U.S. flag

An official website of the United States government

Tyrosine-protein kinase [Caenorhabditis elegans]

NCBI Reference Sequence: NP_494994.1

Identical Proteins FASTA Graphics 

LOCUS       NP_494994                419 aa            linear   INV 04-DEC-2024
DEFINITION  Tyrosine-protein kinase [Caenorhabditis elegans].
ACCESSION   NP_494994
VERSION     NP_494994.1
DBLINK      BioProject: PRJNA158
DBSOURCE    REFSEQ: accession NM_062593.2
KEYWORDS    RefSeq.
SOURCE      Caenorhabditis elegans
  ORGANISM  Caenorhabditis elegans
            Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
            Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
            Caenorhabditis.
REFERENCE   1  (residues 1 to 419)
  AUTHORS   Sulson,J.E. and Waterston,R.
  CONSRTM   Caenorhabditis elegans Sequencing Consortium
  TITLE     Genome sequence of the nematode C. elegans: a platform for
            investigating biology
  JOURNAL   Science 282 (5396), 2012-2018 (1998)
   PUBMED   9851916
  REMARK    Erratum:[Science 1999 Jan 1;283(5398):35]
REFERENCE   2  (residues 1 to 419)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (04-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 419)
  AUTHORS   WormBase.
  CONSRTM   WormBase Consortium
  TITLE     Direct Submission
  JOURNAL   Submitted (17-OCT-2024) WormBase Group, European Bioinformatics
            Institute, Cambridge, CB10 1SA, UK. Email: help@wormbase.org
REFERENCE   4  (residues 1 to 419)
  AUTHORS   Sulson,J.E. and Waterston,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAR-2003) Nematode Sequencing Project: Sanger
            Institute, Hinxton, Cambridge CB10 1SA, UK and The Genome Institute
            at Washington University, St. Louis, MO 63110, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by WormBase. The
            reference sequence is identical to CCD68003.
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Caenorhabditis elegans"
                     /strain="Bristol N2"
                     /db_xref="taxon:6239"
                     /chromosome="II"
     Protein         1..419
                     /product="Tyrosine-protein kinase"
                     /calculated_mol_wt=47771
     Region          25..114
                     /region_name="SH2_Fps_family"
                     /note="Src homology 2 (SH2) domain found in feline
                     sarcoma, Fujinami poultry sarcoma, and fes-related
                     (Fes/Fps/Fer) proteins; cd10361"
                     /db_xref="CDD:198224"
     Site            order(39,55,79,81)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198224"
     Site            order(80,107)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198224"
     Region          138..398
                     /region_name="TyrKc"
                     /note="Tyrosine kinase, catalytic domain; smart00219"
                     /db_xref="CDD:197581"
     Site            order(144..148,152,167,169,218..221,224..225,265,269..270,
                     272,282,302..306,315,349)
                     /site_type="active"
                     /db_xref="CDD:270623"
     Site            order(144..145,147..148,152,167,169,218..221,224..225,
                     269..270,272,282)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270623"
     Site            order(265,269,302..306,315,349)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270623"
     Site            order(281..288,302..308)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270623"
     CDS             1..419
                     /gene="ZK622.1"
                     /locus_tag="CELE_ZK622.1"
                     /standard_name="ZK622.1"
                     /coded_by="NM_062593.2:63..1322"
                     /note="Confirmed by transcript evidence"
                     /db_xref="GeneID:191366"
                     /db_xref="WormBase:WBGene00022780"
ORIGIN      
        1 mqgkqdshra qktveaslrs dgtrkkhqdm dwyhgllpra dintllendg dflvrtshiv
       61 gqdsaktvls vkwkgkchhw qlqekedgsi vieerkfesv ldmvttlrmk rlpvsancpa
      121 lllnpinkqd welrhdqikl gkmlgegafg gvykaafyck gekrmvavkv nkgnekistr
      181 amiedvckea rimrqyqhpn vvcffgvcve kepimlvmel asqgaldsfl kneknnvslr
      241 dklkysfdas kgleylhqhg cihrdvaarn flmhknvvki tdfglskqls dlahkyklkd
      301 iqaklpirwl apevivtaty tfksdvysfg illweifmdg aipypgmkla evkqkvkngy
      361 rmdapdrmpa fvrnimisqc wpqnpedrgn mneirlames vldgkvaasn nrsvyykss
//
Feature
Display: FASTA GenBank Help
Details

Supplemental Content

Change region shown

Customize view

Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the ZK622.1 gene (NM_062593.2).

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
External link. Please review our privacy policy.