chem. 2008]
Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models.
Hudkins RL, Diebold JL, Tao M, Josef KA, Park CH, Angeles TS, Aimone LD, Husten J, Ator MA, Meyer SL, et al. J Med Chem. 2008 Sep 25; 51(18):5680-9. Epub 2008 Aug 21.
Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9. [Acta Pharmacol Sin. 2022]
Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9.
Liang L, Xu WY, Shen A, Cen HY, Chen ZJ, Tan L, Zhang LM, Zhang Y, Fu JJ, Qin AP, et al. Acta Pharmacol Sin. 2022 Nov; 43(11):2946-2955. Epub 2022 Apr 6.

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Reference sequence information

RefSeq mRNA
See reference mRNA sequence for the MAP3K9 gene (NM_033141.4).
RefSeq protein isoforms
See 12 reference sequence protein isoforms for the MAP3K9 gene.

More about the MAP3K9 gene

Enables molecular function activator activity and protein serine/threonine kinase activity. Involved in protein autophosphorylation. Predict...
Also Known As: MEKK9, MLK1, PRKE1

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Ensembl [Ensembl]
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mitogen-activated protein kinase kinase kinase 9 protein [Guide to Pharmacology]
mitogen-activated protein kinase kinase kinase 9 protein
Guide to Pharmacology
OncoMX cancer biomarker resource [OncoMX cancer biomarker resou...]
OncoMX cancer biomarker resource
Transcript/Protein Information [PANTHER Classification System]
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reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome

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