LOCUS NP_494994 419 aa linear INV 04-DEC-2024
DEFINITION Tyrosine-protein kinase [Caenorhabditis elegans].
ACCESSION NP_494994
VERSION NP_494994.1
DBLINK BioProject: PRJNA158
DBSOURCE REFSEQ: accession NM_062593.2
KEYWORDS RefSeq.
SOURCE Caenorhabditis elegans
ORGANISM Caenorhabditis elegans
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
REFERENCE 1 (residues 1 to 419)
AUTHORS Sulson,J.E. and Waterston,R.
CONSRTM Caenorhabditis elegans Sequencing Consortium
TITLE Genome sequence of the nematode C. elegans: a platform for
investigating biology
JOURNAL Science 282 (5396), 2012-2018 (1998)
PUBMED 9851916
REMARK Erratum:[Science 1999 Jan 1;283(5398):35]
REFERENCE 2 (residues 1 to 419)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (04-DEC-2024) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 3 (residues 1 to 419)
AUTHORS WormBase.
CONSRTM WormBase Consortium
TITLE Direct Submission
JOURNAL Submitted (17-OCT-2024) WormBase Group, European Bioinformatics
Institute, Cambridge, CB10 1SA, UK. Email: help@wormbase.org
REFERENCE 4 (residues 1 to 419)
AUTHORS Sulson,J.E. and Waterston,R.
TITLE Direct Submission
JOURNAL Submitted (03-MAR-2003) Nematode Sequencing Project: Sanger
Institute, Hinxton, Cambridge CB10 1SA, UK and The Genome Institute
at Washington University, St. Louis, MO 63110, USA
COMMENT REVIEWED REFSEQ: This record has been curated by WormBase. The
reference sequence is identical to CCD68003.
FEATURES Location/Qualifiers
source 1..419
/organism="Caenorhabditis elegans"
/strain="Bristol N2"
/db_xref="taxon:6239"
/chromosome="II"
Protein 1..419
/product="Tyrosine-protein kinase"
/calculated_mol_wt=47771
Region 25..114
/region_name="SH2_Fps_family"
/note="Src homology 2 (SH2) domain found in feline
sarcoma, Fujinami poultry sarcoma, and fes-related
(Fes/Fps/Fer) proteins; cd10361"
/db_xref="CDD:198224"
Site order(39,55,79,81)
/site_type="other"
/note="phosphotyrosine binding pocket [polypeptide
binding]"
/db_xref="CDD:198224"
Site order(80,107)
/site_type="other"
/note="hydrophobic binding pocket [polypeptide binding]"
/db_xref="CDD:198224"
Region 138..398
/region_name="TyrKc"
/note="Tyrosine kinase, catalytic domain; smart00219"
/db_xref="CDD:197581"
Site order(144..148,152,167,169,218..221,224..225,265,269..270,
272,282,302..306,315,349)
/site_type="active"
/db_xref="CDD:270623"
Site order(144..145,147..148,152,167,169,218..221,224..225,
269..270,272,282)
/site_type="other"
/note="ATP binding site [chemical binding]"
/db_xref="CDD:270623"
Site order(265,269,302..306,315,349)
/site_type="other"
/note="polypeptide substrate binding site [polypeptide
binding]"
/db_xref="CDD:270623"
Site order(281..288,302..308)
/site_type="other"
/note="activation loop (A-loop)"
/db_xref="CDD:270623"
CDS 1..419
/gene="ZK622.1"
/locus_tag="CELE_ZK622.1"
/standard_name="ZK622.1"
/coded_by="NM_062593.2:63..1322"
/note="Confirmed by transcript evidence"
/db_xref="GeneID:191366"
/db_xref="WormBase:WBGene00022780"
ORIGIN
1 mqgkqdshra qktveaslrs dgtrkkhqdm dwyhgllpra dintllendg dflvrtshiv
61 gqdsaktvls vkwkgkchhw qlqekedgsi vieerkfesv ldmvttlrmk rlpvsancpa
121 lllnpinkqd welrhdqikl gkmlgegafg gvykaafyck gekrmvavkv nkgnekistr
181 amiedvckea rimrqyqhpn vvcffgvcve kepimlvmel asqgaldsfl kneknnvslr
241 dklkysfdas kgleylhqhg cihrdvaarn flmhknvvki tdfglskqls dlahkyklkd
301 iqaklpirwl apevivtaty tfksdvysfg illweifmdg aipypgmkla evkqkvkngy
361 rmdapdrmpa fvrnimisqc wpqnpedrgn mneirlames vldgkvaasn nrsvyykss
//